{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:49:46Z","timestamp":1790797786108,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["5U54HG003067"],"award-info":[{"award-number":["5U54HG003067"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"publisher","award":["U54 HG003079"],"award-info":[{"award-number":["U54 HG003079"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Washington University Cancer Genome Initiative"},{"DOI":"10.13039\/100014571","name":"Siteman Cancer Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014571","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare of Korea","award":["HI16C2387"],"award-info":[{"award-number":["HI16C2387"]}]},{"name":"Ministry of Health & Welfare of Korea","award":["HI17C1836"],"award-info":[{"award-number":["HI17C1836"]}]},{"name":"Suh Kyungbae Foundation","award":["SUHF-18010082"],"award-info":[{"award-number":["SUHF-18010082"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2014R1A2A2A05003665"],"award-info":[{"award-number":["NRF-2014R1A2A2A05003665"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Program 2016"},{"name":"Seoul National University College of Medicine Research Foundation","award":["800-20160251"],"award-info":[{"award-number":["800-20160251"]}]},{"name":"Ludwig Center at Harvard"},{"DOI":"10.13039\/501100003708","name":"Korea Institute of Science and Technology Information","doi-asserted-by":"publisher","award":["K-17-L03-C022"],"award-info":[{"award-number":["K-17-L03-C022"]}],"id":[{"id":"10.13039\/501100003708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry, and Energy","doi-asserted-by":"publisher","award":["10067758"],"award-info":[{"award-number":["10067758"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.cell.2019.05.013","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T10:48:02Z","timestamp":1559213282000},"page":"1842-1857.e21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":195,"title":["Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma"],"prefix":"10.1016","volume":"177","author":[{"given":"Jake June-Koo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongyeol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongkeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junehawk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghwan","family":"Youk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Hyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-4189","authenticated-orcid":false,"given":"Young Seok","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2019.05.013_bib1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/ng.3441","article-title":"Clock-like mutational processes in human somatic cells","volume":"47","author":"Alexandrov","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib3","doi-asserted-by":"crossref","first-page":"eaam8419","DOI":"10.1126\/science.aam8419","article-title":"Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors","volume":"361","author":"Anderson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2019.05.013_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molonc.2011.07.007","article-title":"p53: guardian of ploidy","volume":"5","author":"Aylon","year":"2011","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cell.2019.05.013_bib5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cell.2013.03.021","article-title":"Punctuated evolution of prostate cancer genomes","volume":"153","author":"Baca","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature19768","article-title":"Tissue-specific mutation accumulation in human adult stem cells during life","volume":"538","author":"Blokzijl","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib7","article-title":"Pan-cancer analysis of whole genomes","author":"Campbell","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2019.05.013_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature21386","article-title":"Integrated genomic and molecular characterization of cervical cancer","volume":"543","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib10","doi-asserted-by":"crossref","first-page":"e02482","DOI":"10.7554\/eLife.02482","article-title":"SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint","volume":"3","author":"Carvalho","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.cell.2019.05.013_bib11","doi-asserted-by":"crossref","DOI":"10.1200\/PO.17.00011","article-title":"OncoKB: A precision oncology knowledge base","author":"Chakravarty","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.cell.2019.05.013_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng.2202","article-title":"Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration","volume":"44","author":"Chiang","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2019.05.013_bib14","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1141478","article-title":"MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling","volume":"316","author":"Engelman","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2019.05.013_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/annonc\/mdu479","article-title":"Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data","volume":"26","author":"Favero","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cell.2019.05.013_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2014.09.010","article-title":"The architecture and evolution of cancer neochromosomes","volume":"26","author":"Garsed","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib17","article-title":"The evolutionary history of 2,658 cancers","author":"Gerstung","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2019.05.013_bib18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2012.08.024","article-title":"Genomic landscape of non-small cell lung cancer in smokers and never-smokers","volume":"150","author":"Govindan","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.613","article-title":"Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements","volume":"42","author":"Haffner","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrg3729","article-title":"Mechanisms underlying mutational signatures in human cancers","volume":"15","author":"Helleday","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/PAP.0000000000000162","volume":"24","author":"Hendry","year":"2017","journal-title":"Adv. Anat. Pathol."},{"key":"10.1016\/j.cell.2019.05.013_bib22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","article-title":"The biology and management of non-small cell lung cancer","volume":"553","author":"Herbst","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib23","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.cell.2012.08.029","article-title":"Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing","volume":"150","author":"Imielinski","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib24","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1101\/gad.943001","article-title":"Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras","volume":"15","author":"Jackson","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2019.05.013_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ccr.2013.04.012","article-title":"Oncogenic ERBB3 mutations in human cancers","volume":"23","author":"Jaiswal","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib26","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa1616288","article-title":"Tracking the evolution of non-small-cell lung cancer","volume":"376","author":"Jamal-Hanjani","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ccr.2006.04.022","article-title":"The impact of human EGFR kinase domain mutations on lung tumorigenesis and in\u00a0vivo sensitivity to EGFR-targeted therapies","volume":"9","author":"Ji","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gr.133645.111","article-title":"A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing","volume":"22","author":"Ju","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2019.05.013_bib29","doi-asserted-by":"crossref","first-page":"120ra17","DOI":"10.1126\/scitranslmed.3003316","article-title":"Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers","volume":"4","author":"Katayama","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib30","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/hmg\/ddr073","article-title":"Chromothripsis as a mechanism driving complex de\u00a0novo structural rearrangements in the germline","volume":"20","author":"Kloosterman","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1101\/gr.129684.111","article-title":"VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2019.05.013_bib32","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/modpathol.2015.63","article-title":"Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status","volume":"28","author":"Koh","year":"2015","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.cell.2019.05.013_bib33","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1200\/JCO.2016.71.9096","article-title":"Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas","volume":"35","author":"Lee","year":"2017","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2019.05.013_bib34","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/annonc\/mdw686","article-title":"Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma","volume":"28","author":"Lee","year":"2017","journal-title":"Ann. Oncol."},{"issue":"W1","key":"10.1016\/j.cell.2019.05.013_bib35","doi-asserted-by":"crossref","first-page":"W102","DOI":"10.1093\/nar\/gky406","article-title":"Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures","volume":"46","author":"Lee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2019.05.013_bib36","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.cell.2015.11.054","article-title":"Chromothripsis and kataegis induced by telomere crisis","volume":"163","author":"Maciejowski","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMoa1302736","article-title":"Characterization of uterine leiomyomas by whole-genome sequencing","volume":"369","author":"Mehine","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cell.2018.02.020","article-title":"Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal","volume":"173","author":"Mitchell","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrc2091","article-title":"The impact of translocations and gene fusions on cancer causation","volume":"7","author":"Mitelman","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2019.05.013_bib40","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJMoa0810699","article-title":"Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma","volume":"361","author":"Mok","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib41","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2012.04.023","article-title":"The life history of 21 breast cancers","volume":"149","author":"Nik-Zainal","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib42","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.cell.2016.07.005","article-title":"Dual chromatin and cytoskeletal remodeling by SETD2","volume":"166","author":"Park","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib43","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ccell.2015.09.015","article-title":"Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation","volume":"28","author":"Pfister","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2011.12.013","article-title":"Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations","volume":"148","author":"Rausch","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib45","doi-asserted-by":"crossref","first-page":"i333","DOI":"10.1093\/bioinformatics\/bts378","article-title":"DELLY: structural variant discovery by integrated paired-end and split-read analysis","volume":"28","author":"Rausch","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2019.05.013_bib46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng.3720","article-title":"The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies","volume":"49","author":"Redin","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2019.05.013_bib47","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1158\/0008-5472.CAN-14-3282","article-title":"Development of lung adenocarcinomas with exclusive dependence on oncogene fusions","volume":"75","author":"Saito","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2019.05.013_bib48","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.celrep.2014.04.053","article-title":"Break-induced replication is a source of mutation clusters underlying kataegis","volume":"7","author":"Sakofsky","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2019.05.013_bib49","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.devcel.2017.05.022","article-title":"Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system","volume":"41","author":"Santaguida","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib50","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","article-title":"Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs","volume":"28","author":"Saunders","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2019.05.013_bib51","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1101\/gr.145144.112","article-title":"The transcriptional landscape and mutational profile of lung adenocarcinoma","volume":"22","author":"Seo","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2019.05.013_bib52","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1214886","article-title":"Crizotinib versus chemotherapy in advanced ALK-positive lung cancer","volume":"368","author":"Shaw","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib53","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nrc3612","article-title":"Tyrosine kinase gene rearrangements in epithelial malignancies","volume":"13","author":"Shaw","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2019.05.013_bib54","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa1406766","article-title":"Crizotinib in ROS1-rearranged non-small-cell lung cancer","volume":"371","author":"Shaw","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib55","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2010.11.055","article-title":"Massive genomic rearrangement acquired in a single catastrophic event during cancer development","volume":"144","author":"Stephens","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib57","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nature07943","article-title":"The cancer genome","volume":"458","author":"Stratton","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib58","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrc2190","article-title":"Lung cancer in never smokers--a different disease","volume":"7","author":"Sun","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2019.05.013_bib59","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.aaf9011","article-title":"Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention","volume":"355","author":"Tomasetti","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2019.05.013_bib60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature21356","article-title":"Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity","volume":"543","author":"Turner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib61","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ccell.2017.08.006","article-title":"Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations","volume":"32","author":"Vaz","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib62","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/s41467-018-04492-2","article-title":"Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2019.05.013_bib63","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ccell.2015.02.005","article-title":"A functional landscape of resistance to ALK inhibition in lung cancer","volume":"27","author":"Wilson","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2019.05.013_bib64","doi-asserted-by":"crossref","first-page":"10131","DOI":"10.1038\/ncomms10131","article-title":"Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas","volume":"6","author":"Wu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2019.05.013_bib65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41586-018-0811-x","article-title":"Age-related remodelling of oesophageal epithelia by mutated cancer drivers","volume":"565","author":"Yokoyama","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm.4333","article-title":"Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients","volume":"23","author":"Zehir","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2019.05.013_bib67","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1101\/gad.229559.113","article-title":"Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements","volume":"27","author":"Zhang","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2019.05.013_bib68","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature14493","article-title":"Chromothripsis from DNA damage in micronuclei","volume":"522","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.05.013_bib69","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2016.07.045","article-title":"Multi-organ mapping of cancer risk","volume":"166","author":"Zhu","year":"2016","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867419305112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867419305112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:34:10Z","timestamp":1758800050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867419305112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0092867419305112"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2019.05.013","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2019.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}