{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:35:34Z","timestamp":1783114534626,"version":"3.54.6"},"reference-count":113,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010296","name":"James B. Pendleton Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA157877"],"award-info":[{"award-number":["R01CA157877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC016892"],"award-info":[{"award-number":["R01DC016892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006352","name":"Virginia and D K Ludwig Fund for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009724","name":"Roddenberry Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["MB220014"],"award-info":[{"award-number":["MB220014"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cell.2025.05.012","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T10:33:32Z","timestamp":1749465212000},"page":"5020-5038.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling"],"prefix":"10.1016","volume":"188","author":[{"given":"William","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Jin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul K.","family":"Suryawanshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivakamasundari","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngtae","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Gombar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Diehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyoo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-hsiu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita Y.","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar J.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-9046","authenticated-orcid":false,"given":"Philip A.","family":"Beachy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.05.012_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41586-018-0073-7","article-title":"Diverse mechanisms for endogenous regeneration and repair in mammalian organs","volume":"557","author":"Wells","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib2","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1242\/dev.009324","article-title":"Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network","volume":"135","author":"Dessaud","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cell.2025.05.012_bib3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-cellbio-092910-154148","article-title":"Morphogen gradients: from generation to interpretation","volume":"27","author":"Rogers","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/335025a0","article-title":"The molecular genetics of embryonic pattern formation in Drosophila","volume":"335","author":"Ingham","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.stem.2020.03.009","article-title":"The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future","volume":"26","author":"Basil","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41579-021-00542-7","article-title":"Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract","volume":"19","author":"Flerlage","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cell.2025.05.012_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-018-0088-0","article-title":"Pancreas regeneration","volume":"557","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fpubh.2020.00014","article-title":"Environmental and Health Impacts of Air Pollution: A Review","volume":"8","author":"Manisalidis","year":"2020","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cell.2025.05.012_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5152\/eajm.2010.09","article-title":"Acute inhalation injury","volume":"42","author":"Gorguner","year":"2010","journal-title":"Eurasian J. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/srep44095","article-title":"A decade of global volcanic SO2 emissions measured from space","volume":"7","author":"Carn","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.05.012_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.ctdb.2018.12.002","article-title":"Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells","volume":"132","author":"Garg","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4161\/isl.18660","article-title":"Mathematical models of pancreatic islet size distributions","volume":"4","author":"Jo","year":"2012","journal-title":"Islets"},{"key":"10.1016\/j.cell.2025.05.012_bib15","series-title":"The Islets of Langerhans","author":"Islam","year":"2010"},{"key":"10.1016\/j.cell.2025.05.012_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09851","article-title":"Hedgehog\/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder","volume":"472","author":"Shin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib17","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ccell.2017.08.007","article-title":"The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy","volume":"32","author":"Roberts","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","article-title":"Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris","volume":"562","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2922-4","article-title":"A molecular cell atlas of the human lung from single-cell RNA sequencing","volume":"587","author":"Travaglini","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78216","article-title":"Neuroendocrinology of the lung revealed by single-cell RNA sequencing","volume":"11","author":"Kuo","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.05.012_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-cellbio-092910-154048","article-title":"Gli proteins in development and disease","volume":"27","author":"Hui","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib22","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1038\/sj.onc.1203243","article-title":"Gli genes in development and cancer","volume":"18","author":"Matise","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2025.05.012_bib23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0960-9822(02)00480-3","article-title":"Sertoli cell signaling by Desert hedgehog regulates the male germline","volume":"6","author":"Bitgood","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/089583700750019549","article-title":"Animal models of chronic bronchitis and their relevance to studies of particle-induced disease","volume":"12","author":"Nikula","year":"2000","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.cell.2025.05.012_bib25","series-title":"Asthma and COPD Basic Mechanisms and Clinical Management","first-page":"Ix","author":"Barnes","year":"2009"},{"key":"10.1016\/j.cell.2025.05.012_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib27","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib28","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1242\/dev.128.24.5161","article-title":"Gli1 can rescue the in vivo function of Gli2","volume":"128","author":"Bai","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cell.2025.05.012_bib29","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cell.2025.05.012_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib31","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ncb3057","article-title":"Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate","volume":"16","author":"Lim","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.cell.2025.05.012_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.012_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/01902148209069653","article-title":"Neuroendocrine cells of the lung. An overview of morphologic characteristics and development","volume":"3","author":"Cutz","year":"1982","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.cell.2025.05.012_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1097-0029(19970401)37:1<31::AID-JEMT4>3.0.CO;2-Z","article-title":"Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs","volume":"37","author":"Scheuermann","year":"1997","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.cell.2025.05.012_bib36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/157339808785161314","article-title":"Pulmonary Neuroendocrine Cell System in Health and Disease","volume":"4","author":"Cutz","year":"2008","journal-title":"Curr. Respir. Med. Rev."},{"key":"10.1016\/j.cell.2025.05.012_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.62.1","article-title":"The pulmonary neuroendocrine system: the past decade","volume":"62","author":"Van Lommel","year":"1999","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.cell.2025.05.012_bib38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cell.2025.05.012_bib39","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.1074\/jbc.M112.438846","article-title":"Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation","volume":"288","author":"Mills","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.05.012_bib40","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1242\/dev.001966","article-title":"Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning","volume":"134","author":"Vokes","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cell.2025.05.012_bib41","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1073\/pnas.1719109115","article-title":"Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration","volume":"115","author":"Lu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib42","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1016\/j.bmcl.2009.05.096","article-title":"Potent agonists of the Hedgehog signaling pathway","volume":"19","author":"Brunton","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cell.2025.05.012_bib43","doi-asserted-by":"crossref","first-page":"14071","DOI":"10.1073\/pnas.182542899","article-title":"Small molecule modulation of Smoothened activity","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/1475-4924-1-10","article-title":"Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists","volume":"1","author":"Frank-Kamenetsky","year":"2002","journal-title":"J. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib45","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.05.012_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1189\/jlb.0811427","article-title":"Mechanisms of sex disparities in influenza pathogenesis","volume":"92","author":"Klein","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib47","doi-asserted-by":"crossref","first-page":"14194","DOI":"10.1073\/pnas.0606109103","article-title":"Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling","volume":"103","author":"Hale","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/1743-422X-7-75","article-title":"Influenza A viral loads in respiratory samples collected from patients infected with pandemic H1N1, seasonal H1N1 and H3N2 viruses","volume":"7","author":"Ngaosuwankul","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.cell.2025.05.012_bib49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000334612","article-title":"Diffuse endocrine system, neuroendocrine tumors and immunity: what's new?","volume":"95","author":"Ameri","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.cell.2025.05.012_bib50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0079-6336(03)80004-9","article-title":"The diffuse endocrine system: from embryogenesis to carcinogenesis","volume":"38","author":"Montuenga","year":"2003","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1016\/j.cell.2025.05.012_bib51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s001250051322","article-title":"Autonomic regulation of islet hormone secretion--implications for health and disease","volume":"43","author":"Ahr\u00e9n","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2025.05.012_bib52","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.2337\/db09-0797","article-title":"Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells","volume":"59","author":"Braun","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2025.05.012_bib53","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41574-018-0082-5","article-title":"Role of biomarker tests for diagnosis of neuroendocrine tumours","volume":"14","author":"Hofland","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cell.2025.05.012_bib54","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00125-003-1153-1","article-title":"Insulin granule dynamics in pancreatic beta cells","volume":"46","author":"Rorsman","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2025.05.012_bib55","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.012_bib56","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1007\/s00125-020-05186-5","article-title":"Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect","volume":"63","author":"Alma\u00e7a","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2025.05.012_bib57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/dom.13031","article-title":"Signals in the pancreatic islet microenvironment influence beta-cell proliferation","volume":"19","author":"Aamodt","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cell.2025.05.012_bib58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2025.05.012_bib59","doi-asserted-by":"crossref","DOI":"10.1186\/s13765-020-00547-5","article-title":"Sex differences in glucose metabolism of streptozotocin-induced diabetes inbred mice (C57BL\/6J)","volume":"63","author":"Kim","year":"2020","journal-title":"Appl. Biol. Chem."},{"key":"10.1016\/j.cell.2025.05.012_bib60","article-title":"Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2025.05.012_bib61","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1002\/cpz1.78","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"1","author":"Furman","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.cell.2025.05.012_bib62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cell.2025.05.012_bib63","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s11892-013-0432-6","article-title":"Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence","volume":"13","author":"Kuo","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.cell.2025.05.012_bib64","doi-asserted-by":"crossref","DOI":"10.1289\/EHP577","article-title":"The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence","volume":"125","author":"Kuo","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cell.2025.05.012_bib65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2012.11.017","article-title":"Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists","volume":"23","author":"Kim","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib66","doi-asserted-by":"crossref","first-page":"13432","DOI":"10.1073\/pnas.1006822107","article-title":"Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib67","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1172\/JCI42874","article-title":"Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog\/GLI pathway","volume":"121","author":"Beauchamp","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.012_bib68","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41580-023-00591-1","article-title":"Cellular and molecular mechanisms of Hedgehog signalling","volume":"24","author":"Zhang","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib69","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav. Res."},{"key":"10.1016\/j.cell.2025.05.012_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12051935","article-title":"Associations of Tinnitus Incidence with Use of Tumor Necrosis Factor-Alpha Inhibitors among Patients with Autoimmune Conditions","volume":"12","author":"Natarajan","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib71","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2019.03.027","article-title":"Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines","volume":"50","author":"Murakami","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.05.012_bib72","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2025.05.012_bib73","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib74","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2025.05.012_bib75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0034-5687(99)00018-3","article-title":"Neuroepithelial bodies as airway oxygen sensors","volume":"115","author":"Cutz","year":"1999","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.cell.2025.05.012_bib76","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.semcdb.2012.09.003","article-title":"Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors","volume":"24","author":"Cutz","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib77","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/labinvest.3700412","article-title":"Functional facets of the pulmonary neuroendocrine system","volume":"86","author":"Linnoila","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cell.2025.05.012_bib78","first-page":"171","article-title":"Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): chemoreceptors and regulators of lung development","volume":"2","author":"Van Lommel","year":"2001","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.cell.2025.05.012_bib79","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.aad7969","article-title":"Pulmonary neuroendocrine cells function as airway sensors to control lung immune response","volume":"351","author":"Branchfield","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.012_bib80","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8546","article-title":"Pulmonary neuroendocrine cells amplify allergic asthma responses","volume":"360","author":"Sui","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.012_bib81","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2019.09.010","article-title":"Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch","volume":"179","author":"Ouadah","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib82","doi-asserted-by":"crossref","first-page":"17531","DOI":"10.1073\/pnas.1207238109","article-title":"Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis","volume":"109","author":"Song","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib83","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.aba0629","article-title":"Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells","volume":"371","author":"Shivaraju","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.012_bib84","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1242\/dev.083691","article-title":"Roles for Hedgehog signaling in adult organ homeostasis and repair","volume":"141","author":"Petrova","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.cell.2025.05.012_bib85","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ccell.2014.09.001","article-title":"Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors","volume":"26","author":"Shin","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.05.012_bib86","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/dvdy.20741","article-title":"Bmp signaling is required for intestinal growth and morphogenesis","volume":"235","author":"Batts","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cell.2025.05.012_bib87","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-018-0190-3","article-title":"GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells","volume":"558","author":"Degirmenci","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib88","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/j.gastro.2009.05.002","article-title":"Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning","volume":"137","author":"Kolterud","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2025.05.012_bib89","doi-asserted-by":"crossref","first-page":"E7545","DOI":"10.1073\/pnas.1616447113","article-title":"Control of inflammation by stromal Hedgehog pathway activation restrains colitis","volume":"113","author":"Lee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib90","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-018-1559-1","article-title":"Chromosome evolution at the origin of the ancestral vertebrate genome","volume":"19","author":"Sacerdot","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2025.05.012_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074132","article-title":"Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates","volume":"9","author":"Pereira","year":"2014","journal-title":"PLOS One"},{"key":"10.1016\/j.cell.2025.05.012_bib92","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(01)80030-1","article-title":"Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths","volume":"23","author":"Parmantier","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2025.05.012_bib93","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1523\/JNEUROSCI.0157-06.2006","article-title":"The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog","volume":"26","author":"Sharghi-Namini","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2025.05.012_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107801","article-title":"H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells","volume":"31","author":"Ruan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.05.012_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006588","article-title":"Influenza NS1 directly modulates Hedgehog signaling during infection","volume":"13","author":"Smelkinson","year":"2017","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cell.2025.05.012_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102763","article-title":"Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients","volume":"55","author":"Liu","year":"2020","journal-title":"EBiomedicine"},{"key":"10.1016\/j.cell.2025.05.012_bib97","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib98","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/jamainternmed.2020.6615","article-title":"Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial","volume":"181","author":"Salvarani","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib99","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1056\/NEJMoa2028836","article-title":"Efficacy of Tocilizumab in Patients Hospitalized with Covid-19","volume":"383","author":"Stone","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/mi.2012.2","article-title":"Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung","volume":"5","author":"Dienz","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cell.2025.05.012_bib101","doi-asserted-by":"crossref","first-page":"E3641","DOI":"10.1073\/pnas.1409781111","article-title":"IL-6\/STAT3 promotes regeneration of airway ciliated cells from basal stem cells","volume":"111","author":"Tadokoro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.012_bib102","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1172\/JCI19491","article-title":"Stat-3 is required for pulmonary homeostasis during hyperoxia","volume":"113","author":"Hokuto","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.012_bib103","doi-asserted-by":"crossref","first-page":"L342","DOI":"10.1152\/ajplung.00016.2004","article-title":"Protective effect of IL-6 on alveolar epithelial cell death induced by hydrogen peroxide","volume":"288","author":"Kida","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2025.05.012_bib104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2006.11.147","article-title":"STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure","volume":"353","author":"Liu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2025.05.012_bib105","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa020300","article-title":"Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant","volume":"347","author":"Kreiss","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib106","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1056\/NEJMoa0910087","article-title":"Lung function in rescue workers at the World Trade Center after 7 years","volume":"362","author":"Aldrich","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib107","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1101388","article-title":"Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan","volume":"365","author":"King","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.05.012_bib108","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.ymthe.2023.10.011","article-title":"Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon","volume":"31","author":"Stabler","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cell.2025.05.012_bib110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-022-04865-0","article-title":"Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination","volume":"607","author":"Suryawanshi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.012_bib112","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2025.05.012_bib109","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B","article-title":"Cre recombinase: the universal reagent for genome tailoring","volume":"26","author":"Nagy","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.cell.2025.05.012_bib111","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med. Care"},{"key":"10.1016\/j.cell.2025.05.012_bib113","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ymeth.2009.03.001","article-title":"ChIP-seq: Using high-throughput sequencing to discover protein\u2013DNA interactions","volume":"48","author":"Schmidt","year":"2009","journal-title":"Methods"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425005628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425005628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:10:06Z","timestamp":1767820206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425005628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":113,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0092867425005628"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.05.012","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}