{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:49:38Z","timestamp":1792662578315,"version":"4.5.0"},"reference-count":120,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cell.2022.04.019","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T10:28:15Z","timestamp":1651832895000},"page":"1924-1942.e23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":384,"title":["Lymph node colonization induces tumor-immune tolerance to promote distant metastasis"],"prefix":"10.1016","volume":"185","author":[{"given":"Nathan E.","family":"Reticker-Flynn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiruo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Belk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Basto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole K.","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genay O.W.","family":"Pilarowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alborz","family":"Bejnood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A.","family":"Kenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian L.","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreya","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Carmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna L.","family":"Tolentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okmi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Gentles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Sunwoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansuman T.","family":"Satpathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia K.","family":"Plevritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar G.","family":"Engleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2022.04.019_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao4310","article-title":"Tumor-infiltrating human CD4+ regulatory T\u00a0cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity","volume":"4","author":"Ahmadzadeh","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1741-7007-6-13","article-title":"Hue-shifted monomeric variants of Clavularia cyan fluorescent protein: identification of the molecular determinants of color and applications in fluorescence imaging","volume":"6","author":"Ai","year":"2008","journal-title":"BMC Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2022.04.019_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature25432","article-title":"Chromosomal instability drives metastasis through a cytosolic DNA response","volume":"553","author":"Bakhoum","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib5","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2022.04.019_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib7","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2019.07.019","article-title":"Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade","volume":"178","author":"Benci","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib8","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.cell.2016.11.022","article-title":"Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade","volume":"167","author":"Benci","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib9","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing Type-2 dendritic cells to drive protective antitumor CD4+ T\u00a0cell immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00262-017-2001-3","article-title":"MuPeXI: prediction of neo-epitopes from tumor sequencing data","volume":"66","author":"Bjerregaard","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.cell.2022.04.019_bib11","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2022.04.019_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08021","article-title":"Genes that mediate breast cancer metastasis to the brain","volume":"459","author":"Bos","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib13","first-page":"120","article-title":"The OpenCV library","volume":"25","author":"Bradski","year":"2000","journal-title":"Dr Dobbs J."},{"key":"10.1016\/j.cell.2022.04.019_bib14","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti\u2013PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib15","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.aal3662","article-title":"Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice","volume":"359","author":"Brown","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib17","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib18","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1038\/s41467-018-07806-6","article-title":"Interleukin 2 modulates thymic-derived regulatory T\u00a0cell epigenetic landscape","volume":"9","author":"Chorro","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2022.04.019_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly"},{"key":"10.1016\/j.cell.2022.04.019_bib20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/35020106","article-title":"Genomic analysis of metastasis reveals an essential role for RhoC","volume":"406","author":"Clark","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1898","article-title":"The chromatin accessibility landscape of primary human cancers","volume":"362","author":"Corces","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib22","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2022.04.019_bib23","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ng.356","article-title":"Braf(V600E) cooperates with Pten loss to induce metastatic melanoma","volume":"41","author":"Dankort","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2022.04.019_bib24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.8171322","article-title":"Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin","volume":"264","author":"De Togni","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.1258867","article-title":"Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection","volume":"348","author":"Deng","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib27","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","article-title":"Interferons, immunity and cancer immunoediting","volume":"6","author":"Dunn","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib28","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1158\/0008-5472.CAN-11-4026","article-title":"Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice","volume":"72","author":"Duong","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2022.04.019_bib29","series-title":"AJCC cancer staging handbook : from the AJCC cancer staging manual","article-title":"American Joint Committee on Cancer, and American Cancer Society","author":"Edge","year":"2010"},{"key":"10.1016\/j.cell.2022.04.019_bib30","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1038\/ncomms4530","article-title":"Lymph node-independent liver metastasis in a model of metastatic colorectal cancer","volume":"5","author":"Enquist","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2022.04.019_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/bib\/bbl030","article-title":"HCOP: a searchable database of human orthology predictions","volume":"8","author":"Eyre","year":"2007","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.cell.2022.04.019_bib32","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","article-title":"Completion dissection or observation for sentinel-node metastasis in melanoma","volume":"376","author":"Faries","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/newbio242148a0","article-title":"Selection of successive tumour lines for metastasis","volume":"242","author":"Fidler","year":"1973","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib34","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1200\/JCO.1999.17.3.976","article-title":"Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients","volume":"17","author":"Gershenwald","year":"1999","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2022.04.019_bib35","doi-asserted-by":"crossref","first-page":"D1079","DOI":"10.1093\/nar\/gku1071","article-title":"Genenames.org: the HGNC resources in 2015","volume":"43","author":"Gray","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2022.04.019_bib36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.semcancer.2019.03.004","article-title":"The role of SOX family members in solid tumours and metastasis","volume":"67","author":"Grimm","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41591-018-0309-y","article-title":"Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG","volume":"25","author":"Gu","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature14347","article-title":"The evolutionary history of lethal metastatic prostate cancer","volume":"520","author":"Gundem","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib39","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1172\/JCI70354","article-title":"Tracking the clonal origin of lethal prostate cancer","volume":"123","author":"Haffner","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2022.04.019_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-190707000-00001","article-title":"I.\u00a0The results of radical operations for the cure of carcinoma of the breast","volume":"46","author":"Halsted","year":"1907","journal-title":"Ann. Surg."},{"key":"10.1016\/j.cell.2022.04.019_bib41","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib42","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.178.5.2961","article-title":"Regulatory T\u00a0cells dynamically control the primary immune response to foreign antigen","volume":"178","author":"Haribhai","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib43","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib44","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/cncr.21778","article-title":"Metastatic patterns in adenocarcinoma","volume":"106","author":"Hess","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.cell.2022.04.019_bib45","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nbt.2647","article-title":"DNA targeting specificity of RNA-guided Cas9 nucleases","volume":"31","author":"Hsu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib47","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1200\/JCO.1999.17.8.2334","article-title":"Significance of axillary lymph node metastasis in primary breast cancer","volume":"17","author":"Jatoi","year":"1999","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2022.04.019_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molimm.2017.12.005","article-title":"The regulatory network behind MHC class I expression","volume":"113","author":"Jongsma","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1158\/0008-5472.CAN-11-1831","article-title":"ERK1\/2 regulation of CD44 modulates oral cancer aggressiveness","volume":"72","author":"Judd","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2022.04.019_bib50","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.1700893","article-title":"NetMHCpan-4.0: improved peptide-MHC Class I interaction predictions integrating eluted ligand and peptide binding affinity data","volume":"199","author":"Jurtz","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8+ T\u00a0cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib53","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib54","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"Krzywinski","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2022.04.019_bib55","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jso.21815","article-title":"Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients","volume":"103","author":"Leong","year":"2011","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.cell.2022.04.019_bib56","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/ni.3004","article-title":"Continuous requirement for the TCR in regulatory T\u00a0cell function","volume":"15","author":"Levine","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib57","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2022.04.019_bib58","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2022.04.019_bib59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2022.04.019_bib60","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.celrep.2012.01.005","article-title":"VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics","volume":"1","author":"Lund","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2022.04.019_bib62","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ng.3764","article-title":"Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer","volume":"49","author":"Makohon-Moore","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2022.04.019_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2016.02.025","article-title":"Metastatic latency and immune evasion through autocrine inhibition of WNT","volume":"165","author":"Malladi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib64","doi-asserted-by":"crossref","first-page":"33918","DOI":"10.1038\/srep33918","article-title":"Comparing nodal versus bony metastatic spread using tumour phylogenies","volume":"6","author":"Mangiola","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2022.04.019_bib65","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T\u00a0cells","volume":"554","author":"Mariathasan","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGF\u03b2 in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib67","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.cell.2017.10.001","article-title":"Allele-specific HLA loss and immune escape in lung cancer evolution","volume":"171","author":"McGranahan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib68","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib69","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","article-title":"Genes that mediate breast cancer metastasis to lung","volume":"436","author":"Minn","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib70","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cell.2016.03.031","article-title":"Combination cancer therapies with immune checkpoint blockade: convergence on interferon signaling","volume":"165","author":"Minn","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2022.04.019_bib72","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature09807","article-title":"Tumour evolution inferred by single-cell sequencing","volume":"472","author":"Navin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib73","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.aai8515","article-title":"Origins of lymphatic and distant metastases in human colorectal cancer","volume":"357","author":"Naxerova","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib74","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/1471-2407-11-518","article-title":"SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer","volume":"11","author":"Neumann","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cell.2022.04.019_bib75","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cell.2009.04.030","article-title":"WNT\/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis","volume":"138","author":"Nguyen","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib76","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1038\/s41467-020-17046-2","article-title":"Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients","volume":"11","author":"N\u00fa\u00f1ez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2022.04.019_bib77","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ni1239","article-title":"Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in\u00a0vivo and reduces tumor immunosurveillance","volume":"6","author":"Oppenheim","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib78","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1146\/annurev.immunol.21.120601.141135","article-title":"Does the immune system see tumors as foreign or self?","volume":"21","author":"Pardoll","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib79","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2022.04.019_bib80","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2022.04.019_bib81","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1158\/1078-0432.CCR-16-1946","article-title":"Genomic profiling of patient-derived xenografts for lung cancer identifies B2M inactivation impairing immunorecognition","volume":"23","author":"Pereira","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2022.04.019_bib82","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.semcdb.2015.01.008","article-title":"The lymph node microenvironment and its role in the progression of metastatic cancer","volume":"38","author":"Pereira","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib83","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.aal3622","article-title":"Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice","volume":"359","author":"Pereira","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib84","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-cancerbio-030419-033428","article-title":"Regulatory T\u00a0cells in cancer","volume":"4","author":"Plitas","year":"2020","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib85","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.aaf1328","article-title":"SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions","volume":"352","author":"Pucci","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib86","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2022.04.019_bib87","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nri1199","article-title":"Roles of the NKG2D immunoreceptor and its ligands","volume":"3","author":"Raulet","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib88","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.aat7171","article-title":"Minimal functional driver gene heterogeneity among untreated metastases","volume":"361","author":"Reiter","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib89","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical role for CD103(+)\/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T\u00a0cell immunity in melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib90","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"Interferome v2.0: an updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2022.04.019_bib91","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.18632\/oncotarget.6029","article-title":"SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis","volume":"7","author":"Russo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cell.2022.04.019_bib92","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/s41467-017-01062-w","article-title":"Resistance to checkpoint blockade therapy through inactivation of antigen presentation","volume":"8","author":"Sade-Feldman","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2022.04.019_bib93","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2016.03.012","article-title":"Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition","volume":"44","author":"Salmon","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2022.04.019_bib94","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2022.04.019_bib95","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2022.04.019_bib96","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion","volume":"331","author":"Schreiber","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2022.04.019_bib97","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nbt1037","article-title":"Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein","volume":"22","author":"Shaner","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2022.04.019_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004086","article-title":"Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses","volume":"15","author":"Shaw","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib99","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41467-019-14112-2","article-title":"Attenuation of TCR-induced transcription by Bach2 controls regulatory T\u00a0cell differentiation and homeostasis","volume":"11","author":"Sidwell","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2022.04.019_bib100","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2016.12.022","article-title":"Systemic immunity is required for effective cancer immunotherapy","volume":"168","author":"Spitzer","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib101","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006504","article-title":"Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T\u00a0cells","volume":"5","author":"Spranger","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib102","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.cell.2022.04.019_bib103","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2022.04.019_bib104","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2022.04.019_bib105","doi-asserted-by":"crossref","first-page":"127ra37","DOI":"10.1126\/scitranslmed.3003689","article-title":"Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape","volume":"4","author":"Taube","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib106","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature25492","article-title":"TGF\u03b2 drives immune evasion in genetically reconstituted colon cancer metastasis","volume":"554","author":"Tauriello","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib107","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the Gene Ontology KnowledgeBase and resources","volume":"45","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cell.2022.04.019_bib108","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1158\/1078-0432.CCR-09-2384","article-title":"Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host","volume":"16","author":"Tseng","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2022.04.019_bib109","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.7717\/peerj.453","article-title":"Scikit-image: image processing in Python","volume":"2","author":"van der Walt","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.cell.2022.04.019_bib110","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","article-title":"Homing and cellular traffic in lymph nodes","volume":"3","author":"von Andrian","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib111","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T\u00a0cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib112","series-title":"ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.cell.2022.04.019_bib113","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00335-005-0103-2","article-title":"HCOP: the HGNC comparison of orthology predictions search tool","volume":"16","author":"Wright","year":"2005","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.cell.2022.04.019_bib114","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0065-230X(03)90004-2","article-title":"Natural killer cells and cancer","volume":"90","author":"Wu","year":"2003","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.cell.2022.04.019_bib115","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41586-020-2056-8","article-title":"Peripheral T\u00a0cell expansion predicts tumour infiltration and clinical response","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2022.04.019_bib116","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1073\/pnas.0911587107","article-title":"Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in\u00a0vivo","volume":"107","author":"Yang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2022.04.019_bib117","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41591-019-0522-3","article-title":"Clonal replacement of tumor-specific T\u00a0cells following PD-1 blockade","volume":"25","author":"Yost","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2022.04.019_bib118","doi-asserted-by":"crossref","first-page":"615603","DOI":"10.3389\/fimmu.2020.615603","article-title":"Interferon receptor trafficking and signaling: journey to the cross roads","volume":"11","author":"Zanin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2022.04.019_bib119","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2022.04.019_bib120","doi-asserted-by":"crossref","first-page":"986048","DOI":"10.1155\/2014\/986048","article-title":"Advanced heat map and clustering analysis using Heatmap3","volume":"2014","author":"Zhao","year":"2014","journal-title":"BioMed Res. Int."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867422004664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867422004664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:00:52Z","timestamp":1758801652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867422004664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":120,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0092867422004664"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2022.04.019","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymph node colonization induces tumor-immune tolerance to promote distant metastasis","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2022.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}