{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:06:26Z","timestamp":1792047986665,"version":"4.4.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM138852"],"award-info":[{"award-number":["R01GM138852"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD107206"],"award-info":[{"award-number":["R01HD107206"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG074273"],"award-info":[{"award-number":["R01AG074273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3CA256960"],"award-info":[{"award-number":["UH3CA256960"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1DK126138"],"award-info":[{"award-number":["DP1DK126138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG078185"],"award-info":[{"award-number":["R01AG078185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.cell.2025.03.045","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:00:26Z","timestamp":1745406026000},"page":"3513-3529.e26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"188","author":[{"given":"Junchen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Calandrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Lalith Charles","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alborz","family":"Amani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-7453","authenticated-orcid":false,"given":"Sheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.03.045_bib1","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2025.03.045_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2025.03.045_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/humu.20086","article-title":"The role of tau (MAPT) in frontotemporal dementia and related tauopathies","volume":"24","author":"Rademakers","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cell.2025.03.045_bib4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.03.045_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer Disease: An Update on Pathobiology and Treatment Strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.03.045_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","article-title":"Blood biomarkers for Alzheimer\u2019s disease in clinical practice and trials","volume":"3","author":"Hansson","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cell.2025.03.045_bib7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.cub.2020.02.084","article-title":"Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer\u2019s Disease","volume":"30","author":"Yan","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2025.03.045_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111271","article-title":"Insulin and serine metabolism as sex-specific hallmarks of Alzheimer\u2019s disease in the human hippocampus","volume":"40","author":"Maffioli","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.03.045_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cels.2016.11.006","article-title":"A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer\u2019s Disease","volume":"4","author":"Seyfried","year":"2017","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2025.03.045_bib10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jalz.2015.11.002","article-title":"Profiling the human hippocampal proteome at all pathologic stages of Alzheimer\u2019s disease","volume":"12","author":"Hondius","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cell.2025.03.045_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cmet.2022.02.008","article-title":"PHGDH expression increases with progression of Alzheimer\u2019s disease pathology and symptoms","volume":"34","author":"Chen","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.03.045_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1517\/14728222.2016.1135132","article-title":"Accelerating Medicines Partnership: Alzheimer\u2019s Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing","volume":"20","author":"Hodes","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.cell.2025.03.045_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.142","article-title":"A multi-omic atlas of the human frontal cortex for aging and Alzheimer\u2019s disease research","volume":"5","author":"De Jager","year":"2018","journal-title":"Sci. Data"},{"key":"10.1016\/j.cell.2025.03.045_bib14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.03.045_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094839","article-title":"Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer\u2019s and Parkinson's diseases correlate with disease status and features of pathology","volume":"9","author":"Burgos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.03.045_bib16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neurobiolaging.2009.03.013","article-title":"Meta-analysis of linkage studies for Alzheimer\u2019s disease--a web resource","volume":"30","author":"Butler","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cell.2025.03.045_bib17","article-title":"Modeling Sporadic Alzheimer\u2019s Disease in Human Brain Organoids under Serum Exposure","volume":"8","author":"Chen","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cell.2025.03.045_bib18","doi-asserted-by":"crossref","first-page":"41380","DOI":"10.1074\/jbc.M110.187443","article-title":"Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain\u2217","volume":"285","author":"Yang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.03.045_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2020.02.004","article-title":"Impairment of glycolysis-derived l-Serine production in astrocytes contributes to cognitive deficits in Alzheimer\u2019s disease","volume":"31","author":"Le Douce","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.03.045_bib20","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1086\/316886","article-title":"Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis","volume":"67","author":"Klomp","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2025.03.045_bib21","doi-asserted-by":"crossref","DOI":"10.1101\/2021.10.01.462640","article-title":"Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer\u2019s Disease","volume":"15","author":"Javonillo","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cell.2025.03.045_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-5933-5","article-title":"Increased PHGDH expression promotes aberrant melanin accumulation","volume":"19","author":"Mattaini","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cell.2025.03.045_bib23","article-title":"Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cell.2025.03.045_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119598","article-title":"Molecular functions of moonlighting proteins in cell metabolic processes","volume":"1871","author":"Werelusz","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cell.2025.03.045_bib25","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1016\/j.molcel.2021.08.031","article-title":"Moonlighting functions of metabolic enzymes and metabolites in cancer","volume":"81","author":"Pan","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2025.03.045_bib26","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s42255-021-00456-x","article-title":"The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress","volume":"3","author":"Ma","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.03.045_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.abb.2011.10.005","article-title":"Contrasting catalytic and allosteric mechanisms for phosphoglycerate dehydrogenases","volume":"519","author":"Grant","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cell.2025.03.045_bib28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/humu.24388","article-title":"The TALE never ends: A comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects","volume":"43","author":"Mary","year":"2022","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cell.2025.03.045_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)80344-X","article-title":"Identification and characterization of an IkappaB kinase","volume":"90","author":"R\u00e9gnier","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.03.045_bib30","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1253\/circj.CJ-16-0924","article-title":"Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis","volume":"80","author":"Linton","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.cell.2025.03.045_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152508","article-title":"Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt\/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity","volume":"441","author":"Lv","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.cell.2025.03.045_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134609","article-title":"HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities","volume":"21","author":"Paudel","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2025.03.045_bib33","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/ATVBAHA.115.306931","article-title":"Macrophage IKK\u03b1 Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis","volume":"36","author":"Babaev","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cell.2025.03.045_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00427","article-title":"Involvement of Astrocytes in Alzheimer\u2019s Disease from a Neuroinflammatory and Oxidative Stress Perspective","volume":"10","author":"Gonz\u00e1lez-Reyes","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cell.2025.03.045_bib35","article-title":"The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer\u2019s Disease","volume":"23","author":"Sun","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2025.03.045_bib36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s43587-023-00565-0","article-title":"Plasma proteomic profiles predict future dementia in healthy adults","volume":"4","author":"Guo","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cell.2025.03.045_bib37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10787-019-00580-x","article-title":"Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer\u2019s disease","volume":"27","author":"Kaur","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.cell.2025.03.045_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.765376","article-title":"Editorial: Primary Glial and Immune Cell Pathology in Neurodegenerative Diseases","volume":"12","author":"Lakatos","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.cell.2025.03.045_bib39","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nchembio.2070","article-title":"A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate","volume":"12","author":"Pacold","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2025.03.045_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chembiol.2016.11.013","article-title":"Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity","volume":"24","author":"Wang","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cell.2025.03.045_bib41","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.bmc.2018.02.016","article-title":"Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors","volume":"26","author":"Rohde","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cell.2025.03.045_bib42","doi-asserted-by":"crossref","first-page":"21937","DOI":"10.1074\/jbc.274.31.21937","article-title":"Potent Neuroprotective Properties against the Alzheimer \u03b2-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid \u2217","volume":"274","author":"Chyan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.03.045_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2014.00012","article-title":"Cell-type specific mechanisms of D-serine uptake and release in the brain","volume":"6","author":"Martineau","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.cell.2025.03.045_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-023-01206-2","article-title":"A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer\u2019s disease","volume":"15","author":"Boeddrich","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.cell.2025.03.045_bib45","doi-asserted-by":"crossref","first-page":"16337","DOI":"10.1002\/cam4.6256","article-title":"Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer","volume":"12","author":"Zhai","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.cell.2025.03.045_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-022-00547-7","article-title":"Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia","volume":"17","author":"Xia","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.cell.2025.03.045_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.619626","article-title":"The Many Faces of Astrocytes in Alzheimer\u2019s Disease","volume":"12","author":"Monterey","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.cell.2025.03.045_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S1461145711000149","article-title":"Increased NF-\u03baB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer\u2019s disease","volume":"15","author":"Chen","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.cell.2025.03.045_bib49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s11064-021-03227-y","article-title":"Interaction of NF-\u03baB and Wnt\/\u03b2-catenin Signaling Pathways in Alzheimer\u2019s Disease and Potential Active Drug Treatments","volume":"46","author":"Liu","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cell.2025.03.045_bib50","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s10787-024-01502-2","article-title":"An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer\u2019s disease: targeting molecular approach Nrf2, NF-\u03baB, and CREB","volume":"32","author":"Bhardwaj","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.cell.2025.03.045_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12026-008-8025-1","article-title":"The IkappaB kinase complex: master regulator of NF-kappaB signaling","volume":"42","author":"Solt","year":"2008","journal-title":"Immunol. Res."},{"key":"10.1016\/j.cell.2025.03.045_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020383","article-title":"Impact of HMGB1, RAGE, and TLR4 in Alzheimer\u2019s Disease (AD): From Risk Factors to Therapeutic Targeting","volume":"9","author":"Paudel","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cell.2025.03.045_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-023-00717-3","article-title":"HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases","volume":"29","author":"Ren","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.cell.2025.03.045_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020189","article-title":"Age-Dependent and A\u03b2-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer\u2019s Disease","volume":"13","author":"Seol","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.cell.2025.03.045_bib55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2967","article-title":"Amyloid-\u03b2 and tau--a toxic pas de deux in Alzheimer\u2019s disease","volume":"12","author":"Ittner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2025.03.045_bib56","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer\u2019s disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.03.045_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/science.1194653","article-title":"Tau reduction prevents Abeta-induced defects in axonal transport","volume":"330","author":"Vossel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.03.045_bib58","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: from synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.03.045_bib59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.03.045_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19264-0","article-title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer\u2019s disease patient iPSC-derived cerebral organoids","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.03.045_bib61","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-022-04758-2","article-title":"PHGDH heterogeneity potentiates cancer cell dissemination and metastasis","volume":"605","author":"Rossi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.03.045_bib62","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/humu.20934","article-title":"Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics","volume":"30","author":"Tabatabaie","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cell.2025.03.045_bib63","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ajhg.2014.04.015","article-title":"Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH","volume":"94","author":"Shaheen","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2025.03.045_bib64","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04438-4","article-title":"NMDA receptor antagonists reduce amyloid-\u03b2 deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice","volume":"79","author":"Companys-Alemany","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2025.03.045_bib65","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.cdd.4401870","article-title":"Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice","volume":"13","author":"Pasparakis","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2025.03.045_bib66","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1101\/gad.14.14.1729","article-title":"Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation","volume":"14","author":"Li","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.03.045_bib67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2119\/molmed.2014.00063","article-title":"High mobility group box 1 (HMGB1) phenotypic role revealed with stress","volume":"20","author":"Tang","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.cell.2025.03.045_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071714","article-title":"Regulation of neurogenesis in mouse brain by HMGB1","volume":"9","author":"Zhao","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cell.2025.03.045_bib69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.03.045_bib70","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-020-03927-2","article-title":"WACS: improving ChIP-seq peak calling by optimally weighting controls","volume":"22","author":"Awdeh","year":"2021","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cell.2025.03.045_bib71","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2025.03.045_bib72","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2025.03.045_bib73","series-title":"Statistical Computing in C++ and R","author":"Eubank","year":"2011"},{"key":"10.1016\/j.cell.2025.03.045_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.109940","article-title":"Comparison of automated video tracking systems in the open field test: ANY-Maze versus EthoVision XT","volume":"397","author":"Lim","year":"2023","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cell.2025.03.045_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2018.00110","article-title":"D-3-Phosphoglycerate Dehydrogenase","volume":"5","author":"Grant","year":"2018","journal-title":"Front. Mol. Biosci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425003976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425003976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:26:34Z","timestamp":1779452794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425003976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":75,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0092867425003976"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.03.045","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.03.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}