{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:49:49Z","timestamp":1792464589141,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.cell.2019.07.033","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T10:41:16Z","timestamp":1565260876000},"page":"1231-1244.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":517,"title":["GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance"],"prefix":"10.1016","volume":"178","author":[{"given":"Harding H.","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon K.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor E.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Ahasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L.","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insoo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Medzhitov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2019.07.033_bib1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-017-00902-5","article-title":"Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide","volume":"7","author":"Abulizi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2019.07.033_bib2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","article-title":"Inflammation and Stroke: An Overview","volume":"13","author":"Anrather","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cell.2019.07.033_bib4","doi-asserted-by":"crossref","first-page":"25050","DOI":"10.1074\/jbc.M401028200","article-title":"Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression","volume":"279","author":"Augustus","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2019.07.033_bib5","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.1074\/jbc.M509890200","article-title":"Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction","volume":"281","author":"Augustus","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2019.07.033_bib6","doi-asserted-by":"crossref","first-page":"e0129305","DOI":"10.1371\/journal.pone.0129305","article-title":"Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis","volume":"10","author":"Avni","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2019.07.033_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-immunol-020711-075030","article-title":"Tolerance of infections","volume":"30","author":"Ayres","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2019.07.033_bib8","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1534\/genetics.107.083782","article-title":"Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection","volume":"178","author":"Ayres","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2019.07.033_bib9","doi-asserted-by":"crossref","first-page":"e002550","DOI":"10.1161\/JAHA.112.002550","article-title":"Growth differentiation factor-15 deficiency inhibits atherosclerosis progression by regulating interleukin-6-dependent inflammatory response to vascular injury","volume":"1","author":"Bonaterra","year":"2012","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.cell.2019.07.033_bib10","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1073\/pnas.94.21.11514","article-title":"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily","volume":"94","author":"Bootcov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2019.07.033_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2337\/db11-1142","article-title":"Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system","volume":"61","author":"Bruinstroop","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2019.07.033_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.26.061505.111258","article-title":"Fuel metabolism in starvation","volume":"26","author":"Cahill","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cell.2019.07.033_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature13490","article-title":"Functional polarization of tumour-associated macrophages by tumour-derived lactic acid","volume":"513","author":"Colegio","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.07.033_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrclinonc.2015.105","article-title":"Inflammation and cancer: advances and new agents","volume":"12","author":"Crusz","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cell.2019.07.033_bib15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.transproceed.2006.12.012","article-title":"Ischemia-reperfusion injury: processes in pathogenetic networks: a review","volume":"39","author":"de Groot","year":"2007","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.cell.2019.07.033_bib16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nrrheum.2014.6","article-title":"Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE","volume":"10","author":"Deane","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cell.2019.07.033_bib17","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/CCM.0000000000000940","article-title":"The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia","volume":"43","author":"Drewry","year":"2015","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cell.2019.07.033_bib18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cell.2019.07.033_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1573403X12666160111125304","article-title":"GDF 15--A Novel Biomarker in the Offing for Heart Failure","volume":"12","author":"George","year":"2016","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.cell.2019.07.033_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","article-title":"Lipid metabolism and toxicity in the heart","volume":"15","author":"Goldberg","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2019.07.033_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cmet.2014.01.017","article-title":"The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries","volume":"19","author":"Goulbourne","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2019.07.033_bib23","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.07.033_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2019.07.033_bib25","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nm1677","article-title":"Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1","volume":"13","author":"Johnen","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/01.RES.0000202805.73038.48","article-title":"The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia\/reperfusion injury","volume":"98","author":"Kempf","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.cell.2019.07.033_bib27","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1073\/pnas.1301996110","article-title":"Role of caspase-1 in regulation of triglyceride metabolism","volume":"110","author":"Kotas","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2019.07.033_bib28","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cell.2019.07.033_bib67","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2019.07.033_bib29","doi-asserted-by":"crossref","first-page":"e34868","DOI":"10.1371\/journal.pone.0034868","article-title":"Macrophage inhibitory cytokine 1 (MIC-1\/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets","volume":"7","author":"Macia","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2019.07.033_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.molmed.2014.01.007","article-title":"Why have clinical trials in sepsis failed?","volume":"20","author":"Marshall","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib31","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"Medzhitov","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2019.07.033_bib32","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates","volume":"23","author":"Mullican","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.shk.0000101667.49265.fd","article-title":"Humane endpoints in shock research","volume":"21","author":"Nemzek","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.cell.2019.07.033_bib34","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0022-2275(20)41116-2","article-title":"Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in\u00a0vivo","volume":"36","author":"Nonogaki","year":"1995","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2019.07.033_bib35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jcrc.2014.04.011","article-title":"Mortality benefit of vasopressor and inotropic agents in septic shock: a Bayesian network meta-analysis of randomized controlled trials","volume":"29","author":"Oba","year":"2014","journal-title":"J.\u00a0Crit. Care"},{"key":"10.1016\/j.cell.2019.07.033_bib36","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1016\/S0264-410X(01)00078-0","article-title":"Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene","volume":"19","author":"Okuda","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2019.07.033_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/0884533614527774","article-title":"Potential influence of intravenous lipids on the outcomes of acute pancreatitis","volume":"29","author":"Patel","year":"2014","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.cell.2019.07.033_bib38","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1001\/jamainternmed.2016.6875","article-title":"Nonfasting Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis","volume":"176","author":"Pedersen","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.cell.2019.07.033_bib39","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jim.2013.03.012","article-title":"Isolation and analysis of single cells from the mouse heart","volume":"393","author":"Pinto","year":"2013","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2019.07.033_bib40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2014.12.124","article-title":"CD36 is indispensable for thermogenesis under conditions of fasting and cold stress","volume":"457","author":"Putri","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2019.07.033_bib41","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1148526","article-title":"Disentangling genetic variation for resistance and tolerance to infectious diseases in animals","volume":"318","author":"R\u00e5berg","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2019.07.033_bib42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2017.01.006","article-title":"Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission","volume":"168","author":"Rao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2014.09.010","article-title":"O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat","volume":"159","author":"Ruan","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib44","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrcardio.2017.33","article-title":"Inflammatory processes in cardiovascular disease: a route to targeted therapies","volume":"14","author":"Ruparelia","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cell.2019.07.033_bib45","series-title":"Twenty years of testing varieties and strains of winter wheat at the Kansas Agricultural Experiment Station","author":"Salmon","year":"1932"},{"key":"10.1016\/j.cell.2019.07.033_bib46","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2018.07.016","article-title":"Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen","volume":"175","author":"Sanchez","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib47","article-title":"CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis","author":"Santos","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2019.07.033_bib48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.py.09.090171.001315","article-title":"Tolerance to plant disease","volume":"9","author":"Schafer","year":"1971","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.cell.2019.07.033_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nri.2016.136","article-title":"Disease tolerance and immunity in host protection against infection","volume":"17","author":"Soares","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2019.07.033_bib50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.physbeh.2011.08.022","article-title":"Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning","volume":"105","author":"Spencer","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.cell.2019.07.033_bib51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cell.2016.02.044","article-title":"AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue","volume":"165","author":"Steculorum","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib52","doi-asserted-by":"crossref","first-page":"13640","DOI":"10.1523\/JNEUROSCI.1133-09.2009","article-title":"Progressive postnatal motoneuron loss in mice lacking GDF-15","volume":"29","author":"Strelau","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2019.07.033_bib53","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1629","article-title":"High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin","volume":"13","author":"Tanno","year":"2007","journal-title":"Nat. Med."},{"issue":"51","key":"10.1016\/j.cell.2019.07.033_bib54","first-page":"2860","article-title":"Cecal ligation puncture procedure","author":"Toscano","year":"2011","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.cell.2019.07.033_bib55","first-page":"R11","article-title":"Nonshivering thermogenesis and the thermogenic capacity of brown fat in fasted and\/or refed mice","volume":"254","author":"Trayhurn","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2019.07.033_bib56","doi-asserted-by":"crossref","first-page":"e55174","DOI":"10.1371\/journal.pone.0055174","article-title":"TGF-b superfamily cytokine MIC-1\/GDF15 is a physiological appetite and body weight regulator","volume":"8","author":"Tsai","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2019.07.033_bib57","doi-asserted-by":"crossref","first-page":"e100370","DOI":"10.1371\/journal.pone.0100370","article-title":"The anorectic actions of the TGF\u03b2 cytokine MIC-1\/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract","volume":"9","author":"Tsai","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2019.07.033_bib58","doi-asserted-by":"crossref","first-page":"e0133362","DOI":"10.1371\/journal.pone.0133362","article-title":"Serum Levels of Human MIC-1\/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2019.07.033_bib59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2019.07.033_bib60","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/mi.2017.3","article-title":"Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure","volume":"10","author":"Verhamme","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cell.2019.07.033_bib61","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","article-title":"Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation","volume":"166","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib62","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2017.05.031","article-title":"Metabolic Adaptation Establishes Disease Tolerance to Sepsis","volume":"169","author":"Weis","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2019.07.033_bib63","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13054-016-1510-3","article-title":"Risk factors, host response and outcome of hypothermic sepsis","volume":"20","author":"Wiewel","year":"2016","journal-title":"Crit. Care"},{"key":"10.1016\/j.cell.2019.07.033_bib64","doi-asserted-by":"crossref","first-page":"L514","DOI":"10.1152\/ajplung.00324.2017","article-title":"Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung","volume":"314","author":"Wu","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2019.07.033_bib65","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.RES.0000202804.84885.d0","article-title":"GDF15\/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation","volume":"98","author":"Xu","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.cell.2019.07.033_bib66","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","volume":"23","author":"Yang","year":"2017","journal-title":"Nat. Med."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867419308323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867419308323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:39:51Z","timestamp":1758800391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867419308323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0092867419308323"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2019.07.033","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736384080.793563748","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2019.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}