{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:03:41Z","timestamp":1793646221727,"version":"4.5.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,24]],"date-time":"2026-12-24T00:00:00Z","timestamp":1798070400000},"content-version":"am","delay-in-days":388,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32MH019961"],"award-info":[{"award-number":["T32MH019961"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R25MH071584"],"award-info":[{"award-number":["R25MH071584"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK034989"],"award-info":[{"award-number":["P30 DK034989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI162645"],"award-info":[{"award-number":["R01 AI162645"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ZIA BC012034"],"award-info":[{"award-number":["ZIA BC012034"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30AI174787"],"award-info":[{"award-number":["F30AI174787"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001681","name":"Herbert W. Hoover Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001681","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR080104"],"award-info":[{"award-number":["R01 AR080104"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001341","name":"Richard and Susan Smith Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009680","name":"Yale Liver Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF24OC0095902"],"award-info":[{"award-number":["NNF24OC0095902"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0056043"],"award-info":[{"award-number":["NNF19OC0056043"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032292","name":"Food Allergy Science Initiative","doi-asserted-by":"publisher","award":["FASI-000611"],"award-info":[{"award-number":["FASI-000611"]}],"id":[{"id":"10.13039\/100032292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cell.2025.10.005","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:37:14Z","timestamp":1762267034000},"page":"7481-7494.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states"],"prefix":"10.1016","volume":"188","author":[{"given":"Nikolai P.","family":"Jaschke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Luchsinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera C.","family":"Wulfmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel D.","family":"Bachtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman D.","family":"Rachner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Medzhitov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Rinschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8081","authenticated-orcid":false,"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.10.005_bib1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.cell.2020.12.007","article-title":"Food allergy as a biological food quality control system","volume":"184","author":"Florsheim","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib2","article-title":"A nutrition-defence trade-off drives diet choice in a toxic plant generalist","volume":"290","author":"Carlson","year":"2023","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.cell.2025.10.005_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070383","article-title":"30 days in the life: daily nutrient balancing in a wild chacma baboon","volume":"8","author":"Johnson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.10.005_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/obr.12131","article-title":"Protein leverage and energy intake","volume":"15","author":"Gosby","year":"2014","journal-title":"Obes. Rev."},{"key":"10.1016\/j.cell.2025.10.005_bib5","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41430-023-01276-w","article-title":"Evidence for protein leverage in a general population sample of children and adolescents","volume":"77","author":"Saner","year":"2023","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.cell.2025.10.005_bib6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31625","article-title":"Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila","volume":"7","author":"Steck","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.10.005_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2016.09.001","article-title":"Defining the nutritional and metabolic context of FGF21 using the geometric framework","volume":"24","author":"Solon-Biet","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1056\/NEJM199109053251005","article-title":"Catabolic illness. strategies for enhancing recovery","volume":"325","author":"Wilmore","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.10.005_bib9","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0140-6736(22)02469-2","article-title":"The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial","volume":"401","author":"Heyland","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.10.005_bib10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(24)01304-7","article-title":"Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands","volume":"404","author":"Bels","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.10.005_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cell.2025.10.005_bib12","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","article-title":"Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation","volume":"166","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2020.11.010","article-title":"Area postrema cell types that mediate nausea-associated behaviors","volume":"109","author":"Zhang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2025.10.005_bib14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41586-022-05139-5","article-title":"A brainstem map for visceral sensations","volume":"609","author":"Ran","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1152\/ajplegacy.1959.197.6.1345","article-title":"Development of cecal distention in germ-free baby rats","volume":"197","author":"Wostmann","year":"1959","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2025.10.005_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58764","article-title":"Cold-induced hyperphagia requires AgRP neuron activation in mice","volume":"9","author":"Deem","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.10.005_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41586-023-06362-4","article-title":"Immune sensing of food allergens promotes avoidance behaviour","volume":"620","author":"Florsheim","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2019.10.031","article-title":"Genetic identification of vagal sensory neurons that control feeding","volume":"179","author":"Bai","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-024-07685-6","article-title":"Dissociable hindbrain GLP1R circuits for satiety and aversion","volume":"632","author":"Huang","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11905","article-title":"Genetically and functionally defined NTS to PBN brain circuits mediating anorexia","volume":"7","author":"Roman","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.10.005_bib22","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.2527\/jas.2011-4645","article-title":"Triennial Lactation Symposium: Mammary metabolism of amino acids in dairy cows","volume":"90","author":"Lapierre","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.cell.2025.10.005_bib23","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.bbamcr.2015.12.017","article-title":"Glutamine transporters in mammalian cells and their functions in physiology and cancer","volume":"1863","author":"Bhutia","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2025.10.005_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ymgme.2020.10.003","article-title":"CPS1: looking at an ancient enzyme in a modern light","volume":"131","author":"Nitzahn","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/hep.21357","article-title":"Glutamine: a Trojan horse in ammonia neurotoxicity","volume":"44","author":"Albrecht","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.10.005_bib26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41593-018-0318-7","article-title":"Temporal evolution of cortical ensembles promoting remote memory retrieval","volume":"22","author":"DeNardo","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2025.10.005_bib27","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1016\/j.cell.2021.10.013","article-title":"Insular cortex neurons encode and retrieve specific immune responses","volume":"184","author":"Koren","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1523\/JNEUROSCI.4901-08.2009","article-title":"TRPV1 is activated by both acidic and basic pH","volume":"29","author":"Dhaka","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2025.10.005_bib29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and \u03b3\u03b4 T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.10.005_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0889-8553(21)00683-X","article-title":"Small intestinal physiology and pathophysiology","volume":"18","author":"Sarna","year":"1989","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.cell.2025.10.005_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-024-07469-y","article-title":"A body-brain circuit that regulates body inflammatory responses","volume":"630","author":"Jin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin signalling in the gut \u2013 functions, dysfunctions and therapeutic targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.10.005_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.immuni.2020.10.014","article-title":"Interleukin-33 promotes serotonin release from enterochromaffin cells for intestinal homeostasis","volume":"54","author":"Chen","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.10.005_bib36","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cmet.2021.05.002","article-title":"Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism","volume":"33","author":"Borgmann","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","article-title":"Sensory neurons that detect stretch and nutrients in the digestive system","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-nutr-061021-022909","article-title":"Adverse food reactions: physiological and ecological perspectives","volume":"44","author":"Korn","year":"2024","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cell.2025.10.005_bib39","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1073\/pnas.0710787105","article-title":"Lifespan and reproduction in Drosophila: new insights from nutritional geometry","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.10.005_bib40","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s42255-021-00393-9","article-title":"Impact of dietary carbohydrate type and protein\u2013carbohydrate interaction on metabolic health","volume":"3","author":"Wali","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adh4453","article-title":"Seeking satiety: from signals to solutions","volume":"15","author":"Tsch\u00f6p","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.10.005_bib42","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2015.01.033","article-title":"Sensory detection of food rapidly modulates arcuate feeding circuits","volume":"160","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29499-8","article-title":"FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice","volume":"13","author":"Hill","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.10.005_bib44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrn3745","article-title":"Neurobiology of food intake in health and disease","volume":"15","author":"Morton","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2025.10.005_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1017\/S0029665107005599","article-title":"Critical illness and changes in sensory perception","volume":"66","author":"Schiffman","year":"2007","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.cell.2025.10.005_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncpendmet0071","article-title":"Endocrine aspects of acute and prolonged critical illness","volume":"2","author":"Vanhorebeek","year":"2006","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib47","first-page":"273","article-title":"Gastrointestinal dysmotility in critically ill patients","volume":"31","author":"Ladopoulos","year":"2018","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.cell.2025.10.005_bib48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41586-021-04133-7","article-title":"Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response","volume":"600","author":"Mulderrig","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib49","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.cmet.2020.10.023","article-title":"GDF-15 neutralization alleviates platinum-based chemotherapy-induced emesis, anorexia, and weight loss in mice and nonhuman primates","volume":"32","author":"Breen","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1123\/ijsnem.16.2.129","article-title":"A review of issues of dietary protein intake in humans","volume":"16","author":"Bilsborough","year":"2006","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"10.1016\/j.cell.2025.10.005_bib51","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajpa.24281","article-title":"How ancestral subsistence strategies solve salmon starvation and the \u201cprotein problem\u201d of Pacific Rim resources","volume":"175","author":"Tushingham","year":"2021","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.cell.2025.10.005_bib52","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00726-018-2640-5","article-title":"Protein content and amino acid composition of commercially available plant-based protein isolates","volume":"50","author":"Gorissen","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.cell.2025.10.005_bib53","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.nut.2006.04.008","article-title":"Proteolytic and lipolytic responses to starvation","volume":"22","author":"Finn","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.cell.2025.10.005_bib54","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41586-022-04860-5","article-title":"PIEZO1 transduces mechanical itch in mice","volume":"607","author":"Hill","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.005_bib55","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.10.005_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-09993-6","article-title":"An LC-MS approach to quantitative measurement of ammonia isotopologues","volume":"7","author":"Spinelli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.10.005_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aax9760","article-title":"Metabolic rewiring of the hypertensive kidney","volume":"12","author":"Rinschen","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cell.2025.10.005_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/s13104-016-1915-8","article-title":"A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia","volume":"9","author":"Sleigh","year":"2016","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.cell.2025.10.005_bib59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-023-05829-8","article-title":"Gut enterochromaffin cells drive visceral pain and anxiety","volume":"616","author":"Bayrer","year":"2023","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425011341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425011341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:23:49Z","timestamp":1778714629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425011341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":59,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0092867425011341"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.10.005","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}