{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:30:55Z","timestamp":1792783855834,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":393,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japanese Society for the Promotion of Science","doi-asserted-by":"publisher","award":["F32CA200144"],"award-info":[{"award-number":["F32CA200144"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI063331"],"award-info":[{"award-number":["R01AI063331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK091191"],"award-info":[{"award-number":["R01DK091191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA166879"],"award-info":[{"award-number":["R01CA166879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","award":["Plbio-2012-106"],"award-info":[{"award-number":["Plbio-2012-106"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","award":["AR055398"],"award-info":[{"award-number":["AR055398"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Michigan\u2019s Cancer Center"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.cell.2018.09.047","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T11:01:37Z","timestamp":1541070097000},"page":"1651-1664.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":305,"title":["The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection"],"prefix":"10.1016","volume":"175","author":[{"given":"Hideki","family":"Hara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey S.","family":"Seregin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Fukase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Chamaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad S.","family":"Alnemri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Inohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2018.09.047_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11250","article-title":"NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens","volume":"488","author":"Anand","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.09.047_bib3","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1002\/eji.201545655","article-title":"NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5","volume":"45","author":"Baker","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"Suppl 2","key":"10.1016\/j.cell.2018.09.047_bib4","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1007\/BF01639738","article-title":"Invasiveness and intracellular growth of Listeria monocytogenes","volume":"16","author":"Berche","year":"1988","journal-title":"Infection"},{"key":"10.1016\/j.cell.2018.09.047_bib5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.aaf7419","article-title":"A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion","volume":"352","author":"Birchenough","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/318667a0","article-title":"Selective immortalization of murine macrophages from fresh bone marrow by a raf\/myc recombinant murine retrovirus","volume":"318","author":"Blasi","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib7","first-page":"235","article-title":"Type VII secretion systems in Gram-positive bacteria","volume":"404","author":"Bottai","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","article-title":"Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing","volume":"8","author":"Broz","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2018.09.047_bib9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature11419","article-title":"Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1","volume":"490","author":"Broz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib10","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2014.01.063","article-title":"Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation","volume":"156","author":"Cai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib11","doi-asserted-by":"crossref","first-page":"16183","DOI":"10.1038\/nmicrobiol.2016.183","article-title":"The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria","volume":"2","author":"Cao","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2018.09.047_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection","volume":"200","author":"Carrero","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.09.047_bib13","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.4049\/jimmunol.1100412","article-title":"A functional role for Nlrp6 in intestinal inflammation and tumorigenesis","volume":"186","author":"Chen","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chom.2016.07.018","article-title":"The yersinia virulence factor YopM hijacks host kinases to inhibit type III effector-triggered activation of the pyrin inflammasome","volume":"20","author":"Chung","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2018.09.047_bib15","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1128\/IAI.61.9.3863-3872.1993","article-title":"A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides","volume":"61","author":"Di Padova","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2018.09.047_bib16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1859","article-title":"The AIM2 inflammasome is critical for innate immunity to Francisella tularensis","volume":"11","author":"Fernandes-Alnemri","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ni.2263","article-title":"NLRC4-driven production of IL-1\u03b2 discriminates between pathogenic and commensal bacteria and promotes host intestinal defense","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib19","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1246\/bcsj.65.2643","article-title":"Synthetic study on lipoteichoic acid of Gram-positive bacteria. I. Synthesis of proposed fundamental structure of Streptococcus pyogenes lipoteichoic acid","volume":"65","author":"Fukase","year":"1992","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.cell.2018.09.047_bib20","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.1073\/pnas.0701821104","article-title":"Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus","volume":"104","author":"Gr\u00fcndling","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.09.047_bib21","doi-asserted-by":"crossref","first-page":"34474","DOI":"10.1074\/jbc.M112.401406","article-title":"Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-\u03b2 (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens","volume":"287","author":"Gurung","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.09.047_bib22","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","article-title":"Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock","volume":"341","author":"Hagar","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib23","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.4049\/jimmunol.180.12.7859","article-title":"Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm","volume":"180","author":"Hara","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib24","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2018.09.047_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib27","doi-asserted-by":"crossref","first-page":"e35218","DOI":"10.1371\/journal.pone.0035218","article-title":"Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile","volume":"7","author":"Hertz\u00e9n","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.09.047_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1126\/science.1236381","article-title":"Crystal structure of NLRC4 reveals its autoinhibition mechanism","volume":"341","author":"Hu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib30","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib31","doi-asserted-by":"crossref","first-page":"e7411","DOI":"10.1371\/journal.pone.0007411","article-title":"Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2","volume":"4","author":"Jimenez-Dalmaroni","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.09.047_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib33","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib34","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0928-8244(02)00470-4","article-title":"Production of IL-12 and IL-18 in human dendritic cells upon infection by Listeria monocytogenes","volume":"35","author":"Kolb-M\u00e4urer","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.cell.2018.09.047_bib36","doi-asserted-by":"crossref","first-page":"32956","DOI":"10.1074\/jbc.M104700200","article-title":"Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11","volume":"276","author":"Lee","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.09.047_bib37","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1084\/jem.20180589","article-title":"Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation","volume":"215","author":"Lee","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.09.047_bib38","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1016\/j.celrep.2017.12.026","article-title":"The NLR protein NLRP6 does not impact gut microbiota composition","volume":"21","author":"Lemire","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2018.09.047_bib39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib40","doi-asserted-by":"crossref","first-page":"39920","DOI":"10.1074\/jbc.M007255200","article-title":"Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma","volume":"275","author":"Lin","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.09.047_bib41","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1128\/IAI.01651-07","article-title":"Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18","volume":"76","author":"Lochner","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2018.09.047_bib42","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib43","doi-asserted-by":"crossref","first-page":"11813","DOI":"10.1038\/ncomms11813","article-title":"Crystal structure of NOD2 and its implications in human disease","volume":"7","author":"Maekawa","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2018.09.047_bib44","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.immuni.2015.10.010","article-title":"Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium","volume":"43","author":"Maltez","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.09.047_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.immuni.2017.07.011","article-title":"Nlrp6- and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition","volume":"47","author":"Mamantopoulos","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.09.047_bib46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2016.09.012","article-title":"IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes","volume":"167","author":"Man","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib47","doi-asserted-by":"crossref","first-page":"45126","DOI":"10.1038\/srep45126","article-title":"Differential roles of caspase-1 and caspase-11 in infection and inflammation","volume":"7","author":"Man","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2018.09.047_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2018.09.047_bib49","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1128\/IAI.70.5.2657-2664.2002","article-title":"Listeria monocytogenes infection in caspase-11-deficient mice","volume":"70","author":"Mueller","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2018.09.047_bib50","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"M\u00fcller","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib51","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome","volume":"183","author":"Mu\u00f1oz-Planillo","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.micpath.2016.06.007","article-title":"Intracellularly survived Staphylococcus aureus after phagocytosis are more virulent in inducing cytotoxicity in fresh murine peritoneal macrophages utilizing TLR-2 as a possible target","volume":"97","author":"Nandi","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.cell.2018.09.047_bib53","doi-asserted-by":"crossref","first-page":"9601","DOI":"10.1073\/pnas.1100981108","article-title":"Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury","volume":"108","author":"Normand","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.09.047_bib54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection","volume":"200","author":"O\u2019Connell","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.09.047_bib55","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1080\/21505594.2016.1244589","article-title":"Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in\u00a0vivo infection","volume":"8","author":"Pinheiro","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.cell.2018.09.047_bib56","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.celrep.2014.02.015","article-title":"Caspase-11 controls interleukin-1\u03b2 release through degradation of TRPC1","volume":"6","author":"Py","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2018.09.047_bib57","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2012.07.007","article-title":"TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria","volume":"150","author":"Rathinam","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib58","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.09.047_bib59","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/bbrc.1998.9425","article-title":"Cathepsin B-mediated activation of the proinflammatory caspase-11","volume":"251","author":"Schotte","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2018.09.047_bib60","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib61","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.immuni.2015.03.004","article-title":"Distinct commensals induce interleukin-1\u03b2 via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury","volume":"42","author":"Seo","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.09.047_bib62","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/mi.2016.55","article-title":"NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury","volume":"10","author":"Seregin","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib63","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2017.03.080","article-title":"NLRP6 protects Il10-\/- mice from colitis by limiting colonization of Akkermansia muciniphila","volume":"19","author":"Seregin","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2018.09.047_bib64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib65","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.09.047_bib66","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1002\/eji.201444673","article-title":"The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL-18 production in an inflammasome-dependent and -independent manner","volume":"44","author":"Tsuchiya","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib67","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/intimm\/dxh041","article-title":"Roles of caspase-1 in Listeria infection in mice","volume":"16","author":"Tsuji","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib68","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4049\/jimmunol.174.1.340","article-title":"The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1","volume":"174","author":"Tsuneyoshi","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib69","doi-asserted-by":"crossref","first-page":"20580","DOI":"10.1074\/jbc.271.34.20580","article-title":"Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)\/Ced-3 family and an upstream regulator of ICE","volume":"271","author":"Wang","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.09.047_bib70","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.aab3145","article-title":"Nlrp6 regulates intestinal antiviral innate immunity","volume":"350","author":"Wang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib71","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2958.2009.06829.x","article-title":"Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes","volume":"74","author":"Webb","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2018.09.047_bib72","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.stem.2007.10.002","article-title":"Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer","volume":"2","author":"Welm","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib73","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","article-title":"NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion","volume":"156","author":"Wlodarska","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.09.047_bib74","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1126\/science.1189801","article-title":"c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response","volume":"328","author":"Woodward","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.09.047_bib75","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","article-title":"Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes","volume":"30","author":"Wu","year":"2010","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.cell.2018.09.047_bib76","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1128\/IAI.06162-11","article-title":"Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability","volume":"80","author":"Yamamoto","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2018.09.047_bib77","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aaf3036","article-title":"An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells","volume":"352","author":"Zanoni","year":"2016","journal-title":"Science"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418312595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418312595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T08:06:39Z","timestamp":1605341199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867418312595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0092867418312595"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2018.09.047","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734357156.793560837","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2018.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}