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Biochem."},{"key":"10.1016\/j.cell.2025.05.017_bib71","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1111\/j.1742-4658.2010.07822.x","article-title":"Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT\u2013MIM interaction","volume":"277","author":"Osako","year":"2010","journal-title":"FEBS Journal"},{"key":"10.1016\/j.cell.2025.05.017_bib72","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84515","article-title":"The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission","volume":"12","author":"Paine","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.05.017_bib73","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0092-8674(00)80292-5","article-title":"Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor","volume":"89","author":"Aza-Blanc","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.017_bib74","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0168-9525(03)00052-0","article-title":"pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems","volume":"19","author":"Arst","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.cell.2025.05.017_bib75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(00)81960-1","article-title":"Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression","volume":"98","author":"Chen","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.017_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyab180","article-title":"Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging","volume":"220","author":"Huang","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2025.05.017_bib77","article-title":"Protein complex prediction with AlphaFold-Multimer","author":"Evans","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2025.05.017_bib78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/pro.19","article-title":"A summary of the measured pK values of the ionizable groups in folded proteins","volume":"18","author":"Grimsley","year":"2009","journal-title":"Protein Sci."},{"key":"10.1016\/j.cell.2025.05.017_bib79","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/ja108943n","article-title":"Protonation, tautomerization, and rotameric structure of histidine: a comprehensive study by magic-angle-spinning solid-state NMR","volume":"133","author":"Li","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2025.05.017_bib80","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/jacs.9b10984","article-title":"Imidazole\u2013imidazole hydrogen bonding in the pH-sensing histidine side chains of influenza A M2","volume":"142","author":"Movellan","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2025.05.017_bib81","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2024.11.036","article-title":"Molecular basis of proton sensing by G protein-coupled receptors","volume":"188","author":"Howard","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.017_bib82","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1152\/physrev.00014.2022","article-title":"New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN","volume":"104","author":"Monteil","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2025.05.017_bib83","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1093\/molbev\/mss182","article-title":"Phylogeny unites animal sodium leak channels with fungal calcium channels in an ancient, voltage-insensitive clade","volume":"29","author":"Liebeskind","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cell.2025.05.017_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2014.00015","article-title":"Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals","volume":"7","author":"Ghezzi","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cell.2025.05.017_bib85","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/emboj\/21.10.2343","article-title":"Essential role of calcineurin in response to endoplasmic reticulum stress","volume":"21","author":"Bonilla","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.05.017_bib86","doi-asserted-by":"crossref","first-page":"33075","DOI":"10.1074\/jbc.M205037200","article-title":"An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae","volume":"277","author":"Matsumoto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.05.017_bib87","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1046\/j.1365-2958.2002.03246.x","article-title":"The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling","volume":"46","author":"Serrano","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cell.2025.05.017_bib88","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1016\/j.febslet.2005.09.058","article-title":"The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity","volume":"579","author":"Peiter","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2025.05.017_bib89","first-page":"323","article-title":"Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae","volume":"193","author":"Courchesne","year":"2011","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.cell.2025.05.017_bib90","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0968-0004(93)90069-Y","article-title":"Cyclosporin A, FK506 and rapamycin: more than just immunosuppression","volume":"18","author":"Kunz","year":"1993","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cell.2025.05.017_bib91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02737887","article-title":"Calcineurin. Structure, function, and inhibition","volume":"30","author":"Hemenway","year":"1999","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cell.2025.05.017_bib92","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/352803a0","article-title":"Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A","volume":"352","author":"Flanagan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib93","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/357695a0","article-title":"Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation","volume":"357","author":"Clipstone","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib94","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4899-0987-9_17","article-title":"Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT","volume":"365","author":"Ho","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib95","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/PL00000703","article-title":"Nucleocytoplasmic shuttling and the control of NF-AT signaling","volume":"57","author":"Zhu","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2025.05.017_bib96","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1101\/gad.11.24.3445","article-title":"Tcn1p\/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae","volume":"11","author":"Matheos","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.05.017_bib97","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1101\/gad.11.24.3432","article-title":"Calcineurin acts through the CRZ1\/TCN1-encoded transcription factor to regulate gene expression in yeast","volume":"11","author":"Stathopoulos","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.05.017_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051403","article-title":"The Crz1\/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity","volume":"7","author":"Lev","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.05.017_bib99","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5507\/bp.2013.024","article-title":"The CRZ1\/SP1-like gene links survival under limited aeration, cell integrity and biofilm formation in the pathogenic yeast Cryptococcus neoformans","volume":"158","author":"Moranova","year":"2014","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.cell.2025.05.017_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005873","article-title":"Calcineurin targets involved in stress survival and fungal virulence","volume":"12","author":"Park","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2025.05.017_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006667","article-title":"Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans","volume":"13","author":"Chow","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2025.05.017_bib102","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3390\/jof9020252","article-title":"Molecular dissection of Crz1 and its dynamic subcellular localization in Cryptococcus neoformans","volume":"9","author":"Chadwick","year":"2023","journal-title":"J. Fungi"},{"key":"10.1016\/j.cell.2025.05.017_bib103","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/EC.00158-06","article-title":"Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments","volume":"5","author":"Liu","year":"2006","journal-title":"Eukaryot. 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Biotechnol."},{"key":"10.1016\/j.cell.2025.05.017_bib107","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41586-021-04313-5","article-title":"Structural architecture of the human NALCN channelosome","volume":"603","author":"Kschonsak","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib108","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30403-7","article-title":"Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex","volume":"13","author":"Kang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.017_bib109","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01049-22","article-title":"Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus","volume":"13","author":"Hoy","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.cell.2025.05.017_bib110","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.1231573","article-title":"53BP1 regulates DSB repair using Rif1 to control 5\u2032 end resection","volume":"339","author":"Zimmermann","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.017_bib111","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nsmb.3251","article-title":"53BP1 fosters fidelity of homology-directed DNA repair","volume":"23","author":"Ochs","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib112","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41556-018-0140-1","article-title":"Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells","volume":"20","author":"Dev","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib113","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-018-0362-1","article-title":"53BP1 cooperation with the REV7\u2013shieldin complex underpins DNA structure-specific NHEJ","volume":"560","author":"Ghezraoui","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib114","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-018-0324-7","article-title":"53BP1\u2013RIF1\u2013shieldin counteracts DSB resection through CST- and Pol\u03b1-dependent fill-in","volume":"560","author":"Mirman","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41586-018-0340-7","article-title":"The shieldin complex mediates 53BP1-dependent DNA repair","volume":"560","author":"Noordermeer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.017_bib116","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41594-024-01381-9","article-title":"Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice","volume":"32","author":"King","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib117","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.3291120","article-title":"The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae","volume":"241","author":"Weinert","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.017_bib118","first-page":"1882","article-title":"Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage","volume":"9","author":"Schiestl","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib119","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00266239","article-title":"Molecular cloning and analysis of Schizosaccharomyces pombe rad9, a gene involved in DNA repair and mutagenesis","volume":"232","author":"Lieberman","year":"1992","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.cell.2025.05.017_bib120","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2006.10.043","article-title":"Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair","volume":"127","author":"Botuyan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.017_bib121","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.fgb.2006.02.007","article-title":"Improvements to gene deletion in the fungal pathogen Cryptococcus neoformans: absence of Ku proteins increases homologous recombination, and co-transformation of independent DNA molecules allows rapid complementation of deletion phenotypes","volume":"43","author":"Goins","year":"2006","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib122","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15879-5","article-title":"Molecular basis for assembly of the shieldin complex and its implications for NHEJ","volume":"11","author":"Liang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.017_bib123","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.tcb.2021.04.002","article-title":"REV7: Jack of many trades","volume":"31","author":"de Krijger","year":"2021","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cell.2025.05.017_bib124","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1128\/IAI.00089-06","article-title":"CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, Is important for the pathobiology of Cryptococcus neoformans","volume":"74","author":"Chang","year":"2006","journal-title":"Infect. 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