{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:08:34Z","timestamp":1792440514423,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.cell.2018.12.036","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T01:30:28Z","timestamp":1548379828000},"page":"897-912.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":445,"title":["The cis-Regulatory Atlas of the Mouse Immune System"],"prefix":"10.1016","volume":"176","author":[{"given":"Hideyuki","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb A.","family":"Lareau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo N.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Wroblewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Desland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey","family":"Chudnovskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Mortha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Tellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Nabekura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiLin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Robinette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wagers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rhoads","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Nutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mostafavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Buenrostro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2018.12.036_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/biomet\/35.3-4.246","article-title":"The transformation of Poisson, binomial and negative-binomial data","volume":"35","author":"Anscombe","year":"1948","journal-title":"Biometrika"},{"key":"10.1016\/j.cell.2018.12.036_bib2","doi-asserted-by":"crossref","first-page":"10395","DOI":"10.1074\/jbc.M112.437475","article-title":"The SRC family tyrosine kinase HCK and\u00a0the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model","volume":"288","author":"Asai","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.12.036_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature25193","article-title":"A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies","volume":"553","author":"Bahr","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(81)90413-X","article-title":"Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences","volume":"27","author":"Banerji","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/290304a0","article-title":"In\u00a0vivo sequence requirements of the SV40 early promotor region","volume":"290","author":"Benoist","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.molcel.2014.10.014","article-title":"A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin states","volume":"56","author":"Bornstein","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib7","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2018.12.036_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature14590","article-title":"Single-cell chromatin accessibility reveals principles of regulatory variation","volume":"523","author":"Buenrostro","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cub.2015.11.034","article-title":"Shadow enhancers are pervasive features of developmental regulatory networks","volume":"26","author":"Cannav\u00f2","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2018.12.036_bib10","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1101\/gad.259879.115","article-title":"Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1","volume":"29","author":"Champhekar","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2018.12.036_bib11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.cell.2016.10.026","article-title":"Genetic drivers of epigenetic and transcriptional variation in human immune cells","volume":"167","author":"Chen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2008.09.016","article-title":"Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development","volume":"135","author":"Cisse","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib13","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.3646","article-title":"Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution","volume":"48","author":"Corces","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2018.12.036_bib14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41467-017-00769-0","article-title":"Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner","volume":"8","author":"Deczkowska","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2018.12.036_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.immuni.2006.01.012","article-title":"Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells","volume":"24","author":"Delogu","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib16","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1084\/jem.20101158","article-title":"Type\u00a0I interferon is selectively required by dendritic cells for immune rejection of tumors","volume":"208","author":"Diamond","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.12.036_bib17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.molcel.2016.05.018","article-title":"Chromatin domains: the unit of chromosome organization","volume":"62","author":"Dixon","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib18","first-page":"21","article-title":"The role of BTB-zinc finger transcription factors during T\u00a0cell development and in the regulation of T\u00a0cell-mediated immunity","volume":"381","author":"Ellmeier","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.stem.2008.03.004","article-title":"Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence","volume":"2","author":"Ficara","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib21","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1074\/jbc.M117.775304","article-title":"Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease","volume":"292","author":"Fossum","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.12.036_bib22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajhg.2017.06.010","article-title":"CRISPR\/Cas9-mediated scanning for regulatory elements required for HPRT1 expression via thousands of large, programmed genomic deletions","volume":"101","author":"Gasperini","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2018.12.036_bib23","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1084\/jem.20091756","article-title":"The origin and development of nonlymphoid tissue CD103+ DCs","volume":"206","author":"Ginhoux","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.12.036_bib24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib25","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1016\/j.celrep.2016.11.073","article-title":"Inhibition of ROR\u03b3T skews TCR\u03b1 gene rearrangement and limits T\u00a0cell repertoire diversity","volume":"17","author":"Guo","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2018.12.036_bib26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","article-title":"B cell development pathways","volume":"19","author":"Hardy","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib27","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1172\/JCI60659","article-title":"Cross-presenting CD103+ dendritic cells are protected from influenza virus infection","volume":"122","author":"Helft","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2018.12.036_bib28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T\u00a0cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib29","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2016.10.024","article-title":"Insulated neighborhoods: structural and functional units of mammalian gene control","volume":"167","author":"Hnisz","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib30","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1160631","article-title":"Shadow enhancers as a source of evolutionary novelty","volume":"321","author":"Hong","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(01)00153-4","article-title":"Pax5\/BSAP maintains the identity of B cells in late B lymphopoiesis","volume":"14","author":"Horcher","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib32","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.immuni.2018.04.024","article-title":"Transcription factor PU.1 represses and activates gene expression in early T\u00a0cells by redirecting partner transcription factor binding","volume":"48","author":"Hosokawa","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3389\/fimmu.2017.00291","article-title":"Heritable gene regulation in the CD4:CD8 T\u00a0cell lineage choice","volume":"8","author":"Issuree","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib34","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cell.2015.08.008","article-title":"Architectural and functional commonalities between enhancers and promoters","volume":"162","author":"Kim","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ni.3646","article-title":"Guidance of regulatory T\u00a0cell development by Satb1-dependent super-enhancer establishment","volume":"18","author":"Kitagawa","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib36","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ni.3835","article-title":"Different molecular complexes that mediate transcriptional induction and repression by FoxP3","volume":"18","author":"Kwon","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.1256271","article-title":"Immunogenetics. Chromatin state dynamics during blood formation","volume":"345","author":"Lara-Astiaso","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib38","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-385991-4.00005-2","article-title":"Pax5: a master regulator of B cell development and leukemogenesis","volume":"111","author":"Medvedovic","year":"2011","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.immuni.2011.06.013","article-title":"Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors","volume":"35","author":"Mercer","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib41","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/ni.2370","article-title":"Deciphering the transcriptional network of the dendritic cell lineage","volume":"13","author":"Miller","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib42","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2017.08.010","article-title":"An NF-\u03baB transcription-factor-dependent lineage-specific transcriptional program promotes regulatory T\u00a0cell identity and function","volume":"47","author":"Oh","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature25461","article-title":"Enhancer redundancy provides phenotypic robustness in mammalian development","volume":"554","author":"Osterwalder","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nprot.2014.006","article-title":"Full-length RNA-seq from single cells using Smart-seq2","volume":"9","author":"Picelli","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2018.12.036_bib45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.3812","article-title":"MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping","volume":"18","author":"Placek","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib46","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2018.12.036_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri3650","article-title":"FOXP3 and scurfy: how it all began","volume":"14","author":"Ramsdell","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-031210-101345","article-title":"Plasmacytoid dendritic cells: recent progress and open questions","volume":"29","author":"Reizis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib49","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/emboj.2012.155","article-title":"The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis","volume":"31","author":"Revilla-I-Domingo","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2018.12.036_bib50","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Kundaje","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib51","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.1251414","article-title":"The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal","volume":"344","author":"Rosas","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-immunol-032712-100024","article-title":"Transcriptional control of early T and B cell developmental choices","volume":"32","author":"Rothenberg","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cell.2012.06.053","article-title":"Foxp3 exploits a pre-existent enhancer landscape for regulatory T\u00a0cell lineage specification","volume":"151","author":"Samstein","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.12.036_bib54","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2018.12.036_bib55","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.aaa9420","article-title":"MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR\u03b3+ regulatory T\u00a0cells","volume":"349","author":"Sefik","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib56","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11243","article-title":"A map of the cis-regulatory sequences in the mouse genome","volume":"488","author":"Shen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.12.036_bib57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ni.3154","article-title":"Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells","volume":"16","author":"Shi","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib58","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.174.5.2573","article-title":"IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity","volume":"174","author":"Tamura","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib59","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.immuni.2008.09.019","article-title":"The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T\u00a0cells","volume":"29","author":"Wang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2018.12.036_bib60","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.coi.2012.02.002","article-title":"CD4-CD8 differentiation in the thymus: connecting circuits and building memories","volume":"24","author":"Xiong","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib61","doi-asserted-by":"crossref","first-page":"1254665","DOI":"10.1126\/science.1254665","article-title":"Intersection of population variation and autoimmunity genetics in human T\u00a0cell activation","volume":"345","author":"Ye","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.12.036_bib62","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ni.3706","article-title":"Epigenetic landscapes reveal transcription factors that regulate CD8+ T\u00a0cell differentiation","volume":"18","author":"Yu","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib63","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nri3702","article-title":"Developmental gene networks: a triathlon on the course to T\u00a0cell identity","volume":"14","author":"Yui","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2018.12.036_bib64","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature13994","article-title":"Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation","volume":"518","author":"Zabidi","year":"2015","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418316507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418316507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:34:51Z","timestamp":1758800091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867418316507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0092867418316507"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2018.12.036","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cis-Regulatory Atlas of the Mouse Immune System","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2018.12.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}