{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:34:59Z","timestamp":1792902899185,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X012085\/1"],"award-info":[{"award-number":["MR\/X012085\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013468\/1"],"award-info":[{"award-number":["MR\/N013468\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["209200\/Z\/17\/Z"],"award-info":[{"award-number":["209200\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["106917\/Z\/15\/Z"],"award-info":[{"award-number":["106917\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["7200AA20C00017"],"award-info":[{"award-number":["7200AA20C00017"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID-OAA-C-15-00071"],"award-info":[{"award-number":["AID-OAA-C-15-00071"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011889","name":"Diamond Light Source","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["733273"],"award-info":[{"award-number":["733273"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"National Institutes of Health Office of Extramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-027520"],"award-info":[{"award-number":["INV-027520"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-005170"],"award-info":[{"award-number":["INV-005170"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cell.2024.06.015","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:38:34Z","timestamp":1721907514000},"page":"4964-4980.e21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype"],"prefix":"10.1016","volume":"187","author":[{"given":"Jordan R.","family":"Barrett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Pipini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.R.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Gorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Quinkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M.","family":"Lias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra A.","family":"Rigby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Aleshnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnabas G.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil G.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Martinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payton","family":"Kirtley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D.","family":"Wiggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca R.","family":"Donnellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd D.W.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Popplewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Silk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"de Ruiter Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayaka","family":"Kotraiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Noe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall S.","family":"MacGill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Richter","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley J.","family":"Birkett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine A.","family":"Soisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Minassian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Lauffenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoyo","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole A.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon K.","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizb\u00e9","family":"Koekemoer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"McHugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-1357","authenticated-orcid":false,"given":"Simon J.","family":"Draper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2024.06.015_bib1","series-title":"World Malaria Report","year":"2023"},{"key":"10.1016\/j.cell.2024.06.015_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chom.2018.06.008","article-title":"Malaria Vaccines: Recent Advances and New Horizons","volume":"24","author":"Draper","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2024.06.015_bib3","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41590-018-0228-6","article-title":"Malaria prevention: from immunological concepts to effective vaccines and protective antibodies","volume":"19","author":"Cockburn","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2024.06.015_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(15)60721-8","article-title":"Efficacy and safety of RTS,S\/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial","volume":"386","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2024.06.015_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJMoa2203067","article-title":"Low-dose subcutaneous or intravenous monoclonal antibody to prevent malaria","volume":"387","author":"Wu","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2024.06.015_bib6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(23)02511-4","article-title":"Safety and efficacy of malaria vaccine candidate R21\/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial","volume":"403","author":"Datoo","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2024.06.015_bib7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ncomms1615","article-title":"The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody","volume":"2","author":"Douglas","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.06.015_bib8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pt.2020.04.003","article-title":"The RH5-CyRPA-Ripr complex as a malaria vaccine target","volume":"36","author":"Ragotte","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cell.2024.06.015_bib10","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1038\/s41564-022-01261-2","article-title":"PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum","volume":"7","author":"Scally","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2024.06.015_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000490","article-title":"Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans","volume":"17","author":"Galaway","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2024.06.015_bib12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.chom.2014.11.017","article-title":"A PfRH5-Based vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys","volume":"17","author":"Douglas","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2024.06.015_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.medj.2021.03.014","article-title":"Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination","volume":"2","author":"Minassian","year":"2021","journal-title":"Med."},{"key":"10.1016\/j.cell.2024.06.015_bib14","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1038\/s41467-019-09894-4","article-title":"A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates","volume":"10","author":"Douglas","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.06.015_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fimmu.2018.00524","article-title":"Plasmodium falciparum Liver Stage infection and transition to stable blood stage infection in liver-humanized and blood-humanized FRGN KO mice enables testing of blood stage inhibitory antibodies (reticulocyte-binding protein homolog 5) in\u00a0vivo","volume":"9","author":"Foquet","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2024.06.015_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-018-0071-7","article-title":"Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells","volume":"3","author":"Jin","year":"2018","journal-title":"npj Vaccines"},{"key":"10.1016\/j.cell.2024.06.015_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00312-8","article-title":"Blood-stage malaria vaccine candidate RH5.1\/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial","author":"Silk","year":"2024","journal-title":"Lancet Infect. Dis"},{"key":"10.1016\/j.cell.2024.06.015_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96381","article-title":"Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions","volume":"2","author":"Payne","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2024.06.015_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.medj.2023.07.003","article-title":"Superior antibody immunogenicity of a viral-vectored RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults","volume":"4","author":"Silk","year":"2023","journal-title":"Med"},{"key":"10.1016\/j.cell.2024.06.015_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature13715","article-title":"Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies","volume":"515","author":"Wright","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-018-0779-6","article-title":"Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex","volume":"565","author":"Wong","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-023-06856-1","article-title":"The PfRCR complex bridges malaria parasite and erythrocyte during invasion","volume":"625","author":"Farrell","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.1302045","article-title":"Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5","volume":"192","author":"Douglas","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2024.06.015_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20383","article-title":"Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody","volume":"6","author":"Favuzza","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.06.015_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13030","article-title":"Neutralising antibodies block the function of Rh5\/Ripr\/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes","volume":"21","author":"Healer","year":"2019","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cell.2024.06.015_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2019.05.025","article-title":"Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies","volume":"178","author":"Alanine","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.06.015_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28601-4","article-title":"Heterotypic interactions drive antibody synergy against a malaria vaccine candidate","volume":"13","author":"Ragotte","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.06.015_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83681","article-title":"Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes","volume":"12","author":"Jamwal","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.06.015_bib29","doi-asserted-by":"crossref","first-page":"101654","DOI":"10.1016\/j.xcrm.2024.101654","article-title":"Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies","volume":"5","author":"King","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2024.06.015_bib30","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-019-0879-y","article-title":"Commonality despite exceptional diversity in the baseline human antibody repertoire","volume":"566","author":"Briney","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cell.2020.11.043","article-title":"Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.06.015_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04187","article-title":"Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes","volume":"3","author":"Chen","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.06.015_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002991","article-title":"Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens","volume":"8","author":"Williams","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2024.06.015_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67877-8","article-title":"Bliss\u2019 and Loewe\u2019s additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations","volume":"10","author":"Azasi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2024.06.015_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature11174","article-title":"Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing","volume":"487","author":"Manske","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.vaccine.2012.10.106","article-title":"A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants","volume":"31","author":"Bustamante","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2024.06.015_bib44","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2024.06.015_bib45","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.06.015_bib37","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.143958","article-title":"Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention","volume":"6","author":"Kisalu","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2024.06.015_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37890-2","article-title":"Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion","volume":"14","author":"Triglia","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.06.015_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21347","article-title":"Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA","volume":"6","author":"Chen","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.06.015_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3024.1987.tb00483.x","article-title":"Kinetic constraints on the development of a malaria vaccine","volume":"9","author":"Saul","year":"1987","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.cell.2024.06.015_bib41","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/s41564-019-0462-1","article-title":"Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody","volume":"4","author":"Rawlinson","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2024.06.015_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163859","article-title":"Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1\/AS01B malaria vaccine","volume":"8","author":"Nielsen","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2024.06.015_bib43","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/S1473-3099(22)00428-5","article-title":"Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults","volume":"22","author":"van der Boor","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cell.2024.06.015_bib56","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.celrep.2019.03.020","article-title":"Therapeutic monoclonal antibodies for Ebola virus infection derived from vaccinated humans","volume":"27","author":"Rijal","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2024.06.015_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01924-3","article-title":"Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25","volume":"8","author":"Scally","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.06.015_bib50","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"Tiller","year":"2008","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.cell.2024.06.015_bib51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.06.015_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/srep30357","article-title":"Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system","volume":"6","author":"Hjerrild","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2024.06.015_bib67","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib68","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1107\/S0907444911001314","article-title":"REFMAC5 for the refinement of macromolecular crystal structures","volume":"67","author":"Murshudov","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S2052252514009324","article-title":"The PDB_REDO server for macromolecular structure model optimization","volume":"1","author":"Joosten","year":"2014","journal-title":"IUCrJ"},{"key":"10.1016\/j.cell.2024.06.015_bib70","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1107\/S2059798316014534","article-title":"Automated refinement of macromolecular structures at low resolution using prior information","volume":"72","author":"Kovalevskiy","year":"2016","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.cell.2024.06.015_bib46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijpara.2016.12.001","article-title":"Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'","volume":"47","author":"Jin","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.cell.2024.06.015_bib48","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1074\/mcp.O113.028357","article-title":"A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins","volume":"12","author":"Crosnier","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2024.06.015_bib49","article-title":"Protein\/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors","volume":"2","author":"Nielsen","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2024.06.015_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nbt.1601","article-title":"Enhanced antibody half-life improves in\u00a0vivo activity","volume":"28","author":"Zalevsky","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2024.06.015_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01254","article-title":"Functional Comparison of Blood-Stage Plasmodium falciparum Malaria vaccine Candidate Antigens","volume":"10","author":"Illingworth","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2024.06.015_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00647-21","article-title":"Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein","volume":"6","author":"Ragotte","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.cell.2024.06.015_bib55","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1128\/IAI.73.6.3677-3685.2005","article-title":"Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria","volume":"73","author":"Malkin","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2024.06.015_bib57","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.cell.2024.06.015_bib58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1107\/S2059798320014114","article-title":"The low-cost shifter microscope stage transforms the speed and robustness of protein crystal harvesting","volume":"77","author":"Wright","year":"2021","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.cell.2024.06.015_bib59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1107\/S2059798317017235","article-title":"DIALS: implementation and evaluation of a new integration package","volume":"74","author":"Winter","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.cell.2024.06.015_bib60","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1107\/S0021889809045701","article-title":"xia2: an expert system for macromolecular crystallography data reduction","volume":"43","author":"Winter","year":"2010","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib61","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1093\/bioinformatics\/btr535","article-title":"ISPyB: an information management system for synchrotron macromolecular crystallography","volume":"27","author":"Delageni\u00e8re","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2024.06.015_bib62","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1107\/S1600576715004847","article-title":"SynchWeb: a modern interface for ISPyB","volume":"48","author":"Fisher","year":"2015","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib63","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1107\/S0907444903008126","article-title":"A graphical user interface to the CCP4 program suite","volume":"59","author":"Potterton","year":"2003","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib64","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib65","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.cell.2024.06.015_bib66","doi-asserted-by":"crossref","first-page":"D520","DOI":"10.1093\/nar\/gky949","article-title":"Protein Data Bank: the single global archive for 3D macromolecular structure data","volume":"47","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2024.06.015_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-017-0028-2","article-title":"Humoral protection against mosquito bite-transmitted plasmodium falciparum infection in humanized mice","volume":"2","author":"Sack","year":"2017","journal-title":"npj Vaccines"},{"key":"10.1016\/j.cell.2024.06.015_bib73","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4269\/ajtmh.19-0094","article-title":"Beyond blood smears: qualification of Plasmodium 18S rRNA as a biomarker for controlled human malaria infections","volume":"100","author":"Seilie","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742400655X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742400655X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:24:06Z","timestamp":1786217046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286742400655X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":73,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S009286742400655X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2024.06.015","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.04.560576","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}