{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:37:34Z","timestamp":1793057854542,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["LT0022\/2022-L"],"award-info":[{"award-number":["LT0022\/2022-L"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008483","name":"NOMIS Foundation","doi-asserted-by":"publisher","award":["12540449"],"award-info":[{"award-number":["12540449"]}],"id":[{"id":"10.13039\/501100008483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010319","name":"Shurl and Kay Curci Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014895","name":"Open Philanthropy Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011223","name":"Weston Havens Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.cell.2024.04.029","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:36:53Z","timestamp":1715611013000},"page":"2838-2854.e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["The first two blastomeres contribute unequally to the human embryo"],"prefix":"10.1016","volume":"187","author":[{"given":"Sergi","family":"Junyent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Meglicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mandelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Iwamoto-Stohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Reynell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Arrach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Iber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-2471","authenticated-orcid":false,"given":"Magdalena","family":"Zernicka-Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2024.04.029_bib1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41586-021-03345-1","article-title":"Inherent mosaicism and extensive mutation of human placentas","volume":"592","author":"Coorens","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-021-03790-y","article-title":"Extensive phylogenies of human development inferred from somatic mutations","volume":"597","author":"Coorens","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1126\/science.abe0981","article-title":"Early developmental asymmetries in cell lineage trees in living individuals","volume":"371","author":"Fasching","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.04.029_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-021-03786-8","article-title":"Clonal dynamics in early human embryogenesis inferred from somatic mutation","volume":"597","author":"Park","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41586-021-03548-6","article-title":"Lineage tracing of human development through somatic mutations","volume":"595","author":"Spencer Chapman","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib6","series-title":"Current Topics in Developmental Biology","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.ctdb.2019.10.002","article-title":"Comparative analysis of human and mouse development: From zygote to pre-gastrulation","volume":"136","author":"Mol\u00e8","year":"2020"},{"key":"10.1016\/j.cell.2024.04.029_bib7","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.cell.2020.11.003","article-title":"Principles of Self-Organization of the Mammalian Embryo","volume":"183","author":"Zhu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib8","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1073\/pnas.0915063107","article-title":"Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo","volume":"107","author":"Morris","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.04.029_bib9","doi-asserted-by":"crossref","first-page":"130104","DOI":"10.1098\/rsob.130104","article-title":"The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos","volume":"3","author":"Morris","year":"2013","journal-title":"Open Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0092-8674(81)90502-X","article-title":"The foundation of two distinct cell lineages within the mouse morula","volume":"24","author":"Johnson","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib11","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0012-1606(87)90055-8","article-title":"A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst","volume":"119","author":"Fleming","year":"1987","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib12","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1242\/dev.128.19.3739","article-title":"Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development","volume":"128","author":"Piotrowska","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1242\/dev.01602","article-title":"Four-cell stage mouse blastomeres have different developmental properties","volume":"132","author":"Piotrowska-Nitsche","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib14","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1242\/dev.003798","article-title":"Stochastic patterning in the mouse pre-implantation embryo","volume":"134","author":"Dietrich","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.014316","article-title":"Formation of the embryonic-abembryonic axis of the mouse blastocyst: Relationships between orientation of early cleavage divisions and pattern of symmetric\/asymmetric divisions","volume":"135","author":"Bischoff","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2016.01.047","article-title":"Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos","volume":"165","author":"Goolam","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature05458","article-title":"Histone arginine methylation regulates pluripotency in the early mouse embryo","volume":"445","author":"Torres-Padilla","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cell.2016.02.032","article-title":"Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo","volume":"165","author":"White","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1530\/REP-19-0405","article-title":"CARM1 is heterogeneous in mouse four-cell embryo and important to blastocyst development","volume":"159","author":"Sun","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.cell.2024.04.029_bib20","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.cell.2018.11.039","article-title":"Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos","volume":"175","author":"Wang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib21","first-page":"1271","article-title":"The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo","volume":"143","author":"Panamarova","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41586-020-2647-4","article-title":"Keratins are asymmetrically inherited fate determinants in the mammalian embryo","volume":"585","author":"Lim","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib23","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/s41467-018-04155-2","article-title":"Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.04.029_bib24","doi-asserted-by":"crossref","first-page":"R236","DOI":"10.1016\/j.cub.2006.03.016","article-title":"Mosaic and regulative development: two faces of one coin","volume":"16","author":"Lawrence","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib25","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/humrep\/dead107","article-title":"Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1","volume":"38","author":"Regin","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cell.2024.04.029_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ydbio.2011.10.030","article-title":"Human hypoblast formation is not dependent on FGF signalling","volume":"361","author":"Roode","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2012.12.008","article-title":"Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse","volume":"375","author":"Niakan","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.071688","article-title":"The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos","volume":"139","author":"Kuijk","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1242\/dev.107.3.597","article-title":"The human blastocyst: cell number, death and allocation during late preimplantation development in\u00a0vitro","volume":"107","author":"Hardy","year":"1989","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib30","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.bbadis.2012.07.001","article-title":"Genetics of early miscarriage","volume":"1822","author":"van den Berg","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2024.04.029_bib31","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.0001-6349.2005.00882.x","article-title":"Chromosomal anomalies in first-trimester miscarriages","volume":"84","author":"Ljunger","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.cell.2024.04.029_bib32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF01204052","article-title":"Analyses of 95 first-trimester spontaneous abortions by chorionic villus sampling and karyotype","volume":"9","author":"Strom","year":"1992","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.cell.2024.04.029_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fertnstert.2009.07.989","article-title":"Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment","volume":"93","author":"Mart\u00ednez","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cell.2024.04.029_bib34","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/s41467-020-16796-3","article-title":"Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism","volume":"11","author":"Singla","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.04.029_bib35","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1038\/ncomms11165","article-title":"Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential","volume":"7","author":"Bolton","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.04.029_bib36","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/humupd\/dmab016","article-title":"Plasticity of the human preimplantation embryo: Developmental dogmas, variations on themes and self-correction","volume":"27","author":"Coticchio","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.cell.2024.04.029_bib37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41556-021-00660-7","article-title":"Depletion of aneuploid cells in human embryos and gastruloids","volume":"23","author":"Yang","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.6867735","article-title":"Chromosomal Mosaicism Confined to the Placenta in Human Conceptions","volume":"221","author":"Kalousek","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.04.029_bib39","article-title":"Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos","volume":"12","author":"Regin","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.04.029_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/ror.0.0040125","article-title":"Apoptosis in the human embryo","volume":"4","author":"Hardy","year":"1999","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.cell.2024.04.029_bib41","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1095\/biolreprod.102.010090","article-title":"Maintenance of the Inner Cell Mass in Human Blastocysts from Fragmented Embryos","volume":"68","author":"Hardy","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cell.2024.04.029_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/1464727002000198671","article-title":"Apoptosis in mammalian preimplantation embryos: Regulation by survival factors","volume":"3","author":"Brison","year":"2000","journal-title":"Hum. Fertil. (Camb)"},{"key":"10.1016\/j.cell.2024.04.029_bib43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tjog.2017.12.013","article-title":"Effect of morphokinetics and morphological dynamics of cleavage stage on embryo developmental potential: A time-lapse study","volume":"57","author":"Yang","year":"2018","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.cell.2024.04.029_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65068","article-title":"Human embryo polarization requires plc signaling to mediate trophectoderm specification","volume":"10","author":"Zhu","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.04.029_bib45","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/REP-12-0381","article-title":"Early cell fate decisions in the mouse embryo","volume":"145","author":"Saiz","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.cell.2024.04.029_bib46","first-page":"37","article-title":"Cell division and cell allocation in early mouse development","volume":"48","author":"Kelly","year":"1978","journal-title":"J.\u00a0Embryol. Exp. Morphol."},{"key":"10.1016\/j.cell.2024.04.029_bib47","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature21703","article-title":"Somatic mutations reveal asymmetric cellular dynamics in the early human embryo","volume":"543","author":"Ju","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib48","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/humrep\/den190","article-title":"The four blastomeres of a 4-cell stage human embryo are able to develop individually into blastocysts with inner cell mass and trophectoderm","volume":"23","author":"Van De Velde","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cell.2024.04.029_bib49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2759-x","article-title":"Initiation of a conserved trophectoderm program in human, cow and mouse embryos","volume":"587","author":"Gerri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib50","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/35054069","article-title":"Role for sperm in spatial patterning of the early mouse embryo","volume":"409","author":"Piotrowska","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib51","article-title":"Mechanics of human embryo compaction","author":"Firmin","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2024.04.029_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2015.08.007","volume":"104","author":"Rodriguez-Purata","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cell.2024.04.029_bib53","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.cell.2018.11.027","article-title":"CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development","volume":"175","author":"Hupalowska","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.04.029_bib54","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.mod.2004.11.014","article-title":"Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo","volume":"122","author":"Piotrowska-Nitsche","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.cell.2024.04.029_bib55","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1038\/s41467-022-34294-6","article-title":"The first mitotic division of human embryos is highly error prone","volume":"13","author":"Currie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.04.029_bib56","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41586-019-1233-0","article-title":"Genome\u2013lamina interactions are established de novo in the early mouse embryo","volume":"569","author":"Borsos","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.04.029_bib57","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.04.029_bib58","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41592-022-01507-1","article-title":"TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines","volume":"19","author":"Ershov","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.04.029_bib59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: An open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.cell.2024.04.029_bib60","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.fertnstert.2009.03.051","article-title":"Clinical predictors of human blastocyst formation and pregnancy after extended embryo culture and transfer","volume":"94","author":"Thomas","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cell.2024.04.029_bib61","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd2703","article-title":"Developmental clock and mechanism of de novo polarization of the mouse embryo","volume":"370","author":"Zhu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.04.029_bib62","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1242\/dev.126.24.5591","article-title":"Polarity of the mouse embryo is anticipated before implantation","volume":"126","author":"Weber","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib63","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1242\/dev.124.6.1133","article-title":"Following cell fate in the living mouse embryo","volume":"124","author":"Zernicka-Goetz","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib64","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1038\/ncomms6667","article-title":"BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo","volume":"5","author":"Graham","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.04.029_bib65","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3389\/fcell.2020.00857","article-title":"Wwc2 Is a Novel Cell Division Regulator During Preimplantation Mouse Embryo Lineage Formation and Oogenesis","volume":"8","author":"Virnicchi","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2024.04.029_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119381119","article-title":"Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos","volume":"119","author":"Paim","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.04.029_bib67","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1242\/dev.107276","article-title":"Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo","volume":"141","author":"Anani","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.cell.2024.04.029_bib68","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1016\/j.cell.2023.06.003","article-title":"Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy","volume":"186","author":"Domingo-Muelas","year":"2023","journal-title":"Cell"},{"issue":"Suppl 1","key":"10.1016\/j.cell.2024.04.029_bib69","doi-asserted-by":"crossref","first-page":"i72","DOI":"10.1093\/humrep\/des230","article-title":"The blastocyst","volume":"27","author":"Hardarson","year":"2012","journal-title":"Hum. Reprod."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424004550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424004550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T03:25:02Z","timestamp":1722050702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867424004550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":69,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0092867424004550"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2024.04.029","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The first two blastomeres contribute unequally to the human embryo","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}