{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:16:25Z","timestamp":1792412185727,"version":"4.4.0"},"reference-count":146,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZX1402"],"award-info":[{"award-number":["01ZX1402"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031A426B"],"award-info":[{"award-number":["031A426B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009980","name":"Medizinische Universit\u00e4t Innsbruck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALT-755-2018"],"award-info":[{"award-number":["ALT-755-2018"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej","doi-asserted-by":"publisher","award":["POIR.04.04.00-00-5CBE\/17-00"],"award-info":[{"award-number":["POIR.04.04.00-00-5CBE\/17-00"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH 1358\/3-1"],"award-info":[{"award-number":["TH 1358\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GSC-4"],"award-info":[{"award-number":["GSC-4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012360","name":"Heart of England NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000296","name":"British Skin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["757729"],"award-info":[{"award-number":["757729"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C32\/18\/067"],"award-info":[{"award-number":["C32\/18\/067"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32608"],"award-info":[{"award-number":["P32608"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["DK W11"],"award-info":[{"award-number":["DK W11"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014107","name":"Stichting TSC Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cell.2020.12.024","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T10:37:04Z","timestamp":1611571024000},"page":"655-674.e27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":159,"title":["G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling"],"prefix":"10.1016","volume":"184","author":[{"given":"Mirja Tamara","family":"Prentzell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-4222","authenticated-orcid":false,"given":"Ulrike","family":"Rehbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-0023","authenticated-orcid":false,"given":"Marti","family":"Cadena Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-5816","authenticated-orcid":false,"given":"Ann-Sofie","family":"De Meulemeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Baumeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Broh\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Berdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-9969","authenticated-orcid":false,"given":"Mathias","family":"Bockwoldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvagata Roy","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-7726","authenticated-orcid":false,"given":"Constantinos","family":"Demetriades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-8488","authenticated-orcid":false,"given":"Gianluca","family":"Figlia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Eca Guimaraes","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-8707","authenticated-orcid":false,"given":"Alexander M.","family":"Heberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Heiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Holzwarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-2120","authenticated-orcid":false,"given":"Lukas A.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-7865","authenticated-orcid":false,"given":"Jacek","family":"Jaworski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Kopach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor I.","family":"Korolchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineke","family":"van 't Land-Kuper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matylda","family":"Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nellist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Palm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-4249","authenticated-orcid":false,"given":"Stefan","family":"Pusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-5394","authenticated-orcid":false,"given":"Jose Miguel","family":"Ramos Pittol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Reil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Reintjes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-2348","authenticated-orcid":false,"given":"Julian R.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00eb","family":"Scheldeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Siekierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Stefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio A.","family":"Teleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5285","authenticated-orcid":false,"given":"Laura E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-3075","authenticated-orcid":false,"given":"Omar","family":"Torres-Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Trump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-6534","authenticated-orcid":false,"given":"Hannah D.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-9567","authenticated-orcid":false,"given":"Peter","family":"de Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Woltering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-0673","authenticated-orcid":false,"given":"Teodor E.","family":"Yordanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-8732","authenticated-orcid":false,"given":"Justyna","family":"Zmorzynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane A.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Thedieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2020.12.024_bib1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nmeth.2434","article-title":"Whole-brain functional imaging at cellular resolution using light-sheet microscopy","volume":"10","author":"Ahrens","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbamcr.2018.09.001","article-title":"Rasputin a decade on and more promiscuous than ever? A review of G3BPs","volume":"1866","author":"Alam","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cell.2020.12.024_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/humu.22529","article-title":"TBC1D7 mutations are associated with intellectual disability, macrocrania, patellar dislocation, and celiac disease","volume":"35","author":"Alfaiz","year":"2014","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cell.2020.12.024_bib4","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1242\/jcs.115.16.3227","article-title":"Stressful initiations","volume":"115","author":"Anderson","year":"2002","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.bbagrm.2014.11.009","article-title":"Stress granules, P-bodies and cancer","volume":"1849","author":"Anderson","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2020.12.024_bib6","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1038\/s41598-019-46237-1","article-title":"G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10","volume":"9","author":"Anisimov","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2020.12.024_bib7","doi-asserted-by":"crossref","first-page":"e29024","DOI":"10.1371\/journal.pone.0029024","article-title":"Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1","volume":"6","author":"Annibaldi","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2020.12.024_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ajhg.2014.08.013","article-title":"De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies","volume":"95","author":"Appenzeller","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2020.12.024_bib9","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1038\/sj.onc.1205962","article-title":"Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration","volume":"21","author":"Astrinidis","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2020.12.024_bib10","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1038\/sj.onc.1209882","article-title":"Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase","volume":"25","author":"Avruch","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2020.12.024_bib11","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1038\/ncomms3410","article-title":"Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment","volume":"4","author":"Baraban","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201306041","article-title":"Where is mTOR and what is it doing there?","volume":"203","author":"Betz","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib13","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1242\/jcs.084046","article-title":"Arginine methylation of G3BP1 in response to Wnt3a regulates \u03b2-catenin mRNA","volume":"124","author":"Bikkavilli","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib14","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1093\/nar\/gku1275","article-title":"Stress granules are dispensable for mRNA stabilization during cellular stress","volume":"43","author":"Bley","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2020.12.024_bib15","doi-asserted-by":"crossref","first-page":"15957","DOI":"10.1073\/pnas.1902346116","article-title":"Identification of evolutionary and kinetic drivers of NAD-dependent signaling","volume":"116","author":"Bockwoldt","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.12.024_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-4632.2010.04727.x","article-title":"Tuberous sclerosis complex: tumors and tumorigenesis","volume":"50","author":"Borkowska","year":"2011","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.cell.2020.12.024_bib17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/ejn.13595","article-title":"Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation\/inhibition imbalance","volume":"47","author":"Bozzi","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cell.2020.12.024_bib18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3390\/cells8101199","article-title":"Defective Excitatory\/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome","volume":"8","author":"Brenet","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cell.2020.12.024_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cell.2020.12.024_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jmedgenet-2013-101680","article-title":"Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly","volume":"50","author":"Capo-Chichi","year":"2013","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.cell.2020.12.024_bib21","doi-asserted-by":"crossref","first-page":"e11058","DOI":"10.7554\/eLife.11058","article-title":"Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity","volume":"5","author":"Carroll","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cell.2020.12.024_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bios.2009.06.008","article-title":"A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions","volume":"25","author":"Chu","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cell.2020.12.024_bib23","doi-asserted-by":"crossref","first-page":"jcs222570","DOI":"10.1242\/jcs.222570","article-title":"Nutrient regulation of mTORC1 at a glance","volume":"132","author":"Condon","year":"2019","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib24","doi-asserted-by":"crossref","first-page":"a022442","DOI":"10.1101\/cshperspect.a022442","article-title":"mTOR signaling in epilepsy: insights from malformations of cortical development","volume":"5","author":"Crino","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.cell.2020.12.024_bib25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneurol.2016.81","article-title":"The mTOR signalling cascade: paving new roads to cure neurological disease","volume":"12","author":"Crino","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cell.2020.12.024_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1586\/14737175.8.3.457","article-title":"Management of epilepsy in tuberous sclerosis complex","volume":"8","author":"Curatolo","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.cell.2020.12.024_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13039-017-0328-2","article-title":"Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes","volume":"10","author":"Debaize","year":"2017","journal-title":"Mol. Cytogenet."},{"key":"10.1016\/j.cell.2020.12.024_bib28","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cell.2014.01.024","article-title":"Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2","volume":"156","author":"Demetriades","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib29","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1038\/ncomms10662","article-title":"Lysosomal recruitment of TSC2 is a universal response to cellular stress","volume":"7","author":"Demetriades","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2012.06.009","article-title":"TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1","volume":"47","author":"Dibble","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib31","first-page":"2641","article-title":"G3BP1 contributes to tumor metastasis via upregulation of Slug expression in hepatocellular carcinoma","volume":"6","author":"Dou","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cell.2020.12.024_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.cell.2020.12.024_bib33","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.str.2013.08.001","article-title":"From sequence and forces to structure, function, and evolution of intrinsically disordered proteins","volume":"21","author":"Forman-Kay","year":"2013","journal-title":"Structure"},{"key":"10.1016\/j.cell.2020.12.024_bib34","doi-asserted-by":"crossref","first-page":"R371","DOI":"10.1016\/j.cub.2010.02.039","article-title":"Circuit neuroscience in zebrafish","volume":"20","author":"Friedrich","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib35","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1128\/MCB.18.7.3956","article-title":"A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability","volume":"18","author":"Gallouzi","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib36","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1101\/gad.901101","article-title":"TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth","volume":"15","author":"Gao","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2020.12.024_bib37","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cell.2020.12.024_bib38","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","article-title":"Insulin activation of Rheb, a mediator of mTOR\/S6K\/4E-BP signaling, is inhibited by TSC1 and 2","volume":"11","author":"Garami","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2144\/000113083","article-title":"TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays","volume":"46","author":"Geb\u00e4ck","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.cell.2020.12.024_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ccr.2006.08.007","article-title":"Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival","volume":"10","author":"Ghosh","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1165\/rcmb.2005-0374OC","article-title":"Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis","volume":"34","author":"Goncharova","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib42","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1158\/2159-8290.CD-13-0929","article-title":"A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity","volume":"4","author":"Grabiner","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2020.12.024_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cell.2020.03.049","article-title":"RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation","volume":"181","author":"Guill\u00e9n-Boixet","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients","volume":"123","author":"Gy\u00f6rffy","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.cell.2020.12.024_bib45","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.str.2020.05.008","article-title":"Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations","volume":"28","author":"Hansmann","year":"2020","journal-title":"Structure"},{"key":"10.1016\/j.cell.2020.12.024_bib46","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800257","article-title":"The PI3K and MAPK\/p38 pathways control stress granule assembly in a hierarchical manner","volume":"2","author":"Heberle","year":"2019","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.cell.2020.12.024_bib47","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.bpj.2018.10.022","article-title":"Can a Charged Surfactant Unfold an Uncharged Protein?","volume":"115","author":"H\u00f8jgaard","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.cell.2020.12.024_bib48","doi-asserted-by":"crossref","first-page":"26089","DOI":"10.1074\/jbc.M504045200","article-title":"Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase","volume":"280","author":"Holz","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2019","journal-title":"Nat. Rev. Cancer."},{"key":"10.1016\/j.cell.2020.12.024_bib50","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S1097-2765(02)00496-3","article-title":"Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation","volume":"9","author":"Hu","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1-TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2020.12.024_bib52","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1128\/MCB.00289-08","article-title":"The TSC1-TSC2 complex is required for proper activation of mTOR complex 2","volume":"28","author":"Huang","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneumeth.2017.05.024","article-title":"Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy","volume":"287","author":"Hunyadi","year":"2017","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib55","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2020.12.024_bib56","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib57","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1387\/ijdb.041893ki","article-title":"Rasputin, more promiscuous than ever: a review of G3BP","volume":"48","author":"Irvine","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib58","first-page":"5166","article-title":"The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals","volume":"126","author":"Jedrusik-Bode","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib59","doi-asserted-by":"crossref","first-page":"107908","DOI":"10.1016\/j.neuropharm.2019.107908","article-title":"Modifying genetic epilepsies - Results from studies on tuberous sclerosis complex","volume":"166","author":"Jozwiak","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cell.2020.12.024_bib60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0076-6879(07)31005-7","article-title":"Mammalian stress granules and processing bodies","volume":"431","author":"Kedersha","year":"2007","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cell.2020.12.024_bib61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1083\/jcb.201508028","article-title":"G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits","volume":"212","author":"Kedersha","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib62","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1073\/pnas.1910834117","article-title":"TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex","volume":"117","author":"Kedra","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.12.024_bib63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/jcb.1277","article-title":"Characterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies","volume":"84","author":"Kennedy","year":"2001","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.cell.2020.12.024_bib64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3940(96)13021-4","article-title":"Zebrafish elav\/HuC homologue as a very early neuronal marker","volume":"216","author":"Kim","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cell.2020.12.024_bib66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dmm.005587","article-title":"Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin","volume":"4","author":"Kim","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.cell.2020.12.024_bib67","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","author":"Koboldt","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2020.12.024_bib68","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ebiom.2014.12.011","article-title":"mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?","volume":"2","author":"Kwiatkowski","year":"2014","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cell.2020.12.024_bib69","doi-asserted-by":"crossref","first-page":"35402","DOI":"10.1074\/jbc.M204163200","article-title":"Beta 1\/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy","volume":"277","author":"Lavoie","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib70","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2019.08.050","article-title":"RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether","volume":"179","author":"Liao","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib71","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/ijms19051544","article-title":"Role of mTOR Complexes in Neurogenesis","volume":"19","author":"LiCausi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib72","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib73","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Long","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib74","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","article-title":"Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis","volume":"121","author":"Ma","year":"2005","journal-title":"Cell"},{"issue":"W1","key":"10.1016\/j.cell.2020.12.024_bib75","doi-asserted-by":"crossref","first-page":"W636","DOI":"10.1093\/nar\/gkz268","article-title":"The EMBL-EBI search and sequence analysis tools APIs in 2019","volume":"47","author":"Madeira","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2020.12.024_bib76","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1385\/NMM:8:4:531","article-title":"The neurobiology of the tuberous sclerosis complex","volume":"8","author":"Marcotte","year":"2006","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.cell.2020.12.024_bib77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/nan.12463","article-title":"Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy","volume":"44","author":"Marsan","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.cell.2020.12.024_bib78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/jnc.12189","article-title":"Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons","volume":"125","author":"Martin","year":"2013","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.cell.2020.12.024_bib79","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/gtc.12023","article-title":"Both G3BP1 and G3BP2 contribute to stress granule formation","volume":"18","author":"Matsuki","year":"2013","journal-title":"Genes Cells"},{"key":"10.1016\/j.cell.2020.12.024_bib80","doi-asserted-by":"crossref","first-page":"e2005970","DOI":"10.1371\/journal.pbio.2005970","article-title":"CellProfiler 3.0: Next-generation image processing for biology","volume":"16","author":"McQuin","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib81","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2013.11.049","article-title":"Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome","volume":"156","author":"Menon","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib82","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1158\/1078-0432.CCR-11-2123","article-title":"PIK3CA\/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors","volume":"18","author":"Meric-Bernstam","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2020.12.024_bib83","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/s41467-019-09954-9","article-title":"Impaired cortico-striatal excitatory transmission triggers epilepsy","volume":"10","author":"Miyamoto","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib84","series-title":"Regulation of the mammalian target of rapamycin complex 2 (mTORC2). PhD thesis","author":"Molle","year":"2006"},{"key":"10.1016\/j.cell.2020.12.024_bib85","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","article-title":"mTOR signalling and cellular metabolism are mutual determinants in cancer","volume":"18","author":"Mossmann","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2020.12.024_bib86","series-title":"Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics","author":"Mueller","year":"2015"},{"key":"10.1016\/j.cell.2020.12.024_bib87","first-page":"521","article-title":"New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives","volume":"235","author":"M\u00fchlebner","year":"2019","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.cell.2020.12.024_bib88","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.274.50.35647","article-title":"Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin","volume":"274","author":"Nellist","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib89","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1089\/zeb.2015.1085","article-title":"Transgenic Zebrafish Expressing mCherry in the Mitochondria of Dopaminergic Neurons","volume":"12","author":"Noble","year":"2015","journal-title":"Zebrafish"},{"key":"10.1016\/j.cell.2020.12.024_bib90","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1038\/s41467-020-18734-9","article-title":"G3BP1 controls the senescence-associated secretome and its impact on cancer progression","volume":"11","author":"Omer","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib91","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1749-6632.2009.05117.x","article-title":"The tuberous sclerosis complex","volume":"1184","author":"Orlova","year":"2010","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib92","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1083\/jcb.201801214","article-title":"Phosphorylation of G3BP1-S149 does not influence stress granule assembly","volume":"218","author":"Panas","year":"2019","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib93","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1128\/MCB.16.6.2561","article-title":"A Ras-GTPase-activating protein SH3-domain-binding protein","volume":"16","author":"Parker","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib94","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncir.2013.00063","article-title":"The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function","volume":"7","author":"Parker","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.cell.2020.12.024_bib95","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1(-\/-)\/S6K2(-\/-) mice exhibit perinatal lethality and rapamycin-sensitive 5\u2032-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway","volume":"24","author":"Pende","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib96","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(01)00333-6","article-title":"Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size","volume":"105","author":"Potter","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib97","doi-asserted-by":"crossref","first-page":"36441","DOI":"10.1074\/jbc.M004751200","article-title":"IkappaBalpha and IkappaBalpha \/NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2","volume":"275","author":"Prigent","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib98","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3390\/ijms19030818","article-title":"mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome","volume":"19","author":"Rabanal-Ruiz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib99","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2020.12.024_bib100","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/JVI.02791-14","article-title":"The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses","volume":"89","author":"Reineke","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2020.12.024_bib101","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bcp.2018.10.009","article-title":"Differences between acute and chronic stress granules, and how these differences may impact function in human disease","volume":"162","author":"Reineke","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cell.2020.12.024_bib102","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.242487","article-title":"Mammalian stress granules and P bodies at a glance","volume":"133","author":"Riggs","year":"2020","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib103","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1038\/sj.onc.1206776","article-title":"Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38","volume":"22","author":"Rosner","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2020.12.024_bib104","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib105","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1523\/JNEUROSCI.5500-11.2012","article-title":"Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity","volume":"32","author":"Satou","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2020.12.024_bib106","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.nbd.2017.09.004","article-title":"mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis","volume":"108","author":"Scheldeman","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cell.2020.12.024_bib107","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib108","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib109","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1074\/mcp.M114.045807","article-title":"Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate","volume":"14","author":"Schwarz","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2020.12.024_bib110","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/s41418-018-0076-9","article-title":"The mTOR-S6 kinase pathway promotes stress granule assembly","volume":"25","author":"Sfakianos","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2020.12.024_bib111","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2020.12.024_bib112","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1074\/jbc.AC119.007382","article-title":"Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases","volume":"294","author":"Shen","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib113","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41467-018-07953-w","article-title":"Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish","volume":"10","author":"Siekierska","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib114","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/acschemneuro.5b00342","article-title":"Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model","volume":"7","author":"Sourbron","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cell.2020.12.024_bib115","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2016.11.017","article-title":"Molecular neurobiology of mTOR","volume":"341","author":"Switon","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2020.12.024_bib116","doi-asserted-by":"crossref","first-page":"49322","DOI":"10.18632\/oncotarget.10337","article-title":"Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients","volume":"7","author":"Sz\u00e1sz","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cell.2020.12.024_bib117","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","article-title":"The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation","volume":"105","author":"Tapon","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib118","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/ijms19030880","article-title":"The Target of Rapamycin and Mechanisms of Cell Growth","volume":"19","author":"Tee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib119","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.semcdb.2016.01.040","article-title":"The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex","volume":"52","author":"Tee","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib121","doi-asserted-by":"crossref","first-page":"e1217","DOI":"10.1371\/journal.pone.0001217","article-title":"PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis","volume":"2","author":"Thedieck","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2020.12.024_bib122","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2013.07.031","article-title":"Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells","volume":"154","author":"Thedieck","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib123","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2015.01.026","article-title":"TSC1 activates TGF-\u03b2-Smad2\/3 signaling in growth arrest and epithelial-to-mesenchymal transition","volume":"32","author":"Thien","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib124","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: An open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.cell.2020.12.024_bib125","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.200212128","article-title":"The RasGAP-associated endoribonuclease G3BP assembles stress granules","volume":"160","author":"Tourri\u00e8re","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib126","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","article-title":"Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products","volume":"7","author":"van Slegtenhorst","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2020.12.024_bib127","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/2159-8290.CD-13-0353","article-title":"Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib","volume":"4","author":"Wagle","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2020.12.024_bib128","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/bbrc.1997.7273","article-title":"p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase","volume":"238","author":"Wang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2020.12.024_bib129","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41419-018-0504-2","article-title":"G3BP1 promotes tumor progression and metastasis through IL-6\/G3BP1\/STAT3 signaling axis in renal cell carcinomas","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2020.12.024_bib130","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1073\/pnas.1314469111","article-title":"mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy","volume":"111","author":"Weiler","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.12.024_bib131","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.chom.2007.08.006","article-title":"Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase","volume":"2","author":"White","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2020.12.024_bib132","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1476-4598-12-156","article-title":"Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells","volume":"12","author":"Winslow","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cell.2020.12.024_bib133","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cell.2013.01.033","article-title":"Dual specificity kinase DYRK3 couples stress granule condensation\/dissolution to mTORC1 signaling","volume":"152","author":"Wippich","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib134","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","first-page":"1241","article-title":"mTOR and Epileptogenesis in Developmental Brain Malformations","author":"Wong","year":"2012"},{"key":"10.1016\/j.cell.2020.12.024_bib135","doi-asserted-by":"crossref","first-page":"31501","DOI":"10.1074\/jbc.M111.233122","article-title":"Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation","volume":"286","author":"Wu","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2020.12.024_bib136","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib137","doi-asserted-by":"crossref","first-page":"e1004763","DOI":"10.1371\/journal.pgen.1004763","article-title":"Stress granule-defective mutants deregulate stress responsive transcripts","volume":"10","author":"Yang","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2020.12.024_bib138","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cell.2020.03.046","article-title":"G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules","volume":"181","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib139","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2020.08.006","article-title":"The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction","volume":"55","author":"Yang","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2020.12.024_bib140","doi-asserted-by":"crossref","first-page":"e79765","DOI":"10.1371\/journal.pone.0079765","article-title":"Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings","volume":"8","author":"Zdebik","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2020.12.024_bib141","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1128\/MCB.25.19.8703-8716.2005","article-title":"Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP","volume":"25","author":"Zekri","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib142","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib143","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1349-7006.2012.02361.x","article-title":"GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplaitin-mediated cytotoxicity to colon carcinoma HCT116 cells","volume":"103","author":"Zhang","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cell.2020.12.024_bib144","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/ncb2822","article-title":"A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS","volume":"15","author":"Zhang","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2020.12.024_bib145","doi-asserted-by":"crossref","first-page":"17039","DOI":"10.18632\/oncotarget.3636","article-title":"Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cell.2020.12.024_bib146","doi-asserted-by":"crossref","first-page":"e0125898","DOI":"10.1371\/journal.pone.0125898","article-title":"Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2020.12.024_bib147","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/1061186X.2018.1523415","article-title":"The roles and mechanisms of G3BP1 in tumour promotion","volume":"27","author":"Zhang","year":"2019","journal-title":"J.\u00a0Drug Target."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420316949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420316949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:14:14Z","timestamp":1777475654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867420316949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":146,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0092867420316949"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2020.12.024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.16.044081","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}