{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:27:20Z","timestamp":1790774840573,"version":"4.1.0"},"reference-count":186,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.cell.2023.09.008","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:30:00Z","timestamp":1697020200000},"page":"4898-4919.e25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability"],"prefix":"10.1016","volume":"186","author":[{"given":"Terence","family":"Gall-Duncan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla-Marie","family":"Jurkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyota","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit L.","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Mehkary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Leib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"L\u00e9vesque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahreen","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mortezaali","family":"Razzaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Prasolava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Lanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan B.","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo L\u00f3pez","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Tippett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert R.","family":"La Spada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric I.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Michel","family":"Boisvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.M.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly L.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Nakamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9545-4205","authenticated-orcid":false,"given":"Christopher E.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2023.09.008_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gr.269530.120","article-title":"Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences","volume":"32","author":"Gall-Duncan","year":"2022","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2023.09.008_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64674","article-title":"Propensity for somatic expansion increases over the course of life in Huntington disease","volume":"10","author":"Kacher","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.cell.2023.09.008_bib3","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/hmg\/ddaa139","article-title":"Patterns of CAG repeat instability in the central nervous system and periphery in Huntington\u2019s disease and in spinocerebellar ataxia type 1","volume":"29","author":"Mouro Pinto","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib4","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/hmg\/ddp242","article-title":"Somatic expansion of the Huntington\u2019s disease CAG repeat in the brain is associated with an earlier age of disease onset","volume":"18","author":"Swami","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib186","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng0494-409","article-title":"Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm","volume":"6","author":"Telenius","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/JHD-219001","article-title":"Special Issue: DNA repair and somatic repeat expansion in Huntington\u2019s disease","volume":"10","author":"Jones","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib6","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S1474-4422(20)30343-4","article-title":"Interrupting sequence variants and age of onset in Huntington\u2019s disease: clinical implications and emerging therapies","volume":"19","author":"Wright","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/JHD-200421","article-title":"Drugging DNA damage repair pathways for trinucleotide repeat expansion diseases","volume":"10","author":"Benn","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2854","article-title":"Repeat instability as the basis for human diseases and as a potential target for therapy","volume":"11","author":"L\u00f3pez Castel","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/JHD-200448","article-title":"FAN1, a DNA repair nuclease, as a modifier of repeat expansion disorders","volume":"10","author":"Deshmukh","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/brain\/awac160","article-title":"Mosaic divergent repeat interruptions in XDP influence repeat stability and disease onset","volume":"146","author":"Trinh","year":"2022","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib11","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/brain\/awz115","article-title":"MSH3 modifies somatic instability and disease severity in Huntington\u2019s and myotonic dystrophy type 1","volume":"142","author":"Flower","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.cell.2023.09.008_bib12","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ana.24656","article-title":"DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases","volume":"79","author":"Bettencourt","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2015.07.003","article-title":"Identification of genetic factors that modify clinical onset of Huntington\u2019s disease","volume":"162","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG repeat not polyglutamine length determines timing of Huntington\u2019s disease onset","volume":"178","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib15","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1038\/s41467-021-23491-4","article-title":"Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism","volume":"12","author":"Laabs","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2023.09.008_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ajhg.2022.03.004","article-title":"Genetic modifiers of Huntington disease differentially influence motor and cognitive domains","volume":"109","author":"Lee","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib182","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.ajhg.2019.04.007","article-title":"Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease","volume":"104","author":"Wright","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib183","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/s41436-020-0917-z","article-title":"Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range","volume":"22","author":"Findlay Black","year":"2020","journal-title":"Genet. Med."},{"key":"10.1016\/j.cell.2023.09.008_bib184","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1086\/498654","article-title":"Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?","volume":"78","author":"Matsuura","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib185","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1021\/bi972546c","article-title":"Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation","volume":"37","author":"Pearson","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003280","article-title":"MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington\u2019s disease mice","volume":"9","author":"Tom\u00e9","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/70598","article-title":"Msh2 deficiency prevents in\u00a0vivo somatic instability of the CAG repeat in Huntington disease transgenic mice","volume":"23","author":"Manley","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003930","article-title":"Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington\u2019s disease mice: genome-wide and candidate approaches","volume":"9","author":"Pinto","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib20","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1093\/nar\/gkab152","article-title":"Somatic CAG expansion in Huntington\u2019s disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection","volume":"49","author":"Roy","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib21","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature05977","article-title":"Expandable DNA repeats and human disease","volume":"447","author":"Mirkin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.09.008_bib23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrg1689","article-title":"Repeat instability: mechanisms of dynamic mutations","volume":"6","author":"Pearson","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4644(199610)63:1<1::AID-JCB1>3.0.CO;2-3","article-title":"Inverted repeats, stem-loops, and cruciforms: Significance for initiation of DNA replication","volume":"63","author":"Pearson","year":"1996","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.cell.2023.09.008_bib25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/nar\/24.11.1992","article-title":"Stability of intrastrand hairpin structures formed by the CAG\/CTG class of DNA triplet repeats associated with neurological diseases","volume":"24","author":"Petruska","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003866","article-title":"Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues","volume":"9","author":"Axford","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41588-019-0575-8","article-title":"A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in\u00a0vivo","volume":"52","author":"Nakamori","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gde.2020.10.006","article-title":"Structure-forming repeats and their impact on genome stability","volume":"67","author":"Brown","year":"2021","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.cell.2023.09.008_bib28","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/10409238.2020.1813070","article-title":"Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair","volume":"55","author":"Caldwell","year":"2020","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/cr.2008.1","article-title":"Homologous recombination in DNA repair and DNA damage tolerance","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2023.09.008_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2741\/3652","article-title":"Replication protein A: directing traffic at the intersection of replication and repair","volume":"15","author":"Oakley","year":"2010","journal-title":"Front. Biosci."},{"key":"10.1016\/j.cell.2023.09.008_bib31","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/bies.201400107","article-title":"Replication protein A: single-stranded DNA\u2019s first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair","volume":"36","author":"Chen","year":"2014","journal-title":"Bioessays"},{"key":"10.1016\/j.cell.2023.09.008_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.biochem.66.1.61","article-title":"REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism","volume":"66","author":"Wold","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cell.2023.09.008_bib33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molcel.2013.04.032","article-title":"RPA coordinates DNA end resection and prevents formation of DNA hairpins","volume":"50","author":"Chen","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biochi.2014.04.006","article-title":"Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability","volume":"103","author":"Safa","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.cell.2023.09.008_bib35","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1073\/pnas.1321436111","article-title":"G-quadruplex formation in telomeres enhances POT1\/TPP1 protection against RPA binding","volume":"111","author":"Ray","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib36","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.bpj.2013.04.004","article-title":"RPA-Mediated Unfolding of Systematically Varying G-Quadruplex Structures","volume":"104","author":"Ray","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.cell.2023.09.008_bib37","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1021\/jp300546u","article-title":"Replication Protein A Unfolds G-Quadruplex Structures with Varying Degrees of Efficiency","volume":"116","author":"Qureshi","year":"2012","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.cell.2023.09.008_bib38","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1128\/MCB.15.6.3119","article-title":"Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex","volume":"15","author":"Keshav","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib39","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1074\/jbc.M808963200","article-title":"An alternative form of replication protein a prevents viral replication in\u00a0vitro","volume":"284","author":"Mason","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/nar\/gkp1062","article-title":"A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression","volume":"38","author":"Haring","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10815-007-9167-0","article-title":"Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays","volume":"24","author":"Menezo","year":"2007","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib42","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1074\/jbc.M109.079418","article-title":"An alternative form of replication protein a expressed in normal human tissues supports DNA repair","volume":"285","author":"Kemp","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib43","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1021\/bi100380n","article-title":"Functions of alternative replication protein A in initiation and elongation","volume":"49","author":"Mason","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib44","doi-asserted-by":"crossref","first-page":"13660","DOI":"10.1073\/pnas.1007856107","article-title":"Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling","volume":"107","author":"Choi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ana.25413","article-title":"Cerebellar degeneration correlates with motor symptoms in Huntington disease","volume":"85","author":"Singh-Bains","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1750-3639.2012.00629.x","article-title":"Degeneration of the cerebellum in Huntington\u2019s disease (HD): possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process","volume":"23","author":"R\u00fcb","year":"2013","journal-title":"Brain Pathol."},{"key":"10.1016\/j.cell.2023.09.008_bib48","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biopsych.2020.11.009","article-title":"Dynamics of Cortical Degeneration Over a Decade in Huntington\u2019s Disease","volume":"89","author":"Johnson","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cell.2023.09.008_bib49","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s12311-021-01256-5","article-title":"Cerebellar Degeneration Signature in Huntington\u2019s Disease","volume":"20","author":"Padron-Rivera","year":"2021","journal-title":"Cerebellum"},{"key":"10.1016\/j.cell.2023.09.008_bib50","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/mds.25984","article-title":"Cerebellar abnormalities in Huntington\u2019s disease: a role in motor and psychiatric impairment?","volume":"29","author":"Rees","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.cell.2023.09.008_bib51","doi-asserted-by":"crossref","first-page":"fcaa184","DOI":"10.1093\/braincomms\/fcaa184","article-title":"Brainstem and striatal volume changes are detectable in under 1 year and predict motor decline in spinocerebellar ataxia type 1","volume":"2","author":"Koscik","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.cell.2023.09.008_bib52","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/brain\/aws369","article-title":"Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6","volume":"136","author":"Reetz","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.cell.2023.09.008_bib53","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3174\/ajnr.A4760","article-title":"MR Imaging in Spinocerebellar Ataxias: A Systematic Review","volume":"37","author":"Klaes","year":"2016","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.cell.2023.09.008_bib54","doi-asserted-by":"crossref","first-page":"W636","DOI":"10.1093\/nar\/gkz268","article-title":"The EMBL-EBI search and sequence analysis tools APIs in 2019","volume":"47","author":"Madeira","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib55","unstructured":"The PyMOL Molecular Graphics System (2015)"},{"key":"10.1016\/j.cell.2023.09.008_bib56","doi-asserted-by":"crossref","first-page":"W522","DOI":"10.1093\/nar\/gkm276","article-title":"PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations","volume":"35","author":"Dolinsky","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110078","article-title":"FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability","volume":"37","author":"Deshmukh","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2023.09.008_bib58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-3701-1-11","article-title":"The Role of XPG in Processing (CAG)n\/(CTG)n DNA Hairpins","volume":"1","author":"Hou","year":"2011","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cell.2023.09.008_bib59","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nsmb959","article-title":"Slipped (CTG)\u2217(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair","volume":"12","author":"Panigrahi","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib60","doi-asserted-by":"crossref","first-page":"12593","DOI":"10.1073\/pnas.0909087107","article-title":"Isolated short CTG\/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired","volume":"107","author":"Panigrahi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib61","doi-asserted-by":"crossref","first-page":"20452","DOI":"10.1074\/jbc.C109.014977","article-title":"Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in\u00a0vitro","volume":"284","author":"Tian","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib62","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1093\/nar\/gkf572","article-title":"Slipped-strand DNAs formed by long (CAG)\u2217(CTG) repeats: slipped-out repeats and slip-out junctions","volume":"30","author":"Pearson","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib63","doi-asserted-by":"crossref","first-page":"12496","DOI":"10.1021\/bi981110+","article-title":"The 32- and 14-kilodalton subunits of replication protein A are responsible for species-specific interactions with single-stranded DNA","volume":"37","author":"Sibenaller","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib64","doi-asserted-by":"crossref","first-page":"41844","DOI":"10.1074\/jbc.M112.420398","article-title":"Human mismatch repair protein hMutL\u03b1 is required to repair short slipped-DNAs of trinucleotide repeats","volume":"287","author":"Panigrahi","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2005.06.027","article-title":"Reconstitution of 5\u2019-directed human mismatch repair in a purified system","volume":"122","author":"Zhang","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib66","doi-asserted-by":"crossref","first-page":"21536","DOI":"10.1074\/jbc.M109.021287","article-title":"Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5\u2019-directed mismatch repair","volume":"284","author":"Genschel","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib67","doi-asserted-by":"crossref","first-page":"21607","DOI":"10.1074\/jbc.M603504200","article-title":"Regulation of replication protein A functions in DNA mismatch repair by phosphorylation","volume":"281","author":"Guo","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib68","doi-asserted-by":"crossref","first-page":"20935","DOI":"10.1074\/jbc.M401931200","article-title":"Evidence for involvement of HMGB1 protein in human DNA mismatch repair","volume":"279","author":"Yuan","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib69","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S1097-2765(03)00428-3","article-title":"Mechanism of 5\u2019-directed excision in human mismatch repair","volume":"12","author":"Genschel","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib70","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1128\/MCB.22.7.2037-2046.2002","article-title":"Partial reconstitution of human DNA mismatch repair in\u00a0vitro: characterization of the role of human replication protein A","volume":"22","author":"Ramilo","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib71","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/bi301369b","article-title":"Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome","volume":"52","author":"Slean","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000749","article-title":"Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington\u2019s disease transgenic mice","volume":"5","author":"Goula","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib73","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1021\/bi300410d","article-title":"The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excisi on repair outcome at CAG\/CTG repeats","volume":"51","author":"Goula","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib74","doi-asserted-by":"crossref","first-page":"28352","DOI":"10.1074\/jbc.M109.050286","article-title":"Coordination between Polymerase \u03b2 and FEN1 Can Modulate CAG Repeat Expansion","volume":"284","author":"Liu","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbagrm.2009.11.008","article-title":"HMGB1: roles in base excision repair and related function","volume":"1799","author":"Liu","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2023.09.008_bib76","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/bi00006a028","article-title":"Recombinant human replication protein A binds to polynucleotides with low cooperativity","volume":"34","author":"Kim","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib77","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1021\/bi982371m","article-title":"Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding\/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions","volume":"38","author":"Lao","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2023.09.008_bib78","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0027-5107(01)00074-4","article-title":"Role of magnesium in genomic stability","volume":"475","author":"Hartwig","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cell.2023.09.008_bib79","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.dnarep.2014.03.022","article-title":"The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once","volume":"19","author":"Tsutakawa","year":"2014","journal-title":"DNA Repair"},{"key":"10.1016\/j.cell.2023.09.008_bib80","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0022-2836(03)00880-5","article-title":"Slipped (CTG)\u00b7(CAG) Repeats of the Myotonic Dystrophy Locus: Surface Probing with Anti-DNA Antibodies","volume":"332","author":"Tam","year":"2003","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib81","doi-asserted-by":"crossref","first-page":"E1170","DOI":"10.1073\/pnas.1516674113","article-title":"Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins","volume":"113","author":"Myler","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib82","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.jmb.2014.07.014","article-title":"Diffusion of human replication protein A along single-stranded DNA","volume":"426","author":"Nguyen","year":"2014","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087922","article-title":"Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imaging","volume":"9","author":"Gibb","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.09.008_bib84","series-title":"Enzyme-Mediated Ligation Methods Methods in Molecular Biology","first-page":"299","article-title":"BioID as a Tool for Protein-Proximity Labeling in Living Cells","author":"Sears","year":"2019"},{"key":"10.1016\/j.cell.2023.09.008_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/cpps.51","article-title":"BioID: A Screen for Protein-Protein Interactions","volume":"91","author":"Roux","year":"2018","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.cell.2023.09.008_bib86","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/pmic.201600123","article-title":"Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID","volume":"16","author":"Varnait\u0117","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.cell.2023.09.008_bib87","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1091\/mbc.E15-12-0844","article-title":"An improved smaller biotin ligase for BioID proximity labeling","volume":"27","author":"Kim","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib88","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn\u00a0\u2013 a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.cell.2023.09.008_bib89","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1074\/jbc.RA119.009737","article-title":"Human replication protein A induces dynamic changes in single-stranded DNA and RNA structures","volume":"294","author":"Wang","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.15252\/embr.201439458","article-title":"RNA-processing proteins regulate Mec1\/ATR activation by promoting generation of RPA-coated ssDNA","volume":"16","author":"Manfrini","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cell.2023.09.008_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000496","article-title":"The DNA\/RNA-dependent RNA polymerase QDE-1 generates aberrant RNA and dsRNA for RNAi in a process requiring replication protein A and a DNA helicase","volume":"8","author":"Lee","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib92","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.molcel.2017.01.029","article-title":"Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1","volume":"65","author":"Nguyen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib93","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1101\/gad.348858.121","article-title":"Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology","volume":"35","author":"Feng","year":"2021","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2023.09.008_bib94","doi-asserted-by":"crossref","first-page":"zcaa022","DOI":"10.1093\/narcan\/zcaa022","article-title":"Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond","volume":"2","author":"Dueva","year":"2020","journal-title":"NAR Cancer"},{"key":"10.1016\/j.cell.2023.09.008_bib95","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2014.147","article-title":"RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response","volume":"25","author":"Mar\u00e9chal","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2023.09.008_bib96","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/srep11020","article-title":"Large expansion of CTG\u22c5CAG repeats is exacerbated by MutS\u03b2 in human cells","volume":"5","author":"Nakatani","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.09.008_bib99","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/hmg\/11.2.191","article-title":"Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch\u2013repair proteins","volume":"11","author":"van den Broek","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dnarep.2012.10.006","article-title":"Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues","volume":"12","author":"Tom\u00e9","year":"2013","journal-title":"DNA Repair"},{"key":"10.1016\/j.cell.2023.09.008_bib101","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/hmg\/ddh186","article-title":"Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion","volume":"13","author":"Gomes-Pereira","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib102","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.dnarep.2009.04.024","article-title":"Diverse Effects of Individual Mismatch Repair Components on Transcription-Induced CAG Repeat Instability in Human Cells","volume":"8","author":"Lin","year":"2009","journal-title":"DNA Repair"},{"key":"10.1016\/j.cell.2023.09.008_bib103","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1126\/science.1139517","article-title":"CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease","volume":"315","author":"Jung","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.09.008_bib104","doi-asserted-by":"crossref","first-page":"E8392","DOI":"10.1073\/pnas.1711283114","article-title":"Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae","volume":"114","author":"Su","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib105","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1128\/MCB.00739-07","article-title":"Transcription-Induced CAG Repeat Contraction in Human Cells Is Mediated in Part by Transcription-Coupled Nucleotide Excision Repair","volume":"27","author":"Lin","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib106","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/365079a0","article-title":"Inhibition of DNA replication factor RPA by p53","volume":"365","author":"Dutta","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.09.008_bib107","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0092-8674(93)90649-B","article-title":"The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in\u00a0vitro BPV-1 DNA replication","volume":"73","author":"Li","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib108","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0092-8674(93)90650-F","article-title":"The transactivator proteins VP16 and GAL4 bind replication factor A","volume":"73","author":"He","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib109","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1128\/MCB.17.4.2194","article-title":"Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA","volume":"17","author":"Miller","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib110","doi-asserted-by":"crossref","first-page":"15412","DOI":"10.1073\/pnas.0504614102","article-title":"Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A","volume":"102","author":"Bochkareva","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib111","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/hmg\/ddq501","article-title":"Bidirectional transcription stimulates expansion and contraction of expanded (CTG)\u2217(CAG)\u00a0repeats","volume":"20","author":"Nakamori","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib112","first-page":"4432","article-title":"RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair","volume":"25","author":"Taniguchi","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib113","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/hmg\/ddn019","article-title":"Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline","volume":"17","author":"Dion","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib114","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1093\/hmg\/ddr421","article-title":"Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1","volume":"20","author":"Hubert","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib115","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0896-6273(02)00733-X","article-title":"A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration","volume":"34","author":"Watase","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.09.008_bib116","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/hmg\/ddg300","article-title":"Regional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1","volume":"12","author":"Watase","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib117","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ana.410410414","article-title":"Brain regional differences in the expansion of a CAG repeat in\u00a0the spinocerebellar ataxias: dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and spinocerebellar ataxia type 1","volume":"41","author":"Hashida","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib118","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002247","article-title":"Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome","volume":"7","author":"Outwin","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib119","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/excr.1999.4770","article-title":"Stability and nuclear distribution of mammalian replication protein A heterotrimeric complex","volume":"254","author":"Dimitrova","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cell.2023.09.008_bib120","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1093\/nar\/28.17.3354","article-title":"The majority of human replication protein A remains complexed throughout the cell cycle","volume":"28","author":"Loo","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib121","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1752-0509-4-29","article-title":"A novel approach to investigate tissue-specific trinucleotide repeat instability","volume":"4","author":"Lee","year":"2010","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.cell.2023.09.008_bib122","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00223234","article-title":"Cell number and cell density in the cerebellar cortex of man and some other mammals","volume":"157","author":"Lange","year":"1975","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cell.2023.09.008_bib123","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/ana.25393","article-title":"DNA damage signatures in peripheral blood cells as biomarkers in prodromal huntington disease","volume":"85","author":"Castaldo","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib124","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1038\/s41598-018-27985-y","article-title":"Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington\u2019s disease patients","volume":"8","author":"Askeland","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2023.09.008_bib125","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jnr.21881","article-title":"DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates","volume":"87","author":"Illuzzi","year":"2009","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.cell.2023.09.008_bib126","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/hmg\/ddg242","article-title":"DNA damage induced by polyglutamine-expanded proteins","volume":"12","author":"Giuliano","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib127","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.molcel.2004.06.034","article-title":"Expanded CAG Repeats Activate the DNA Damage Checkpoint Pathway","volume":"15","author":"Lahiri","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib128","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022940118","article-title":"CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration","volume":"118","author":"Peng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001339","article-title":"Expanded CAG\/CTG Repeat DNA Induces a Checkpoint Response That Impacts Cell Proliferation in Saccharomyces cerevisiae","volume":"7","author":"Sundararajan","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1534\/genetics.109.111039","article-title":"Double-Strand Break Repair Pathways Protect against CAG\/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in Saccharomyces cerevisiae","volume":"184","author":"Sundararajan","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2023.09.008_bib131","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuron.2017.03.027","article-title":"Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport","volume":"94","author":"Gasset-Rosa","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.09.008_bib132","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.dnarep.2004.03.028","article-title":"Replication protein A phosphorylation and the cellular response to DNA damage","volume":"3","author":"Binz","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.cell.2023.09.008_bib133","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jcp.20622","article-title":"Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses","volume":"208","author":"Zou","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.cell.2023.09.008_bib134","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuron.2022.11.017","article-title":"Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles","volume":"111","author":"Handler","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.09.008_bib135","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cell.2023.09.008_bib136","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/hmg\/7.5.777","article-title":"Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats","volume":"7","author":"Li","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib137","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/nbdi.1998.0168","article-title":"Intranuclear neuronal inclusions in Huntington\u2019s disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length","volume":"4","author":"Becher","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib138","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/hmg\/8.7.1227","article-title":"Ultrastructural localization and progressive formation of neuropil aggregates in Huntington\u2019s disease transgenic mice","volume":"8","author":"Li","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib139","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/78054","article-title":"Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity","volume":"25","author":"Li","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123527","article-title":"Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington's Disease: An In\u00a0Vivo High-Content Imaging Study","volume":"10","author":"Carty","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2023.09.008_bib141","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0896-6273(00)81035-1","article-title":"Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice","volume":"24","author":"Cummings","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2023.09.008_bib142","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1128\/jb.178.16.5042-5044.1996","article-title":"Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli","volume":"178","author":"Rosche","year":"1996","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cell.2023.09.008_bib143","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1073\/pnas.1913416117","article-title":"Large-scale contractions of Friedreich\u2019s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability","volume":"117","author":"Khristich","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib144","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.febslet.2009.11.042","article-title":"Overexpression of the single-stranded DNA-binding protein (SSB) stabilises CAG\u2217CTG triplet repeats in an orientation dependent manner","volume":"584","author":"Andreoni","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2023.09.008_bib145","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2008.09.014","article-title":"Intergenerational and striatal CAG repeat instability in Huntington\u2019s disease knock-in mice involve different DNA repair genes","volume":"33","author":"Dragileva","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006190","article-title":"A MutS\u03b2-Dependent Contribution of MutS\u03b1 to Repeat Expansions in Fragile X Premutation Mice?","volume":"12","author":"Zhao","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib147","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/hmg\/ddt551","article-title":"Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age","volume":"23","author":"Mason","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib148","first-page":"395","article-title":"Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex","volume":"26","author":"Maiuri","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib149","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42988","article-title":"Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription","volume":"8","author":"Gao","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.cell.2023.09.008_bib150","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2023.09.008_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2022.100275","article-title":"HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration","volume":"21","author":"Kennedy","year":"2022","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2023.09.008_bib152","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3233\/JHD-210485","article-title":"Association Analysis of Chromosome X to Identify Genetic Modifiers of Huntington\u2019s Disease","volume":"10","author":"Hong","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.cell.2023.09.008_bib153","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00439-014-1467-8","article-title":"Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD\/SCA3) transmissions: an association study with DNA replication, repair and recombination genes","volume":"133","author":"Martins","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib154","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1086\/518696","article-title":"Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling","volume":"81","author":"O\u2019Driscoll","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib155","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fgene.2018.00080","article-title":"Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3","volume":"9","author":"Blazejewski","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib157","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.2021011980","article-title":"Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue","volume":"139","author":"Sharma","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.cell.2023.09.008_bib156","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/sj.emboj.7600087","article-title":"XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells","volume":"23","author":"Yoshihara","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2023.09.008_bib158","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000460278","article-title":"Large Duplications Can Be Benign Copy Number Variants: A Case of a 3.6-Mb Xq21.33 Duplication","volume":"151","author":"Maurin","year":"2017","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.cell.2023.09.008_bib159","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/mds.25026","article-title":"Clinical severity of Huntington\u2019s disease does not always correlate with neuropathologic stage","volume":"27","author":"Pillai","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.cell.2023.09.008_bib160","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/jnnp.74.7.968","article-title":"Genetically confirmed clinical Huntington\u2019s disease with no observable cell loss","volume":"74","author":"Caramins","year":"2003","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cell.2023.09.008_bib161","first-page":"94","article-title":"An autopsy case with clinically and molecular genetically diagnosed Huntington\u2019s disease with only minimal non-specific neuropathological findings","volume":"19","author":"Mizuno","year":"2000","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.cell.2023.09.008_bib162","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12883-020-01739-8","article-title":"Late-onset oro-facial dyskinesia in Spinocerebellar Ataxia type 2: a case report","volume":"20","author":"Giardina","year":"2020","journal-title":"BMC Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib163","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/ene.14601","article-title":"Genetic profile and clinical characteristics of Chinese patients with spinocerebellar ataxia type 2: A multicenter experience over 10 years","volume":"28","author":"Yang","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib164","first-page":"2692","article-title":"Dopaminergic function in spinocerebellar ataxia type 6 patients with and without parkinsonism","volume":"267","author":"Horimoto","year":"2020","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.cell.2023.09.008_bib165","article-title":"Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum","author":"M\u00e4tlik","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2023.09.008_bib166","article-title":"Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington\u2019s Disease","author":"Pressl","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2023.09.008_bib167","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00018-022-04419-7","article-title":"The extra-cerebellar effects of spinocerebellar ataxia type 1 (SCA1): looking beyond the cerebellum","volume":"79","author":"Olmos","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2023.09.008_bib168","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.3390\/cells11172632","article-title":"Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex","volume":"11","author":"Luttik","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cell.2023.09.008_bib169","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature02821","article-title":"Replication protein A interacts with AID to promote deamination of somatic hypermutation targets","volume":"430","author":"Chaudhuri","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cell.2023.09.008_bib170","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.dnarep.2008.03.014","article-title":"Mutagenic roles of DNA \u201crepair\u201d proteins in antibody diversity and disease-associated trinucleotide repeat instability","volume":"7","author":"Slean","year":"2008","journal-title":"DNA Repair"},{"key":"10.1016\/j.cell.2023.09.008_bib171","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007952","article-title":"Dual functions for the ssDNA-binding protein RPA in meiotic recombination","volume":"15","author":"Shi","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2023.09.008_bib172","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2020.06.015","article-title":"The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates","volume":"79","author":"Hinch","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib177","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0076-6879(05)09002-6","article-title":"Functional assays for replication protein A (RPA)","volume":"409","author":"Binz","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cell.2023.09.008_bib173","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2023.09.008_bib175","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1091\/mbc.E18-09-0590","article-title":"A patient-derived cellular model for Huntington\u2019s disease reveals phenotypes at clinically relevant CAG lengths","volume":"29","author":"Hung","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2023.09.008_bib174","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2006.354","article-title":"Immunohistochemical staining of post-mortem adult human brain sections","volume":"1","author":"Waldvogel","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2023.09.008_bib176","doi-asserted-by":"crossref","first-page":"11121","DOI":"10.1016\/S0021-9258(19)78100-9","article-title":"Recombinant replication protein A: expression, complex formation, and functional characterization","volume":"269","author":"Henricksen","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2023.09.008_bib178","first-page":"e50320","article-title":"GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins","author":"Maity","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.cell.2023.09.008_bib179","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bioinformatics\/btw580","article-title":"DAPAR\u00a0& ProStaR: software to perform statistical analyses in quantitative discovery proteomics","volume":"33","author":"Wieczorek","year":"2017","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.cell.2023.09.008_bib180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nmeth.1541","article-title":"SAINT: probabilistic scoring of affinity purification-mass spectrometry data","volume":"8","author":"Choi","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2023.09.008_bib181","doi-asserted-by":"crossref","first-page":"E626","DOI":"10.3390\/cancers11050626","article-title":"Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4\u03b1 in\u00a0Colorectal Cancer Cells","volume":"11","author":"Babeu","year":"2019","journal-title":"Cancers"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423010309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867423010309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:11:06Z","timestamp":1758802266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867423010309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":186,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0092867423010309"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2023.09.008","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2023.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}