{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:54:06Z","timestamp":1790679246617,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002912","name":"Government of Guangdong Province","doi-asserted-by":"publisher","award":["2018B020207013"],"award-info":[{"award-number":["2018B020207013"]}],"id":[{"id":"10.13039\/501100002912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002912","name":"Government of Guangdong Province","doi-asserted-by":"publisher","award":["2020B111108001"],"award-info":[{"award-number":["2020B111108001"]}],"id":[{"id":"10.13039\/501100002912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AI129269"],"award-info":[{"award-number":["RO1 AI129269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AI060699"],"award-info":[{"award-number":["P01 AI060699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2020YFC0841400"],"award-info":[{"award-number":["2020YFC0841400"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10301403"],"award-info":[{"award-number":["2018ZX10301403"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1200100"],"award-info":[{"award-number":["2018YFC1200100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2018B020207013"],"award-info":[{"award-number":["2018B020207013"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2020B111108001"],"award-info":[{"award-number":["2020B111108001"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001024","name":"Roy J. Carver Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.cell.2020.06.010","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T05:01:24Z","timestamp":1591765284000},"page":"734-743.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":447,"title":["Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment"],"prefix":"10.1016","volume":"182","author":[{"given":"Jing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy Lok-Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer N.","family":"Alshukairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfen","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah R.","family":"Leidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiekai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul B.","family":"McCray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-2354","authenticated-orcid":false,"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2020.06.010_bib1","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1128\/JVI.03427-14","article-title":"Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease","volume":"89","author":"Agrawal","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.06.010_bib2","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/sj.gt.3301197","article-title":"A simple method for the rapid generation of recombinant adenovirus vectors","volume":"7","author":"Anderson","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.cell.2020.06.010_bib3","first-page":"7","article-title":"The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice","volume":"2020","author":"Bao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.06.010_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0002-9610(05)80589-6","article-title":"Growth factors and wound healing: Part II. Role in normal and chronic wound healing","volume":"166","author":"Bennett","year":"1993","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.cell.2020.06.010_bib5","article-title":"STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters","author":"Boudewijns","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2020.06.010_bib6","first-page":"ciaa325","article-title":"Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility","author":"Chan","year":"2020","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.cell.2020.06.010_bib7","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunological features of severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2020.06.010_bib8","doi-asserted-by":"crossref","first-page":"16226","DOI":"10.1038\/nmicrobiol.2016.226","article-title":"A mouse model for MERS coronavirus-induced acute respiratory distress syndrome","volume":"2","author":"Cockrell","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2020.06.010_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ng0994-42","article-title":"Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis","volume":"8","author":"Crystal","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2020.06.010_bib10","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1371\/journal.pmed.0030525","article-title":"Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants","volume":"3","author":"Deming","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.cell.2020.06.010_bib11","first-page":"213","article-title":"Platelet-derived growth factor: a multifunctional regulator of normal and abnormal cell growth","volume":"1","author":"Deuel","year":"1988","journal-title":"Biofactors"},{"key":"10.1016\/j.cell.2020.06.010_bib12","doi-asserted-by":"crossref","first-page":"e1000849","DOI":"10.1371\/journal.ppat.1000849","article-title":"SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism","volume":"6","author":"Frieman","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2020.06.010_bib13","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2007016","article-title":"Compassionate Use of Remdesivir for Patients with Severe Covid-19","author":"Grein","year":"2020","journal-title":"New Engl J Med."},{"key":"10.1016\/j.cell.2020.06.010_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.cell.2020.06.011","article-title":"A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies","volume":"182","author":"Hassan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.06.010_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2020.06.010_bib16","first-page":"1","article-title":"glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data","volume":"3","author":"Hutchins","year":"2014","journal-title":"Cell Regen. (Lond.)"},{"key":"10.1016\/j.cell.2020.06.010_bib17","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1128\/JVI.79.23.14614-14621.2005","article-title":"ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia","volume":"79","author":"Jia","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.06.010_bib18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2020.03.023","article-title":"Infection and Rapid Transmission of SARS-CoV-2 in Ferrets","volume":"27","author":"Kim","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2020.06.010_bib19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.06.010_bib20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and Distinct Functions of Type I and Type III Interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2020.06.010_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cell.2020.06.010_bib22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/jiv499","article-title":"Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4","volume":"213","author":"Li","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2020.06.010_bib23","first-page":"E3119","article-title":"Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.06.010_bib24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2020.06.010_bib25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/JVI.02012-06","article-title":"Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus","volume":"81","author":"McCray","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.06.010_bib26","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41374-018-0057-0","article-title":"Principles and approaches for reproducible scoring of tissue stains in research","volume":"98","author":"Meyerholz","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cell.2020.06.010_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm990","article-title":"Genetic, cellular and immune approaches to disease therapy: past and future","volume":"10","author":"Nabel","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2020.06.010_bib28","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2353\/ajpath.2008.071060","article-title":"Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice","volume":"172","author":"Nagata","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2020.06.010_bib29","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1073\/pnas.1510830112","article-title":"Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection","volume":"112","author":"Pascal","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.06.010_bib30","doi-asserted-by":"crossref","first-page":"e20200653","DOI":"10.1084\/jem.20200653","article-title":"COVID-19 and emerging viral infections: The case for interferon lambda","volume":"217","author":"Prokunina-Olsson","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2020.06.010_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"Risso","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cell.2020.06.010_bib32","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.ppat.0030005","article-title":"A mouse-adapted SARS-coronavirus causes disease and mortality in BALB\/c mice","volume":"3","author":"Roberts","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2020.06.010_bib33","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.abb7015","article-title":"Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2","volume":"368","author":"Shi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.06.010_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jcb.240400208","article-title":"Role of growth factors in inflammation and repair","volume":"40","author":"Wahl","year":"1989","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.cell.2020.06.010_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in\u00a0vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2020.06.010_bib36","first-page":"450","article-title":"Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection","volume":"57","author":"Yang","year":"2007","journal-title":"Comp. Med."},{"key":"10.1016\/j.cell.2020.06.010_bib37","first-page":"eabc1560","article-title":"Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir","author":"Yin","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.06.010_bib38","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1128\/JVI.02272-08","article-title":"Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2","volume":"83","author":"Yoshikawa","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.06.010_bib39","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.cell.2020.06.010_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ame2.12108","article-title":"Age-related rhesus macaque models of COVID-19","volume":"3","author":"Yu","year":"2020","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.cell.2020.06.010_bib41","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1128\/JVI.01049-10","article-title":"T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice","volume":"84","author":"Zhao","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.06.010_bib43","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1073\/pnas.1323279111","article-title":"Rapid generation of a mouse model for Middle East respiratory syndrome","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.06.010_bib44","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.immuni.2016.05.006","article-title":"Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses","volume":"44","author":"Zhao","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2020.06.010_bib45","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420307418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420307418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:34:19Z","timestamp":1778664859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867420307418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0092867420307418"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2020.06.010","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.06.011","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}