{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:34:33Z","timestamp":1793385273069,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kroner-Fresenius Foundation","doi-asserted-by":"publisher","award":["2023_EKMS.03"],"award-info":[{"award-number":["2023_EKMS.03"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["865026"],"award-info":[{"award-number":["865026"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030B_201271"],"award-info":[{"award-number":["310030B_201271"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_215050"],"award-info":[{"award-number":["310030_215050"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21OC0066381"],"award-info":[{"award-number":["NNF21OC0066381"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["FR 1720\/29-1"],"award-info":[{"award-number":["FR 1720\/29-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["EN 1328\/3-1"],"award-info":[{"award-number":["EN 1328\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["426788273"],"award-info":[{"award-number":["426788273"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["GL 589\/12-1"],"award-info":[{"award-number":["GL 589\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["KE 774\/6-1"],"award-info":[{"award-number":["KE 774\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["WO 2835\/1-1"],"award-info":[{"award-number":["WO 2835\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["FR 1720\/30-1"],"award-info":[{"award-number":["FR 1720\/30-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cell.2025.05.029","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:01:51Z","timestamp":1750158111000},"page":"4567-4585.e32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis"],"prefix":"10.1016","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-2708","authenticated-orcid":false,"given":"Marcel S.","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5581-803X","authenticated-orcid":false,"given":"Johannes","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-2311","authenticated-orcid":false,"given":"Lukas C.","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-7493","authenticated-orcid":false,"given":"Manuela","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-9532","authenticated-orcid":false,"given":"Mark","family":"Walkenhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0205-9669","authenticated-orcid":false,"given":"Vanessa","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6788-5009","authenticated-orcid":false,"given":"Inbal","family":"Ipenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-389X","authenticated-orcid":false,"given":"Nicola","family":"Rothammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-836X","authenticated-orcid":false,"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batuhan","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-149X","authenticated-orcid":false,"given":"Desir\u00e9e","family":"Loreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-2822","authenticated-orcid":false,"given":"Christina","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4636-3659","authenticated-orcid":false,"given":"Darwin","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-9799","authenticated-orcid":false,"given":"Ingrid","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3057-6492","authenticated-orcid":false,"given":"Lena Kristina","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-6875","authenticated-orcid":false,"given":"Peter","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-4284","authenticated-orcid":false,"given":"Marco","family":"van Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3428-7264","authenticated-orcid":false,"given":"Kuno M.-J.","family":"Mattern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-7070","authenticated-orcid":false,"given":"Ingo","family":"Winschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-457X","authenticated-orcid":false,"given":"Noah","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-272X","authenticated-orcid":false,"given":"Jana K.","family":"Sonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-5494","authenticated-orcid":false,"given":"Henrike K.","family":"Grosshans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-874X","authenticated-orcid":false,"given":"Albert","family":"Miguela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-231X","authenticated-orcid":false,"given":"Simone","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-0123","authenticated-orcid":false,"given":"Nina","family":"Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-5706","authenticated-orcid":false,"given":"Anke","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-3210","authenticated-orcid":false,"given":"Lars","family":"Binkle-Ladisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-2669","authenticated-orcid":false,"given":"Gabriela","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-1181","authenticated-orcid":false,"given":"Lothar","family":"J\u00e4nsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-1214","authenticated-orcid":false,"given":"Daniela C.","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-998X","authenticated-orcid":false,"given":"Maria","family":"Riedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-242X","authenticated-orcid":false,"given":"Elke","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-8917","authenticated-orcid":false,"given":"Frank L.","family":"Heppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-8817","authenticated-orcid":false,"given":"Markus","family":"Glatzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-5462","authenticated-orcid":false,"given":"Victor G.","family":"Puelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-2076","authenticated-orcid":false,"given":"Jan Broder","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-4646","authenticated-orcid":false,"given":"Jens Randel","family":"Nyengaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-6794","authenticated-orcid":false,"given":"Thomas","family":"Misgeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-9383","authenticated-orcid":false,"given":"Martin","family":"Kerschensteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-2007","authenticated-orcid":false,"given":"Doron","family":"Merkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-5188","authenticated-orcid":false,"given":"Catherine","family":"Meyer-Schwesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-2420","authenticated-orcid":false,"given":"Manuel A.","family":"Friese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.05.029_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41583-024-00823-z","article-title":"The neuropathobiology of multiple sclerosis","volume":"25","author":"Woo","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41577-022-00718-z","article-title":"The immunology of multiple sclerosis","volume":"22","author":"Attfield","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15626-w","article-title":"\u03b1-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson\u2019s disease","volume":"11","author":"Lindestam Arlehamn","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib6","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1177\/1352458514564482","article-title":"Subclinical central inflammation is risk for RIS and CIS conversion to MS","volume":"21","author":"Rossi","year":"2015","journal-title":"Mult. Scler."},{"key":"10.1016\/j.cell.2025.05.029_bib7","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41591-021-01456-w","article-title":"Microglial activation and tau propagate jointly across Braak stages","volume":"27","author":"Pascoal","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib8","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cell.2018.07.049","article-title":"Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping","volume":"175","author":"Di Liberto","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib10","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41593-023-01415-3","article-title":"Infiltrating CD8+ T cells exacerbate Alzheimer\u2019s disease pathology in a 3D human neuroimmune axis model","volume":"26","author":"Jorfi","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18755-4","article-title":"Interferon-\u03b3 signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells","volume":"11","author":"Panagiotakopoulou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib12","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/s41593-022-01183-6","article-title":"CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging","volume":"25","author":"Kaya","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib13","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41593-023-01323-6","article-title":"The contribution of the peripheral immune system to neurodegeneration","volume":"26","author":"Berriat","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib14","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201290","article-title":"Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation","volume":"218","author":"Woo","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-019-0385-4","article-title":"Bassoon proteinopathy drives neurodegeneration in multiple sclerosis","volume":"22","author":"Schattling","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61798","article-title":"Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis","volume":"10","author":"Rosenkranz","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.05.029_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40478-023-01617-7","article-title":"Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS","volume":"11","author":"Jhelum","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib18","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41418-023-01195-0","article-title":"Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression","volume":"30","author":"Van San","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2025.05.029_bib19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41423-022-00883-0","article-title":"Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis","volume":"19","author":"Luoqian","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s42255-023-00838-3","article-title":"Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions","volume":"5","author":"Tai","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.05.029_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177692","article-title":"The NR4A2\/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis","volume":"134","author":"Woo","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.029_bib22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/s42255-024-01049-0","article-title":"Weak neuronal glycolysis sustains cognition and organismal fitness","volume":"6","author":"Jimenez-Blasco","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.05.029_bib23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C\u2013Cdh1","volume":"11","author":"Herrero-Mendez","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib24","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/cdd.2012.33","article-title":"Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration","volume":"19","author":"Rodriguez-Rodriguez","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2025.05.029_bib25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41467-022-28191-1","article-title":"Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis","volume":"13","author":"Lopez-Fabuel","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41419-021-03441-0","article-title":"Expanding the role of proteasome homeostasis in Parkinson\u2019s disease: beyond protein breakdown","volume":"12","author":"Bi","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2025.05.029_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41580-018-0040-z","article-title":"Regulation of proteasome assembly and activity in health and disease","volume":"19","author":"Rousseau","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ni.2203","article-title":"Mice completely lacking immunoproteasomes show major changes in antigen presentation","volume":"13","author":"Kincaid","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-46273-0","article-title":"The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration","volume":"15","author":"Sachs","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cell.2010.07.036","article-title":"Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress","volume":"142","author":"Seifert","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.982786","article-title":"Immunoproteasomes control activation of innate immune signaling and microglial function","volume":"13","author":"\u00c7etin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib32","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/brain\/awt083","article-title":"Reactive glia show increased immunoproteasome activity in Alzheimer\u2019s disease","volume":"136","author":"Orre","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.cell.2025.05.029_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf2018","article-title":"An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses","volume":"380","author":"Sun","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.029_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-020-1999-0","article-title":"MAFG-driven astrocytes promote CNS inflammation","volume":"578","author":"Wheeler","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat7554","article-title":"Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation","volume":"363","author":"Jord\u00e3o","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.029_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","article-title":"A lymphocyte\u2013microglia\u2013astrocyte axis in chronic active multiple sclerosis","volume":"597","author":"Absinta","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib37","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/nbt.4016","article-title":"Cell-type-specific metabolic labeling of nascent proteomes in vivo","volume":"35","author":"Alvarez-Castelao","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2025.05.029_bib38","article-title":"Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis","volume":"14","author":"Reichelt","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.15252\/emmm.201708089","article-title":"The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis","volume":"10","author":"Althof","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib40","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.bbmt.2015.06.010","article-title":"Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen\u2013Disparate Murine Model","volume":"21","author":"Zilberberg","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.cell.2025.05.029_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41514-017-0002-2","article-title":"Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress","volume":"3","author":"Kamogashira","year":"2017","journal-title":"npj Aging Mech. Dis."},{"key":"10.1016\/j.cell.2025.05.029_bib42","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/emmm.201000102","article-title":"Mitochondrial fission and cristae disruption increase the response of cell models of Huntington\u2019s disease to apoptotic stimuli","volume":"2","author":"Costa","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib43","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.yexcr.2018.10.009","article-title":"Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment","volume":"373","author":"Eustaquio","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cell.2025.05.029_bib44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.029_bib45","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.celrep.2014.11.025","article-title":"MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies","volume":"9","author":"Baek","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.05.029_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14420-x","article-title":"Late-onset Alzheimer\u2019s disease is associated with inherent changes in bioenergetics profiles","volume":"7","author":"Sonntag","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.05.029_bib47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib48","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib49","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib51","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","article-title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","volume":"608","author":"Mishima","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1471-4159.2008.05616.x","article-title":"Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction","volume":"107","author":"Sun","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2025.05.029_bib53","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/emboj.2008.195","article-title":"Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity","volume":"27","author":"Maestre","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.05.029_bib54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1479-5876-10-95","article-title":"Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation","volume":"10","author":"Telang","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib55","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1111\/cas.14625","article-title":"PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through vascular endothelial growth factor A reduction","volume":"111","author":"Chang","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cell.2025.05.029_bib56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nri.2016.123","article-title":"Cytokine networks in neuroinflammation","volume":"17","author":"Becher","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg2979","article-title":"Long 3\u2032UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation","volume":"8","author":"Dorrity","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102211","article-title":"Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and \u2026guilty","volume":"77","author":"Merkler","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cell.2025.05.029_bib59","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41593-022-01191-6","article-title":"Bassoon contributes to tau-seed propagation and neurotoxicity","volume":"25","author":"Martinez","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib60","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/mds.29363","article-title":"Brain and Systemic Inflammation in De Novo Parkinson\u2019s Disease","volume":"38","author":"Yacoubian","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.cell.2025.05.029_bib61","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.isci.2019.01.018","article-title":"Alzheimer A\u03b2 Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK\u03b13 Neurons by Secretion","volume":"13","author":"Komura","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.cell.2025.05.029_bib62","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1471-4159.2010.06914.x","article-title":"Proteasome inhibition modeling nigral neuron degeneration in Parkinson\u2019s disease","volume":"115","author":"Xie","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2025.05.029_bib63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1471-4159.2004.02456.x","article-title":"A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells","volume":"90","author":"Li","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2025.05.029_bib64","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1523\/JNEUROSCI.2218-08.2008","article-title":"Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies","volume":"28","author":"Bedford","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib65","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1002\/alz.13680","article-title":"Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons","volume":"20","author":"Hsieh","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cell.2025.05.029_bib66","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0896-6273(03)00606-8","article-title":"The Ubiquitin Proteasome System in Neurodegenerative Diseases: sometimes the chicken, sometimes the egg","volume":"40","author":"Ciechanover","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2025.05.029_bib67","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1089\/ars.2013.5802","article-title":"The Ubiquitin-Proteasome System in Neurodegeneration","volume":"21","author":"McKinnon","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cell.2025.05.029_bib68","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1016\/j.neuron.2023.05.031","article-title":"Tipping points in neurodegeneration","volume":"111","author":"Simons","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2025.05.029_bib69","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1073\/pnas.0501711102","article-title":"IFN-\u03b3-induced immune adaptation of the proteasome system is an accelerated and transient response","volume":"102","author":"Heink","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.029_bib70","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1172\/JCI58414","article-title":"A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans","volume":"121","author":"Kitamura","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.029_bib71","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1172\/JCI81260","article-title":"Additive loss-of-function proteasome subunit mutations in CANDLE\/PRAAS patients promote type I IFN production","volume":"125","author":"Brehm","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.05.029_bib72","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.stemcr.2018.04.004","article-title":"Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress","volume":"10","author":"Honda-Ozaki","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.cell.2025.05.029_bib73","doi-asserted-by":"crossref","first-page":"eabk2252","DOI":"10.1126\/sciadv.abk2252","article-title":"Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer\u2019s-like pathology in mouse and fly APP overexpression models","volume":"8","author":"Chocron","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2025.05.029_bib74","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1073\/pnas.0913668107","article-title":"E3 ubiquitin ligase APC\/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation","volume":"107","author":"Almeida","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.029_bib75","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-020-2493-1","article-title":"Chk1-mediated phosphorylation of Cdh1 promotes the SCF\u03b2TRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression","volume":"11","author":"Pal","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2025.05.029_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11638-3","article-title":"Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination","volume":"10","author":"Kirby","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib77","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41591-018-0236-y","article-title":"Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis","volume":"24","author":"Falc\u00e3o","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.05.029_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2022.577995","article-title":"Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis","volume":"373","author":"Li","year":"2022","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cell.2025.05.029_bib79","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.1523\/JNEUROSCI.1749-20.2020","article-title":"Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination","volume":"40","author":"Jhelum","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib80","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm6131","article-title":"Restoring hippocampal glucose metabolism rescues cognition across Alzheimer\u2019s disease pathologies","volume":"385","author":"Minhas","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.029_bib81","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-024-07516-8","article-title":"Senescent glia link mitochondrial dysfunction and lipid accumulation","volume":"630","author":"Byrns","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib82","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","article-title":"A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain","volume":"624","author":"Yao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib83","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/s41586-025-08615-w","article-title":"Cell-autonomous innate immunity by proteasome-derived defence peptides","volume":"639","author":"Goldberg","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.05.029_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01019-z","article-title":"Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras","volume":"8","author":"Peeters","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib85","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.abb2683","article-title":"Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity","volume":"371","author":"Xu","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.05.029_bib86","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.chembiol.2022.10.005","article-title":"Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death","volume":"29","author":"Chang","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1478-811X-11-76","article-title":"The proteases HtrA2\/Omi and UCH-L1 regulate TNF-induced necroptosis","volume":"11","author":"Sosna","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cell.2025.05.029_bib88","article-title":"Generating Single Cell\u2013Derived Knockout Clones in Mammalian Cells with CRISPR\/Cas9","volume":"128","author":"Giuliano","year":"2019","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib89","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.05.029_bib90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.05.029_bib91","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.05.029_bib92","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2025.05.029_bib93","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2025.05.029_bib94","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.cell.2025.05.029_bib95","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/nprot.2007.268","article-title":"Preparation of the functionalizable methionine surrogate azidohomoalanine via copper-catalyzed diazo transfer","volume":"2","author":"Link","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2025.05.029_bib96","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1073\/pnas.0601637103","article-title":"Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)","volume":"103","author":"Dieterich","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.05.029_bib97","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1016\/j.apsb.2021.05.013","article-title":"Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cell.2025.05.029_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13275","article-title":"Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model","volume":"7","author":"Romanelli","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.05.029_bib99","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.05.029_bib100","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70018","article-title":"Tidyplots empowers life scientists with easy code-based data visualization","volume":"4","author":"Engler","year":"2025","journal-title":"Imeta"}],"updated-by":[{"DOI":"10.1016\/j.cell.2025.09.019","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000}},{"DOI":"10.1016\/j.cell.2026.04.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000}},{"DOI":"10.1016\/j.cell.2026.04.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000}}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425006166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425006166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:19:12Z","timestamp":1775765952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425006166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":100,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0092867425006166"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.05.029","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}