{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:16:07Z","timestamp":1792206967300,"version":"4.4.0"},"reference-count":104,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":393,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.cell.2020.09.022","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T10:33:36Z","timestamp":1602066816000},"page":"650-665.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens"],"prefix":"10.1016","volume":"183","author":[{"given":"Melissa","family":"Ellermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alline R.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel G.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan M.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian E.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Sperandio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2020.09.022_bib1","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1128\/IAI.70.7.3500-3509.2002","article-title":"Bicarbonate ion stimulates the expression of locus of enterocyte effacement-encoded genes in enterohemorrhagic Escherichia coli O157:H7","volume":"70","author":"Abe","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib2","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1096\/fj.10-176602","article-title":"Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation","volume":"25","author":"Alhouayek","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2020.09.022_bib3","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1016\/j.bmc.2011.04.057","article-title":"New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis","volume":"19","author":"Andrzejak","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cell.2020.09.022_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/msb4100050","article-title":"Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection","volume":"2","author":"Baba","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cell.2020.09.022_bib5","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"71","author":"Barthel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"B\u00e4umler","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.09.022_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.micpath.2007.10.001","article-title":"The role of the QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium","volume":"44","author":"Bearson","year":"2008","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.cell.2020.09.022_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bj3220671","article-title":"Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells","volume":"322","author":"Bisogno","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2020.09.022_bib9","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.chembiol.2007.11.006","article-title":"A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol","volume":"14","author":"Blankman","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.cell.2020.09.022_bib10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.cell.2020.09.022_bib11","doi-asserted-by":"crossref","first-page":"R349","DOI":"10.1152\/ajpregu.00933.2005","article-title":"Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators","volume":"291","author":"Bradshaw","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cell.2020.09.022_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrendo.2015.211","article-title":"Endocannabinoids--at the crossroads between the gut microbiota and host metabolism","volume":"12","author":"Cani","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cell.2020.09.022_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01852-16","article-title":"Catabolite and Oxygen Regulation of Enterohemorrhagic Escherichia coli Virulence","volume":"7","author":"Carlson-Banning","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.cell.2020.09.022_bib14","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/j.1365-2958.2005.04792.x","article-title":"Transcriptional regulation of flhDC by QseBC and sigma (FliA) in enterohaemorrhagic Escherichia coli","volume":"57","author":"Clarke","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib15","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1073\/pnas.0604343103","article-title":"The QseC sensor kinase: a bacterial adrenergic receptor","volume":"103","author":"Clarke","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/BJ20070745","article-title":"Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids","volume":"408","author":"C\u00f4tes","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2020.09.022_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.lfs.2012.06.009","article-title":"Sex differences in cannabinoid pharmacology: a reflection of differences in the endocannabinoid system?","volume":"92","author":"Craft","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.cell.2020.09.022_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chom.2014.11.005","article-title":"The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape","volume":"16","author":"Curtis","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2020.09.022_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02165-14","article-title":"QseC inhibitors as an antivirulence approach for Gram-negative pathogens","volume":"5","author":"Curtis","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.cell.2020.09.022_bib20","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1096\/fj.05-4943fje","article-title":"Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation","volume":"20","author":"D\u2019Argenio","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2020.09.022_bib21","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib22","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1046\/j.1365-2958.1999.01312.x","article-title":"Environmental regulation of Salmonella pathogenicity island 2 gene expression","volume":"31","author":"Deiwick","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib23","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.0400326101","article-title":"Dissecting virulence: systematic and functional analyses of a pathogenicity island","volume":"101","author":"Deng","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0006-2952(93)90486-G","article-title":"Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist","volume":"46","author":"Deutsch","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib25","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.09.022_bib26","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1128\/JB.00261-10","article-title":"A monoacylglycerol lipase from Mycobacterium smegmatis Involved in bacterial cell interaction","volume":"192","author":"Dhouib","year":"2010","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cell.2020.09.022_bib27","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/mi.2011.18","article-title":"The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease","volume":"4","author":"Di Sabatino","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cell.2020.09.022_bib28","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1073\/pnas.152334899","article-title":"Brain monoglyceride lipase participating in endocannabinoid inactivation","volume":"99","author":"Dinh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib29","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1124\/mol.104.002071","article-title":"RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol","volume":"66","author":"Dinh","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib30","doi-asserted-by":"crossref","first-page":"R805","DOI":"10.1152\/ajpregu.00239.2015","article-title":"Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways","volume":"309","author":"DiPatrizio","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cell.2020.09.022_bib31","doi-asserted-by":"crossref","first-page":"49563","DOI":"10.1074\/jbc.R400026200","article-title":"Bacterial long chain fatty acid transport: gateway to a fatty acid-responsive signaling system","volume":"279","author":"Dirusso","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.09.022_bib32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/ml500439x","article-title":"Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis","volume":"6","author":"El Bakali","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.cell.2020.09.022_bib33","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1128\/IAI.68.11.6115-6126.2000","article-title":"The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohemorrhagic Escherichia coli","volume":"68","author":"Elliott","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib34","first-page":"673","article-title":"Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide","volume":"59","author":"Engel","year":"2008","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib35","first-page":"89","article-title":"Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis","volume":"61","author":"Engel","year":"2010","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib36","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/jcs.99.2.283","article-title":"Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells","volume":"99","author":"Finlay","year":"1991","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.09.022_bib38","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1073\/pnas.86.16.6383","article-title":"Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells","volume":"86","author":"Gal\u00e1n","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0014-2999(96)00279-8","article-title":"123I-labeled AM251: a radioiodinated ligand which binds in\u00a0vivo to mouse brain cannabinoid CB1 receptors","volume":"307","author":"Gatley","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fmicb.2011.00149","article-title":"Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue","volume":"2","author":"Geurts","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib41","first-page":"388","article-title":"Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis","volume":"10","author":"Gibson","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/MEG.0000000000000779","article-title":"Role of cannabis in digestive disorders","volume":"29","author":"Goyal","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2020.09.022_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2017.09.001","article-title":"Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice","volume":"67","author":"Guida","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbi.2019.04.006","article-title":"Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain","volume":"85","author":"Guida","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib45","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1365-2958.2011.07660.x","article-title":"A central metabolic circuit controlled by QseC in pathogenic Escherichia coli","volume":"80","author":"Hadjifrangiskou","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib46","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1128\/JB.00345-15","article-title":"Response of Vibrio cholerae to the Catecholamine Hormones Epinephrine and Norepinephrine","volume":"197","author":"Halang","year":"2015","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cell.2020.09.022_bib47","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/IAI.72.2.795-809.2004","article-title":"Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice","volume":"72","author":"Hapfelmeier","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib48","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/nmo.12931","article-title":"The gastrointestinal tract - a central organ of cannabinoid signaling in health and disease","volume":"28","author":"Hasenoehrl","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.cell.2020.09.022_bib49","doi-asserted-by":"crossref","first-page":"e1000553","DOI":"10.1371\/journal.ppat.1000553","article-title":"The QseC adrenergic signaling cascade in Enterohemorrhagic E.\u00a0coli (EHEC)","volume":"5","author":"Hughes","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2020.09.022_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3389\/fimmu.2014.00481","article-title":"Salmonella-host interactions - modulation of the host innate immune system","volume":"5","author":"Hurley","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2020.09.022_bib51","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1073\/pnas.92.17.7996","article-title":"Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation","volume":"92","author":"Jarvis","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib52","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41564-019-0641-0","article-title":"Diet-derived galacturonic acid regulates virulence and intestinal colonization in enterohaemorrhagic Escherichia coli and Citrobacter rodentium","volume":"5","author":"Jimenez","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib54","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1128\/iai.57.4.1290-1298.1989","article-title":"Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli","volume":"57","author":"Knutton","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib55","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1365-2958.2009.06826.x","article-title":"QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli","volume":"73","author":"Kostakioti","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01031-19","article-title":"Indole Signaling at the Host-Microbiota-Pathogen Interface","volume":"10","author":"Kumar","year":"2019","journal-title":"MBio"},{"key":"10.1016\/j.cell.2020.09.022_bib57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1128\/IAI.00131-19","article-title":"Taming the Beast: Interplay between Gut Small Molecules and Enteric Pathogens","volume":"87","author":"Kumar","year":"2019","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2020.05.004","article-title":"The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens","volume":"28","author":"Kumar","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2020.09.022_bib59","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/JB.182.3.771-781.2000","article-title":"OmpR regulates the two-component system SsrA-ssrB in Salmonella pathogenicity island 2","volume":"182","author":"Lee","year":"2000","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cell.2020.09.022_bib61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/MIB.0000000000001004","article-title":"Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review","volume":"23","author":"Leinwand","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.cell.2020.09.022_bib60","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/ecco-jcc\/jjx096","article-title":"Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn\u2019s Disease","volume":"11","author":"Leinwand","year":"2017","journal-title":"J.\u00a0Crohn\u2019s Colitis"},{"key":"10.1016\/j.cell.2020.09.022_bib62","doi-asserted-by":"crossref","first-page":"37447","DOI":"10.1038\/srep37447","article-title":"Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2020.09.022_bib63","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0016-5085(03)00881-3","article-title":"Possible endocannabinoid control of colorectal cancer growth","volume":"125","author":"Ligresti","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2020.09.022_bib64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nchembio.129","article-title":"Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects","volume":"5","author":"Long","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2020.09.022_bib65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1286-4579(01)01387-9","article-title":"Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia","volume":"3","author":"Luperchio","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cell.2020.09.022_bib66","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1194\/jlr.RA119000424","article-title":"Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling","volume":"61","author":"Manca","year":"2020","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2020.09.022_bib67","doi-asserted-by":"crossref","first-page":"e6893","DOI":"10.1371\/journal.pone.0006893","article-title":"Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissue","volume":"4","author":"Marqu\u00e9z","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2020.09.022_bib68","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI200419465","article-title":"The endogenous cannabinoid system protects against colonic inflammation","volume":"113","author":"Massa","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2020.09.022_bib69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib70","doi-asserted-by":"crossref","first-page":"15645","DOI":"10.1038\/s41598-017-15154-6","article-title":"Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity","volume":"7","author":"Mehrpouya-Bahrami","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2020.09.022_bib71","doi-asserted-by":"crossref","first-page":"12387","DOI":"10.1073\/pnas.1919683117","article-title":"l-Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens","volume":"117","author":"Menezes-Garcia","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib72","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1128\/IAI.00803-12","article-title":"Interplay between the QseC and QseE bacterial adrenergic sensor kinases in Salmonella enterica serovar Typhimurium pathogenesis","volume":"80","author":"Moreira","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib73","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/IAI.01038-09","article-title":"QseC mediates Salmonella enterica serovar typhimurium virulence in\u00a0vitro and in\u00a0vivo","volume":"78","author":"Moreira","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib74","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00826-16","article-title":"Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut","volume":"7","author":"Moreira","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.cell.2020.09.022_bib75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41579-019-0252-z","article-title":"Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism","volume":"17","author":"Mullineaux-Sanders","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib76","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.05921-11","article-title":"Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE","volume":"80","author":"Njoroge","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib77","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00280-12","article-title":"Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli","volume":"3","author":"Njoroge","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.cell.2020.09.022_bib78","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1016\/j.bmcl.2008.08.007","article-title":"Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels","volume":"18","author":"Nomura","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cell.2020.09.022_bib79","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2009.11.027","article-title":"Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis","volume":"140","author":"Nomura","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.09.022_bib80","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1209200","article-title":"Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation","volume":"334","author":"Nomura","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.09.022_bib81","doi-asserted-by":"crossref","first-page":"7800","DOI":"10.1073\/pnas.93.15.7800","article-title":"Identification of a pathogenicity island required for Salmonella survival in host cells","volume":"93","author":"Ochman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature11623","article-title":"Fucose sensing regulates bacterial intestinal colonization","volume":"492","author":"Pacheco","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.09.022_bib83","first-page":"134","article-title":"Role of cannabis in inflammatory bowel diseases","volume":"33","author":"Perisetti","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.cell.2020.09.022_bib84","doi-asserted-by":"crossref","first-page":"E10712","DOI":"10.1073\/pnas.1813451115","article-title":"Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut","volume":"115","author":"Pifer","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib85","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbalip.2011.07.006","article-title":"High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography\u2013mass spectrometry","volume":"1811","author":"Quehenberger","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2020.09.022_bib86","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1160354","article-title":"Targeting QseC signaling and virulence for antibiotic development","volume":"321","author":"Rasko","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.09.022_bib87","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/bph.12120","article-title":"The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis","volume":"169","author":"Romano","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib88","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1073\/pnas.1612836114","article-title":"QseC inhibition as an antivirulence approach for colitis-associated bacteria","volume":"114","author":"Rooks","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.09.022_bib89","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S1286-4579(01)01495-2","article-title":"Animal models of Salmonella infections: enteritis versus typhoid fever","volume":"3","author":"Santos","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cell.2020.09.022_bib90","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/j.gastro.2016.10.012","article-title":"Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches","volume":"152","author":"Sartor","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2020.09.022_bib91","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/nn.2616","article-title":"Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system","volume":"13","author":"Schlosburg","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2020.09.022_bib92","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2016.06.008","article-title":"Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation","volume":"59","author":"Shamran","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib93","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1128\/IAI.72.4.2329-2337.2004","article-title":"Modulation of enteropathogenic Escherichia coli virulence by quorum sensing","volume":"72","author":"Sircili","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2020.09.022_bib94","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1365-2958.2002.02803.x","article-title":"Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E.\u00a0coli","volume":"43","author":"Sperandio","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2020.09.022_bib95","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00109-008-0359-6","article-title":"Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors","volume":"86","author":"Storr","year":"2008","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.cell.2020.09.022_bib96","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/3-540-26573-2_11","article-title":"Effects of cannabinoids on neurotransmission","volume":"168","author":"Szabo","year":"2005","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib97","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1111\/bph.13224","article-title":"Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic \u03bc-opioid receptor sensitivity","volume":"172","author":"Taschler","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib98","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/164_2016_105","article-title":"Cannabinoid Receptors in Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance","volume":"239","author":"Taschler","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cell.2020.09.022_bib99","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1189\/jlb.3RU0115-021R","article-title":"Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites","volume":"97","author":"Turcotte","year":"2015","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.cell.2020.09.022_bib100","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s00018-016-2300-4","article-title":"The CB2 receptor and its role as a regulator of inflammation","volume":"73","author":"Turcotte","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2020.09.022_bib101","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1021\/jm020818q","article-title":"Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase","volume":"45","author":"van der Stelt","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2020.09.022_bib102","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.yfrne.2016.01.003","article-title":"Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis","volume":"40","author":"Wagner","year":"2016","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.cell.2020.09.022_bib103","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cca.2015.12.023","article-title":"Simultaneous determination of 8 neurotransmitters and their metabolite levels in rat brain using liquid chromatography in tandem with mass spectrometry: Application to the murine Nrf2 model of depression","volume":"453","author":"Wojnicz","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cell.2020.09.022_bib104","first-page":"5664","article-title":"Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice","volume":"14","author":"Zhao","year":"2017","journal-title":"Exp. Ther. Med."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420311636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420311636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:48:26Z","timestamp":1758800906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867420311636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":104,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0092867420311636"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2020.09.022","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}