{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:16:03Z","timestamp":1791342963290,"version":"4.3.1"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI135995-02"],"award-info":[{"award-number":["U19AI135995-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CIVIC5N93019C00052"],"award-info":[{"award-number":["CIVIC5N93019C00052"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01CA260476 \\u2013 01"],"award-info":[{"award-number":["1U01CA260476 \\u2013 01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI42790-01"],"award-info":[{"award-number":["U19AI42790-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006919","name":"Massachusetts Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007301","name":"Harvard University Center for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-001650"],"award-info":[{"award-number":["INV-001650"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1146996"],"award-info":[{"award-number":["OPP1146996"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["3R37AI080289-11S1"],"award-info":[{"award-number":["3R37AI080289-11S1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI146785"],"award-info":[{"award-number":["R01AI146785"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cell.2020.12.027","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T21:46:23Z","timestamp":1608673583000},"page":"628-642.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":210,"title":["Compromised SARS-CoV-2-specific placental antibody transfer"],"prefix":"10.1016","volume":"184","author":[{"given":"Caroline","family":"Atyeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Pullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan A.","family":"Bordt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fischinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlin","family":"Michell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Slein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Loos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia L.","family":"Shook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline A.","family":"Boatin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Yockey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pepin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Charlotte","family":"Meinsohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Minh Phuong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Chauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drucilla","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona T.","family":"Goldfarb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Matute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn E.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lael M.","family":"Yonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Bebell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali J.","family":"Kaimal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Lauffenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Edlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2020.12.027_bib1","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1016\/j.vaccine.2014.08.038","article-title":"The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - a prospective study","volume":"32","author":"Abu Raya","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2020.12.027_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jim.2010.12.016","article-title":"A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples","volume":"366","author":"Ackerman","year":"2011","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2020.12.027_bib3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI65708","article-title":"Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity","volume":"123","author":"Ackerman","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2020.12.027_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.smim.2018.05.003","article-title":"Antibody glycosylation in inflammation, disease and vaccination","volume":"39","author":"Alter","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-0040-1710050","article-title":"Severe COVID-19 during Pregnancy and Possible Vertical Transmission","volume":"37","author":"Alzamora","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.cell.2020.12.027_bib6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/infdis\/jiv401","article-title":"Impact of placental malaria and hypergammaglobulinemia on transplacental transfer of respiratory syncytial virus antibody in Papua New Guinea","volume":"213","author":"Atwell","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2020.12.027_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.immuni.2020.07.020","article-title":"Distinct Early Serological Signatures Track with SARS-CoV-2 Survival","volume":"53","author":"Atyeo","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2020.12.027_bib8","first-page":"401","article-title":"Transport of maternal immunoglobulins through the human placental barrier in normal pregnancy and during inflammation","volume":"16","author":"Ben-Hur","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cell.2020.12.027_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.15585\/mmwr.mm6914e4","article-title":"Coronavirus Disease 2019 in Children \u2014 United States, February 12\u2013April 2, 2020","volume":"69","author":"Bialek","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.cell.2020.12.027_bib10","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1021\/pr400589m","article-title":"Association between galactosylation of immunoglobulin G and improvement of rheumatoid arthritis during pregnancy is independent of sialylation","volume":"12","author":"Bondt","year":"2013","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.cell.2020.12.027_bib11","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.1073\/pnas.2004325117","article-title":"FcRn, but not Fc\u03bbcRn, but not Fc\"\\\"\"galactosylation of immunoglobulin G and improvement of","volume":"117","author":"Borghi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2020.12.027_bib12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1172\/JCI129520","article-title":"Selective induction of antibody effector functional responses using MF59-adjuvanted vaccination","volume":"130","author":"Boudreau","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2020.12.027_bib13","doi-asserted-by":"crossref","first-page":"100118","DOI":"10.1016\/j.ajogmf.2020.100118","article-title":"Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals","volume":"2","author":"Breslin","year":"2020","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"10.1016\/j.cell.2020.12.027_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jim.2017.01.010","article-title":"Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles","volume":"443","author":"Brown","year":"2017","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2020.12.027_bib15","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1001\/jama.2020.8707","article-title":"Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults","volume":"323","author":"Bunyavanich","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2020.12.027_bib16","doi-asserted-by":"crossref","first-page":"e0007246","DOI":"10.1371\/journal.pntd.0007246","article-title":"Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil","volume":"13","author":"Castanha","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cell.2020.12.027_bib17","unstructured":"CDC. (2020). Data on COVID-19 during Pregnancy. Available at: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/cases-updates\/special-populations\/pregnancy-data-on-covid-19.html (Accessed: 13 December 2020)."},{"key":"10.1016\/j.cell.2020.12.027_bib18","article-title":"Symptomatic SARS-CoV-2 infections display specific IgG Fc structures","author":"Chakraborty","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.cell.2020.12.027_bib19","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cell.2015.10.027","article-title":"Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology","volume":"163","author":"Chung","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.027_bib20","doi-asserted-by":"crossref","first-page":"e13288","DOI":"10.1111\/aji.13288","article-title":"Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika-specific antibodies","volume":"84","author":"Collier","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1086\/519845","article-title":"Maternal HIV infection and placental malaria reduce transplacental antibody transfer and tetanus antibody levels in newborns in Kenya","volume":"196","author":"Cumberland","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2020.12.027_bib23","doi-asserted-by":"crossref","first-page":"e20200702","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among children in China","volume":"145","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.cell.2020.12.027_bib24","doi-asserted-by":"crossref","first-page":"e2030455","DOI":"10.1001\/jamanetworkopen.2020.30455","article-title":"Assessment of maternal and neonatal SARS-CoV-2 viral load, transplacental antibody transfer, and placental pathology in pregnancies during the COVID-19 pandemic","volume":"3","author":"Edlow","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cell.2020.12.027_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.15585\/mmwr.mm6925a1","article-title":"Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status \u2014 United States, January 22\u2013June 7, 2020","volume":"69","author":"Ellington","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"issue":"Suppl 1","key":"10.1016\/j.cell.2020.12.027_bib26","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.jcpa.2007.04.006","article-title":"The influence of maternal immunization on infant immune responses","volume":"137","author":"Englund","year":"2007","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.cell.2020.12.027_bib27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/01.qai.0000168179.68781.95","article-title":"High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody","volume":"40","author":"Farquhar","year":"2005","journal-title":"J.\u00a0Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.cell.2020.12.027_bib28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. Children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2020.12.027_bib29","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/intimm\/13.8.993","article-title":"The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of \u03b3-globulin in humans","volume":"13","author":"Firan","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib30","doi-asserted-by":"crossref","first-page":"112630","DOI":"10.1016\/j.jim.2019.07.002","article-title":"A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation","volume":"473","author":"Fischinger","year":"2019","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2020.12.027_bib31","first-page":"ciaa1411","article-title":"Infant Outcomes Following Maternal Infection with SARS-CoV-2: First Report from the PRIORITY Study","author":"Flaherman","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cell.2020.12.027_bib32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4049\/immunohorizons.1700057","article-title":"The Impact of IgG transplacental transfer on early life immunity","volume":"2","author":"Fouda","year":"2018","journal-title":"Immunohorizons"},{"issue":"Suppl 1","key":"10.1016\/j.cell.2020.12.027_bib33","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/S0163-4453(17)30205-0","article-title":"Development of respiratory syncytial virus (RSV) vaccines for infants","volume":"74","author":"Gerretsen","year":"2017","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.cell.2020.12.027_bib34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/AOG.0000000000004005","article-title":"Prevalence and severity of coronavirus disease 2019 (COVID-19) illness in symptomatic pregnant and postpartum women stratified by hispanic ethnicity","volume":"136","author":"Goldfarb","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cell.2020.12.027_bib35","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0950268899002046","article-title":"Transplacental transfer of measles and total IgG","volume":"122","author":"Gon\u00e7alves","year":"1999","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.cell.2020.12.027_bib36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/INF.0b013e318193ead7","article-title":"Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns","volume":"28","author":"Heininger","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.cell.2020.12.027_bib37","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1172\/JCI139569","article-title":"SARS-CoV-2 infection of the placenta","volume":"130","author":"Hosier","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2020.12.027_bib39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cell.2019.05.044","article-title":"Fc Glycan-Mediated Regulation of Placental Antibody Transfer","volume":"178","author":"Jennewein","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.027_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jim.2019.05.006","article-title":"A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis","volume":"471","author":"Karsten","year":"2019","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2020.12.027_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3164\/jcbn.21.57","article-title":"Glycosylation and placental transport of immunoglobulin G","volume":"21","author":"Kibe","year":"1996","journal-title":"J.\u00a0Clin. Biochem. Nutr."},{"key":"10.1016\/j.cell.2020.12.027_bib42","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.15585\/mmwr.mm6932e3","article-title":"Hospitalization Rates and Characteristics of Children Aged\u00a0< 18 Years Hospitalized with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1\u2013July 25, 2020","volume":"69","author":"Kim","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.cell.2020.12.027_bib44","doi-asserted-by":"crossref","first-page":"e1008303","DOI":"10.1371\/journal.ppat.1008303","article-title":"Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection","volume":"16","author":"Langel","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2020.12.027_bib45","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.4049\/jimmunol.157.8.3317","article-title":"Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport","volume":"157","author":"Leach","year":"1996","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib46","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00431-020-03684-7","article-title":"SARS-COV-2 infection in children and newborns: a systematic review","volume":"179","author":"Liguoro","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.cell.2020.12.027_bib47","doi-asserted-by":"crossref","first-page":"103122","DOI":"10.1016\/j.jri.2020.103122","article-title":"Why are pregnant women susceptible to COVID-19? An immunological viewpoint","volume":"139","author":"Liu","year":"2020","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib48","doi-asserted-by":"crossref","first-page":"e1005456","DOI":"10.1371\/journal.ppat.1005456","article-title":"Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination","volume":"12","author":"Mahan","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2020.12.027_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cell.2019.05.046","article-title":"Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women","volume":"178","author":"Martinez","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2020.12.027_bib50","first-page":"e102","article-title":"Cardiovascular disease, drug therapy, and mortality in COVID-19","volume":"382","author":"Mehra","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2020.12.027_bib51","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpeds.2020.06.047","article-title":"SARS-CoV-2 Infection in Infants Less than 90 Days Old","volume":"224","author":"Mithal","year":"2020","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.cell.2020.12.027_bib52","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1001\/jama.2014.3633","article-title":"Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial","volume":"311","author":"Munoz","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2020.12.027_bib53","article-title":"Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans","author":"Ng","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2020.12.027_bib54","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1128\/CVI.00270-15","article-title":"Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pregnancy","volume":"22","author":"Ogolla","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib55","first-page":"59","article-title":"Influence of placental malaria infection and maternal hypergammaglobulinaemia on materno-foetal transfer of measles and tetanus antibodies in a rural west African population","volume":"19","author":"Okoko","year":"2001","journal-title":"J.\u00a0Health Popul. Nutr."},{"key":"10.1016\/j.cell.2020.12.027_bib56","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fped.2020.00294","article-title":"SARS-CoV-2 Infection and the Newborn","volume":"8","author":"Oval\u0131","year":"2020","journal-title":"Front Pediatr."},{"key":"10.1016\/j.cell.2020.12.027_bib57","doi-asserted-by":"crossref","first-page":"985646","DOI":"10.1155\/2012\/985646","article-title":"IgG placental transfer in healthy and pathological pregnancies","volume":"2012","author":"Palmeira","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib58","doi-asserted-by":"crossref","first-page":"100145","DOI":"10.1016\/j.ajogmf.2020.100145","article-title":"Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth","volume":"2","author":"Patan\u00e8","year":"2020","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"10.1016\/j.cell.2020.12.027_bib59","doi-asserted-by":"crossref","first-page":"100133","DOI":"10.1016\/j.ajogmf.2020.100133","article-title":"Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples","volume":"2","author":"Penfield","year":"2020","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"10.1016\/j.cell.2020.12.027_bib60","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jinf.2004.10.003","article-title":"Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers","volume":"51","author":"Perret","year":"2005","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.cell.2020.12.027_bib61","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ni.2939","article-title":"Type I and type II Fc receptors regulate innate and adaptive immunity","volume":"15","author":"Pincetic","year":"2014","journal-title":"Nat. Immunol."},{"issue":"3, Suppl","key":"10.1016\/j.cell.2020.12.027_bib62","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2012.06.068","article-title":"Effects of influenza on pregnant women and infants","volume":"207","author":"Rasmussen","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cell.2020.12.027_bib63","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jinf.2019.02.012","article-title":"Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study","volume":"78","author":"Reeves","year":"2019","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.cell.2020.12.027_bib64","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area","volume":"323","author":"Richardson","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2020.12.027_bib66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12874-020-01102-y","article-title":"Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled","volume":"20","author":"Shook","year":"2020","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.cell.2020.12.027_bib67","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/eji.1830260718","article-title":"An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta","volume":"26","author":"Simister","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib68","doi-asserted-by":"crossref","first-page":"e0007648","DOI":"10.1371\/journal.pntd.0007648","article-title":"Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy","volume":"13","author":"Singh","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cell.2020.12.027_bib69","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1080\/19420862.2016.1218586","article-title":"The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc \u03b3 receptor","volume":"8","author":"Subedi","year":"2016","journal-title":"MAbs"},{"key":"10.1016\/j.cell.2020.12.027_bib70","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMc2009316","article-title":"Universal screening for SARS-CoV-2 in women admitted for delivery","volume":"382","author":"Sutton","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2020.12.027_bib71","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1186\/ar2892","article-title":"Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study","volume":"11","author":"van de Geijn","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cell.2020.12.027_bib72","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib73","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2020.12.027_bib74","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1001\/jama.2020.7197","article-title":"Variation in COVID-19 Hospitalizations and Deaths Across New York City Boroughs","volume":"323","author":"Wadhera","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2020.12.027_bib75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11306-009-0185-z","article-title":"Multivariate paired data analysis: multilevel PLSDA versus OPLSDA","volume":"6","author":"Westerhuis","year":"2010","journal-title":"Metabolomics"},{"key":"10.1016\/j.cell.2020.12.027_bib76","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3389\/fimmu.2017.01294","article-title":"Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy","volume":"8","author":"Wilcox","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2020.12.027_bib77","doi-asserted-by":"crossref","first-page":"104356","DOI":"10.1016\/j.jcv.2020.104356","article-title":"Clinical characteristics and risk assessment of newborns born to mothers with COVID-19","volume":"127","author":"Yang","year":"2020","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.cell.2020.12.027_bib78","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ppul.24748","article-title":"Lessons unfolding from pediatric cases of COVID-19 disease caused by SARS-CoV-2 infection","volume":"55","author":"Yonker","year":"2020","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.cell.2020.12.027_bib79","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1056\/NEJMoa0708630","article-title":"Effectiveness of maternal influenza immunization in mothers and infants","volume":"359","author":"Zaman","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2020.12.027_bib81","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jamapediatrics.2020.0878","article-title":"Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China","volume":"174","author":"Zeng","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.cell.2020.12.027_bib82","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and variable selection via the elastic net","volume":"67","author":"Zou","year":"2005","journal-title":"J.\u00a0R. Stat. Soc. Series B Stat. Methodol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420317499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867420317499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:13:55Z","timestamp":1777475635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867420317499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0092867420317499"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2020.12.027","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compromised SARS-CoV-2-specific placental antibody transfer","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}