{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:27Z","timestamp":1792176027694,"version":"4.4.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2023SHZDZX02"],"award-info":[{"award-number":["2023SHZDZX02"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2018SHZDZX01"],"award-info":[{"award-number":["2018SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["23XD1420400"],"award-info":[{"award-number":["23XD1420400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402381"],"award-info":[{"award-number":["82402381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071997"],"award-info":[{"award-number":["82071997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92249305"],"award-info":[{"award-number":["92249305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472055"],"award-info":[{"award-number":["82472055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071201"],"award-info":[{"award-number":["82071201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471940"],"award-info":[{"award-number":["82471940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271471"],"award-info":[{"award-number":["82271471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3605400"],"award-info":[{"award-number":["2023YFC3605400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010120","name":"Huashan Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010120","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20230089"],"award-info":[{"award-number":["BX20230089"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20230087"],"award-info":[{"award-number":["BX20230087"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20240073"],"award-info":[{"award-number":["BX20240073"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B18015"],"award-info":[{"award-number":["B18015"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cell.2024.10.045","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T13:51:39Z","timestamp":1732283499000},"page":"253-271.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":334,"title":["Atlas of the plasma proteome in health and disease in 53,026 adults"],"prefix":"10.1016","volume":"188","author":[{"given":"Yue-Ting","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Wen","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Ming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Feng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2024.10.045_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2024.10.045_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41380-021-01200-3","article-title":"Treatment resistance in psychiatry: state of the art and new directions","volume":"27","author":"Howes","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cell.2024.10.045_bib3","series-title":"Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease","article-title":"The National Academies Collection: Reports funded by National Institutes of Health","year":"2011"},{"key":"10.1016\/j.cell.2024.10.045_bib4","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2021.01.015","article-title":"Precision medicine in 2030-seven ways to transform healthcare","volume":"184","author":"Denny","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.10.045_bib5","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib6","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1194\/jlr.R026658","article-title":"The PCSK9 decade","volume":"53","author":"Lambert","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cell.2024.10.045_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pharmthera.2012.03.005","article-title":"Novel therapeutic agents for lowering low density lipoprotein cholesterol","volume":"135","author":"Joy","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cell.2024.10.045_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13059-020-02252-4","article-title":"Exploiting the GTEx resources to decipher the mechanisms at GWAS loci","volume":"22","author":"Barbeira","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2024.10.045_bib9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1126\/science.abj5117","article-title":"Multiple causal variants underlie genetic associations in humans","volume":"375","author":"Abell","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.10.045_bib10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s42255-023-00753-7","article-title":"Proteogenomic links to human metabolic diseases","volume":"5","author":"Koprulu","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2024.10.045_bib11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to\u00a0disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.10.045_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s43587-021-00064-0","article-title":"Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk","volume":"1","author":"Walker","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.cell.2024.10.045_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-scale proteomic analysis of Alzheimer\u2019s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib14","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.jacc.2016.10.031","article-title":"Proteomics Research in Cardiovascular Medicine and Biomarker Discovery","volume":"68","author":"Lam","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.cell.2024.10.045_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s43587-023-00565-0","article-title":"Plasma proteomic profiles predict future dementia in healthy adults","volume":"4","author":"Guo","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.cell.2024.10.045_bib16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/CIRCULATIONAHA.117.028213","article-title":"Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib","volume":"137","author":"Williams","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2024.10.045_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrg3461","article-title":"Pleiotropy in complex traits: challenges and strategies","volume":"14","author":"Solovieff","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002654","article-title":"Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis","volume":"15","author":"Udler","year":"2018","journal-title":"PLoS Med."},{"key":"10.1016\/j.cell.2024.10.045_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-021-03855-y","article-title":"Rare variant contribution to human disease in 281,104\u00a0UK Biobank exomes","volume":"597","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/eurheartj\/eht463","article-title":"Natriuretic peptide-guided heart failure management","volume":"35","author":"Troughton","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cell.2024.10.045_bib22","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cell.2024.10.045_bib23","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/jmv.25957","article-title":"Elevations of serum cancer biomarkers correlate with severity of COVID-19","volume":"92","author":"Wei","year":"2020","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.cell.2024.10.045_bib24","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1629","article-title":"High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin","volume":"13","author":"Tanno","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib25","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1182\/blood-2008-06-165738","article-title":"Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I","volume":"112","author":"Tamary","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cell.2024.10.045_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10408363.2019.1615034","article-title":"Growth differentiation factor 15: A novel biomarker with high clinical potential","volume":"56","author":"Desmedt","year":"2019","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.cell.2024.10.045_bib27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.kint.2023.08.025","article-title":"A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation","volume":"104","author":"Lanktree","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2024.10.045_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41581-021-00415-5","article-title":"Key metalloproteinase-mediated pathways in the kidney","volume":"17","author":"Wozniak","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cell.2024.10.045_bib29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/pr.120.019398","article-title":"Is Oxytocin \u201cNature\u2019s Medicine\u201d?","volume":"72","author":"Carter","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cell.2024.10.045_bib30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41588-019-0550-4","article-title":"Identifying cross-disease components of genetic risk across hospital data in the UK Biobank","volume":"52","author":"Cortes","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/physrev.00045.2017","article-title":"The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond","volume":"99","author":"Dostert","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2024.10.045_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-physiol-022020-045449","article-title":"The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?","volume":"83","author":"Breit","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cell.2024.10.045_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cmet.2023.01.001","article-title":"Activity-balanced GLP-1\/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2024.10.045_bib34","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","volume":"23","author":"Yang","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2009.11.007","article-title":"Antidiabetic effects of IGFBP2, a leptin-regulated gene","volume":"11","author":"Hedbacker","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2024.10.045_bib36","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00125-023-05943-2","article-title":"Associations of plasma proteomics with type 2 diabetes and related traits: results from the longitudinal KORA S4\/F4\/FF4 Study","volume":"66","author":"Luo","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2024.10.045_bib37","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1210\/clinem\/dgaa953","article-title":"A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA\/KORA Study Population","volume":"106","author":"Thorand","year":"2021","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cell.2024.10.045_bib38","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-021-04103-z","article-title":"Exome sequencing and analysis of 454,787\u00a0UK Biobank participants","volume":"599","author":"Backman","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib39","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2337\/db18-1048","article-title":"Liver\u00a0Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study","volume":"68","author":"De Silva","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2024.10.045_bib40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/mp.2008.11","article-title":"Identifying blood biomarkers for mood disorders using convergent functional genomics","volume":"14","author":"Le-Niculescu","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cell.2024.10.045_bib41","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s12276-023-01036-7","article-title":"Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"55","author":"Baek","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib42","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.14309\/ajg.0000000000000340","article-title":"Alcohol Consumption and Risk\u00a0of Liver Cirrhosis: A Systematic Review and Meta-Analysis","volume":"114","author":"Roerecke","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cell.2024.10.045_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4254\/wjh.v6.i4.207","article-title":"Mechanisms of fibrogenesis in liver cirrhosis: the molecular aspects of epithelial-mesenchymal transition","volume":"6","author":"Lee","year":"2014","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.cell.2024.10.045_bib44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.transproceed.2006.01.039","article-title":"Neurological complications of liver cirrhosis and orthotopic liver transplant","volume":"38","author":"Ardizzone","year":"2006","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.cell.2024.10.045_bib45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnins.2020.00213","article-title":"Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?","volume":"14","author":"Muddapu","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cell.2024.10.045_bib46","doi-asserted-by":"crossref","first-page":"946","DOI":"10.14336\/AD.2019.0923","article-title":"Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development","volume":"11","author":"Joseph","year":"2020","journal-title":"Aging Dis."},{"key":"10.1016\/j.cell.2024.10.045_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12545","article-title":"Autophagy in neurodegenerative diseases: pathogenesis and therapy","volume":"28","author":"Guo","year":"2018","journal-title":"Brain Pathol."},{"key":"10.1016\/j.cell.2024.10.045_bib48","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1080\/15384101.2020.1823731","article-title":"The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional","volume":"19","author":"Wang","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cell.2024.10.045_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40596-0","article-title":"Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence","volume":"14","author":"Lluch","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.10.045_bib50","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.clinbiochem.2013.05.045","article-title":"Obesity and diabetes related plasma amino acid alterations","volume":"46","author":"Zhou","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cell.2024.10.045_bib51","article-title":"Sharp Downregulation of Hub Genes Associated With the Pathogenesis of Breast Cancer From Ductal Carcinoma In Situ to Invasive Ductal Carcinoma","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cell.2024.10.045_bib52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrcardio.2016.127","article-title":"Immune system and cardiovascular disease","volume":"13","author":"Fern\u00e1ndez-Ruiz","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cell.2024.10.045_bib53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","article-title":"The role of the adaptive immune system and T\u00a0cell dysfunction in neurodegenerative diseases","volume":"19","author":"DeMaio","year":"2022","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.cell.2024.10.045_bib54","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrg.2015.33","article-title":"Autoimmune diseases \u2014 connecting risk alleles with molecular traits of the immune system","volume":"17","author":"Gutierrez-Arcelus","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41574-023-00826-3","article-title":"Why does the immune system destroy pancreatic \u03b2-cells but not \u03b1-cells in type 1 diabetes?","volume":"19","author":"Eizirik","year":"2023","journal-title":"Nat.\u00a0Rev. Endocrinol."},{"key":"10.1016\/j.cell.2024.10.045_bib56","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","article-title":"Interferons, immunity and cancer immunoediting","volume":"6","author":"Dunn","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2024.10.045_bib57","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cell.2024.10.045_bib58","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/17474124.2021.1949289","article-title":"Chronic liver disease and oxidative stress - a narrative review","volume":"15","author":"Seen","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2024.10.045_bib59","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1093\/eurheartj\/ehq396","article-title":"Is oxidative stress a therapeutic target in cardiovascular disease?","volume":"31","author":"M\u00fcnzel","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cell.2024.10.045_bib60","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db08-0057","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes","volume":"57","author":"Forbes","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2024.10.045_bib61","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1038\/s41591-022-01980-3","article-title":"Metabolomic profiles predict individual multidisease outcomes","volume":"28","author":"Buergel","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib62","article-title":"An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.10.045_bib63","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3748\/wjg.v30.i13.1899","article-title":"Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease","volume":"30","author":"Tonkic","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cell.2024.10.045_bib64","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1021\/acsptsci.3c00325","article-title":"Functional Roles of Furin in Cardio-Cerebrovascular Diseases","volume":"7","author":"Wichaiyo","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.cell.2024.10.045_bib65","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3390\/ijms24021796","article-title":"The uPA\/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression","volume":"24","author":"Kanno","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2024.10.045_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.788411","article-title":"Ectodysplasin A\/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases","volume":"12","author":"Cai","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cell.2024.10.045_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag1166","article-title":"The druggable genome and support for target identification and validation in drug development","volume":"9","author":"Finan","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nbt.2151","article-title":"Use of genome-wide association studies for drug repositioning","volume":"30","author":"Sanseau","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2024.10.045_bib69","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib70","doi-asserted-by":"crossref","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank 6.0: the DrugBank Knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2024.10.045_bib71","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: Therapeutic Target Database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2024.10.045_bib72","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41573-020-0087-3","article-title":"Improving target assessment in biomedical research: the GOT-IT recommendations","volume":"20","author":"Emmerich","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2024.10.045_bib73","article-title":"The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer\u2019s Disease and Aging","volume":"108","author":"Greenwood","year":"2020","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/alz.079328","article-title":"Agora: An open-access platform for the exploration of nascent targets for Alzheimer\u2019s disease therapeutics","volume":"19","author":"Britton","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cell.2024.10.045_bib75","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41591-019-0665-2","article-title":"Plasma protein patterns as comprehensive indicators of health","volume":"25","author":"Williams","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.10.045_bib77","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrd3534","article-title":"A call to reform the taxonomy of human disease","volume":"10","author":"Kola","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2024.10.045_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008785","article-title":"Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits","volume":"16","author":"Bretherick","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib79","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41588-020-0682-6","article-title":"Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases","volume":"52","author":"Zheng","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib80","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41586-022-04394-w","article-title":"Genetic associations of protein-coding variants in human disease","volume":"603","author":"Sun","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib81","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41591-022-01822-2","article-title":"Performance of plasma phosphorylated tau 181 and 217 in the community","volume":"28","author":"Mielke","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib82","article-title":"Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841\u00a0UK Biobank exomes","volume":"2","author":"Karczewski","year":"2022","journal-title":"Cell Genom."},{"key":"10.1016\/j.cell.2024.10.045_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36231-7","article-title":"Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank","volume":"14","author":"Julkunen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.10.045_bib84","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib85","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ije\/dyx204","article-title":"Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank","volume":"47","author":"Millard","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.cell.2024.10.045_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100168","article-title":"Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis","volume":"20","author":"Wik","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cell.2024.10.045_bib88","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib89","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-023-06547-x","article-title":"Rare variant associations with plasma protein levels in the UK Biobank","volume":"622","author":"Dhindsa","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib90","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.10.045_bib91","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ije\/dym276","article-title":"The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine","volume":"37","author":"Elliott","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.cell.2024.10.045_bib92","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.cell.2024.10.045_bib93","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.cell.2024.10.045_bib94","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.10.045_bib95","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41591-021-01266-0","article-title":"Plasma metabolites to profile pathways in noncommunicable disease multimorbidity","volume":"27","author":"Pietzner","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2024.10.045_bib96","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2024.10.045_bib97","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1093\/bioinformatics\/btz166","article-title":"GREP: genome for REPositioning drugs","volume":"35","author":"Sakaue","year":"2019","journal-title":"Bioinformatics"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424012686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424012686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:24:07Z","timestamp":1778714647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867424012686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0092867424012686"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2024.10.045","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atlas of the plasma proteome in health and disease in 53,026 adults","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}