{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:22:31Z","timestamp":1792686151323,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009730","name":"Stand Up To Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.cell.2020.10.026","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:34:37Z","timestamp":1605263677000},"page":"1665-1681.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1010,"title":["High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue"],"prefix":"10.1016","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-948X","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-3825","authenticated-orcid":false,"given":"Mingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-8086","authenticated-orcid":false,"given":"Yanxiang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-0180","authenticated-orcid":false,"given":"Graham","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archibald","family":"Enninful","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-6990","authenticated-orcid":false,"given":"Cindy C.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-1631","authenticated-orcid":false,"given":"Toma","family":"Tebaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-9868","authenticated-orcid":false,"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-8166","authenticated-orcid":false,"given":"Dongjoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-3057","authenticated-orcid":false,"given":"Zhiliang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-3471","authenticated-orcid":false,"given":"Eileen","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-0396","authenticated-orcid":false,"given":"Alisia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0084-2470","authenticated-orcid":false,"given":"Jiatong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-4923","authenticated-orcid":false,"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2737-9810","authenticated-orcid":false,"given":"Stephanie","family":"Halene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2020.10.026_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2020.10.026_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2017.01.023","article-title":"eMouseAtlas: An atlas-based resource for understanding mammalian embryogenesis","volume":"423","author":"Armit","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2020.10.026_bib3","doi-asserted-by":"crossref","first-page":"gix131","DOI":"10.1093\/gigascience\/gix131","article-title":"eHistology image and annotation data from the Kaufman Atlas of Mouse Development","volume":"7","author":"Baldock","year":"2018","journal-title":"Gigascience"},{"key":"10.1016\/j.cell.2020.10.026_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41576-019-0129-z","article-title":"Spatial transcriptomics coming of age","volume":"20","author":"Burgess","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2020.10.026_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2020.10.026_bib6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.10.026_bib7","doi-asserted-by":"crossref","first-page":"W305-11","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2020.10.026_bib8","doi-asserted-by":"crossref","first-page":"aaa6090","DOI":"10.1126\/science.aaa6090","article-title":"RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells","volume":"348","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.1253462","article-title":"Spatial and temporal diversity in genomic instability processes defines lung cancer evolution","volume":"346","author":"de Bruin","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib10","first-page":"1512","article-title":"Global signatures of protein and mRNA expression levels","volume":"5","author":"de Sousa Abreu","year":"2009","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.cell.2020.10.026_bib11","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1101\/gad.303123.117","article-title":"Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock","volume":"31","author":"Deschamps","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2020.10.026_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41586-019-1049-y","article-title":"Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH","volume":"568","author":"Eng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.10.026_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(04)00255-7","article-title":"Socializing with the neighbors: stem cells and their niche","volume":"116","author":"Fuchs","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib14","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1039\/b906523g","article-title":"Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates","volume":"9","author":"Gervais","year":"2009","journal-title":"Lab Chip"},{"key":"10.1016\/j.cell.2020.10.026_bib15","doi-asserted-by":"crossref","first-page":"a008391","DOI":"10.1101\/cshperspect.a008391","article-title":"Eye development and retinogenesis","volume":"4","author":"Heavner","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cell.2020.10.026_bib16","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1242\/dev.134866","article-title":"Human haematopoietic stem cell development: from the embryo to the dish","volume":"144","author":"Ivanovs","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.cell.2020.10.026_bib17","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2015.04.044","article-title":"Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells","volume":"161","author":"Klein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/317040a0","article-title":"Spatial and temporal patterns of Kr\u00fcppel gene expression in early Drosophila embryos","volume":"317","author":"Knipple","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.10.026_bib19","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1073\/pnas.88.20.9228","article-title":"A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12","volume":"88","author":"Kwon","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.10.026_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nprot.2014.191","article-title":"Fluorescent in\u00a0situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues","volume":"10","author":"Lee","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2020.10.026_bib21","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1021\/ac400082e","article-title":"High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity","volume":"85","author":"Lu","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cell.2020.10.026_bib22","doi-asserted-by":"crossref","first-page":"E607","DOI":"10.1073\/pnas.1416756112","article-title":"Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands","volume":"112","author":"Lu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.10.026_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nmeth.2892","article-title":"Single-cell in\u00a0situ RNA profiling by sequential hybridization","volume":"11","author":"Lubeck","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.10.026_bib24","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib25","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1242\/dev.02031","article-title":"Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells","volume":"132","author":"Matt","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cell.2020.10.026_bib26","first-page":"03426","article-title":"Umap: Uniform manifold approximation and projection for dimension reduction","volume":"1802","author":"McInnes","year":"2018","journal-title":"arXiv"},{"key":"10.1016\/j.cell.2020.10.026_bib27","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.devcel.2007.10.004","article-title":"Genomic analysis of gastrulation and organogenesis in the mouse","volume":"13","author":"Mitiku","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib28","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1242\/dev.106567","article-title":"The melanocyte lineage in development and disease","volume":"142","author":"Mort","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.cell.2020.10.026_bib29","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/bioinformatics\/btx211","article-title":"ST Pipeline: an automated pipeline for spatial mapping of unique transcripts","volume":"33","author":"Navarro","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2020.10.026_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/d41586-019-02477-9","article-title":"Starfish enterprise: finding RNA patterns in single cells","volume":"572","author":"Perkel","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.10.026_bib31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.12688\/f1000research.11290.1","article-title":"Gene length and detection bias in single cell RNA sequencing protocols","volume":"6","author":"Phipson","year":"2017","journal-title":"F1000Res."},{"key":"10.1016\/j.cell.2020.10.026_bib32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molcel.2018.07.022","article-title":"A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges","volume":"71","author":"Pichon","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-019-0933-9","article-title":"A single-cell molecular map of mouse gastrulation and early organogenesis","volume":"566","author":"Pijuan-Sala","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.10.026_bib34","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaw1219","article-title":"Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution","volume":"363","author":"Rodriques","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2014.02.013","article-title":"Nice neighborhood: emerging concepts of the stem cell niche","volume":"157","author":"Scadden","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib36","doi-asserted-by":"crossref","first-page":"44447","DOI":"10.1038\/srep44447","article-title":"Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding","volume":"7","author":"Shahi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2020.10.026_bib37","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1126\/science.1162782","article-title":"Origin of stem cells in organogenesis","volume":"322","author":"Slack","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib38","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.037341","article-title":"Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis","volume":"136","author":"Smith","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cell.2020.10.026_bib39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics","volume":"353","author":"St\u00e5hl","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib40","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nmeth.4380","article-title":"Simultaneous epitope and transcriptome measurement in single cells","volume":"14","author":"Stoeckius","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.10.026_bib41","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.10.026_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.4636","article-title":"SpatialDE: identification of spatially variable genes","volume":"15","author":"Svensson","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.10.026_bib43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mee.2014.10.013","article-title":"Lab-on-a-chip devices: How to close and plug the lab?","volume":"132","author":"Temiz","year":"2015","journal-title":"Microelectron. Eng."},{"key":"10.1016\/j.cell.2020.10.026_bib44","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/nprot.2017.030","article-title":"mRNA quantification using single-molecule FISH in Drosophila embryos","volume":"12","author":"Trcek","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2020.10.026_bib45","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cels.2018.03.009","article-title":"Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions","volume":"6","author":"van Vliet","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2020.10.026_bib46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in\u00a0situ tissue profiling","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.10.026_bib47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2020.10.026_bib48","doi-asserted-by":"crossref","first-page":"eaat5691","DOI":"10.1126\/science.aat5691","article-title":"Three-dimensional intact-tissue sequencing of single-cell transcriptional states","volume":"361","author":"Wang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1134966","article-title":"Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B","volume":"315","author":"Yudushkin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.10.026_bib50","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1242\/dev.041202","article-title":"Lhx2 links the intrinsic and extrinsic factors that control optic cup formation","volume":"136","author":"Yun","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cell.2020.10.026_bib51","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/dev.129.19.4435","article-title":"BMP signaling is required for development of the ciliary body","volume":"129","author":"Zhao","year":"2002","journal-title":"Development"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420313908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420313908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:48:00Z","timestamp":1758800880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867420313908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0092867420313908"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2020.10.026","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/788992","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}