{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:22:34Z","timestamp":1792797754889,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP2MH107056"],"award-info":[{"award-number":["DP2MH107056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01NS013522"],"award-info":[{"award-number":["U01NS013522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01NS090604"],"award-info":[{"award-number":["U01NS090604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH101214"],"award-info":[{"award-number":["R01MH101214"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01NS103571"],"award-info":[{"award-number":["U01NS103571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21MH126073"],"award-info":[{"award-number":["R21MH126073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM128997"],"award-info":[{"award-number":["R01GM128997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH12478"],"award-info":[{"award-number":["R01MH12478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017117","name":"Denali Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","award":["T32GM113770"],"award-info":[{"award-number":["T32GM113770"]}],"id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","award":["5T32GM099608"],"award-info":[{"award-number":["5T32GM099608"]}],"id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["AAZ-A-154"],"award-info":[{"award-number":["AAZ-A-154"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.cell.2021.03.043","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T11:40:04Z","timestamp":1619610004000},"page":"2779-2792.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Psychedelic-inspired drug discovery using an engineered biosensor"],"prefix":"10.1016","volume":"184","author":[{"given":"Chunyang","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee E.","family":"Dunlap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxemiliano V.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Wook","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Azinfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Chan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Wetsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2, Suppl","key":"10.1016\/j.cell.2021.03.043_bib1","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1016\/S0893-133X(98)00135-3","article-title":"Serotonin and hallucinogens","volume":"21","author":"Aghajanian","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cell.2021.03.043_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00702-005-0386-1","article-title":"Lisuride treatment of restless legs syndrome: first studies with monotherapy in de novo patients and in combination with levodopa in advanced disease","volume":"113","author":"Benes","year":"2006","journal-title":"J.\u00a0Neural Transm. (Vienna)"},{"key":"10.1016\/j.cell.2021.03.043_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1124\/mol.54.1.94","article-title":"Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus","volume":"54","author":"Berg","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cell.2021.03.043_bib4","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1021\/jm000339w","article-title":"Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines","volume":"43","author":"Blair","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2021.03.043_bib5","series-title":"Biochemical Approaches for Glutamatergic Neurotransmission","first-page":"117","article-title":"Imaging Glutamate with Genetically Encoded Fluorescent Sensors","author":"Broussard","year":"2018"},{"key":"10.1016\/j.cell.2021.03.043_bib6","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acschemneuro.8b00134","article-title":"Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression","volume":"9","author":"Cameron","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib7","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1021\/acschemneuro.8b00692","article-title":"Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents","volume":"10","author":"Cameron","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-020-3008-z","article-title":"A non-hallucinogenic psychedelic analogue with therapeutic potential","volume":"589","author":"Cameron","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.03.043_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.03.043_bib10","doi-asserted-by":"crossref","first-page":"116715","DOI":"10.1016\/j.jns.2020.116715","article-title":"A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses","volume":"411","author":"Chi","year":"2020","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.cell.2021.03.043_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2008.07.040","article-title":"Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq\/11 activation and calcium mobilisation in CHO cells","volume":"594","author":"Cussac","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cell.2021.03.043_bib12","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1021\/acschemneuro.8b00155","article-title":"Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine","volume":"9","author":"Dunlap","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/acs.jmedchem.9b01404","article-title":"Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies","volume":"63","author":"Dunlap","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2021.03.043_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mol.63.1.36","article-title":"Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy","volume":"63","author":"Ebersole","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cell.2021.03.043_bib15","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2011.09.055","article-title":"Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs","volume":"147","author":"Fribourg","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.043_bib16","doi-asserted-by":"crossref","first-page":"10520","DOI":"10.1523\/JNEUROSCI.4388-06.2007","article-title":"Vmat2 heterozygous mutant mice display a depressive-like phenotype","volume":"27","author":"Fukui","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0014-2999(83)90196-6","article-title":"DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines","volume":"86","author":"Glennon","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cell.2021.03.043_bib18","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1523\/JNEUROSCI.23-26-08836.2003","article-title":"Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex","volume":"23","author":"Gonz\u00e1lez-Maeso","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","article-title":"Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior","volume":"53","author":"Gonz\u00e1lez-Maeso","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2021.03.043_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","article-title":"Identification of a serotonin\/glutamate receptor complex implicated in psychosis","volume":"452","author":"Gonz\u00e1lez-Maeso","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.03.043_bib21","doi-asserted-by":"crossref","first-page":"107933","DOI":"10.1016\/j.neuropharm.2019.107933","article-title":"Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species","volume":"167","author":"Halberstadt","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cell.2021.03.043_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/cn300138m","article-title":"Animal models of serotonergic psychedelics","volume":"4","author":"Hanks","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib23","series-title":"Mood and Anxiety Related Phenotypes in Mice","first-page":"85","article-title":"The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants","author":"Hasco\u00ebt","year":"2009"},{"key":"10.1016\/j.cell.2021.03.043_bib24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2021.03.043_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41594-017-0011-7","article-title":"Structure and dynamics of GPCR signaling complexes","volume":"25","author":"Hilger","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2021.03.043_bib26","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1523\/JNEUROSCI.1171-11.2011","article-title":"Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in\u00a0vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time","volume":"31","author":"Huot","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature12000","article-title":"Conformational biosensors reveal GPCR signalling from endosomes","volume":"495","author":"Irannejad","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.03.043_bib28","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1021\/jm00342a019","article-title":"Synthesis and Pharmacological Activity of Fluorinated Tryptamine Derivatives","volume":"6","author":"Kalir","year":"1963","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2021.03.043_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1124\/pr.108.000992","article-title":"Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery","volume":"62","author":"Kenakin","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cell.2021.03.043_bib30","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.cell.2020.08.024","article-title":"Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor","volume":"182","author":"Kim","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.043_bib31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nn.4293","article-title":"Serotonin modulates spike probability in the axon initial segment through HCN channels","volume":"19","author":"Ko","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib32","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/nn.3256","article-title":"Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number","volume":"15","author":"Kwon","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.03.043_bib34","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.celrep.2018.05.022","article-title":"Psychedelics Promote Structural and Functional Neural Plasticity","volume":"23","author":"Ly","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2021.03.043_bib35","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1039\/b900750d","article-title":"Microwave-promoted mono-N-alkylation of aromatic amines in water: A new efficient and green method for an old and problematic reaction","volume":"11","author":"Marzaro","year":"2009","journal-title":"Green Chem."},{"key":"10.1016\/j.cell.2021.03.043_bib36","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/S0957-4166(01)00442-6","article-title":"A new convenient approach to chiral \u03b2-aryl(heteroaryl)alkylamines","volume":"12","author":"Nenajdenko","year":"2001","journal-title":"Tetrahedron Asymmetry"},{"key":"10.1016\/j.cell.2021.03.043_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.aaf5206","article-title":"De novo synaptogenesis induced by GABA in the developing mouse cortex","volume":"353","author":"Oh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.03.043_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41589-020-0535-8","article-title":"TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome","volume":"16","author":"Olsen","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2021.03.043_bib39","article-title":"Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics","volume":"12","author":"Olson","year":"2018","journal-title":"J.\u00a0Exp. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib40","article-title":"The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects","author":"Olson","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.cell.2021.03.043_bib41","doi-asserted-by":"crossref","first-page":"eaat4422","DOI":"10.1126\/science.aat4422","article-title":"Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors","volume":"360","author":"Patriarchi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.03.043_bib42","doi-asserted-by":"crossref","first-page":"e35082","DOI":"10.7554\/eLife.35082","article-title":"Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor","volume":"7","author":"Preller","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cell.2021.03.043_bib43","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nprot.2010.181","article-title":"Circular polymerase extension cloning for high-throughput cloning of complex and combinatorial DNA libraries","volume":"6","author":"Quan","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2021.03.043_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-3057(01)00720-1","article-title":"5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens","volume":"72","author":"Rabin","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.cell.2021.03.043_bib45","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2018.07.043","article-title":"Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems","volume":"175","author":"Ren","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.043_bib46","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nchembio.2490","article-title":"Discovery of new GPCR ligands to illuminate new biology","volume":"13","author":"Roth","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2021.03.043_bib47","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1523\/JNEUROSCI.1665-10.2010","article-title":"Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a \u00df-arrestin2\/Src\/Akt signaling complex in\u00a0vivo","volume":"30","author":"Schmid","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib48","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1073\/pnas.0708862105","article-title":"Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in\u00a0vivo","volume":"105","author":"Schmid","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.03.043_bib49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/med.21318","article-title":"Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective","volume":"34","author":"Shonberg","year":"2014","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cell.2021.03.043_bib50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1248\/cpb.49.87","article-title":"The chemistry of indoles. CIII. Simple syntheses of serotonin, N-methylserotonin, bufotenine, 5-methoxy-N-methyltryptamine, bufobutanoic acid, N-(indol-3-yl)methyl-5-methoxy-N-methyltryptamine, and lespedamine based on 1-hydroxyindole chemistry","volume":"49","author":"Somei","year":"2001","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.cell.2021.03.043_bib51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(01)02286-4","article-title":"A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels","volume":"493","author":"Stockklausner","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2021.03.043_bib52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","article-title":"A simple method for organotypic cultures of nervous tissue","volume":"37","author":"Stoppini","year":"1991","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.cell.2021.03.043_bib53","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1016\/j.tet.2007.07.012","article-title":"An organo-catalytic approach to the enantioselective synthesis of (R)-selegiline","volume":"63","author":"Talluri","year":"2007","journal-title":"Tetrahedron"},{"key":"10.1016\/j.cell.2021.03.043_bib54","doi-asserted-by":"crossref","first-page":"e3073","DOI":"10.21769\/BioProtoc.3073","article-title":"Generation of Stable Expression Mammalian Cell Lines Using Lentivirus","volume":"8","author":"Tandon","year":"2018","journal-title":"Bio Protoc."},{"key":"10.1016\/j.cell.2021.03.043_bib55","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nmeth.1398","article-title":"Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators","volume":"6","author":"Tian","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2021.03.043_bib56","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1021\/acschembio.9b00548","article-title":"Ex\u00a0Vivo Analysis of Tryptophan Metabolism Using 19F NMR","volume":"14","author":"Tombari","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cell.2021.03.043_bib57","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.cell.2020.11.040","article-title":"Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning","volume":"183","author":"Unger","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.043_bib58","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cell.2016.12.033","article-title":"Crystal Structure of an LSD-Bound Human Serotonin Receptor","volume":"168","author":"Wacker","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.03.043_bib59","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1074\/jbc.RA118.001975","article-title":"Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells","volume":"293","author":"Wan","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.03.043_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-021-00823-7","article-title":"A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo","author":"Wan","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2021.03.043_bib61","article-title":"The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects","author":"Yaden","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.cell.2021.03.043_bib62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J.\u00a0Biomol. Screen."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421003743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421003743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:14:45Z","timestamp":1777475685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421003743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0092867421003743"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.03.043","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740012273.793585306","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychedelic-inspired drug discovery using an engineered biosensor","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.03.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}