{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:50:50Z","timestamp":1793429450117,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI142737"],"award-info":[{"award-number":["U19 AI142737"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI168631"],"award-info":[{"award-number":["U19 AI168631"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54CA267776"],"award-info":[{"award-number":["U54CA267776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","award":["U19 AI142737"],"award-info":[{"award-number":["U19 AI142737"]}],"id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","award":["U19 AI168631"],"award-info":[{"award-number":["U19 AI168631"]}],"id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004343","name":"Stavros Niarchos Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006231","name":"Brookhaven National Laboratory","doi-asserted-by":"publisher","award":["DE-SC0012704"],"award-info":[{"award-number":["DE-SC0012704"]}],"id":[{"id":"10.13039\/100006231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006151","name":"Basic Energy Sciences","doi-asserted-by":"publisher","award":["DE-AC02-76SF00515"],"award-info":[{"award-number":["DE-AC02-76SF00515"]}],"id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30GM133894"],"award-info":[{"award-number":["P30GM133894"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022531","name":"School Library Association of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006206","name":"Biological and Environmental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011664","name":"SLAC National Accelerator Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cell.2025.08.004","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:42:33Z","timestamp":1756219353000},"page":"6236-6252.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Human monoclonal antibodies targeting A35 protect from death caused by mpox"],"prefix":"10.1016","volume":"188","author":[{"given":"Raianna F.","family":"Fantin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Chan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Bozarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallie","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxinne","family":"Ignacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Earl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alesandro","family":"Civljak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Laghlali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson","family":"Crandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajakta","family":"Warang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garc\u00eda-Bernalt Diego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz A.","family":"Lugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Pischel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inci","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad B.","family":"Omer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Bajic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-5096","authenticated-orcid":false,"given":"Viviana","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-3132","authenticated-orcid":false,"given":"Michael","family":"Schotsaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-9996","authenticated-orcid":false,"given":"Camila H.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.08.004_bib1","article-title":"Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development","volume":"14","author":"Liu","year":"2025","journal-title":"Infect. Dis. Pover."},{"key":"10.1016\/j.cell.2025.08.004_bib2","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1128\/JVI.00116-06","article-title":"Obligatory Requirement for Antibody in Recovery from a Primary Poxvirus Infection","volume":"80","author":"Chaudhri","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1195674","article-title":"Evaluation of Monkeypox- and Vaccinia virus-neutralizing antibodies in human serum samples after vaccination and natural infection","volume":"11","author":"Manenti","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cell.2025.08.004_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-065X.2010.00975.x","article-title":"Smallpox vaccines: targets of protective immunity","volume":"239","author":"Moss","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cell.2025.08.004_bib5","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nm917","article-title":"Duration of antiviral immunity after smallpox vaccination","volume":"9","author":"Hammarlund","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.08.004_bib6","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.amjmed.2008.08.019","article-title":"Immunity from Smallpox Vaccine Persists for Decades: A Longitudinal Study","volume":"121","author":"Taub","year":"2008","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cell.2025.08.004_bib7","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.4049\/jimmunol.171.10.4969","article-title":"Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination","volume":"171","author":"Crotty","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2025.08.004_bib8","article-title":"The monkeypox outbreak in 2022: adaptive evolution associated with APOBEC3 may account for","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cell.2025.08.004_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00062-23","article-title":"An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses","volume":"8","author":"Forni","year":"2023","journal-title":"mSphere"},{"key":"10.1016\/j.cell.2025.08.004_bib10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.adg8116","article-title":"APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016","volume":"382","author":"O\u2019Toole","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib11","article-title":"The Durability and Avidity of MPXV-specific Antibodies Induced by the Two-dose MVA-BN Mpox Vaccine","author":"Oom","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.cell.2025.08.004_bib12","article-title":"Rapid Decline of Mpox Antibody Responses Following MVA-BN Vaccination","author":"Collier","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.cell.2025.08.004_bib13","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1128\/jvi.66.7.4170-4179.1992","article-title":"Role of cell-associated enveloped vaccinia virus in cell-to-cell spread","volume":"66","author":"Blasco","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1099\/0022-1317-50-1-89","article-title":"Significance of extracellular enveloped virus in the in vitro and in vivo dissemination of vaccinia","volume":"50","author":"Payne","year":"1980","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib15","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1128\/jvi.65.11.5910-5920.1991","article-title":"Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein","volume":"65","author":"Blasco","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib16","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1128\/jvi.66.3.1610-1621.1992","article-title":"Identification and characterization of an extracellular envelope glycoprotein affecting vaccinia virus egress","volume":"66","author":"Duncan","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib17","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1128\/jvi.66.12.7217-7224.1992","article-title":"Characterization of a vaccinia virus-encoded 42-kilodalton class I membrane glycoprotein component of the extracellular virus envelope","volume":"66","author":"Isaacs","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib18","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1128\/JVI.72.5.4192-4204.1998","article-title":"The Envelope Protein Encoded by the A33R Gene Is Required for Formation of Actin-Containing Microvilli and Efficient Cell-to-Cell Spread of Vaccinia Virus","volume":"72","author":"Roper","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/viro.2002.1446","article-title":"Analysis of the monkeypox virus genome","volume":"297","author":"Shchelkunov","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2022.198975","article-title":"Evolution of the orthopoxvirus core genome","volume":"323","author":"Molteni","year":"2023","journal-title":"Virus Res."},{"key":"10.1016\/j.cell.2025.08.004_bib21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cell.2016.09.049","article-title":"Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections","volume":"167","author":"Gilchuk","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.08.004_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41421-023-00556-w","article-title":"Two long-lasting human monoclonal antibodies cross-react with monkeypox virus A35 antigen","volume":"9","author":"Zhou","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.cell.2025.08.004_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005148","article-title":"Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer","volume":"11","author":"Matho","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2025.08.004_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.virol.2020.02.004","article-title":"Particle-specific neutralizing activity of a monoclonal antibody targeting the poxvirus A33 protein reveals differences between cell associated and extracellular enveloped virions","volume":"544","author":"Mucker","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10071084","article-title":"Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers","volume":"10","author":"Gu","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.cell.2025.08.004_bib26","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1016\/S2666-5247(23)00365-8","article-title":"Human antibody responses to circulating monkeypox virus emphasise the need for the first mpox-specific vaccine","volume":"5","author":"Fantin","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib27","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S1473-3099(23)00352-3","article-title":"Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study","volume":"23","author":"Cohn","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cell.2025.08.004_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.105957","article-title":"Monkeypox infection elicits strong antibody and B cell response against A35R and H3L antigens","volume":"26","author":"Yefet","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.cell.2025.08.004_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29134","article-title":"Development of a novel serological assay for the detection of mpox infection in vaccinated populations","volume":"95","author":"Yates","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2024.100987","article-title":"Assessment of MpoxPlex, a high throughput and multiplexed immunoassay: a diagnostic accuracy study","volume":"6","author":"Jones","year":"2025","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib31","article-title":"The two-dose MVA-BN mpox vaccine induces a nondurable and low avidity MPXV-specific antibody response","author":"Oom","year":"2025","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jaci.2005.08.003","article-title":"Selection, design, and engineering of therapeutic antibodies","volume":"116","author":"Presta","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cell.2025.08.004_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s13238-017-0447-x","article-title":"Molecular and functional analysis of monoclonal antibodies in support of biologics development","volume":"9","author":"Wang","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.cell.2025.08.004_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101533","article-title":"Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence\u2013based affinity maturation","volume":"298","author":"Kielczewska","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.08.004_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virol.2005.07.006","article-title":"Physical and immunological characterization of a recombinant secreted form of the membrane protein encoded by the vaccinia virus L1R gene","volume":"341","author":"Aldaz-Carroll","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib36","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1128\/JVI.00606-07","article-title":"Two distinct low-pH steps promote entry of vaccinia virus","volume":"81","author":"Townsley","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virol.2013.11.017","article-title":"Susceptibility of the wild-derived inbred CAST\/Ei mouse to infection by orthopoxviruses analyzed by live bioluminescence imaging","volume":"449","author":"Americo","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib38","doi-asserted-by":"crossref","first-page":"W529","DOI":"10.1093\/nar\/gkq399","article-title":"ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids","volume":"38","author":"Ashkenazy","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2025.08.004_bib39","doi-asserted-by":"crossref","first-page":"W34","DOI":"10.1093\/nar\/gkt382","article-title":"IgBLAST: an immunoglobulin variable domain sequence analysis tool","volume":"41","author":"Ye","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2025.08.004_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/v14020388","article-title":"An Update of Orthopoxvirus Molecular Evolution","volume":"14","author":"Babkin","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.cell.2025.08.004_bib41","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2023.02.005","article-title":"Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease","volume":"56","author":"Zhou","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.08.004_bib42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib43","article-title":"IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity","volume":"6","author":"Avnir","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.08.004_bib44","series-title":"Topline Results from PALM 007 Study of SIGA\u2019s Tecovirimat in Treatment of Mpox Released","year":"2024"},{"key":"10.1016\/j.cell.2025.08.004_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2024.105995","article-title":"Treatment efficacy of cidofovir and brincidofovir against clade II Monkeypox virus isolates","volume":"231","author":"Pr\u00e9vost","year":"2024","journal-title":"Antiviral Res."},{"key":"10.1016\/j.cell.2025.08.004_bib46","article-title":"Interim Clinical Considerations for Use of Vaccine for Mpox Prevention in the United States","year":"2024","journal-title":"Mpox"},{"key":"10.1016\/j.cell.2025.08.004_bib47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(23)00273-8","article-title":"Mpox in people with advanced HIV infection: a global case series","volume":"401","author":"Mitj\u00e0","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.08.004_bib48","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-5793(01)03144-1","article-title":"Human monkeypox and smallpox viruses: genomic comparison","volume":"509","author":"Shchelkunov","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2025.08.004_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: a phylogenetic analysis","volume":"85","author":"Gubser","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-47328-y","article-title":"Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection","volume":"15","author":"Tamir","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.08.004_bib51","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1128\/JVI.01593-09","article-title":"Heavily Isotype-Dependent Protective Activities of Human Antibodies against Vaccinia Virus Extracellular Virion Antigen B5","volume":"83","author":"Benhnia","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virol.2004.07.024","article-title":"Synergistic neutralizing activities of antibodies to outer membrane proteins of the two infectious forms of vaccinia virus in the presence of complement","volume":"328","author":"Lustig","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0042-6822(02)00038-7","article-title":"Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates","volume":"306","author":"Hooper","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.cell.2025.08.004_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-024-01052-2","article-title":"Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation","volume":"9","author":"Cotter","year":"2024","journal-title":"npj Vaccines"},{"key":"10.1016\/j.cell.2025.08.004_bib55","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1128\/JVI.01797-08","article-title":"Vaccinia Virus Extracellular Enveloped Virion Neutralization In Vitro and Protection In Vivo Depend on Complement","volume":"83","author":"Benhnia","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020597","article-title":"Antibody against extracellular vaccinia virus (EV) protects mice through complement and Fc receptors","volume":"6","author":"Cohen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.08.004_bib57","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.chom.2023.05.001","article-title":"Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals","volume":"31","author":"Hubert","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib58","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1348-0421.1968.tb00393.x","article-title":"Complement requirement of the neutralizing antibody appearing after immunization with smallpox vaccine","volume":"12","author":"Nishimura","year":"1968","journal-title":"Jpn. J. Microbiol."},{"key":"10.1016\/j.cell.2025.08.004_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030441","article-title":"Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection","volume":"3","author":"Huber","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.cell.2025.08.004_bib60","doi-asserted-by":"crossref","first-page":"13463","DOI":"10.1128\/JVI.05193-11","article-title":"Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies","volume":"85","author":"Terajima","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib61","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.cell.2024.02.011","article-title":"mRNA-based monkeypox virus vaccine prevents disease in non-human primates","volume":"187","author":"Nitido","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.08.004_bib62","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.immuni.2022.03.019","article-title":"A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2","volume":"55","author":"Wang","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.08.004_bib63","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.1207227","article-title":"Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding","volume":"333","author":"Scheid","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib64","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.celrep.2017.08.084","article-title":"Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem","volume":"20","author":"Lang","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.08.004_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-021-00376-7","article-title":"Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor na\u00efve human B cells","volume":"6","author":"Lee","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.cell.2025.08.004_bib66","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.abd2321","article-title":"Structural basis of a shared antibody response to SARS-CoV-2","volume":"369","author":"Yuan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib67","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.chom.2018.09.010","article-title":"Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene","volume":"24","author":"Wu","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib68","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.immuni.2020.10.023","article-title":"Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity","volume":"53","author":"Liu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.08.004_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-03700-6","article-title":"Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron","volume":"5","author":"Liu","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cell.2025.08.004_bib70","article-title":"The D Gene in CDR H3 Determines a Public Class of Human Antibodies to SARS-CoV-2","volume":"12","author":"Yuan","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cell.2025.08.004_bib71","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.chom.2013.05.008","article-title":"Convergent Antibody Signatures in Human Dengue","volume":"13","author":"Parameswaran","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib72","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chom.2014.05.013","article-title":"Human Responses to Influenza Vaccination Show Seroconversion Signatures and Convergent Antibody Rearrangements","volume":"16","author":"Jackson","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109604","article-title":"Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals","volume":"36","author":"Chen","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.08.004_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116122","article-title":"Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody","volume":"44","author":"Rao","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.08.004_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21955-1","article-title":"A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes","volume":"12","author":"Coelho","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.08.004_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02975-21","article-title":"Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike","volume":"12","author":"Changrob","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.cell.2025.08.004_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2024.199437","article-title":"Identification of neutralizing antibodies against monkeypox virus using high-throughput sequencing of A35+H3L+B cells from patients with convalescent monkeypox","volume":"347","author":"Hou","year":"2024","journal-title":"Virus Res."},{"key":"10.1016\/j.cell.2025.08.004_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2025.101103","article-title":"Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis","author":"Fantin","year":"2025","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.cell.2025.08.004_bib79","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1222908","article-title":"Highly Conserved Protective Epitopes on Influenza B Viruses","volume":"337","author":"Dreyfus","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib80","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1128\/JVI.77.19.10684-10688.2003","article-title":"Development and Use of a Vaccinia Virus Neutralization Assay Based on Flow Cytometric Detection of Green Fluorescent Protein","volume":"77","author":"Earl","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2025.08.004_bib81","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1056\/NEJMoa032299","article-title":"The Detection of Monkeypox in Humans in the Western Hemisphere","volume":"350","author":"Reed","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.08.004_bib82","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.immuni.2023.01.012","article-title":"A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine","volume":"56","author":"Tang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.08.004_bib83","series-title":"AVMA Guidelines for the Euthanasia of Animals: 2013 edition","year":"2013"},{"key":"10.1016\/j.cell.2025.08.004_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232311","article-title":"Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing","volume":"15","author":"Lieu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.08.004_bib85","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.cell.2025.08.004_bib86","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.abh1139","article-title":"Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants","volume":"373","author":"Yuan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.08.004_bib87","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.08.004_bib88","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.cell.2025.08.004_bib89","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.cell.2025.08.004_bib90","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425009183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425009183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:37:10Z","timestamp":1778665030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425009183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":90,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0092867425009183"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.08.004","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human monoclonal antibodies targeting A35 protect from death caused by mpox","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.07.040","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.08.005","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}