{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:27:12Z","timestamp":1792067232840,"version":"4.4.0"},"reference-count":121,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.cell.2023.04.026","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T15:24:44Z","timestamp":1684164284000},"page":"2361-2379.e25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":150,"title":["Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway"],"prefix":"10.1016","volume":"186","author":[{"given":"Junbing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Berner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison B.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Ordulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Weiss-Sadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Possemato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Harry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan F.","family":"Hubertus de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt R.","family":"D\u00fcrr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Vornb\u00e4umen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina O.","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Mahamdeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Pooladanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bouberhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo R.","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy J.","family":"Soberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Bardeesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B.","family":"Liau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt P.","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Beausoleil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-9546","authenticated-orcid":false,"given":"Liron","family":"Bar-Peled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2023.04.026_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nmeth.2759","article-title":"A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles","volume":"11","author":"Wang","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2023.04.026_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.molmed.2017.03.004","article-title":"ROS in cancer: the burning question","volume":"23","author":"Chio","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","article-title":"ROS-dependent signal transduction","volume":"33","author":"Reczek","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib4","doi-asserted-by":"crossref","first-page":"16810","DOI":"10.1074\/jbc.R117.789628","article-title":"Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms","volume":"292","author":"Chouchani","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.04.026_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1242\/jcs.098475","article-title":"Mitochondrial redox signalling at a glance","volume":"125","author":"Collins","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2023.04.026_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-cancerbio-030518-055844","article-title":"The hallmarks of ferroptosis","volume":"3","author":"Dixon","year":"2019","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: the bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib9","series-title":"Cancer Chemotherapy and Biotherapy: Principles and Practice","author":"Chabner","year":"2011"},{"key":"10.1016\/j.cell.2023.04.026_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.cell.2023.04.026_bib11","first-page":"375","article-title":"Applications of reactive cysteine profiling","volume":"420","author":"Backus","year":"2019","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.cell.2023.04.026_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2016.06.056","article-title":"NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer","volume":"166","author":"Chio","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2017.08.051","article-title":"Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer","volume":"171","author":"Bar-Peled","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2020.02.012","article-title":"A quantitative tissue-specific landscape of protein redox regulation during aging","volume":"180","author":"Xiao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib15","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1158\/1078-0432.CCR-12-2442","article-title":"Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias","volume":"18","author":"Karp","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.leukres.2017.09.005","article-title":"Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia","volume":"61","author":"Webster","year":"2017","journal-title":"Leuk. Res."},{"key":"10.1016\/j.cell.2023.04.026_bib17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1200\/JCO.2014.57.5027","article-title":"Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors","volume":"33","author":"Daud","year":"2015","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2023.04.026_bib18","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s12013-014-0352-3","article-title":"Efficacy of arsenic trioxide in the treatment of malignant pleural effusion caused by pleural metastasis of lung cancer","volume":"71","author":"Xie","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cell.2023.04.026_bib19","first-page":"3893","article-title":"Mechanisms of action of arsenic trioxide","volume":"62","author":"Miller","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib20","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41416-018-0278-4","article-title":"Phase 1 study of ARQ 761, a beta-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis","volume":"119","author":"Gerber","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2023.04.026_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112962","article-title":"A comprehensive review on beta-lapachone: mechanisms, structural modifications, and therapeutic potentials","volume":"210","author":"Gong","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cell.2023.04.026_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4103\/0973-1482.139267","article-title":"An overview of doxorubicin formulations in cancer therapy","volume":"10","author":"Rivankar","year":"2014","journal-title":"J.\u00a0Cancer Res. Ther."},{"key":"10.1016\/j.cell.2023.04.026_bib23","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.freeradbiomed.2012.03.017","article-title":"The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells","volume":"52","author":"Nagai","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13543784.2021.1840550","article-title":"Repurposing elesclomol, an investigational drug for the treatment of copper metabolism disorders","volume":"30","author":"Gohil","year":"2021","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.cell.2023.04.026_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02485-0","article-title":"Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy","volume":"41","author":"Zheng","year":"2022","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/biom12101365","article-title":"Cisplatin resistance: genetic and epigenetic factors involved","volume":"12","author":"Lugones","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.cell.2023.04.026_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10608","article-title":"Cisplatin for cancer therapy and overcoming chemoresistance","volume":"8","author":"Ranasinghe","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.cell.2023.04.026_bib28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/np990549f","article-title":"Bleomycin: new perspectives on the mechanism of action","volume":"63","author":"Hecht","year":"2000","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.cell.2023.04.026_bib29","first-page":"3","article-title":"Bleomycin pharmacology: mechanism of action and resistance, and clinical pharmacokinetics","volume":"19","author":"Dorr","year":"1992","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.cell.2023.04.026_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2023.04.026_bib31","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1111\/jcmm.16548","article-title":"Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: conventional drug in new use","volume":"25","author":"Zhuang","year":"2021","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib32","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s10120-017-0720-y","article-title":"Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)","volume":"20","author":"Shitara","year":"2017","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.cell.2023.04.026_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijwd.2020.01.009","article-title":"Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential","volume":"6","author":"Mushtaq","year":"2020","journal-title":"Int. J. Womens Dermatol."},{"key":"10.1016\/j.cell.2023.04.026_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1592\/phco.23.2.165.32088","article-title":"2-methoxyestradiol, a promising anticancer agent","volume":"23","author":"Lakhani","year":"2003","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.cell.2023.04.026_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.steroids.2010.02.016","article-title":"2-methoxyestradiol--biology and mechanism of action","volume":"75","author":"Mueck","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.cell.2023.04.026_bib36","article-title":"The gold complex auranofin: new perspectives for cancer therapy","volume":"12","author":"Abdalbari","year":"2021","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.cell.2023.04.026_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10549-011-1889-0","article-title":"Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II\u2013IIIc breast cancer","volume":"132","author":"Montero","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.cell.2023.04.026_bib38","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1158\/0008-5472.CAN-07-5957","article-title":"NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance","volume":"68","author":"Townsend","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib39","first-page":"145","article-title":"Sources and implications of NADH\/NAD(+) redox imbalance in diabetes and its complications","volume":"9","author":"Wu","year":"2016","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.cell.2023.04.026_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature22797","article-title":"The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival","volume":"546","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.04.026_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12856","article-title":"Structure-function insights reveal the human ribosome as a cancer target for antibiotics","volume":"7","author":"Myasnikov","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.04.026_bib42","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.cell.2020.07.001","article-title":"An activity-guided map of electrophile-cysteine interactions in primary human T\u00a0cells","volume":"182","author":"Vinogradova","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib43","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41587-020-00778-3","article-title":"Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries","volume":"39","author":"Kuljanin","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.04.026_bib44","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41586-021-03513-3","article-title":"A lysine-cysteine redox switch with an NOS bridge regulates enzyme function","volume":"593","author":"Wensien","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.04.026_bib45","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/acs.chemrestox.9b00152","article-title":"N-acetylcysteine: antioxidant, aldehyde scavenger, and more","volume":"32","author":"Zhitkovich","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cell.2023.04.026_bib47","series-title":"Auranofin and Sirolimus in Treating Participants With Ovarian Cancer","year":"2018"},{"key":"10.1016\/j.cell.2023.04.026_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf7444","article-title":"Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy","volume":"10","author":"Stafford","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib49","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib50","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cmet.2019.01.020","article-title":"Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion","volume":"29","author":"Harris","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.04.026_bib51","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8\u2014a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.04.026_bib52","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1084\/jem.20190251","article-title":"Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion","volume":"216","author":"Zarei","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature01680","article-title":"Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate","volume":"423","author":"Salmeen","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.04.026_bib54","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41375-021-01394-z","article-title":"The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia","volume":"36","author":"Niederkorn","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.cell.2023.04.026_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26125-x","article-title":"Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response","volume":"12","author":"Gajewska","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.04.026_bib56","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.devcel.2018.10.026","article-title":"Oxidative stress in cells with extra centrosomes drives non-cell-autonomous invasion","volume":"47","author":"Arnandis","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib59","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1091\/mbc.e03-12-0874","article-title":"Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation","volume":"15","author":"Katsuragi","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib60","doi-asserted-by":"crossref","first-page":"31532","DOI":"10.1074\/jbc.M109.059246","article-title":"Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases","volume":"284","author":"Gutscher","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.04.026_bib61","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cmet.2020.02.003","article-title":"Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function","volume":"31","author":"Pak","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.04.026_bib62","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1039\/b719986d","article-title":"A chemical approach for detecting sulfenic acid-modified proteins in living cells","volume":"4","author":"Reddie","year":"2008","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.cell.2023.04.026_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/mcp.O115.056051","article-title":"The expanding landscape of the thiol redox proteome","volume":"15","author":"Yang","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2023.04.026_bib64","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1021\/acschembio.5b00124","article-title":"A chemical approach for the detection of protein sulfinylation","volume":"10","author":"Lo Conte","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06533-2","article-title":"Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction","volume":"9","author":"Steinhorn","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.04.026_bib58","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0092-8674(00)80704-7","article-title":"The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation","volume":"100","author":"Chen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib66","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00726-011-0843-0","article-title":"Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association","volume":"42","author":"Permyakov","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.cell.2023.04.026_bib67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1158\/1535-7163.MCT-10-0928","article-title":"Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening","volume":"10","author":"Guzi","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cell.2023.04.026_bib68","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.molcel.2017.01.015","article-title":"Nek7 protects telomeres from oxidative DNA damage by phosphorylation and stabilization of TRF1","volume":"65","author":"Tan","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib69","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-8-r78","article-title":"A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1","volume":"12","author":"Blasius","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib70","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1100\/tsw.2003.09","article-title":"DNA polymerase gamma in mitochondrial DNA replication and repair","volume":"3","author":"Copeland","year":"2003","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.cell.2023.04.026_bib71","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/nar\/gkt988","article-title":"Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication","volume":"42","author":"Rajala","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.04.026_bib72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"Dikalova","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.cell.2023.04.026_bib73","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1080\/10409238.2020.1828258","article-title":"Riding the tiger - physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix","volume":"55","author":"Brand","year":"2020","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib74","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.cmet.2016.08.012","article-title":"Suppressors of superoxide-H(2)O(2) production at Site I(Q) of mitochondrial Complex I protect against stem cell hyperplasia and ischemia-reperfusion injury","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.04.026_bib75","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nchembio.1910","article-title":"Suppressors of superoxide production from mitochondrial complex III","volume":"11","author":"Orr","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf8631","article-title":"The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication","volume":"7","author":"Jiang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2023.04.026_bib77","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1158\/0008-5472.CAN-15-1626","article-title":"Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research","volume":"75","author":"Chatzispyrou","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2023.04.026_bib78","doi-asserted-by":"crossref","DOI":"10.6061\/clinics\/2018\/e478s","article-title":"DNA repair pathways and cisplatin resistance: an intimate relationship","volume":"73","author":"Rocha","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.cell.2023.04.026_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.465","article-title":"Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in\u00a0vitro and in\u00a0vivo","volume":"5","author":"Rocha","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2023.04.026_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.cell.2023.04.026_bib81","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bbagen.2008.01.011","article-title":"Redox compartmentalization in eukaryotic cells","volume":"1780","author":"Go","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2023.04.026_bib82","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nmeth.1212","article-title":"Real-time imaging of the intracellular glutathione redox potential","volume":"5","author":"Gutscher","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2023.04.026_bib83","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3892\/ijmm.2016.2697","article-title":"Mitochondrial DNA depletion causes decreased ROS production and resistance to apoptosis","volume":"38","author":"Chen","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cell.2023.04.026_bib84","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.04.026_bib85","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071586","article-title":"The role of tumor microenvironment in chemoresistance: to survive, keep your enemies closer","volume":"18","author":"Senthebane","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2023.04.026_bib87","doi-asserted-by":"crossref","first-page":"59950","DOI":"10.18632\/oncotarget.19048","article-title":"The molecular mechanisms of chemoresistance in cancers","volume":"8","author":"Zheng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cell.2023.04.026_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10120471","article-title":"Chemoresistance and the self-maintaining tumor microenvironment","volume":"10","author":"Yeldag","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cell.2023.04.026_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2023.04.026_bib90","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/368651","article-title":"Nucleic acid oxidation in human health and disease","volume":"2013","author":"Chao","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cell.2023.04.026_bib91","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/iub.2434","article-title":"Not all mitochondrial DNAs are made equal and the nucleus knows it","volume":"73","author":"Lechuga-Vieco","year":"2021","journal-title":"IUBMB Life"},{"key":"10.1016\/j.cell.2023.04.026_bib92","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/foy088","article-title":"Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae","volume":"18","author":"Guaragnella","year":"2018","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.cell.2023.04.026_bib93","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cmet.2018.09.002","article-title":"PML-regulated mitochondrial metabolism enhances chemosensitivity in human ovarian cancers","volume":"29","author":"Gentric","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2023.04.026_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030497","article-title":"The role of mitochondria in the chemoresistance of pancreatic cancer cells","volume":"10","author":"Fu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cell.2023.04.026_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112549","article-title":"Mitochondrial integration and ovarian cancer chemotherapy resistance","volume":"401","author":"Shen","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cell.2023.04.026_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.769036","article-title":"Mitochondria-shaping proteins and chemotherapy","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cell.2023.04.026_bib97","doi-asserted-by":"crossref","first-page":"15084","DOI":"10.1073\/pnas.1521316112","article-title":"Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.04.026_bib98","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1021\/acsomega.9b00529","article-title":"Dynamic basis for auranofin drug recognition by thiol-reductases of human pathogens and intermediate coordinated adduct formation with catalytic cysteine residues","volume":"4","author":"Abhishek","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.cell.2023.04.026_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/psc.1204","article-title":"COMU: a third generation of uronium-type coupling reagents","volume":"16","author":"El-Faham","year":"2010","journal-title":"J.\u00a0Pept. Sci."},{"key":"10.1016\/j.cell.2023.04.026_bib100","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/acs.accounts.9b00562","article-title":"Activity-based sensing for site-specific proteomic analysis of cysteine oxidation","volume":"53","author":"Shi","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.cell.2023.04.026_bib101","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1002\/anie.201201812","article-title":"Chemoselective ligation of sulfinic acids with aryl-nitroso compounds","volume":"51","author":"Lo Conte","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.cell.2023.04.026_bib102","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1021\/acs.jproteome.6b00905","article-title":"Multiplexed phosphoproteomic profiling using titanium dioxide and immunoaffinity enrichments reveals complementary phosphorylation events","volume":"16","author":"Possemato","year":"2017","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.cell.2023.04.026_bib103","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","article-title":"MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics","volume":"8","author":"Ting","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2023.04.026_bib104","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1007\/s13361-016-1434-9","article-title":"A triple knockout (TKO) proteomics standard for diagnosing ion interference in isobaric labeling experiments","volume":"27","author":"Paulo","year":"2016","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.cell.2023.04.026_bib105","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cell.2023.04.026_bib106","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","article-title":"A tissue-specific atlas of mouse protein phosphorylation and expression","volume":"143","author":"Huttlin","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib107","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to\u00a0correlate tandem mass spectral data of peptides with amino acid sequences in a protein database","volume":"5","author":"Eng","year":"1994","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.cell.2023.04.026_bib108","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pmic.201200439","article-title":"Comet: an open-source MS\/MS sequence database search tool","volume":"13","author":"Eng","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.cell.2023.04.026_bib109","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1073\/pnas.0609836104","article-title":"Large-scale phosphorylation analysis of mouse liver","volume":"104","author":"Vill\u00e9n","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.04.026_bib110","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1093\/bioinformatics\/bti694","article-title":"Mapping PDB chains to UniProtKB entries","volume":"21","author":"Martin","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2023.04.026_bib111","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nmeth.2646","article-title":"pLogo: a probabilistic approach to visualizing sequence motifs","volume":"10","author":"O'Shea","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2023.04.026_bib112","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molcel.2018.11.035","article-title":"SubCellBarCode: proteome-wide mapping of protein localization and relocalization","volume":"73","author":"Orre","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib113","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/bioinformatics\/btl140","article-title":"Improved scoring of functional groups from gene expression data by decorrelating GO graph structure","volume":"22","author":"Alexa","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2023.04.026_bib114","doi-asserted-by":"crossref","first-page":"D512","DOI":"10.1093\/nar\/gku1267","article-title":"PhosphoSitePlus, 2014: mutations, PTMs and recalibrations","volume":"43","author":"Hornbeck","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.04.026_bib115","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.04.026_bib116","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/ng.3984","article-title":"Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells","volume":"49","author":"Meyers","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.04.026_bib117","doi-asserted-by":"crossref","first-page":"D1057","DOI":"10.1093\/nar\/gku1113","article-title":"The GOA database: gene Ontology annotation updates for 2015","volume":"43","author":"Huntley","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.04.026_bib118","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2023.04.026_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/CCI.17.00096","article-title":"Reannotation and analysis of clinical and chemotherapy outcomes in the ovarian data set from the cancer genome atlas","volume":"2","author":"Villalobos","year":"2018","journal-title":"JCO Clin. Cancer Inform."},{"key":"10.1016\/j.cell.2023.04.026_bib120","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.04.026_bib121","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/78999","article-title":"Structural basis for copper transfer by the metallochaperone for the Menkes\/Wilson disease proteins","volume":"7","author":"Wernimont","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.cell.2023.04.026_bib122","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.febslet.2005.01.034","article-title":"Structure of a type II thymidine kinase with bound dTTP","volume":"579","author":"Birringer","year":"2005","journal-title":"FEBS Lett."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423004221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423004221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:07:45Z","timestamp":1758802065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867423004221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":121,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0092867423004221"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2023.04.026","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2023.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}