{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:26:18Z","timestamp":1792121178683,"version":"4.4.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":417,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.cell.2023.03.014","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T10:36:48Z","timestamp":1681123008000},"page":"1968-1984.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease"],"prefix":"10.1016","volume":"186","author":[{"given":"Zixi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunguan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Gordillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Hsiung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Hoare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Hoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2023.03.014_bib1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.aab4082","article-title":"Somatic mutation in cancer and normal cells","volume":"349","author":"Martincorena","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.03.014_bib2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41586-019-1670-9","article-title":"Somatic mutations and clonal dynamics in healthy and cirrhotic human liver","volume":"574","author":"Brunner","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.03.014_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.03.026","article-title":"Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease","volume":"177","author":"Zhu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.03.014_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.aba8347","article-title":"Extensive heterogeneity in somatic mutation and selection in the human bladder","volume":"370","author":"Lawson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.03.014_bib5","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1503519","article-title":"Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis","volume":"377","author":"Diehl","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2023.03.014_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-021-03974-6","article-title":"Convergent somatic mutations in metabolism genes in chronic liver disease","volume":"598","author":"Ng","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.03.014_bib7","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.03.014_bib8","doi-asserted-by":"crossref","first-page":"100031","DOI":"10.1194\/jlr.RA120000856","article-title":"Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and\u00a0fatty liver","volume":"62","author":"Xia","year":"2021","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2023.03.014_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2013.03.026","article-title":"A direct in\u00a0vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration","volume":"153","author":"Wuestefeld","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.03.014_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2022.01.001","article-title":"In\u00a0vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration","volume":"29","author":"Jia","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2023.03.014_bib11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s41587-019-0246-4","article-title":"In\u00a0vivo CRISPR screening in CD8 T\u00a0cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma","volume":"37","author":"Ye","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.03.014_bib12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/mt.2014.254","article-title":"Hybrid nonviral\/viral vector systems for improved piggyBac DNA transposon in\u00a0vivo delivery","volume":"23","author":"Cooney","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cell.2023.03.014_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cmet.2017.08.002","article-title":"Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases","volume":"27","author":"Samuel","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.03.014_bib14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2023.03.014_bib15","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2023.03.014_bib16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.ymthe.2021.11.007","article-title":"An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis","volume":"30","author":"Yenilmez","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cell.2023.03.014_bib17","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1016\/S0021-9258(19)85266-3","article-title":"Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization","volume":"268","author":"Wang","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.03.014_bib18","doi-asserted-by":"crossref","first-page":"14490","DOI":"10.1016\/S0021-9258(19)85265-1","article-title":"Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence","volume":"268","author":"Briggs","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.03.014_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.03.014_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/352073a0","article-title":"Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein","volume":"352","author":"Sun","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.03.014_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2008.05.007","article-title":"Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding","volume":"8","author":"Kubota","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.03.014_bib22","doi-asserted-by":"crossref","first-page":"12977","DOI":"10.1038\/ncomms12977","article-title":"Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity","volume":"7","author":"Kubota","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.03.014_bib23","doi-asserted-by":"crossref","first-page":"e115922","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.03.014_bib24","doi-asserted-by":"crossref","first-page":"12541","DOI":"10.1038\/s41598-019-48746-5","article-title":"Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease","volume":"9","author":"Hoang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.03.014_bib25","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1053\/j.gastro.2013.01.021","article-title":"Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis","volume":"144","author":"Hoshida","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2023.03.014_bib26","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.03.014_bib27","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2023.03.014_bib28","doi-asserted-by":"crossref","first-page":"100179","DOI":"10.1016\/j.jhepr.2020.100179","article-title":"Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor","volume":"2","author":"Wang","year":"2020","journal-title":"JHEP Rep."},{"key":"10.1016\/j.cell.2023.03.014_bib29","doi-asserted-by":"crossref","first-page":"594710","DOI":"10.1155\/2014\/594710","article-title":"Influence of the A3669G glucocorticoid receptor gene polymorphism on the metabolic profile of pediatric patients with congenital adrenal hyperplasia","volume":"2014","author":"Moreira","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.cell.2023.03.014_bib30","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1111\/liv.12794","article-title":"Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis","volume":"35","author":"Pizarro","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.cell.2023.03.014_bib31","doi-asserted-by":"crossref","first-page":"E1415","DOI":"10.1152\/ajpendo.00419.2013","article-title":"Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet","volume":"305","author":"Wada","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cell.2023.03.014_bib32","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/HYPERTENSIONAHA.116.08798","article-title":"Downregulation of plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat","volume":"69","author":"Li\u0161ka","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.cell.2023.03.014_bib33","doi-asserted-by":"crossref","first-page":"e41949","DOI":"10.1371\/journal.pone.0041949","article-title":"Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N\/+) mice to hepatic steatosis upon feeding liquid alcohol diet","volume":"7","author":"Kutay","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.03.014_bib34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jhep.2020.09.037","article-title":"Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis","volume":"74","author":"Mohs","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cell.2023.03.014_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.12.014","article-title":"Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development","volume":"91","author":"Ramadori","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cell.2023.03.014_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.11.074","article-title":"Loss of transcriptional repression by BCL6 confers insulin sensitivity in the setting of obesity","volume":"25","author":"Senagolage","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2023.03.014_bib37","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1038\/s41598-020-66539-z","article-title":"Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice","volume":"10","author":"Chikada","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.03.014_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43922","article-title":"Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis","volume":"8","author":"Sommars","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cell.2023.03.014_bib39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.5582\/bst.2017.01043","article-title":"The T-Box transcription factor 3 in development and cancer","volume":"11","author":"Willmer","year":"2017","journal-title":"BioSci. Trends"},{"key":"10.1016\/j.cell.2023.03.014_bib40","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.abn9886","article-title":"An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice","volume":"378","author":"Nikkanen","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.03.014_bib41","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.str.2011.06.011","article-title":"Structural basis of substrate methylation and inhibition of SMYD2","volume":"19","author":"Ferguson","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.cell.2023.03.014_bib42","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.03.014_bib43","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","article-title":"A protein-truncating HSD17B13 variant and protection from chronic liver disease","volume":"378","author":"Abul-Husn","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2023.03.014_bib44","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2023.03.014_bib45","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2023.03.014_bib46","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2023.03.014_bib47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cell.2023.03.014_bib48","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ng.593","article-title":"Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies","volume":"42","author":"Zhu","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.03.014_bib49","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.03.014_bib50","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nprot.2018.005","article-title":"Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments","volume":"13","author":"Canver","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2023.03.014_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2023.03.014_bib52","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.03.014_bib53","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.celrep.2016.03.090","article-title":"Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells","volume":"15","author":"Topol","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2023.03.014_bib54","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2023.03.014_bib55","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gr.169508.113","article-title":"ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs","volume":"24","author":"Balwierz","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2023.03.014_bib56","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1073\/pnas.0630591100","article-title":"Integrating regulatory motif discovery and genome-wide expression analysis","volume":"100","author":"Conlon","year":"2003","journal-title":"Proc. Natl.\u00a0Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.03.014_bib57","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrg1315","article-title":"Applied bioinformatics for the identification of regulatory elements","volume":"5","author":"Wasserman","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2023.03.014_bib58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nar\/gkg108","article-title":"TRANSFAC: transcriptional regulation, from patterns to profiles","volume":"31","author":"Matys","year":"2003","journal-title":"Nucleic Acids Res."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423002751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423002751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:08:02Z","timestamp":1758802082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867423002751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0092867423002751"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2023.03.014","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.03.20.533505","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2023.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}