{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:37:15Z","timestamp":1792503435772,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cell.2021.06.028","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T13:24:50Z","timestamp":1626873890000},"page":"4495-4511.e19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":404,"title":["Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway"],"prefix":"10.1016","volume":"184","author":[{"given":"Charles L.","family":"Evavold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Hafner-Bratkovi\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Devant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin M.","family":"D\u2019Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsy M.","family":"Ngwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Bor\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Doench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"LaFleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene H.","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Thiagarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2021.06.028_bib1","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.06.028_bib2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.molcel.2012.12.026","article-title":"The tangled circuitry of metabolism and apoptosis","volume":"49","author":"Andersen","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib3","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1182\/blood-2014-05-573188","article-title":"Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization","volume":"124","author":"Avbelj","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cell.2021.06.028_bib4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.1100613","article-title":"Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome","volume":"187","author":"Bauernfeind","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2021.06.028_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.20172222","article-title":"Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity","volume":"215","author":"Boucher","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib6","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1084\/jem.20100257","article-title":"Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella","volume":"207","author":"Broz","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib7","doi-asserted-by":"crossref","first-page":"e20190314","DOI":"10.1084\/jem.20190314","article-title":"Inflammasome signaling and regulation of interleukin-1 family cytokines","volume":"217","author":"Chan","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib8","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1084\/jem.20081297","article-title":"TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species","volume":"205","author":"Chen","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2021.06.028_bib10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2021.06.028_bib11","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022120118","article-title":"Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction","volume":"118","author":"Condon","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.06.028_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41418-018-0106-7","article-title":"Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture","volume":"26","author":"de Vasconcelos","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2021.06.028_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cell.2021.06.028_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2021.06.028_bib17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.06.028_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages","volume":"7","author":"Franchi","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2021.06.028_bib20","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","article-title":"Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock","volume":"341","author":"Hagar","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib21","doi-asserted-by":"crossref","first-page":"23510","DOI":"10.1074\/jbc.C800100200","article-title":"Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging","volume":"283","author":"Haggie","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.06.028_bib22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/eji.201747404","article-title":"The Gasdermin-D pore acts as a conduit for IL-1\u03b2 secretion in mice","volume":"48","author":"Heilig","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cell.2021.06.028_bib23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2021.06.028_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tem.2010.12.003","article-title":"mTOR couples cellular nutrient sensing to organismal metabolic homeostasis","volume":"22","author":"Howell","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cell.2021.06.028_bib25","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1101\/gad.1624008","article-title":"WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase","volume":"22","author":"Hu","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2021.06.028_bib26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2021.06.028_bib27","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.abb9818","article-title":"Succination inactivates gasdermin D and blocks pyroptosis","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molcel.2018.03.009","article-title":"Galectins Control mTOR in Response to Endomembrane Damage","volume":"70","author":"Jia","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib29","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib31","doi-asserted-by":"crossref","first-page":"eaax4917","DOI":"10.1126\/scisignal.aax4917","article-title":"IRF2 transcriptionally induces GSDMD expression for pyroptosis","volume":"12","author":"Kayagaki","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cell.2021.06.028_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: Effectors of Pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cell.2021.06.028_bib35","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/s41467-019-09656-2","article-title":"A CRISPR-Cas9 delivery system for in\u00a0vivo screening of genes in the immune system","volume":"10","author":"LaFleur","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.06.028_bib36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200711082","article-title":"Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity","volume":"181","author":"Li","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2021.06.028_bib37","doi-asserted-by":"crossref","first-page":"eaav1447","DOI":"10.1126\/sciimmunol.aav1447","article-title":"Gasdermin D activity in inflammation and host defense","volume":"4","author":"Lieberman","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2021.06.028_bib38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2021.06.028_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2019.04.017","article-title":"Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization","volume":"51","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.06.028_bib41","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1073\/pnas.1402911111","article-title":"Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex","volume":"111","author":"Man","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.06.028_bib42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.celrep.2015.05.046","article-title":"mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation","volume":"12","author":"Moon","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2021.06.028_bib43","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1084\/jem.20160027","article-title":"Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity","volume":"213","author":"Napier","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib44","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cmet.2017.06.018","article-title":"Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control","volume":"26","author":"Pr\u00f3chnicki","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2021.06.028_bib47","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2012.07.007","article-title":"TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria","volume":"150","author":"Rathinam","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib48","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.20151809","article-title":"NAIP proteins are required for cytosolic detection of specific bacterial ligands in\u00a0vivo","volume":"213","author":"Rauch","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.06.028_bib49","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.06.028_bib50","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.aay0166","article-title":"Structural basis for the docking of mTORC1 on the lysosomal surface","volume":"366","author":"Rogala","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-018-0058-6","article-title":"Cryo-EM structure of the gasdermin A3 membrane pore","volume":"557","author":"Ruan","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib53","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"R\u00fchl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.06.028_bib54","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib65","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.cell.2021.06.028_bib55","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embj.201694696","article-title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death","volume":"35","author":"Sborgi","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2021.06.028_bib56","doi-asserted-by":"crossref","first-page":"27643","DOI":"10.1074\/jbc.M603536200","article-title":"The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity","volume":"281","author":"Schieke","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.06.028_bib57","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2019.10.036","article-title":"Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex","volume":"179","author":"Shen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib59","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib60","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.06.028_bib61","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.cell.2021.06.028_bib62","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2021.06.028_bib63","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1","volume":"284","author":"Thoreen","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.06.028_bib64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11351","article-title":"Rapid induction of inflammatory lipid mediators by the inflammasome in\u00a0vivo","volume":"490","author":"von Moltke","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib66","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2020.02.002","article-title":"Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.06.028_bib67","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib68","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41586-019-1244-x","article-title":"Long-term ex\u00a0vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation","volume":"571","author":"Wilkinson","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib69","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41467-020-20522-4","article-title":"Structural insights into TSC complex assembly and GAP activity on Rheb","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.06.028_bib70","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.06.028_bib71","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421007960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421007960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:55:07Z","timestamp":1758801307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421007960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":70,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0092867421007960"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.06.028","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740505059.793588817","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.02.362517","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}