{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:14:21Z","timestamp":1793718861502,"version":"4.6.1"},"reference-count":85,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070108"],"award-info":[{"award-number":["82070108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330050"],"award-info":[{"award-number":["32330050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302706"],"award-info":[{"award-number":["82302706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32425027"],"award-info":[{"award-number":["32425027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22120250374"],"award-info":[{"award-number":["22120250374"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2021YFA1100900"],"award-info":[{"award-number":["2021YFA1100900"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFA1103200"],"award-info":[{"award-number":["2022YFA1103200"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016096","name":"Shanghai Key Basic Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cell.2025.06.036","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T14:37:59Z","timestamp":1753108679000},"page":"5194-5211.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration"],"prefix":"10.1016","volume":"188","author":[{"given":"Qiaoling","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoyuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-369X","authenticated-orcid":false,"given":"Rui","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.06.036_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03008207.2016.1177036","article-title":"Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis","volume":"57","author":"Wei","year":"2016","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.cell.2025.06.036_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052619","article-title":"Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2025.06.036_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: relevance and biology","volume":"15","author":"van der Kraan","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00147-z","article-title":"Subchondral bone microenvironment in osteoarthritis and pain","volume":"9","author":"Hu","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.cell.2025.06.036_bib5","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cell.2025.06.036_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.06.036_bib8","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1177\/0363546514528093","article-title":"Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial","volume":"42","author":"Saris","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.cell.2025.06.036_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.603444","article-title":"Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering","volume":"9","author":"Zhao","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cell.2025.06.036_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s004290100178","article-title":"The development of articular cartilage: evidence for an appositional growth mechanism","volume":"203","author":"Hayes","year":"2001","journal-title":"Anat. Embryol. (Berl.)"},{"key":"10.1016\/j.cell.2025.06.036_bib11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/art.39030","article-title":"Identification of a Prg4-expressing articular cartilage progenitor cell population in mice","volume":"67","author":"Kozhemyakina","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cell.2025.06.036_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ydbio.2017.04.006","article-title":"Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs","volume":"426","author":"Decker","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib13","doi-asserted-by":"crossref","first-page":"26486","DOI":"10.1016\/S0021-9258(18)47220-1","article-title":"Identification, cloning, and regulation of a novel endothelial cell protein C\/activated protein C receptor","volume":"269","author":"Fukudome","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.06.036_bib14","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood-2007-06-096651","article-title":"The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells","volume":"110","author":"Bae","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cell.2025.06.036_bib15","doi-asserted-by":"crossref","first-page":"19830","DOI":"10.1073\/pnas.1107140108","article-title":"Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation","volume":"108","author":"Vetrano","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.06.036_bib16","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1182\/blood-2005-06-2249","article-title":"Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow","volume":"107","author":"Balazs","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cell.2025.06.036_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1182\/blood-2009-08-240903","article-title":"Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver","volume":"116","author":"Iwasaki","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.cell.2025.06.036_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature17997","article-title":"Tracing haematopoietic stem cell formation at single-cell resolution","volume":"533","author":"Zhou","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.06.036_bib19","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1182\/blood-2016-11-750729","article-title":"EPCR expression marks UM171-expanded CD34(+) cord blood stem cells","volume":"129","author":"Fares","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.cell.2025.06.036_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature13851","article-title":"Identification of multipotent mammary stem cells by protein C receptor expression","volume":"517","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.06.036_bib21","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/cr.2016.85","article-title":"Identification of blood vascular endothelial stem cells by the expression of protein C receptor","volume":"26","author":"Yu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2025.06.036_bib22","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/stem.2630","article-title":"The Endothelial Protein C Receptor Is a Potential Stem Cell Marker for Epidermal Keratinocytes","volume":"35","author":"Xue","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.cell.2025.06.036_bib23","article-title":"Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.06.036_bib24","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.02.048","article-title":"Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr(+) Progenitors","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.06.036_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00163-z","article-title":"Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs","volume":"9","author":"Gan","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.cell.2025.06.036_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.cell.2025.06.036_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-04411-2","article-title":"Mechanical compression creates a quiescent muscle stem cell niche","volume":"6","author":"Tao","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00774-003-0426-6","article-title":"Changes in bone turnover markers during 14-day 6 degrees head-down bed rest","volume":"21","author":"Kim","year":"2003","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.cell.2025.06.036_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nrrheum.2018.37","article-title":"Skeletal changes during and after spaceflight","volume":"14","author":"Vico","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cell.2025.06.036_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11914-020-00588-1","article-title":"Exercise and Peak Bone Mass.","volume":"18","author":"Karlsson","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.cell.2025.06.036_bib31","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/art.10462","article-title":"Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement","volume":"46","author":"Vanwanseele","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2025.06.036_bib32","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/art.22990","article-title":"Effect of physical activity on articular knee joint structures in community-based adults","volume":"57","author":"Racunica","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2025.06.036_bib33","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/jor.25222","article-title":"Articular contact motion at the knee during daily activities","volume":"40","author":"Thomeer","year":"2022","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cell.2025.06.036_bib34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3389\/fphys.2018.00824","article-title":"Cellular Mechanotransduction: From Tension to Function","volume":"9","author":"Martino","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cell.2025.06.036_bib35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.06.036_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.06.036_bib37","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm.2017.92","article-title":"Piezos thrive under pressure: mechanically activated ion channels in health and disease","volume":"18","author":"Murthy","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib38","doi-asserted-by":"crossref","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.06.036_bib39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00223-022-01052-1","article-title":"Mechanical Loading Promotes the Migration of Endogenous Stem Cells and Chondrogenic Differentiation in a Mouse Model of Osteoarthritis","volume":"112","author":"Li","year":"2023","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.cell.2025.06.036_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.06.036_bib41","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib42","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib43","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/nm.4437","article-title":"Enhancing the precision of genetic lineage tracing using dual recombinases","volume":"23","author":"He","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.06.036_bib44","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ncb3067","article-title":"A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones","volume":"16","author":"Ono","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib45","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib46","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1469-7580.2003.00226.x","article-title":"In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage","volume":"203","author":"Shibata","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.cell.2025.06.036_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2020.105446","article-title":"Finite-Element analysis of a lateral femoro-tibial impact on the total knee arthroplasty","volume":"192","author":"Arab","year":"2020","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cell.2025.06.036_bib48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jot.2018.12.004","article-title":"Effect of degenerative and radial tears of the meniscus and resultant meniscectomy on the knee joint: a finite element analysis","volume":"18","author":"Zhang","year":"2019","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.cell.2025.06.036_bib49","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1111\/jth.15504","article-title":"Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension","volume":"19","author":"Zhao","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cell.2025.06.036_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105963","article-title":"The role of the Piezo1 channel in osteoblasts under cyclic stretching: A study on osteogenic and osteoclast factors","volume":"163","author":"Kang","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-07524-y","article-title":"Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-kappaB\/p65 axis","volume":"8","author":"Zeng","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib52","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1182\/blood-2002-01-0046","article-title":"Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2)","volume":"100","author":"Dekker","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.cell.2025.06.036_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells11142191","article-title":"Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2\/4 Expression via CaMKII\/MEKK3\/ERK5 Axis in Endothelial Cells","volume":"11","author":"Zheng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cell.2025.06.036_bib54","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.cell.2025.06.036_bib55","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.joca.2023.11.015","article-title":"Osteoarthritis year in review 2023: Biomechanics","volume":"32","author":"Diamond","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib56","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s11999-016-4921-1","article-title":"Hip, Knee, and Ankle Osteoarthritis Negatively Affects Mechanical Energy Exchange","volume":"474","author":"Queen","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.cell.2025.06.036_bib57","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.06.036_bib58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tips.2019.02.004","article-title":"Targeting Mechanosensitive Transcription Factors in Atherosclerosis","volume":"40","author":"Niu","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cell.2025.06.036_bib59","doi-asserted-by":"crossref","first-page":"109782","DOI":"10.1016\/j.celrep.2021.109782","article-title":"Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish","volume":"37","author":"Paolini","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.06.036_bib60","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.06.036_bib61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/dbio.2002.0802","article-title":"The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis","volume":"251","author":"Enomoto-Iwamoto","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib62","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.joca.2014.10.010","article-title":"Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis","volume":"23","author":"Thysen","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib63","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIRCRESAHA.121.320565","article-title":"Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion","volume":"131","author":"Choi","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.cell.2025.06.036_bib64","doi-asserted-by":"crossref","first-page":"eadf2664","DOI":"10.1126\/sciadv.adf2664","article-title":"Varying mechanical forces drive sensory epithelium formation","volume":"9","author":"Xia","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2025.06.036_bib65","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cub.2015.03.038","article-title":"Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development","volume":"25","author":"Heckel","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2025.06.036_bib67","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","article-title":"Mechanisms of mechanotransduction and physiological roles of PIEZO channels","volume":"25","author":"Xiao","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.06.036_bib68","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-022-00239-4","article-title":"The role of TGF-beta3 in cartilage development and osteoarthritis","volume":"11","author":"Du","year":"2023","journal-title":"Bone Res."},{"key":"10.1016\/j.cell.2025.06.036_bib69","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.joca.2009.06.008","article-title":"TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads","volume":"17","author":"van der Kraan","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bpj.2016.11.013","article-title":"GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels","volume":"112","author":"Gnanasambandam","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.cell.2025.06.036_bib71","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-018-0554-8","article-title":"Discovery of a periosteal stem cell mediating intramembranous bone formation","volume":"562","author":"Debnath","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.06.036_bib72","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108415","article-title":"Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools","volume":"41","author":"Mo","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.06.036_bib73","doi-asserted-by":"crossref","first-page":"107158","DOI":"10.1016\/j.jbc.2024.107158","article-title":"Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone","volume":"300","author":"Nookaew","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.06.036_bib74","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2014.12.002","article-title":"Identification and specification of the mouse skeletal stem cell","volume":"160","author":"Chan","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.06.036_bib75","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1016\/j.biomaterials.2013.01.044","article-title":"The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties","volume":"34","author":"Su","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.cell.2025.06.036_bib76","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0076-6879(06)19006-0","article-title":"Postnatal skeletal stem cells","volume":"419","author":"Bianco","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cell.2025.06.036_bib77","doi-asserted-by":"crossref","first-page":"427S","DOI":"10.1177\/1947603520973240","article-title":"Assessment of Native Human Articular Cartilage: A Biomechanical Protocol","volume":"13","author":"Kabir","year":"2021","journal-title":"Cartilage"},{"key":"10.1016\/j.cell.2025.06.036_bib78","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-016-0191-9","article-title":"Age-related changes in behavior in C57BL\/6J mice from young adulthood to middle age","volume":"9","author":"Shoji","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.cell.2025.06.036_bib79","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.reth.2022.04.004","article-title":"Advanced Therapy medicinal products for autologous chondrocytes and comparison of regulatory systems in target countries","volume":"20","author":"Kim","year":"2022","journal-title":"Regen. Ther."},{"key":"10.1016\/j.cell.2025.06.036_bib80","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biomaterials.2018.11.014","article-title":"Chasing Chimeras - The elusive stable chondrogenic phenotype","volume":"192","author":"Graceffa","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.cell.2025.06.036_bib81","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002386R","article-title":"Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration","volume":"35","author":"Shen","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2025.06.036_bib82","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2004.02.010","article-title":"Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity","volume":"12","author":"Barbero","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cell.2025.06.036_bib83","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"Zhang","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2025.06.036_bib84","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.06.036_bib85","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742500738X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286742500738X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:24:33Z","timestamp":1777476273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286742500738X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":85,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S009286742500738X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.06.036","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.06.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}