{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:02:11Z","timestamp":1792317731211,"version":"4.4.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["ZMVI1-2520COR201"],"award-info":[{"award-number":["ZMVI1-2520COR201"]}],"id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021372","name":"Hector Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021727","name":"Berlin University Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["IA 200829\/Z\/16\/Z"],"award-info":[{"award-number":["IA 200829\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007210","name":"RWTH Aachen University","doi-asserted-by":"publisher","award":["125\/17"],"award-info":[{"award-number":["125\/17"]}],"id":[{"id":"10.13039\/501100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007210","name":"RWTH Aachen University","doi-asserted-by":"publisher","award":["148\/21"],"award-info":[{"award-number":["148\/21"]}],"id":[{"id":"10.13039\/501100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["733100"],"award-info":[{"award-number":["733100"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["860003"],"award-info":[{"award-number":["860003"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["260687"],"award-info":[{"award-number":["260687"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["305147"],"award-info":[{"award-number":["305147"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005637","name":"MDC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU 04.816"],"award-info":[{"award-number":["TTU 04.816"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["04.817"],"award-info":[{"award-number":["04.817"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP1937"],"award-info":[{"award-number":["SPP1937"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 217\/577-1"],"award-info":[{"award-number":["INST 217\/577-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2168 \\u2013 272482170"],"award-info":[{"award-number":["GRK 2168 \\u2013 272482170"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2151-390873048"],"award-info":[{"award-number":["EXC2151-390873048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 269\/768-1"],"award-info":[{"award-number":["INST 269\/768-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 37\/1049-1"],"award-info":[{"award-number":["INST 37\/1049-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SA1383\/3-1"],"award-info":[{"award-number":["SA1383\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TR57"],"award-info":[{"award-number":["SFB TR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 217\/988-1"],"award-info":[{"award-number":["INST 217\/988-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 216\/981-1"],"award-info":[{"award-number":["INST 216\/981-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ERA CVD 00160389"],"award-info":[{"award-number":["ERA CVD 00160389"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2157"],"award-info":[{"award-number":["GRK2157"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 3644\/5-1"],"award-info":[{"award-number":["ME 3644\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 257\/605-1"],"award-info":[{"award-number":["INST 257\/605-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1454 \\u2013 432325352"],"award-info":[{"award-number":["SFB 1454 \\u2013 432325352"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO3755\/13-1 Project-ID 454024652"],"award-info":[{"award-number":["BO3755\/13-1 Project-ID 454024652"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR219 322900939"],"award-info":[{"award-number":["SFB-TRR219 322900939"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2424"],"award-info":[{"award-number":["RTG2424"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TR84 114933180"],"award-info":[{"award-number":["SFB-TR84 114933180"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["FC001134"],"award-info":[{"award-number":["FC001134"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001656","name":"Helmholtz-Gemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["STOP-FSGS-01GM1901A"],"award-info":[{"award-number":["STOP-FSGS-01GM1901A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01KX2021"],"award-info":[{"award-number":["FKZ 01KX2021"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["02NUK047E"],"award-info":[{"award-number":["02NUK047E"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031L0220A"],"award-info":[{"award-number":["031L0220A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI20337"],"award-info":[{"award-number":["01KI20337"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI2021"],"award-info":[{"award-number":["01KI2021"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KX2021"],"award-info":[{"award-number":["01KX2021"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.cell.2021.12.040","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:30:59Z","timestamp":1640651459000},"page":"493-512.e25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":195,"title":["Complement activation induces excessive T cell cytotoxicity in severe COVID-19"],"prefix":"10.1016","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-7415","authenticated-orcid":false,"given":"Philipp","family":"Georg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Astaburuaga-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-7208","authenticated-orcid":false,"given":"Lorenzo","family":"Bonaguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-6684","authenticated-orcid":false,"given":"Sophia","family":"Brumhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-5828","authenticated-orcid":false,"given":"Laura","family":"Michalick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena J.","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-8335","authenticated-orcid":false,"given":"Tomislav","family":"Kostevc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"G\u00e4bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Streitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-9412","authenticated-orcid":false,"given":"Vadim","family":"Demichev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Gem\u00fcnd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-6464","authenticated-orcid":false,"given":"Matthias","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-3663","authenticated-orcid":false,"given":"Pinkus","family":"Tober-Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa T.","family":"Helbig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-9050","authenticated-orcid":false,"given":"David","family":"Hillus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-0900","authenticated-orcid":false,"given":"Lev","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-8073","authenticated-orcid":false,"given":"Julia","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah-Philine","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Paclik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Iwert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00fclleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-7144","authenticated-orcid":false,"given":"Simran Kaur","family":"Aulakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Djudjaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman D.","family":"B\u00fclow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik E.","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel R.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hippenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine-Emmanuel","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-2199","authenticated-orcid":false,"given":"Marcus A.","family":"Mall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Stricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobst","family":"R\u00f6hmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Corman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Beule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Wyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Landthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Obermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-8494","authenticated-orcid":false,"given":"Saskia","family":"von Stillfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcnevver","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Wesselmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Suttorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-6743","authenticated-orcid":false,"given":"Alexander","family":"Uhrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"M\u00fcller-Redetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-0780","authenticated-orcid":false,"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang M.","family":"Kuebler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-991X","authenticated-orcid":false,"given":"Christian","family":"Meisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-7413","authenticated-orcid":false,"given":"Markus","family":"Ralser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim L.","family":"Schultze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-5457","authenticated-orcid":false,"given":"Anna C.","family":"Aschenbrenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Thibeault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif E.","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Bl\u00fcthgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-8579","authenticated-orcid":false,"given":"Birgit","family":"Sawitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2021.12.040_bib1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2021.12.040_bib2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/bioinformatics\/btv715","article-title":"destiny: diffusion maps for large-scale single-cell data in R","volume":"32","author":"Angerer","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2021.12.040_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib4","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1038\/s41467-018-06706-z","article-title":"Complement receptor CD46 co-stimulates optimal human CD8+ T\u00a0cell effector function via fatty acid metabolism","volume":"9","author":"Arbore","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2021.12.040_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1183\/09059180.00003214","article-title":"Cellular interactions in the pathogenesis of interstitial lung diseases","volume":"24","author":"Bagnato","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.cell.2021.12.040_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.immuni.2021.05.010","article-title":"Longitudinal analysis reveals that delayed bystander CD8+ T\u00a0cell activation and early immune pathology distinguish severe COVID-19 from mild disease","volume":"54","author":"Bergamaschi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib7","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.4049\/jimmunol.181.6.4219","article-title":"Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T\u00a0cells with NK cell-like function in chronic hepatitis C virus infection","volume":"181","author":"Bj\u00f6rkstr\u00f6m","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00292-021-00925-w","article-title":"Practical aspects of COVID-19 autopsies","volume":"42","author":"Boor","year":"2021","journal-title":"Pathologe"},{"key":"10.1016\/j.cell.2021.12.040_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2021.12.040_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-020-2600-6","article-title":"Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis","volume":"588","author":"Carvelli","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.12.040_bib11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/eji.202048959","article-title":"Complement cascade in severe forms of COVID-19: recent advances in therapy","volume":"51","author":"Chouaki Benmansour","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/CJI.0b013e31822801d4","article-title":"Fc\u03b3RIIIa (CD16) induction on human T lymphocytes and CD16pos T-lymphocyte amplification","volume":"34","author":"Cl\u00e9menceau","year":"2011","journal-title":"J.\u00a0Immunother."},{"key":"10.1016\/j.cell.2021.12.040_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib14","doi-asserted-by":"crossref","first-page":"742446","DOI":"10.3389\/fimmu.2021.742446","article-title":"Complement alternative and mannose-binding lectin pathway activation is associated with COVID-19 mortality","volume":"12","author":"Defendi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib15","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100024R","article-title":"Endothelial cell, myeloid, and adaptive immune responses in SARS-CoV-2 infection","volume":"35","author":"Degauque","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.cell.2021.12.040_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2021.12.040_bib17","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cels.2021.05.005","article-title":"A time-resolved proteomic and prognostic map of COVID-19","volume":"12","author":"Demichev","year":"2021","journal-title":"Cell Syst"},{"key":"10.1016\/j.cell.2021.12.040_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2021.12.040_bib19","article-title":"The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes","author":"Feng","year":"2020","journal-title":"MedRxiv, MedRxiv"},{"key":"10.1016\/j.cell.2021.12.040_bib20","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1002\/jmv.27037","article-title":"Characterization of T lymphocytes in severe COVID-19 patients","volume":"93","author":"Fenoglio","year":"2021","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.cell.2021.12.040_bib21","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.4049\/jimmunol.1103812","article-title":"Malaria inhibits surface expression of complement receptor 1 in monocytes\/macrophages, causing decreased immune complex internalization","volume":"190","author":"Fernandez-Arias","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib22","doi-asserted-by":"crossref","first-page":"12669","DOI":"10.1073\/pnas.1108455108","article-title":"Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose","volume":"108","author":"Ferrara","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.12.040_bib23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2020.12.015","article-title":"COVID-19-neutralizing antibodies predict disease severity and survival","volume":"184","author":"Garcia-Beltran","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib24","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2021.12.040_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abc4557","article-title":"Tissue-resident CD8+ T\u00a0cells drive age-associated chronic lung sequelae after viral pneumonia","volume":"5","author":"Goplen","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib26","doi-asserted-by":"crossref","first-page":"e01753","DOI":"10.1128\/mBio.01753-18","article-title":"Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis","volume":"9","author":"Gralinski","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.cell.2021.12.040_bib27","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2021.12.040_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2020.08.009","article-title":"Immunopathology of hyperinflammation in COVID-19","volume":"191","author":"Gustine","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2021.12.040_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.cell.2021.12.040_bib30","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.immuni.2016.08.003","article-title":"Complement-mediated regulation of metabolism and basic cellular processes","volume":"45","author":"Hess","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf8654","article-title":"High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages","volume":"13","author":"Hoepel","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biom. J."},{"key":"10.1016\/j.cell.2021.12.040_bib34","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1093\/bioinformatics\/btab358","article-title":"Cellsnp-lite: an efficient tool for genotyping single cells","volume":"37","author":"Huang","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2021.12.040_bib35","doi-asserted-by":"crossref","first-page":"108591","DOI":"10.1016\/j.clim.2020.108591","article-title":"On the genetics and immunopathogenesis of COVID-19","volume":"220","author":"Jacob","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib36","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1681\/ASN.2019080847","article-title":"Terminally differentiated effector memory CD8+ T\u00a0cells identify kidney transplant recipients at high risk of graft failure","volume":"31","author":"Jacquemont","year":"2020","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2021.12.040_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cell.2021.12.040_bib38","series-title":"phenoptr: inForm Helper Functions. R package version 0.3.1","author":"Johnson","year":"2021"},{"key":"10.1016\/j.cell.2021.12.040_bib39","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.autrev.2008.06.002","article-title":"Immune complex clearance by complement receptor type 1 in SLE","volume":"8","author":"Kavai","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cell.2021.12.040_bib40","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2021.12.040_bib41","article-title":"Web-based analysis and publication of flow cytometry experiments","volume":"53","author":"Kotecha","year":"2010","journal-title":"Curr. Protoc. Cytom."},{"key":"10.1016\/j.cell.2021.12.040_bib42","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.immuni.2021.09.002","article-title":"Early IFN-\u03b1 signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19","volume":"54","author":"Kr\u00e4mer","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib43","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3389\/fimmu.2018.01393","article-title":"Invariant natural killer T\u00a0cell subsets-more than just developmental intermediates","volume":"9","author":"Krovi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib44","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s15010-020-01464-x","article-title":"Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)","volume":"48","author":"Kurth","year":"2020","journal-title":"Infection"},{"key":"10.1016\/j.cell.2021.12.040_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/cyto.a.22855","article-title":"Age and gender leucocytes variances and references values generated using the standardized one-study protocol","volume":"89","author":"Kverneland","year":"2016","journal-title":"Cytometry A"},{"key":"10.1016\/j.cell.2021.12.040_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202617","article-title":"Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection","volume":"218","author":"Le Bert","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib47","doi-asserted-by":"crossref","first-page":"100296","DOI":"10.1016\/j.xcrm.2021.100296","article-title":"Decay of Fc-dependent antibody functions after mild to moderate COVID-19","volume":"2","author":"Lee","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib48","first-page":"1","article-title":"Least-squares means: the R package lsmeans","volume":"69","author":"Lenth","year":"2016","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.cell.2021.12.040_bib49","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis","volume":"162","author":"Levine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib50","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.cell.2021.12.040_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cei.12952","article-title":"Production of complement components by cells of the immune system","volume":"188","author":"Lubbers","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abh2259","article-title":"Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection","volume":"6","author":"Ma","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib54","series-title":"DirichletReg: Dirichlet Regression for Compositional Data in R","author":"Maier","year":"2014"},{"key":"10.1016\/j.cell.2021.12.040_bib55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J"},{"key":"10.1016\/j.cell.2021.12.040_bib56","doi-asserted-by":"crossref","first-page":"108450","DOI":"10.1016\/j.clim.2020.108450","article-title":"The first case of COVID-19 treated with the complement C3 inhibitor AMY-101","volume":"215","author":"Mastaglio","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib57","doi-asserted-by":"crossref","first-page":"108598","DOI":"10.1016\/j.clim.2020.108598","article-title":"Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacy","volume":"220","author":"Mastellos","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8511","article-title":"Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications","volume":"369","author":"Mathew","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2021.12.040_bib59","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chom.2020.05.009","article-title":"The innate immune system: fighting on the front lines or fanning the flames of COVID-19?","volume":"27","author":"McKechnie","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2021.12.040_bib60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cels.2020.05.012","article-title":"Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection","volume":"11","author":"Messner","year":"2020","journal-title":"Cell Syst"},{"key":"10.1016\/j.cell.2021.12.040_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s41232-020-00148-1","article-title":"Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection","volume":"40","author":"Miyazawa","year":"2020","journal-title":"Inflam. Regen."},{"key":"10.1016\/j.cell.2021.12.040_bib62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.immuni.2020.11.005","article-title":"Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8+ T\u00a0cells as conserved hallmark of inflammaging","volume":"54","author":"Mogilenko","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.cdd.4402170","article-title":"NK cells at the interface between innate and adaptive immunity","volume":"15","author":"Moretta","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cell.2021.12.040_bib64","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s40520-020-01581-5","article-title":"COVID-19 in older adults","volume":"32","author":"Nanda","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.cell.2021.12.040_bib65","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.semnephrol.2013.08.001","article-title":"Overview of complement activation and regulation","volume":"33","author":"Noris","year":"2013","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.cell.2021.12.040_bib66","doi-asserted-by":"crossref","first-page":"748","DOI":"10.12688\/f1000research.11622.1","article-title":"CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets","volume":"6","author":"Nowicka","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.cell.2021.12.040_bib67","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/mi.2017.94","article-title":"Trigger-happy resident memory CD4+ T\u00a0cells inhabit the human lungs","volume":"11","author":"Oja","year":"2018","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.cell.2021.12.040_bib68","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41590-020-0782-6","article-title":"Broad and strong memory CD4+ and CD8+ T\u00a0cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19","volume":"21","author":"Peng","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib69","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012642","article-title":"Rationale for targeting complement in COVID-19","volume":"12","author":"Polycarpou","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib70","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nbt.1991","article-title":"Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE","volume":"29","author":"Qiu","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2021.12.040_bib71","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s13054-020-03218-5","article-title":"Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients","volume":"24","author":"Remmelink","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.cell.2021.12.040_bib72","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-021-03475-6","article-title":"The spatial landscape of lung pathology during COVID-19 progression","volume":"593","author":"Rendeiro","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2021.12.040_bib73","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.cell.2020.09.038","article-title":"Antigen-specific adaptive immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity","volume":"183","author":"Rydyznski Moderbacher","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib74","doi-asserted-by":"crossref","first-page":"108716","DOI":"10.1016\/j.clim.2021.108716","article-title":"Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19","volume":"226","author":"Satyam","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib75","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(20)30167-7","article-title":"Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1\/2A trials","volume":"395","author":"Sawitzki","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2021.12.040_bib76","doi-asserted-by":"crossref","first-page":"628971","DOI":"10.3389\/fimmu.2020.628971","article-title":"Disease severity, fever, age, and sex correlate With SARS-CoV-2 neutralizing antibody responses","volume":"11","author":"Schlickeiser","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib77","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 is marked by a dysregulated myeloid cell compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib78","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.3389\/fimmu.2019.02367","article-title":"Minimizing batch effects in mass cytometry data","volume":"10","author":"Schuyler","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib79","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2021.01.007","article-title":"Adaptive immunity to SARS-CoV-2 and COVID-19","volume":"184","author":"Sette","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib80","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137858","article-title":"Pulmonary mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment","volume":"5","author":"Shanmugasundaram","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2021.12.040_bib81","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.cell.2021.12.040_bib82","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/febs.13699","article-title":"Extracellular Granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1","volume":"283","author":"Sharma","year":"2016","journal-title":"FEBS J"},{"key":"10.1016\/j.cell.2021.12.040_bib83","first-page":"720","article-title":"Alterations in T and B cell function persist in convalescent COVID-19 patients","volume":"2","author":"Shuwa","year":"2021","journal-title":"Med (N. Y.)"},{"key":"10.1016\/j.cell.2021.12.040_bib84","doi-asserted-by":"crossref","first-page":"663187","DOI":"10.3389\/fimmu.2021.663187","article-title":"Complement overactivation and consumption predicts in-hospital mortality in SARS-CoV-2 infection","volume":"12","author":"Sinkovits","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib85","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/tra.12490","article-title":"Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes","volume":"18","author":"Spessott","year":"2017","journal-title":"Traffic"},{"key":"10.1016\/j.cell.2021.12.040_bib86","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41591-021-01329-2","article-title":"Single-cell multi-omics analysis of the immune response in COVID-19","volume":"27","author":"Stephenson","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2047-1440-2-17","article-title":"Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study","volume":"2","author":"Streitz","year":"2013","journal-title":"Transplant. Res."},{"key":"10.1016\/j.cell.2021.12.040_bib88","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2021.12.040_bib89","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2021.12.040_bib90","doi-asserted-by":"crossref","first-page":"108728","DOI":"10.1016\/j.celrep.2021.108728","article-title":"Early induction of functional SARS-CoV-2-specific T\u00a0cells associates with rapid viral clearance and mild disease in COVID-19 patients","volume":"34","author":"Tan","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.cell.2021.12.040_bib91","doi-asserted-by":"crossref","first-page":"100092","DOI":"10.1016\/j.xcrm.2020.100092","article-title":"Robust T\u00a0cell response toward spike, membrane, and nucleocapsid SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients","volume":"1","author":"Thieme","year":"2020","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2021.12.040_bib92","doi-asserted-by":"crossref","first-page":"ofab019","DOI":"10.1093\/ofid\/ofab019","article-title":"Dysregulated Host Response in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Critical Illness","volume":"8","author":"Tiwari-Heckler","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.cell.2021.12.040_bib93","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2020.05.002","article-title":"Immunology of COVID-19: current state of the science","volume":"52","author":"Vabret","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2021.12.040_bib94","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2021.12.040_bib95","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib96","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/1751-7915.13828","article-title":"SARS-CoV-2 RNA screening in routine pathology specimens","volume":"14","author":"von Stillfried","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.cell.2021.12.040_bib97","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41422-020-00455-9","article-title":"Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages","volume":"31","author":"Wauters","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.cell.2021.12.040_bib98","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-immunol-042617-053245","article-title":"Complement and the regulation of T\u00a0cell responses","volume":"36","author":"West","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib99","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.3390\/cells10081900","article-title":"Multisystemic cellular tropism of SARS-CoV-2 in autopsies of COVID-19 patients","volume":"10","author":"Wong","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cell.2021.12.040_bib100","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg0833","article-title":"SARS-CoV-2 drives JAK1\/2-dependent local complement hyperactivation","volume":"6","author":"Yan","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009804","article-title":"Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients","volume":"17","author":"Youngs","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cell.2021.12.040_bib102","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.cell.2021.12.040_bib103","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41392-021-00759-1","article-title":"Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cell.2021.12.040_bib104","doi-asserted-by":"crossref","first-page":"655934","DOI":"10.3389\/fimmu.2021.655934","article-title":"T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19","volume":"12","author":"Zenarruzabeitia","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2021.12.040_bib105","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-020-0762-x","article-title":"Single-cell landscape of immunological responses in patients with COVID-19","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat. Immunol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421015622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867421015622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:15:56Z","timestamp":1777475756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867421015622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":105,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0092867421015622"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2021.12.040","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.08.21258481","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.741374589.793596174","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement activation induces excessive T cell cytotoxicity in severe COVID-19","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2021.12.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}