{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:22:20Z","timestamp":1771474940855,"version":"3.50.1"},"reference-count":8,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD078641"],"award-info":[{"award-number":["R01HD078641"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["209451"],"award-info":[{"award-number":["209451"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRU326"],"award-info":[{"award-number":["CRU326"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["918-15-667"],"award-info":[{"award-number":["918-15-667"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.cell.2021.03.001","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T23:30:27Z","timestamp":1618529427000},"page":"1941-1942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lack of evidence for a role of PIWIL1 variants in human male infertility"],"prefix":"10.1016","volume":"184","author":[{"given":"M.S.","family":"Oud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Volozonoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kliesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nagirnaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gilissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.","family":"O\u2019Bryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.I.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.I.","family":"Aston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"T\u00fcttelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.F.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Veltman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2021.03.001_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1534-5807(02)00165-X","article-title":"miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis","volume":"2","author":"Deng","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2021.03.001_bib2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/cr.2014.41","article-title":"Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis","volume":"24","author":"Gou","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2021.03.001_bib3","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2017.04.034","article-title":"Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis","volume":"169","author":"Gou","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.001_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.03.001_bib5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ajhg.2017.08.004","article-title":"Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes","volume":"101","author":"Lelieveld","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2021.03.001_bib6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/humrep\/dez022","article-title":"A systematic review and standardized clinical validity assessment of male infertility genes","volume":"34","author":"Oud","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cell.2021.03.001_bib7","first-page":"12","article-title":"Disorders of spermatogenesis: Perspectives for novel genetic diagnostics after 20 years of unchanged routine","volume":"30","author":"T\u00fcttelmann","year":"2018","journal-title":"Med Genet."},{"key":"10.1016\/j.cell.2021.03.001_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.devcel.2012.12.006","article-title":"piRNA-triggered MIWI ubiquitination and removal by APC\/C in late spermatogenesis","volume":"24","author":"Zhao","year":"2013","journal-title":"Dev. Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421002865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421002865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:51:30Z","timestamp":1758801090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421002865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0092867421002865"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.03.001","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lack of evidence for a role of PIWIL1 variants in human male infertility","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2017.04.034","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.03.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}