{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:24:02Z","timestamp":1792668242797,"version":"4.5.0"},"reference-count":184,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.cell.2023.02.002","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T13:15:41Z","timestamp":1681391741000},"page":"1689-1707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":592,"title":["Cancer neuroscience: State of the field, emerging directions"],"prefix":"10.1016","volume":"186","author":[{"given":"Frank","family":"Winkler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humsa S.","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Amit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Batchelor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan Ekin","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Deneen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Hervey-Jumper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Mabbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Platten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Rolls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica K.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Venkataramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3547-237X","authenticated-orcid":false,"given":"Michelle","family":"Monje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2023.02.002_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ccell.2017.02.005","article-title":"Nerve dependence: from regeneration to cancer","volume":"31","author":"Boilly","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tins.2012.08.003","article-title":"Nerve dependence in tissue, organ, and appendage regeneration","volume":"35","author":"Kumar","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cell.2020.03.034","article-title":"Roadmap for the emerging field of cancer neuroscience","volume":"181","author":"Monje","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuron.2015.12.008","article-title":"The cellular and molecular landscapes of the developing human central nervous system","volume":"89","author":"Silbereis","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity","volume":"485","author":"F\u00fcnfschilling","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1949.sp004335","article-title":"Evidence for saltatory conduction in peripheral myelinated nerve fibres","volume":"108","author":"Huxley","year":"1949","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cell.2023.02.002_bib7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature05300","article-title":"Electrical activity in early neuronal development","volume":"444","author":"Spitzer","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib8","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1523\/JNEUROSCI.17-18-07037.1997","article-title":"Cell coupling and uncoupling in the ventricular zone of developing neocortex","volume":"17","author":"Bittman","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib9","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1242\/dev.088005","article-title":"Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain","volume":"140","author":"Berg","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.cell.2023.02.002_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1126\/science.aar2866","article-title":"Synaptic transmission from subplate neurons controls radial migration of neocortical neurons","volume":"360","author":"Ohtaka-Maruyama","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0896-6273(01)00217-3","article-title":"Electrical activity modulates growth cone guidance by diffusible factors","volume":"29","author":"Ming","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.281.5376.559","article-title":"Activity-dependent cortical target selection by thalamic axons","volume":"281","author":"Catalano","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib13","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1523\/JNEUROSCI.18-11-04145.1998","article-title":"The development of local, layer-specific visual cortical axons in the absence of extrinsic influences and intrinsic activity","volume":"18","author":"Dantzker","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/dneu.20737","article-title":"Gap junctions are involved in cell migration in the early postnatal subventricular zone","volume":"69","author":"Marins","year":"2009","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.cell.2023.02.002_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0896-6273(93)90246-N","article-title":"Extensive dye coupling between rat neocortical neurons during the period of circuit formation","volume":"10","author":"Peinado","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib16","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1152\/jn.00972.2002","article-title":"Early development of voltage-gated ion currents and firing properties in neurons of the mouse cerebral cortex","volume":"89","author":"Picken Bahrey","year":"2003","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cell.2023.02.002_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrn2759","article-title":"Mechanisms underlying spontaneous patterned activity in developing neural circuits","volume":"11","author":"Blankenship","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/jphysiol.2004.071621","article-title":"Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones","volume":"560","author":"Corlew","year":"2004","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cell.2023.02.002_bib19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41586-022-04406-9","article-title":"A discrete neuronal population coordinates brain-wide developmental activity","volume":"602","author":"Bajar","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.274.5290.1133","article-title":"Synaptic activity and the construction of cortical circuits","volume":"274","author":"Katz","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neuron.2013.10.030","article-title":"A role for correlated spontaneous activity in the assembly of neural circuits","volume":"80","author":"Kirkby","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnsyn.2019.00033","article-title":"Early actions of neurotransmitters during cortex development and maturation of reprogrammed neurons","volume":"11","author":"Ojeda","year":"2019","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature06488","article-title":"Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation","volume":"451","author":"And\u00e4ng","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib24","doi-asserted-by":"crossref","first-page":"1252304","DOI":"10.1126\/science.1252304","article-title":"Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain","volume":"344","author":"Gibson","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nn.3734","article-title":"Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis","volume":"17","author":"Paez-Gonzalez","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib26","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.aal3839","article-title":"Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis","volume":"356","author":"Paul","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0896-6273(04)00266-1","article-title":"Excitation-neurogenesis coupling in adult neural stem\/progenitor cells","volume":"42","author":"Deisseroth","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuron.2005.08.023","article-title":"GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells","volume":"47","author":"Tozuka","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41467-017-02719-2","article-title":"Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner","volume":"9","author":"Mitew","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib30","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41593-018-0121-5","article-title":"Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex","volume":"21","author":"Hughes","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1126\/science.1254960","article-title":"Motor skill learning requires active central myelination","volume":"346","author":"McKenzie","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuron.2019.04.032","article-title":"Loss of adaptivemyelinationcontributes to methotrexatechemotherapy-relatedcognitiveimpairment","volume":"103","author":"Geraghty","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuron.2019.10.013","article-title":"Disruption of oligodendrogenesisimpairsmemoryconsolidation in adultmice","volume":"105","author":"Steadman","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41593-019-0582-1","article-title":"Preservation of a remote fear memory requires new myelin formation","volume":"23","author":"Pan","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib35","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1220845","article-title":"A critical period for social experience-dependent oligodendrocyte maturation and myelination","volume":"337","author":"Makinodan","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib36","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/nn.3263","article-title":"Impaired adult myelination in the prefrontal cortex of socially isolated mice","volume":"15","author":"Liu","year":"2012","journal-title":"Nat.Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd2109","article-title":"Neuron class-specific responses govern adaptive myelin remodeling in the neocortex","volume":"370","author":"Yang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2013.11.007","article-title":"Role of myelin plasticity in oscillations and synchrony of neuronal activity","volume":"276","author":"Pajevic","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2023.02.002_bib39","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.1073\/pnas.1916646117","article-title":"Activity-dependent myelination: A glial mechanism of oscillatory self-organization in large-scale brain networks","volume":"117","author":"Noori","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.02.002_bib40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/35012083","article-title":"Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus","volume":"405","author":"Bergles","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nn1162","article-title":"Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus","volume":"7","author":"Lin","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nn.2500","article-title":"Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum","volume":"13","author":"Etxeberria","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib43","doi-asserted-by":"crossref","first-page":"e49291","DOI":"10.7554\/eLife.49291","article-title":"Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity","volume":"8","author":"Mount","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cell.2023.02.002_bib44","doi-asserted-by":"crossref","first-page":"8518","DOI":"10.1038\/ncomms9518","article-title":"Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors","volume":"6","author":"Gautier","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib45","article-title":"Neuronal activity in\u00a0vivo enhances functional myelin repair","volume":"5","author":"Ortiz","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2023.02.002_bib46","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nn.3990","article-title":"GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury","volume":"18","author":"Zonouzi","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41586-020-2200-5","article-title":"Injured adult neurons regress to an embryonic transcriptional growth state","volume":"581","author":"Poplawski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib48","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal regulation of the blood-brain barrier and neurovascular coupling","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib49","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/1099","article-title":"Dopaminergic regulation of cerebral cortical microcirculation","volume":"1","author":"Krimer","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib50","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuron.2020.09.002","article-title":"Neuronal activityregulatesblood-brainbarriereffluxtransport through endothelialcircadiangenes","volume":"108","author":"Pulido","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.02.002_bib51","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.1147710","article-title":"Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate","volume":"318","author":"Kumar","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib52","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.1192046","article-title":"Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis","volume":"329","author":"Knox","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib53","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2015.06.017","article-title":"Nerves regulate cardiomyocyte proliferation and heart regeneration","volume":"34","author":"Mahmoud","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib54","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1113\/JP270917","article-title":"Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal","volume":"593","author":"Kreipke","year":"2015","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cell.2023.02.002_bib55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-020-1935-3","article-title":"Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells","volume":"577","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib56","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.stem.2011.02.021","article-title":"Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells","volume":"8","author":"Brownell","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib57","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.stem.2015.02.006","article-title":"Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches","volume":"16","author":"Peterson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib58","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1038\/s41598-018-24768-3","article-title":"Enteric nervous system regulation of intestinal stem cell differentiation and epithelial monolayer function","volume":"8","author":"Puzan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.02.002_bib59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cell.2005.10.041","article-title":"Signals from the sympathetic nervous system regulate hematopoieticstem cell egress from bone marrow","volume":"124","author":"Katayama","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib60","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2011.09.053","article-title":"Nonmyelinating Schwann cells maintain hematopoieticstem cell hibernation in the bone marrow niche","volume":"147","author":"Yamazaki","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib61","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ncomms2493","article-title":"Parasympathetic stimulation improves epithelial organ regeneration","volume":"4","author":"Knox","year":"2013","journal-title":"Nat.Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41577-020-0387-1","article-title":"Neuronal regulation of immunity: why, how and where?","volume":"21","author":"Schiller","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2023.02.002_bib63","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib64","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.immuni.2021.04.007","article-title":"Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation","volume":"54","author":"Schiller","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2023.02.002_bib65","first-page":"333","article-title":"Structural development in gliomas","volume":"34","author":"Scherer","year":"1938","journal-title":"Am. J. Cancer"},{"key":"10.1016\/j.cell.2023.02.002_bib66","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2015.04.012","article-title":"Neuronal activitypromotesgliomagrowth through Neuroligin-3 secretion","volume":"161","author":"Venkatesh","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib67","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-021-03580-6","article-title":"NF1 mutation drives neuronal activity-dependent initiation of optic glioma","volume":"594","author":"Pan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib68","article-title":"Glioma synapses recruit mechanisms of adaptive plasticity","author":"Taylor","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2023.02.002_bib69","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature24014","article-title":"Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma","volume":"549","author":"Venkatesh","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib70","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41586-022-04719-9","article-title":"Olfactory sensory experience regulates gliomagenesis via neuronal IGF1","volume":"606","author":"Chen","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib71","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","article-title":"Electrical and synaptic integration of glioma into neural circuits","volume":"573","author":"Venkatesh","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib72","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/s41586-019-1564-x","article-title":"Glutamatergic synaptic input to glioma cells drives brain tumour progression","volume":"573","author":"Venkataramani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib73","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/j.cell.2022.06.054","article-title":"Glioblastoma hijacks neuronal mechanisms for brain invasion","volume":"185","author":"Venkataramani","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib74","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","article-title":"Synaptic proximity enables NMDAR signalling to promote brain metastasis","volume":"573","author":"Zeng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib75","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nm.2453","article-title":"Glutamate release by primary brain tumors induces epileptic activity","volume":"17","author":"Buckingham","year":"2011","journal-title":"Nat.Med."},{"key":"10.1016\/j.cell.2023.02.002_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/glia.22730","article-title":"GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy","volume":"63","author":"Campbell","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.cell.2023.02.002_bib77","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nn.4493","article-title":"Identification of diverse astrocyte populations and their malignant analogs","volume":"20","author":"John Lin","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib78","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-020-1952-2","article-title":"PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis","volume":"578","author":"Yu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib79","article-title":"Glioblastoma remodeling of neural circuits in the human brain decreases survival","author":"Krishna","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2023.02.002_bib80","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1093\/brain\/awac180","article-title":"Regional healthy brain activity, glioma occurrence and symptomatology","volume":"145","author":"Numan","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.cell.2023.02.002_bib81","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib82","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1523\/JNEUROSCI.3532-16.2017","article-title":"Tweety-homolog 1 drivesbraincolonization of gliomas","volume":"37","author":"Jung","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41556-019-0443-x","article-title":"p120-catenin-dependent collective brain infiltration by glioma cell networks","volume":"22","author":"Gritsenko","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2023.02.002_bib84","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.molcel.2019.08.030","article-title":"Histone variant and cellcontextdetermine H3K27M reprogramming of the enhancerlandscape and oncogenicstate","volume":"76","author":"Nagaraja","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib85","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41467-021-21117-3","article-title":"Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma","volume":"12","author":"Jung","year":"2021","journal-title":"Nat.Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib86","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/j.celrep.2019.02.063","article-title":"Modeling patient-derivedglioblastoma with cerebralorganoids","volume":"26","author":"Linkous","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2023.02.002_bib87","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/neuonc\/nox070","article-title":"Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas","volume":"19","author":"Weil","year":"2017","journal-title":"Neuro. Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/ph14030195","article-title":"Inhibition of intercellular cytosolic traffic via gap junctions reinforces lomustine-induced toxicity in glioblastomain dependent of MGMT promoter methylation status","volume":"14","author":"Schneider","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cell.2023.02.002_bib89","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1074\/jbc.M113.508390","article-title":"Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress","volume":"289","author":"Le","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.02.002_bib90","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib91","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41586-022-05520-4","article-title":"Autonomous rhythmic activity in glioma networks drives brain tumour growth","volume":"613","author":"Hausmann","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.2.1.1","article-title":"On the presence of nerves in tumors and of otherstructures in them as revealed by a modification of Ehrlich's method of \"vitalstaining\" with methylene blue","volume":"2","author":"Young","year":"1897","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib93","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/000348948509400420","article-title":"Nerves and neurotropic carcinomas","volume":"94","author":"Batsakis","year":"1985","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.cell.2023.02.002_bib94","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-020-1996-3","article-title":"Loss of p53 drives neuron reprogramming in head and neck cancer","volume":"578","author":"Amit","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib95","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/(SICI)1096-9098(199707)65:3<164::AID-JSO4>3.0.CO;2-4","article-title":"Perineural invasion by ductal adenocarcinoma of the pancreas","volume":"65","author":"Takahashi","year":"1997","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib96","first-page":"763","article-title":"The role of perineural space invasion in the local spread of prostatic adenocarcinoma","volume":"142","author":"Villers","year":"1989","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.cell.2023.02.002_bib97","doi-asserted-by":"crossref","first-page":"12842","DOI":"10.1074\/jbc.M117.785865","article-title":"Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells","volume":"292","author":"Zhang","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.02.002_bib98","doi-asserted-by":"crossref","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib99","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1158\/0008-5472.CAN-10-0522","article-title":"The sympathetic nervous system induces a metastatic switch in primary breast cancer","volume":"70","author":"Sloan","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2023.02.002_bib100","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nm1447","article-title":"Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma","volume":"12","author":"Thaker","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve growth factorpromotesgastrictumorigenesis through aberrantcholinergicsignaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib102","doi-asserted-by":"crossref","first-page":"250ra115","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib103","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","article-title":"Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness","volume":"8","author":"Renz","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2023.02.002_bib104","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41593-019-0430-3","article-title":"Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression","volume":"22","author":"Kamiya","year":"2019","journal-title":"Nat.Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"beta2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer","volume":"33","author":"Renz","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib106","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cell.2023.02.002_bib107","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.psyneuen.2018.09.012","article-title":"Circulating epinephrine is not required for chronic stress to enhance metastasis","volume":"99","author":"Walker","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cell.2023.02.002_bib108","doi-asserted-by":"crossref","first-page":"10634","DOI":"10.1038\/ncomms10634","article-title":"Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination","volume":"7","author":"Le","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib109","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/s41467-022-30466-6","article-title":"Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1","volume":"13","author":"Anastasaki","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib110","doi-asserted-by":"crossref","first-page":"E2008","DOI":"10.1073\/pnas.1402944111","article-title":"GFRalpha1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling","volume":"111","author":"He","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cell.2023.02.002_bib111","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/01.sla.0000217642.68697.55","article-title":"The neurotrophic factor artemin promotes pancreatic cancer invasion","volume":"244","author":"Ceyhan","year":"2006","journal-title":"Ann. Surg."},{"key":"10.1016\/j.cell.2023.02.002_bib112","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2006.01.046","article-title":"The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons","volume":"399","author":"Anand","year":"2006","journal-title":"Neurosci.Lett."},{"key":"10.1016\/j.cell.2023.02.002_bib113","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1200\/JCO.1999.17.8.2419","article-title":"Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer","volume":"17","author":"Zhu","year":"1999","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib114","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.canlet.2009.02.025","article-title":"Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome","volume":"281","author":"Au","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cell.2023.02.002_bib115","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1182\/blood-2004-08-3096","article-title":"A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival","volume":"105","author":"Pearse","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cell.2023.02.002_bib116","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.aah5072","article-title":"Adrenergic nerves activate an angio-metabolic switch in prostate cancer","volume":"358","author":"Zahalka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib117","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2020.10.016","article-title":"Neurons releaseserine to support mRNA translation in pancreaticcancer","volume":"183","author":"Banh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib118","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1158\/1078-0432.CCR-08-1164","article-title":"Cancer-related axonogenesis and neurogenesis in prostate cancer","volume":"14","author":"Ayala","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.02.002_bib119","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-019-1219-y","article-title":"Progenitors from the central nervous system drive neurogenesis in cancer","volume":"569","author":"Mauffrey","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib120","doi-asserted-by":"crossref","first-page":"103767","DOI":"10.1016\/j.ebiom.2021.103767","article-title":"Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer","volume":"75","author":"Payne","year":"2022","journal-title":"EBiomedicine"},{"key":"10.1016\/j.cell.2023.02.002_bib121","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/s41588-022-01182-0","article-title":"The NALCN channel regulates metastasis and nonmalignant cell dissemination","volume":"54","author":"Rahrmann","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.02.002_bib122","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13058-015-0655-3","article-title":"beta2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion","volume":"17","author":"Creed","year":"2015","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cell.2023.02.002_bib123","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41586-021-04075-0","article-title":"Dietary palmitic acid promotes a prometastatic memory via Schwann cells","volume":"599","author":"Pascual","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib124","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib125","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1084\/jem.20160723","article-title":"Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes","volume":"213","author":"Suzuki","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib126","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"M\u00e9ndez-Ferrer","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib127","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.immuni.2021.03.025","article-title":"Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses","volume":"54","author":"Devi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2023.02.002_bib128","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-022-04890-z","article-title":"Brain motor and fear circuits regulate leukocytes during acute stress","volume":"607","author":"Poller","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib129","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib130","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1172\/JCI129502","article-title":"Beta2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells","volume":"129","author":"Mohammadpour","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2023.02.002_bib131","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1136\/gutjnl-2018-317479","article-title":"GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner","volume":"68","author":"Jiang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.cell.2023.02.002_bib132","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/s41467-020-15676-0","article-title":"Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib133","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1158\/2326-6066.CIR-17-0401","article-title":"beta-Adrenergic Signaling Impairs antitumor CD8+ T-cell Responses to B-cell Lymphoma Immunotherapy","volume":"6","author":"Nissen","year":"2018","journal-title":"Cancer Immunol.Res."},{"key":"10.1016\/j.cell.2023.02.002_bib134","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/2326-6066.CIR-20-0445","article-title":"Chronic adrenergicstresscontributes to metabolicdysfunction and an exhaustedphenotype in Tcells in the tumormicroenvironment","volume":"9","author":"Qiao","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cell.2023.02.002_bib135","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib136","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/cns.13465","article-title":"Activation of dopaminergic VTA inputs to the mPFC ameliorates chronic stress-induced breast tumor progression","volume":"27","author":"Xu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cell.2023.02.002_bib137","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/s41467-018-05283-5","article-title":"Modulation of anti-tumor immunity by the brain's reward system","volume":"9","author":"Ben-Shaanan","year":"2018","journal-title":"Nat.Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib138","doi-asserted-by":"crossref","first-page":"e1405205","DOI":"10.1080\/2162402X.2017.1405205","article-title":"Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice","volume":"7","author":"Kokolus","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cell.2023.02.002_bib139","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41586-021-04082-1","article-title":"B cell-derived GABA elicits IL-10+macrophages to limit anti-tumour immunity","volume":"599","author":"Zhang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib140","doi-asserted-by":"crossref","first-page":"eabc8188","DOI":"10.1126\/scitranslmed.abc8188","article-title":"Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models","volume":"13","author":"Schneider","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib141","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2023.02.002_bib142","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib143","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-022-05474-7","article-title":"Brain borders at the central stage of neuroimmunology","volume":"612","author":"Rustenhoven","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.02.002_bib144","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1016\/j.cell.2021.10.013","article-title":"Insular cortex neurons encode and retrieve specific immune responses","volume":"184","author":"Koren","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib145","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41467-020-15770-3","article-title":"Midkine activation of CD8+ Tcells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth","volume":"11","author":"Guo","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.02.002_bib146","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neo.2015.10.002","article-title":"RNA sequencing of tumor-associatedmicrogliareveals Ccl5 as a stromalchemokinecritical for Neurofibromatosis-1 gliomagrowth","volume":"17","author":"SOlga","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.cell.2023.02.002_bib147","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/sj.bjc.6601772","article-title":"Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target","volume":"90","author":"Wefel","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2023.02.002_bib148","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy-induced peripheral neuropathy: A current review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cell.2023.02.002_bib149","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1200\/JCO.20.02315","article-title":"Brain imaging in pediatriccancersurvivors: correlates of cognitiveimpairment","volume":"39","author":"Kesler","year":"2021","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib150","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s13311-021-01096-5","article-title":"Structural neuroimagingfindingsrelated to adultnon-CNS cancer and treatment: Review, integration, and implications for treatment of cognitive dysfunction: Review","volume":"18","author":"McDonald","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cell.2023.02.002_bib151","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1523\/JNEUROSCI.0560-17.2017","article-title":"Changes in white mattermicrostructureimpactcognition by disrupting the ability of neuralassemblies to synchronize","volume":"37","author":"Bells","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib152","doi-asserted-by":"crossref","first-page":"108285","DOI":"10.1016\/j.neuropsychologia.2022.108285","article-title":"Structural connectivity and intelligence in brain-injured children","volume":"173","author":"Oyefiade","year":"2022","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.cell.2023.02.002_bib153","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1002\/cne.24717","article-title":"Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury","volume":"527","author":"Gauvreau","year":"2019","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cell.2023.02.002_bib154","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tins.2021.02.003","article-title":"Microglia in cancertherapy-relatedcognitiveimpairment","volume":"44","author":"Gibson","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib155","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1523\/JNEUROSCI.19-11-04508.1999","article-title":"Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat","volume":"19","author":"Parent","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2023.02.002_bib156","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm749","article-title":"Irradiation induces neural precursor-cell dysfunction","volume":"8","author":"Monje","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib157","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.02.002_bib158","first-page":"22","article-title":"CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in\u00a0vitro and in\u00a0vivo","volume":"5","author":"Dietrich","year":"2006","journal-title":"J.\u00a0Biol."},{"key":"10.1016\/j.cell.2023.02.002_bib159","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cell.2018.10.049","article-title":"Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment","volume":"176","author":"Gibson","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib160","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ana.21214","article-title":"Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies","volume":"62","author":"Monje","year":"2007","journal-title":"Ann.Neurol."},{"key":"10.1016\/j.cell.2023.02.002_bib161","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2009.02.025","article-title":"Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats","volume":"201","author":"Seigers","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cell.2023.02.002_bib162","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2014.02.020","article-title":"Low-doses of cisplatin injure hippocampal synapses: a mechanism for 'chemo' brain?","volume":"255","author":"Andres","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cell.2023.02.002_bib163","doi-asserted-by":"crossref","first-page":"12822","DOI":"10.1073\/pnas.1307301110","article-title":"Cranial irradiation compromises neuronal architecture in the hippocampus","volume":"110","author":"Parihar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cell.2023.02.002_bib164","doi-asserted-by":"crossref","first-page":"e110464","DOI":"10.1371\/journal.pone.0110464","article-title":"Ionising radiation immediately impairs synaptic plasticity-associated cytoskeletal signalling pathways in HT22 cells and in mouse brain: an in\u00a0vitro\/in\u00a0vivo comparison study","volume":"9","author":"Kempf","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.02.002_bib165","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41591-020-0985-2","article-title":"Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin","volume":"26","author":"Ayoub","year":"2020","journal-title":"Nat.Med."},{"key":"10.1016\/j.cell.2023.02.002_bib166","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1002\/cncr.26127","article-title":"Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood","volume":"117","author":"Mabbott","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.cell.2023.02.002_bib167","first-page":"440","article-title":"Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training","volume":"19","author":"Riggs","year":"2017","journal-title":"Neuro. Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib168","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2018.04.021","article-title":"A role for hypocretin\/orexin in metabolic and sleep abnormalities in a mouse model of non-metastatic breast cancer","volume":"28","author":"Borniger","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.cell.2023.02.002_bib169","doi-asserted-by":"crossref","first-page":"837","DOI":"10.5665\/sleep.3642","article-title":"Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer","volume":"37","author":"Palesh","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.cell.2023.02.002_bib170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcsm.12059","article-title":"Pathophysiology of anorexia in the cancer cachexia syndrome","volume":"6","author":"Ezeoke","year":"2015","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.cell.2023.02.002_bib171","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nm.1976","article-title":"Hematopoieticcolony-stimulating factors mediate tumor-nerve interactions and bone cancer pain","volume":"15","author":"Schweizerhof","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.02.002_bib172","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ccell.2015.04.017","article-title":"A functionalrole for VEGFR1 expressed in peripheralsensoryneurons in cancerpain","volume":"27","author":"Selvaraj","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib173","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1053\/j.gastro.2020.04.037","article-title":"CXCL10 and CCL21 promotemigration of pancreatic cancer cells toward sensory neurons and neural remodeling in tumors in mice, associated with pain in patients","volume":"159","author":"Hirth","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2023.02.002_bib174","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2217\/fon.10.142","article-title":"Impact of stress on cancer metastasis","volume":"6","author":"Moreno-Smith","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib175","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S1470-2045(21)00596-9","article-title":"Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities","volume":"23","author":"Shi","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cell.2023.02.002_bib176","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s43018-020-00146-9","article-title":"Future directions in preclinical and translational cancer neuroscience research","volume":"1","author":"Demir","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2023.02.002_bib177","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41568-022-00475-0","article-title":"Disconnecting multicellular networks in brain tumours","volume":"22","author":"Venkataramani","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2023.02.002_bib178","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41587-020-0411-9","article-title":"Cancer-neuronal crosstalk and the startups working to silence it","volume":"38","author":"Dolgin","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.02.002_bib179","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s41556-022-00978-w","article-title":"Insights and opportunities at the crossroads of cancer and neuroscience","volume":"24","author":"Pan","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2023.02.002_bib180","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1158\/1078-0432.CCR-19-2641","article-title":"Preoperative beta-blockade with propranololreducesbiomarkers of metastasis in breastcancer: A Phase II randomized trial","volume":"26","author":"Hiller","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.02.002_bib181","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1158\/1078-0432.CCR-17-0152","article-title":"Perioperative COX-2 and beta-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a Phase-II randomized trial","volume":"23","author":"Shaashua","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.02.002_bib182","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.cell.2022.04.038","article-title":"Glioma progression is shaped by genetic evolution and microenvironment interactions","volume":"185","author":"Varn","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.02.002_bib183","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1148\/radiol.2019191347","article-title":"Structural nerveremodeling at 3-T MR neurographydiffers between painful and painlessdiabeticpolyneuropathy in Type 1 or 2 diabetes","volume":"294","author":"Jende","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.cell.2023.02.002_bib184","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41586-022-04489-4","article-title":"GD2-CAR T\u00a0cell therapy for H3K27M-mutated diffuse midline gliomas","volume":"603","author":"Majzner","year":"2022","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423001046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423001046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:09:34Z","timestamp":1758802174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867423001046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":184,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0092867423001046"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2023.02.002","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer neuroscience: State of the field, emerging directions","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2023.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}