{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:07:41Z","timestamp":1791576461174,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":394,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.cell.2021.08.035","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T10:38:30Z","timestamp":1632220710000},"page":"5230-5246.e22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":272,"title":["Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion"],"prefix":"10.1016","volume":"184","author":[{"given":"Guilherme Pedreira de Freitas","family":"Nader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ag\u00fcera-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Routet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-258X","authenticated-orcid":false,"given":"Matthieu","family":"Gratia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Maurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cancila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7143-2706","authenticated-orcid":false,"given":"Clotilde","family":"Cadart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Palamidessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Nalio","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel","family":"San Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Gentili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3162-3318","authenticated-orcid":false,"given":"Ayako","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Williart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-9743","authenticated-orcid":false,"given":"Catalina","family":"Lodillinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lagoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Villard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Viovy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Galon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Scita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Manel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-733X","authenticated-orcid":false,"given":"Philippe","family":"Chavrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Piel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2021.08.035_bib1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s12276-020-0416-y","article-title":"The cGAS\/STING\/TBK1\/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels","volume":"52","author":"Basit","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cell.2021.08.035_bib2","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/bcr2358","article-title":"An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in\u00a0situ","volume":"11","author":"Behbod","year":"2009","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cell.2021.08.035_bib3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2019.07.019","article-title":"Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade","volume":"178","author":"Benci","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib4","doi-asserted-by":"crossref","first-page":"045001","DOI":"10.1088\/1758-5090\/aa869d","article-title":"A microfluidic platform for modeling metastatic cancer cell matrix invasion","volume":"9","author":"Blaha","year":"2017","journal-title":"Biofabrication"},{"key":"10.1016\/j.cell.2021.08.035_bib5","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1038\/s41388-018-0422-x","article-title":"Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function","volume":"37","author":"Castagnino","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2021.08.035_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.04.020","article-title":"Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest","volume":"49","author":"Cho","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2006.06.005","article-title":"The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death","volume":"23","author":"Chowdhury","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib8","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1093\/hmg\/ddr344","article-title":"Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies","volume":"20","author":"De Vos","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2021.08.035_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.aad7297","article-title":"Nuclear envelope rupture and repair during cancer cell migration","volume":"352","author":"Denais","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.08.035_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41563-019-0563-5","article-title":"Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells","volume":"19","author":"Earle","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.cell.2021.08.035_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1101\/gad.289769.116","article-title":"A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1","volume":"31","author":"Erdal","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2021.08.035_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.devcel.2018.08.025","article-title":"Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs","volume":"47","author":"Feinberg","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib13","first-page":"3316","article-title":"Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells","volume":"41","author":"Feng","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cell.2021.08.035_bib14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrm2720","article-title":"Collective cell migration in morphogenesis, regeneration and cancer","volume":"10","author":"Friedl","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib15","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.celrep.2019.01.105","article-title":"The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus","volume":"26","author":"Gentili","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2021.08.035_bib16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular Senescence: Defining a Path Forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.08.035_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ceb.2018.02.001","article-title":"Nuclear envelope rupture: little holes, big openings","volume":"52","author":"Hatch","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.201603053","article-title":"Nuclear envelope rupture is induced by actin-based nucleus confinement","volume":"215","author":"Hatch","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib20","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1038\/s41467-018-04865-7","article-title":"LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration","volume":"9","author":"Infante","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.08.035_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cub.2016.11.049","article-title":"DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration","volume":"27","author":"Irianto","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yexcr.2019.05.011","article-title":"Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression","volume":"381","author":"Jiang","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cell.2021.08.035_bib23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nchembio.2342","article-title":"Chemical screening identifies ATM as a target for alleviating senescence","volume":"13","author":"Kang","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4048\/jbc.2018.21.2.197","article-title":"Microinvasive carcinoma versus ductal carcinoma in\u00a0situ: A comparison of clinicopathological features and clinical outcomes","volume":"21","author":"Kim","year":"2018","journal-title":"J.\u00a0Breast Cancer"},{"key":"10.1016\/j.cell.2021.08.035_bib25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2013.11.002","article-title":"The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells","volume":"39","author":"Lahaye","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.08.035_bib26","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1039\/c2ib20056b","article-title":"Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes","volume":"4","author":"Le Berre","year":"2012","journal-title":"Integr. Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/B978-0-12-800281-0.00014-2","article-title":"Methods for Two-Dimensional Cell Confinement","volume":"121","author":"Le Berre","year":"2014","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00109-007-0199-9","article-title":"A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus","volume":"85","author":"Lee-Kirsch","year":"2007","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.cell.2021.08.035_bib29","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ng2091","article-title":"Mutations in the gene encoding the 3\u2032-5\u2032 DNA exonuclease TREX1 are associated with systemic lupus erythematosus","volume":"39","author":"Lee-Kirsch","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2021.08.035_bib30","doi-asserted-by":"crossref","first-page":"31649","DOI":"10.1074\/jbc.M806155200","article-title":"The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease","volume":"283","author":"Lehtinen","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.08.035_bib31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2015.01.007","article-title":"Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-018-0629-6","article-title":"Nuclear cGAS suppresses DNA repair and promotes tumorigenesis","volume":"563","author":"Liu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.08.035_bib33","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/onc.2015.87","article-title":"p63\/MT1-MMP axis is required for in\u00a0situ to invasive transition in basal-like breast cancer","volume":"35","author":"Lodillinsky","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2021.08.035_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ceb.2020.01.011","article-title":"CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier","volume":"64","author":"Lusk","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib35","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.cell.2015.11.054","article-title":"Chromothripsis and Kataegis Induced by Telomere Crisis","volume":"163","author":"Maciejowski","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib36","article-title":"APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis","author":"Maciejowski","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2021.08.035_bib37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tcb.2011.03.008","article-title":"The nucleoplasmic reticulum: form and function","volume":"21","author":"Malhas","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmat4848","article-title":"Endocytic reawakening of motility in jammed epithelia","volume":"16","author":"Malinverno","year":"2017","journal-title":"Nat. Mater."},{"key":"10.1016\/j.cell.2021.08.035_bib39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2005.02.004","article-title":"Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis","volume":"22","author":"Martinvalet","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.08.035_bib40","first-page":"647","article-title":"Mapping the distributions and quantifying the labelling intensities of cell compartments by immunoelectron microscopy: progress towards a coherent set of methods","volume":"219","author":"Mayhew","year":"2011","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.cell.2021.08.035_bib41","doi-asserted-by":"crossref","first-page":"17022","DOI":"10.1074\/jbc.M100623200","article-title":"Excision of 3\u2032 termini by the Trex1 and TREX2 3\u2032\u21925\u2032 exonucleases. Characterization of the recombinant proteins","volume":"276","author":"Mazur","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.08.035_bib42","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.molcel.2020.12.037","article-title":"ER-directed TREX1 limits cGAS activation at micronuclei","volume":"81","author":"Mohr","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib60","author":"Nader","year":"2021","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.cell.2021.08.035_bib43","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/s41563-019-0425-1","article-title":"Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma","volume":"18","author":"Palamidessi","year":"2019","journal-title":"Nat. Mater."},{"key":"10.1016\/j.cell.2021.08.035_bib44","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1074\/jbc.RA119.007897","article-title":"Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM\/Akt\/GSK3\u03b2\/Snail signaling pathway","volume":"294","author":"Peng","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2021.08.035_bib45","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aad7611","article-title":"ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death","volume":"352","author":"Raab","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.08.035_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/bs.ircmb.2017.07.013","article-title":"Loss of Nuclear Envelope Integrity in Aging and Disease","volume":"336","author":"Robijns","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol"},{"key":"10.1016\/j.cell.2021.08.035_bib47","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/ncb3605","article-title":"Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle","volume":"19","author":"Roman","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib48","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tcb.2017.02.008","article-title":"Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability?","volume":"27","author":"Shah","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib49","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cub.2020.11.037","article-title":"Nuclear Deformation Causes DNA Damage by Increasing Replication Stress","volume":"31","author":"Shah","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib50","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1038\/nprot.2007.365","article-title":"Cryosectioning and immunolabeling","volume":"2","author":"Slot","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2021.08.035_bib51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ceb.2021.01.007","article-title":"Nuclear fragility, blaming the blebs","volume":"70","author":"Srivastava","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2008.06.032","article-title":"Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity","volume":"134","author":"Stetson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.08.035_bib53","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jmcb\/mjs048","article-title":"Activation of the ATM-Snail pathway promotes breast cancer metastasis","volume":"4","author":"Sun","year":"2012","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib54","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-018-03555-8","article-title":"Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.08.035_bib55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1242\/dev.01583","article-title":"Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia","volume":"132","author":"Teuli\u00e8re","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cell.2021.08.035_bib56","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ceb.2015.04.005","article-title":"Establishment of NE asymmetry\u2014targeting of membrane proteins to the inner nuclear membrane","volume":"34","author":"Ungricht","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cell.2021.08.035_bib57","doi-asserted-by":"crossref","first-page":"15618","DOI":"10.1038\/ncomms15618","article-title":"DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity","volume":"8","author":"Vanpouille-Box","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.08.035_bib58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/nucl.18954","article-title":"Transient nuclear envelope rupturing during interphase in human cancer cells","volume":"3","author":"Vargas","year":"2012","journal-title":"Nucleus"},{"key":"10.1016\/j.cell.2021.08.035_bib59","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2007.10.017","article-title":"Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease","volume":"131","author":"Yang","year":"2007","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421010461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421010461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:57:18Z","timestamp":1758801438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421010461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":60,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0092867421010461"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.08.035","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.22.110122","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}