{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:50:17Z","timestamp":1793555417769,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":396,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000011","name":"HHMI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA029206"],"award-info":[{"award-number":["R21AA029206"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["BX003259-05A1"],"award-info":[{"award-number":["BX003259-05A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R03AI159275"],"award-info":[{"award-number":["R03AI159275"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AA022057"],"award-info":[{"award-number":["AA022057"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01 AA026962-03"],"award-info":[{"award-number":["U01 AA026962-03"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DK124272"],"award-info":[{"award-number":["DK124272"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cell.2023.07.017","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:29:04Z","timestamp":1691576944000},"page":"3793-3809.e26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions"],"prefix":"10.1016","volume":"186","author":[{"given":"Eleanna","family":"Kaffe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Roulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen","family":"Sefik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haris","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Charkoftaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Vasiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Vatner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajahat Z.","family":"Mehal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Yuval Kluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-0778","authenticated-orcid":false,"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2023.07.017_bib1","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2023.07.017_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1126\/science.abg4864","article-title":"In the zone for liver proliferation","volume":"371","author":"Andersson","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.07.017_bib3","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","article-title":"Contemporary epidemiology of chronic liver disease and cirrhosis","volume":"18","author":"Moon","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2023.07.017_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Sepanlou","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2023.07.017_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00204-020-02939-4","article-title":"Cross-species analysis of hepatic cytochrome P450 and transport protein expression","volume":"95","author":"Hammer","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cell.2023.07.017_bib6","doi-asserted-by":"crossref","first-page":"e78550","DOI":"10.1371\/journal.pone.0078550","article-title":"Mice with chimeric livers are an improved model for human lipoprotein metabolism","volume":"8","author":"Ellis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.07.017_bib7","doi-asserted-by":"crossref","first-page":"25963","DOI":"10.1074\/jbc.M200824200","article-title":"The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate","volume":"277","author":"Cui","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.07.017_bib8","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1194\/jlr.M071183","article-title":"Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans","volume":"57","author":"Takahashi","year":"2016","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2023.07.017_bib9","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/hep.28712","article-title":"Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice","volume":"64","author":"Xu","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2023.07.017_bib10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1194\/jlr.M070888","article-title":"Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters","volume":"58","author":"Dong","year":"2017","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2023.07.017_bib11","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/dom.12681","article-title":"Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers","volume":"18","author":"Pencek","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cell.2023.07.017_bib12","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2013.05.042","article-title":"Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease","volume":"145","author":"Mudaliar","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2023.07.017_bib13","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nbt1326","article-title":"Robust expansion of human hepatocytes in Fah-\/-\/Rag2-\/-\/Il2rg-\/- mice","volume":"25","author":"Azuma","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.07.017_bib14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood-2016-04-709584","article-title":"A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production","volume":"129","author":"Yu","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.cell.2023.07.017_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nbt.2858","article-title":"Development and function of human innate immune cells in a humanized mouse model","volume":"32","author":"Rongvaux","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2023.07.017_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1126\/science.abe2485","article-title":"Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells","volume":"371","author":"Song","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.07.017_bib17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.1063889","article-title":"Liver organogenesis promoted by endothelial cells prior to vascular function","volume":"294","author":"Matsumoto","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.07.017_bib18","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/hep.30563","article-title":"Tissue repair in the mouse liver following acute carbon tetrachloride depends on injury-induced Wnt\/beta-catenin signaling","volume":"69","author":"Zhao","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2023.07.017_bib19","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.07.017_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.bmt.1702564","article-title":"Preparation and analysis of fetal liver extracts","volume":"26","author":"Zwicky","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.cell.2023.07.017_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jhep.2003.11.007","article-title":"Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7\/8+ cells express markers for stellate cells","volume":"40","author":"Suskind","year":"2004","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cell.2023.07.017_bib22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0168-8278(98)80064-0","article-title":"Isolation from human fetal liver of cells co-expressing CD34 haematopoietic stem cell and CAM 5.2 pancytokeratin markers","volume":"29","author":"Lemmer","year":"1998","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cell.2023.07.017_bib23","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","article-title":"Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors","volume":"95","author":"Peichev","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cell.2023.07.017_bib24","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.07.017_bib25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: the oxygen gradient revisited","volume":"11","author":"Kietzmann","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.cell.2023.07.017_bib26","doi-asserted-by":"crossref","first-page":"44356","DOI":"10.1038\/srep44356","article-title":"Immunofluorescence identifies distinct subsets of endothelial cells in the human liver","volume":"7","author":"Strauss","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.07.017_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000452214","article-title":"Immunohistochemical heterogeneity of the endothelium of blood and lymphatic vessels in the developing human liver and in adulthood","volume":"203","author":"Nikoli\u0107","year":"2017","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.cell.2023.07.017_bib28","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1074\/jbc.272.3.1456","article-title":"Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice","volume":"272","author":"Oka","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.07.017_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1096-4959(03)00046-0","article-title":"Genomic evidence for the absence of a functional cholesteryl ester transfer protein gene in mice and rats","volume":"135","author":"Hogarth","year":"2003","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.cell.2023.07.017_bib30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1161\/01.ATV.0000054658.91146.64","article-title":"Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis","volume":"23","author":"Barter","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cell.2023.07.017_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1194\/jlr.RA119000307","article-title":"Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism","volume":"61","author":"Straniero","year":"2020","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2023.07.017_bib32","doi-asserted-by":"crossref","first-page":"19375","DOI":"10.1016\/S0021-9258(17)32178-6","article-title":"Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase","volume":"269","author":"Falany","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.07.017_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1182\/blood-2015-12-684688","article-title":"Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in\u00a0vivo","volume":"128","author":"Pan","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.cell.2023.07.017_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.dld.2004.11.009","article-title":"Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation","volume":"37","author":"Carpino","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.cell.2023.07.017_bib35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/j.2040-4603.2013.tb00517.x","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.cell.2023.07.017_bib36","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0016-5085(67)80123-9","article-title":"Importance of bile acids and of an intact distal small intestine for fat absorption","volume":"52","author":"Austad","year":"1967","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2023.07.017_bib37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","article-title":"Choline: an essential nutrient for public health","volume":"67","author":"Zeisel","year":"2009","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.cell.2023.07.017_bib38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hep.21473","article-title":"Wnt'er in liver: expression of Wnt and frizzled genes in mouse","volume":"45","author":"Zeng","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2023.07.017_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9060612","article-title":"SR-B1, a key receptor involved in the progression of cardiovascular disease: a perspective from mice and human genetic studies","volume":"9","author":"Gracia-Rubio","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.cell.2023.07.017_bib40","doi-asserted-by":"crossref","first-page":"e2930","DOI":"10.1371\/journal.pone.0002930","article-title":"Liposomal packaging generates Wnt protein with in\u00a0vivo biological activity","volume":"3","author":"Morrell","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.07.017_bib41","doi-asserted-by":"crossref","first-page":"100754","DOI":"10.1016\/j.xcrm.2022.100754","article-title":"Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b","volume":"3","author":"Hu","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2023.07.017_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46206","article-title":"Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts","volume":"9","author":"Ma","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cell.2023.07.017_bib43","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3892\/ijmm.2013.1243","article-title":"Analysis of differentially expressed genes and microRNAs in alcoholic liver disease","volume":"31","author":"Liu","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cell.2023.07.017_bib44","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jgh.15709","article-title":"Altered bile acid glycine: taurine ratio in the progression of chronic liver disease","volume":"37","author":"Chen","year":"2022","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2023.07.017_bib51","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.07.017_bib54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.07.017_bib45","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1073\/pnas.1919035117","article-title":"Expansion, in\u00a0vivo-ex\u00a0vivo cycling, and genetic manipulation of primary human hepatocytes","volume":"117","author":"Michailidis","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.07.017_bib46","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3389\/fmicb.2018.00908","article-title":"A chimeric humanized mouse model by engrafting the human induced pluripotent stem cell-derived hepatocyte-like cell for the chronic hepatitis B virus infection","volume":"9","author":"Yuan","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cell.2023.07.017_bib47","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.3748\/wjg.v20.i42.15539","article-title":"Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Takahashi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cell.2023.07.017_bib48","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/00000478-199512000-00007","article-title":"Chronic hepatitis. An update on terminology and reporting","volume":"19","author":"Batts","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.cell.2023.07.017_bib49","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.07.017_bib50","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41467-021-27729-z","article-title":"Zero-preserving imputation of single-cell RNA-seq data","volume":"13","author":"Linderman","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.07.017_bib52","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1021\/acschembio.8b00438","article-title":"Lipidomics suggests a new role for ceramide synthase in phagocytosis","volume":"13","author":"Pathak","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cell.2023.07.017_bib53","doi-asserted-by":"crossref","first-page":"G1204","DOI":"10.1152\/ajpgi.00302.2010","article-title":"Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity","volume":"299","author":"Xie","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cell.2023.07.017_bib55","doi-asserted-by":"crossref","first-page":"100278","DOI":"10.1016\/j.jhepr.2021.100278","article-title":"Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity","volume":"3","author":"Payen","year":"2021","journal-title":"JHEP Rep."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742300795X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742300795X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:18:16Z","timestamp":1777475896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286742300795X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":55,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S009286742300795X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2023.07.017","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2023.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}