{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:54:35Z","timestamp":1792803275977,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.cell.2024.08.046","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T11:53:36Z","timestamp":1726746816000},"page":"6272-6289.e21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"187","author":[{"given":"Mitsuaki","family":"Kashiwagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goichi","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kanuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaeko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Tatsuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki C.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ikuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodaka","family":"Yamakado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-4532","authenticated-orcid":false,"given":"Yu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2024.08.046_bib1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2010.11.032","article-title":"Sleep state switching","volume":"68","author":"Saper","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib2","first-page":"133","article-title":"Mapping of cholinoceptive brainstem structures responsible for the generation of paradoxical sleep in the cat","volume":"127","author":"Vanni-Mercier","year":"1989","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.cell.2024.08.046_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-8993(81)90752-6","article-title":"Are the gigantocellular tegmental field neurons responsible for paradoxical sleep?","volume":"229","author":"Sastre","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2024.08.046_bib4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0028-3908(64)90076-0","article-title":"A cholinergic mechanism in the brainstem reticular formation: induction of paradoxical sleep","volume":"3","author":"George","year":"1964","journal-title":"Int. J. Neuropharmacol."},{"key":"10.1016\/j.cell.2024.08.046_bib5","first-page":"959","article-title":"Persistance du sommeil paradoxal chez le chat apr\u00e8s destruction de l\u2019aire gigantocellulaire du tegmentum pontique par l\u2019acide ka\u00efnique","volume":"289","author":"Sastre","year":"1979","journal-title":"C.\u00a0R. Seances Acad. Sci. D"},{"key":"10.1016\/j.cell.2024.08.046_bib6","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1046\/j.1460-9568.2002.02257.x","article-title":"The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: A combined microinjection and functional neuroanatomical study","volume":"16","author":"Boissard","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0006-8993(02)03956-2","article-title":"Rapid eye movement Sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat","volume":"962","author":"Pollock","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2024.08.046_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature04767","article-title":"A putative flip\u00a0\u2013 flop switch for control of REM sleep","volume":"441","author":"Lu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.08.046_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024998","article-title":"Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia","volume":"6","author":"Krenzer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2024.08.046_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/brain\/aww310","article-title":"Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder","volume":"140","author":"Valencia Garcia","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.cell.2024.08.046_bib11","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1523\/JNEUROSCI.0688-20.2020","article-title":"A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice","volume":"41","author":"Uchida","year":"2021","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib12","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.aad1023","article-title":"Cells of a common developmental origin regulate REM \/ non-REM sleep and wakefulness in mice","volume":"350","author":"Hayashi","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib13","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cub.2020.01.047","article-title":"Widely distributed neurotensinergic neurons in the brainstem regulate NREM sleep in mice","volume":"30","author":"Kashiwagi","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2024.08.046_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00755","article-title":"Differential role of pontomedullary glutamatergic neuronal populations in sleep-wake control","volume":"13","author":"Erickson","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib15","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/nn.3522","article-title":"Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus","volume":"16","author":"Jego","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib16","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1523\/JNEUROSCI.5344-13.2014","article-title":"Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep\/wake regulation","volume":"34","author":"Tsunematsu","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2016.08.046","article-title":"Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice","volume":"336","author":"Vetrivelan","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2024.08.046_bib18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature14979","article-title":"Control of REM sleep by ventral medulla GABAergic neurons","volume":"526","author":"Weber","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.08.046_bib19","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.abl6618","article-title":"Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice","volume":"375","author":"Hasegawa","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib20","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1523\/JNEUROSCI.0598-18.2018","article-title":"Sleep and wakefulness are controlled by ventral medial midbrain\/pons GABAergic neurons in mice","volume":"38","author":"Takata","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02761-0","article-title":"Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder","volume":"9","author":"Valencia Garcia","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.08.046_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/sleep\/9.2.293","article-title":"Chronic behavioral disorders of human REM sleep: A new category of parasomnia","volume":"9","author":"Schenck","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.cell.2024.08.046_bib23","first-page":"1","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.cell.2024.08.046_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1212\/WNL.46.2.388","article-title":"Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder","volume":"46","author":"Schenck","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2024.08.046_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/brain\/123.2.331","article-title":"Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases","volume":"123","author":"Olson","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.cell.2024.08.046_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1474-4422(13)70056-5","article-title":"Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study","volume":"12","author":"Iranzo","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cell.2024.08.046_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.sleep.2005.03.011","article-title":"Progressive sleep \u201cdestructuring\u201d in Parkinson\u2019s disease. A polysomnographic study in 46 patients","volume":"6","author":"Diederich","year":"2005","journal-title":"Sleep Med."},{"key":"10.1016\/j.cell.2024.08.046_bib28","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.aad5252","article-title":"Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation","volume":"352","author":"Boyce","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib29","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuron.2020.05.008","article-title":"Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation","volume":"107","author":"Kumar","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib30","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1016\/j.neuron.2022.09.004","article-title":"REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation","volume":"110","author":"Qin","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib31","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.45.4.709","article-title":"Incidental lewy body disease in a patient with REM sleep behavior disorder","volume":"45","author":"Uchiyama","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2024.08.046_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroscience.2015.09.063","article-title":"Paradoxical (rapid eye movement) sleep-on neurons in the laterodorsal pontine tegmentum in mice","volume":"310","author":"Sakai","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2024.08.046_bib33","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1523\/JNEUROSCI.2617-13.2014","article-title":"Discharge profiles across the sleep-waking cycle of identified cholinergic, GABAergic, and glutamatergic neurons in the pontomesencephalic tegmentum of the rat","volume":"34","author":"Boucetta","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096851","article-title":"The inhibition of the dorsal paragigantocellular reticular nucleus induces waking and the activation of all adrenergic and noradrenergic neurons: A combined pharmacological and functional neuroanatomical study","volume":"9","author":"Cl\u00e9ment","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2024.08.046_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004272","article-title":"Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep","volume":"4","author":"Sapin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2024.08.046_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13217-y","article-title":"Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep","volume":"10","author":"Gutierrez Herrera","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.08.046_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/syn.1109","article-title":"GABAergic neurons in prepositus hypoglossi regulate REM sleep by its action on locus coeruleus in freely moving rats","volume":"42","author":"Kaur","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.cell.2024.08.046_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cub.2021.10.030","article-title":"Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla","volume":"32","author":"Stucynski","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2024.08.046_bib39","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2007.12.014","article-title":"Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat","volume":"152","author":"Goutagny","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2024.08.046_bib40","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/ejn.13963","article-title":"Behavioural state-specific neurons in the mouse medulla involved in sleep-wake switching","volume":"47","author":"Sakai","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39496-0","article-title":"A medullary hub for controlling REM sleep and pontine waves","volume":"14","author":"Schott","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.08.046_bib42","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.08.046_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","author":"Lin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.08.046_bib44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.08.046_bib45","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neures.2012.03.010","article-title":"\u03b1-synuclein BAC transgenic mice as a model for Parkinson\u2019s disease manifested decreased anxiety-like behavior and hyperlocomotion","volume":"73","author":"Yamakado","year":"2012","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cell.2024.08.046_bib46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/brain\/awz380","article-title":"\u03b1-synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson\u2019s disease model","volume":"143","author":"Taguchi","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.cell.2024.08.046_bib47","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1152\/jn.1964.27.2.152","article-title":"Temporal patterns of discharge of pyramidal tract neurons during sleep and waking in the monkey","volume":"27","author":"Evarts","year":"1964","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cell.2024.08.046_bib48","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41593-018-0164-7","article-title":"Thalamic dual control of sleep and wakefulness","volume":"21","author":"Gent","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cell.2024.08.046_bib50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib51","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans","volume":"363","author":"Holth","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cophys.2020.03.007","article-title":"The existence of two states of sleep as a common trait in various animals and its molecular and neuronal mechanisms","volume":"15","author":"Kashiwagi","year":"2020","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.cell.2024.08.046_bib53","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1538\/expanim.16-0016","article-title":"Generation of CRISPR\/Cas9-mediated bicistronic knock-in INS1-cre driver mice","volume":"65","author":"Hasegawa","year":"2016","journal-title":"Exp. Anim."},{"key":"10.1016\/j.cell.2024.08.046_bib54","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.08.046_bib55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.celrep.2018.06.010","article-title":"Forebrain Ptf1a is required for sexual differentiation of the brain","volume":"24","author":"Fujiyama","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2024.08.046_bib56","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1073\/pnas.1304124110","article-title":"Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification","volume":"110","author":"Zhou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.08.046_bib57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cmet.2007.04.001","article-title":"Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia","volume":"5","author":"Tong","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2024.08.046_bib58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","article-title":"Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons","volume":"71","author":"Vong","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib59","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuron.2011.07.026","article-title":"A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex","volume":"71","author":"Taniguchi","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib60","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.0700293104","article-title":"Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand","volume":"104","author":"Armbruster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.08.046_bib61","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2024.08.046_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2012.00047","article-title":"Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons","volume":"6","author":"Saunders","year":"2012","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.cell.2024.08.046_bib63","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmeth.2996","article-title":"Targeting cells with single vectors using multiple-feature Boolean logic","volume":"11","author":"Fenno","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.08.046_bib64","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.08.046_bib65","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neuron.2016.09.021","article-title":"A designer AAV variant permits efficient retrograde access to projection neurons","volume":"92","author":"Tervo","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib66","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib67","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuron.2012.03.017","article-title":"Whole-brain mapping of direct inputs to midbrain dopamine neurons","volume":"74","author":"Watabe-Uchida","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib68","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1523\/JNEUROSCI.2835-17.2018","article-title":"Monoamines inhibit GABAergic neurons in ventrolateral preoptic area that make direct synaptic connections to hypothalamic arousal neurons","volume":"38","author":"Saito","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib69","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2011.07.005","article-title":"New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits","volume":"71","author":"Osakada","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib70","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature13307","article-title":"Galanin neurons in the medial preoptic area govern parental behaviour","volume":"509","author":"Wu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.08.046_bib71","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1073\/pnas.1523341113","article-title":"Structural foundations of optogenetics: determinants of channelrhodopsin ion selectivity","volume":"113","author":"Berndt","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.08.046_bib72","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature13186","article-title":"A mesoscale connectome of the mouse brain","volume":"7495","author":"Oh","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.08.046_bib73","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2015.02.022","article-title":"Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance","volume":"85","author":"Madisen","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.08.046_bib74","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jsr.12269","article-title":"Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin\/orexin neuronal activation before, during and after deprivation","volume":"24","author":"Arthaud","year":"2015","journal-title":"J.\u00a0Sleep Res."},{"key":"10.1016\/j.cell.2024.08.046_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109558","article-title":"Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors","volume":"36","author":"Tsai","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2024.08.046_bib76","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.08.046_bib77","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1046\/j.1460-9568.1998.00063.x","article-title":"Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield","volume":"10","author":"Watanabe","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cell.2024.08.046_bib78","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424009759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424009759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:29:47Z","timestamp":1730435387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867424009759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":78,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0092867424009759"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2024.08.046","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.08.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}