{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:49:27Z","timestamp":1792633767952,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI125743"],"award-info":[{"award-number":["R01AI125743"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024704"],"award-info":[{"award-number":["R01EY024704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08-AR065577"],"award-info":[{"award-number":["K08-AR065577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR070116"],"award-info":[{"award-number":["R01AR070116"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077007"],"award-info":[{"award-number":["R01AR077007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AI125743"],"award-info":[{"award-number":["R01AI125743"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01EY024704"],"award-info":[{"award-number":["R01EY024704"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K08-AR065577"],"award-info":[{"award-number":["K08-AR065577"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR070116"],"award-info":[{"award-number":["R01AR070116"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR077007"],"award-info":[{"award-number":["R01AR077007"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["R01AI125743"],"award-info":[{"award-number":["R01AI125743"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["R01EY024704"],"award-info":[{"award-number":["R01EY024704"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["K08-AR065577"],"award-info":[{"award-number":["K08-AR065577"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["R01AR070116"],"award-info":[{"award-number":["R01AR070116"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["R01AR077007"],"award-info":[{"award-number":["R01AR077007"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001946","name":"American Skin Association","doi-asserted-by":"publisher","award":["R01AI125743"],"award-info":[{"award-number":["R01AI125743"]}],"id":[{"id":"10.13039\/100001946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001946","name":"American Skin Association","doi-asserted-by":"publisher","award":["R01EY024704"],"award-info":[{"award-number":["R01EY024704"]}],"id":[{"id":"10.13039\/100001946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001946","name":"American Skin Association","doi-asserted-by":"publisher","award":["K08-AR065577"],"award-info":[{"award-number":["K08-AR065577"]}],"id":[{"id":"10.13039\/100001946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001946","name":"American Skin Association","doi-asserted-by":"publisher","award":["R01AR070116"],"award-info":[{"award-number":["R01AR070116"]}],"id":[{"id":"10.13039\/100001946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001946","name":"American Skin Association","doi-asserted-by":"publisher","award":["R01AR077007"],"award-info":[{"award-number":["R01AR077007"]}],"id":[{"id":"10.13039\/100001946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cell.2021.05.017","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T10:42:10Z","timestamp":1623753730000},"page":"3762-3773.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem"],"prefix":"10.1016","volume":"184","author":[{"given":"Fengxian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.W.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2021.05.017_bib1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0014-4886(78)90097-3","article-title":"Discharge of respiratory neurons in sneezes resulting from ethmoidal nerve stimulation","volume":"58","author":"Batsel","year":"1978","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cell.2021.05.017_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/emj.2004.014829","article-title":"Acute aortic dissection provoked by sneeze: a case report","volume":"22","author":"Baydin","year":"2005","journal-title":"Emerg. Med. J."},{"key":"10.1016\/j.cell.2021.05.017_bib3","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1056\/NEJMicm1501197","article-title":"IMAGES IN CLINICAL MEDICINE. A Sneeze","volume":"375","author":"Bourouiba","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2021.05.017_bib4","first-page":"1837","article-title":"Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19","volume":"323","author":"Bourouiba","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2021.05.017_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/jfm.2014.88","article-title":"Violent expiratory events: on coughing and sneezing","volume":"745","author":"Bourouiba","year":"2014","journal-title":"J.\u00a0Fluid Mech."},{"key":"10.1016\/j.cell.2021.05.017_bib6","first-page":"323","article-title":"Sneeze-induced hemiparesis from unruptured intracranial aneurysm","volume":"9","author":"Bradley","year":"1982","journal-title":"J.\u00a0Neuroradiol."},{"key":"10.1016\/j.cell.2021.05.017_bib7","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0022-5223(00)70103-6","article-title":"Spontaneous anterior thoracic lung hernias","volume":"119","author":"Brock","year":"2000","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.cell.2021.05.017_bib8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.05.017_bib9","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1523\/JNEUROSCI.6451-10.2011","article-title":"Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells","volume":"31","author":"Cavanaugh","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0196-6553(98)70046-X","article-title":"Characterization of infectious aerosols in health care facilities: an aid to effective engineering controls and preventive strategies","volume":"26","author":"Cole","year":"1998","journal-title":"Am. J. Infect. Control"},{"key":"10.1016\/j.cell.2021.05.017_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/ilar.43.4.207","article-title":"Sample size determination","volume":"43","author":"Dell","year":"2002","journal-title":"ILAR J."},{"key":"10.1016\/j.cell.2021.05.017_bib12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0929-6646(09)60066-8","article-title":"Human coronaviruses 229E and NL63: close yet still so far","volume":"108","author":"Dijkman","year":"2009","journal-title":"J.\u00a0Formos. Med. Assoc."},{"key":"10.1016\/j.cell.2021.05.017_bib13","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0091-6749(05)80156-3","article-title":"Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy","volume":"86","author":"Doyle","year":"1990","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.cell.2021.05.017_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-0102(02)00197-9","article-title":"Brainstem and spinal projections of augmenting expiratory neurons in the rat","volume":"45","author":"Ezure","year":"2003","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cell.2021.05.017_bib15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-physiol-040510-130049","article-title":"Understanding the rhythm of breathing: so near, yet so far","volume":"75","author":"Feldman","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cell.2021.05.017_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1476-5381.1988.tb10305.x","article-title":"Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man","volume":"93","author":"Geppetti","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2021.05.017_bib17","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0092-8674(89)90688-0","article-title":"The major human rhinovirus receptor is ICAM-1","volume":"56","author":"Greve","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.05.017_bib18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1152\/japplphysiol.00785.2001","article-title":"Periodic breathing in the mouse","volume":"92","author":"Han","year":"2002","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.cell.2021.05.017_bib19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nn.3289","article-title":"A subpopulation of nociceptors specifically linked to itch","volume":"16","author":"Han","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1212\/WNL.54.2.520","article-title":"Loss of ability to sneeze in lateral medullary syndrome","volume":"54","author":"Hersch","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2021.05.017_bib21","first-page":"218","article-title":"On the sneeze-reflex and its control","volume":"45","author":"Hyd\u00e9n","year":"2007","journal-title":"Rhinology"},{"key":"10.1016\/j.cell.2021.05.017_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0301-0082(98)00046-X","article-title":"Control of abdominal muscles","volume":"56","author":"Iscoe","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cell.2021.05.017_bib23","first-page":"127","article-title":"Activity of bulbar respiratory neurones during cough and other respiratory tract reflexes in cats","volume":"34","author":"Jakus","year":"1985","journal-title":"Physiol. Bohemoslov."},{"key":"10.1016\/j.cell.2021.05.017_bib24","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1172\/JCI20449","article-title":"Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control","volume":"113","author":"Karai","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2021.05.017_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature05901","article-title":"Transvascular delivery of small interfering RNA to the central nervous system","volume":"448","author":"Kumar","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.05.017_bib26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jaci.2006.09.003","article-title":"Human mast cells are capable of serotonin synthesis and release","volume":"119","author":"Kushnir-Sukhov","year":"2007","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.cell.2021.05.017_bib27","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.4049\/jimmunol.180.4.2251","article-title":"Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions","volume":"180","author":"Lee","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2021.05.017_bib28","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1128\/JVI.02615-14","article-title":"Receptor recognition mechanisms of coronaviruses: a decade of structural studies","volume":"89","author":"Li","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2021.05.017_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature16964","article-title":"The peptidergic control circuit for sighing","volume":"530","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.05.017_bib30","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1038\/s41467-019-13536-0","article-title":"TRPV1 activity and substance P release are required for corneal cold nociception","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.05.017_bib31","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nn1937","article-title":"Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch","volume":"10","author":"Liu","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.902470108","article-title":"Central projections of the ethmoidal nerve of the cat as determined by the horseradish peroxidase tracer technique","volume":"247","author":"Lucier","year":"1986","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cell.2021.05.017_bib33","doi-asserted-by":"crossref","first-page":"e36355","DOI":"10.1371\/journal.pone.0036355","article-title":"CGRP\u03b1-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch","volume":"7","author":"McCoy","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2021.05.017_bib34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/emboj.2010.325","article-title":"TRPV1-lineage neurons are required for thermal sensation","volume":"30","author":"Mishra","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2021.05.017_bib35","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1523\/JNEUROSCI.1533-12.2012","article-title":"A nociceptive signaling role for neuromedin B","volume":"32","author":"Mishra","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib36","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1182\/blood-2013-02-483792","article-title":"Redefinition of the human mast cell transcriptome by deep-CAGE sequencing","volume":"123","author":"Motakis","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cell.2021.05.017_bib37","first-page":"896732","article-title":"Subarachnoid hemorrhage secondary to forceful sneeze","volume":"2015","author":"Nomani","year":"2015","journal-title":"Case Rep. Neurol. Med."},{"key":"10.1016\/j.cell.2021.05.017_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(90)90171-7","article-title":"Sneeze-evoking region within the brainstem","volume":"511","author":"Nonaka","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2021.05.017_bib39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0006-8993(86)90440-3","article-title":"The activity of retrofacial expiratory cells during behavioral respiratory responses and active expiration","volume":"374","author":"Orem","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2021.05.017_bib40","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.neuroscience.2006.04.055","article-title":"Brainstem projections from recipient zones of the anterior ethmoidal nerve in the medullary dorsal horn","volume":"141","author":"Panneton","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2021.05.017_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0168-0102(98)00075-3","article-title":"Upper airway motor outputs during sneezing and coughing in decerebrate cats","volume":"32","author":"Satoh","year":"1998","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cell.2021.05.017_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00348-015-2078-4","article-title":"Visualization of sneeze ejecta: steps of fluid fragmentation leading to respiratory droplets","volume":"57","author":"Scharfman","year":"2016","journal-title":"Exp. Fluids"},{"key":"10.1016\/j.cell.2021.05.017_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/jnnp.2005.068601","article-title":"Sneeze related area in the medulla: localisation of the human sneezing centre?","volume":"77","author":"Seijo-Mart\u00ednez","year":"2006","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cell.2021.05.017_bib44","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1523\/JNEUROSCI.0001-07.2007","article-title":"Multifunctional laryngeal premotor neurons: their activities during breathing, coughing, sneezing, and swallowing","volume":"27","author":"Shiba","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib45","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/1753465809340571","article-title":"Sneeze reflex: facts and fiction","volume":"3","author":"Songu","year":"2009","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.cell.2021.05.017_bib47","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jhin.2006.05.022","article-title":"Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises","volume":"64","author":"Tang","year":"2006","journal-title":"J.\u00a0Hosp. Infect."},{"key":"10.1016\/j.cell.2021.05.017_bib48","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2005.08.043","article-title":"Nasal sensory nerve populations responding to histamine and capsaicin","volume":"116","author":"Taylor-Clark","year":"2005","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.cell.2021.05.017_bib49","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1398-9995.1985.tb00246.x","article-title":"Nasal challenge with serotonin and histamine in normal persons","volume":"40","author":"T\u00f8nnesen","year":"1985","journal-title":"Allergy"},{"issue":"Suppl 1","key":"10.1016\/j.cell.2021.05.017_bib50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2500\/aap.2012.33.3535","article-title":"Chapter 5: Allergic rhinitis","volume":"33","author":"Uzzaman","year":"2012","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.cell.2021.05.017_bib51","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1523\/JNEUROSCI.10-09-02917.1990","article-title":"Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system","volume":"10","author":"Wada","year":"1990","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2021.05.017_bib52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0896-6273(91)90250-4","article-title":"cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor","volume":"6","author":"Wada","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2021.05.017_bib53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0304-3940(91)90843-I","article-title":"Trigeminal afferences implied in the triggering or inhibition of sneezing in cats","volume":"122","author":"Wallois","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cell.2021.05.017_bib54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0006-8993(97)00602-1","article-title":"Role of respiratory and non-respiratory neurones in the region of the NTS in the elaboration of the sneeze reflex in cat","volume":"768","author":"Wallois","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2021.05.017_bib55","doi-asserted-by":"crossref","first-page":"15466","DOI":"10.1038\/s41598-017-15756-0","article-title":"Distinct roles of NMB and GRP in itch transmission","volume":"7","author":"Wan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2021.05.017_bib56","first-page":"8","article-title":"Ultrasonic sound as an indicator of acute pain in laboratory mice","volume":"47","author":"Williams","year":"2008","journal-title":"J.\u00a0Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.cell.2021.05.017_bib57","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1152\/japplphysiol.00069.2008","article-title":"Effects of buspirone on posthypoxic ventilatory behavior in the C57BL\/6J and A\/J mouse strains","volume":"105","author":"Yamauchi","year":"2008","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.cell.2021.05.017_bib58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.resp.2008.05.003","article-title":"Post-sigh breathing behavior and spontaneous pauses in the C57BL\/6J (B6) mouse","volume":"162","author":"Yamauchi","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cell.2021.05.017_bib59","doi-asserted-by":"crossref","first-page":"12402","DOI":"10.1523\/JNEUROSCI.1709-14.2014","article-title":"Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission","volume":"34","author":"Zhao","year":"2014","journal-title":"J.\u00a0Neurosci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421006346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421006346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:55:29Z","timestamp":1758801329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421006346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":59,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0092867421006346"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.05.017","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740292140.793588754","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.740292140.793586526","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}