{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:00:26Z","timestamp":1792116026525,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cell.2024.11.001","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:53:44Z","timestamp":1733223224000},"page":"7433-7449.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Structure-guided design of a peripherally restricted chemogenetic system"],"prefix":"10.1016","volume":"187","author":[{"given":"Hye Jin","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Krumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Tassou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan","family":"Geron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"DiBerto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Kapolka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan H.","family":"Gumpper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dewran Kocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid H.J.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saheem A.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MyV.T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jeong","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod","family":"Katritch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Fay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan L.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2024.11.001_bib1","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.0700293104","article-title":"Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand","volume":"104","author":"Armbruster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.11.001_bib2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nn1525","article-title":"Millisecond-timescale, genetically targeted optical control of neural activity","volume":"8","author":"Boyden","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2024.11.001_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0960-9822(98)70198-8","article-title":"Design of allele-specific inhibitors to probe protein kinase signaling","volume":"8","author":"Bishop","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1073\/pnas.95.1.352","article-title":"Controlling signaling with a specifically designed Gi-coupled receptor","volume":"95","author":"Coward","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.11.001_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-023-00276-1","article-title":"Chemogenetics for cell-type-specific modulation of signalling and neuronal activity","volume":"3","author":"Kang","year":"2023","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.cell.2024.11.001_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0223-5234(99)80094-4","article-title":"Engineering a region of bulk tolerance in the 5-HT2A receptor","volume":"34","author":"Westkaemper","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.11.001_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2009.06.014","article-title":"Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors","volume":"63","author":"Alexander","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.11.001_bib9","doi-asserted-by":"crossref","first-page":"19197","DOI":"10.1073\/pnas.0906593106","article-title":"A chemical-genetic approach to study G protein regulation of beta cell function in\u00a0vivo","volume":"106","author":"Guettier","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.11.001_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002221","article-title":"A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells","volume":"4","author":"Yagi","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cell.2024.11.001_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1124\/mol.112.080358","article-title":"Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor","volume":"82","author":"Nakajima","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cell.2024.11.001_bib12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2024.11.001_bib13","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.neuron.2015.03.065","article-title":"A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior","volume":"86","author":"Vardy","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2024.11.001_bib14","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1210\/en.2012-2127","article-title":"A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in\u00a0vivo","volume":"154","author":"Li","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.cell.2024.11.001_bib15","article-title":"Adipocyte G(i) signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.11.001_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152852","article-title":"Gq signaling in \u03b1 cells is critical for maintaining euglycemia","volume":"6","author":"Liu","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2024.11.001_bib17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/jnc.15314","article-title":"Chemogenetic approaches to identify metabolically important GPCR signaling pathways: therapeutic implications","volume":"158","author":"Meister","year":"2021","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.cell.2024.11.001_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-023-05829-8","article-title":"Gut enterochromaffin cells drive visceral pain and anxiety","volume":"616","author":"Bayrer","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.11.001_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aan2475","article-title":"Chemogenetics revealed: DREADD occupancy and activation via converted clozapine","volume":"357","author":"Gomez","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2024.11.001_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","article-title":"Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia","volume":"3","author":"Roth","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2024.11.001_bib21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/s41593-020-0661-3","article-title":"Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys","volume":"23","author":"Nagai","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2024.11.001_bib22","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1096\/fj.12-223933","article-title":"The role of HCA2 (GPR109A) in regulating macrophage function","volume":"27","author":"Zandi-Nejad","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2024.11.001_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02762-5","article-title":"Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in\u00a0vivo and in\u00a0vitro models","volume":"20","author":"He","year":"2023","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.cell.2024.11.001_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.metabol.2015.10.001","article-title":"Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2","volume":"65","author":"Graff","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.cell.2024.11.001_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4944","article-title":"The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages","volume":"5","author":"Rahman","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.11.001_bib26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2008.08.040","article-title":"Anatomical profiling of G protein-coupled receptor expression","volume":"135","author":"Regard","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.11.001_bib27","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1073\/pnas.0230374100","article-title":"The G protein-coupled receptor repertoires of human and mouse","volume":"100","author":"Vassilatis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.11.001_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacl.2008.08.445","article-title":"Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans","volume":"2","author":"Lai","year":"2008","journal-title":"J.\u00a0Clin. Lipidol."},{"key":"10.1016\/j.cell.2024.11.001_bib29","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1021\/jm800258p","article-title":"3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice","volume":"51","author":"Semple","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib30","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nsmb.3014","article-title":"PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome","volume":"22","author":"Kroeze","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib31","article-title":"Structural insights into the human niacin receptor HCA2-Gi signalling complex","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.11.001_bib32","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41589-020-0535-8","article-title":"TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome","volume":"16","author":"Olsen","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib33","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1021\/jm2010964","article-title":"(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans","volume":"55","author":"Boatman","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib34","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.bmcl.2010.03.062","article-title":"Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)","volume":"20","author":"Boatman","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cell.2024.11.001_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cell.2024.11.001_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj9837","article-title":"Developing nociceptor-selective treatments for acute and chronic pain","volume":"13","author":"Jayakar","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2024.11.001_bib37","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1073\/pnas.0914725107","article-title":"Deletion of PIK3C3\/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway","volume":"107","author":"Zhou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2024.11.001_bib38","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1523\/JNEUROSCI.1299-11.2011","article-title":"Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons","volume":"31","author":"Cavanaugh","year":"2011","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.cell.2024.11.001_bib39","doi-asserted-by":"crossref","first-page":"10769","DOI":"10.1523\/JNEUROSCI.3480-15.2016","article-title":"Gi-DREADD expression in peripheral nerves produces ligand-dependent analgesia, as well as ligand-independent functional changes in sensory neurons","volume":"36","author":"Saloman","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2024.11.001_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63377","article-title":"DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels","volume":"10","author":"Bohnslav","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cell.2024.11.001_bib57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"Phenix: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.11.001_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11691","article-title":"Automated design of ligands to polypharmacological profiles","volume":"492","author":"Besnard","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2024.11.001_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1107\/S2052252522000069","article-title":"High-speed high-resolution data collection on a 200 keV cryo-TEM","volume":"9","author":"Peck","year":"2022","journal-title":"IUCrJ"},{"key":"10.1016\/j.cell.2024.11.001_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","article-title":"Automated electron microscope tomography using robust prediction of specimen movements","volume":"152","author":"Mastronarde","year":"2005","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18952-1","article-title":"Topaz-denoise: general deep denoising models for cryoEM and cryoET","volume":"11","author":"Bepler","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2024.11.001_bib44","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41592-020-00990-8","article-title":"Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction","volume":"17","author":"Punjani","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2024.11.001_bib45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jmb.2003.07.013","article-title":"Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy","volume":"333","author":"Rosenthal","year":"2003","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jsb.2006.06.006","article-title":"Bsoft: image processing and molecular modeling for electron microscopy","volume":"157","author":"Heymann","year":"2007","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib47","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s42003-021-02399-1","article-title":"DeepEMhancer: a deep learning solution for cryo-EM volume post-processing","volume":"4","author":"Sanchez-Garcia","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cell.2024.11.001_bib48","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib49","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2024.11.001_bib51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cell.2024.11.001_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.cell.2024.11.001_bib53","doi-asserted-by":"crossref","first-page":"D370","DOI":"10.1093\/nar\/gkr703","article-title":"OPM database and PPM web server: resources for positioning of proteins in membranes","volume":"40","author":"Lomize","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2024.11.001_bib54","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: the biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib55","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of Molecular Dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J.\u00a0Chem. Theor. Comput."},{"key":"10.1016\/j.cell.2024.11.001_bib56","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.cell.2024.11.001_bib58","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1038\/s41598-017-04520-z","article-title":"A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cell.2024.11.001_bib59","doi-asserted-by":"crossref","first-page":"170185","DOI":"10.1038\/sdata.2017.185","article-title":"An RNA-Seq atlas of gene expression in mouse and rat normal tissues","volume":"4","author":"S\u00f6llner","year":"2017","journal-title":"Sci Data"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424012753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867424012753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:39:13Z","timestamp":1781699953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867424012753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":59,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0092867424012753"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2024.11.001","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-guided design of a peripherally restricted chemogenetic system","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}