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Dermatol."},{"key":"10.1016\/j.cell.2025.10.042_bib95","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.immuni.2015.05.001","article-title":"Clonal Deletion Prunes but Does Not Eliminate Self-Specific \u03b1\u03b2 CD8+ T Lymphocytes","volume":"42","author":"Yu","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.10.042_bib96","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/imm.12791","article-title":"Regulatory T cells in skin","volume":"152","author":"Ali","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.cell.2025.10.042_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk3248","article-title":"Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection","volume":"387","author":"Klawon","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.10.042_bib98","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.aaa1292","article-title":"Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals","volume":"346","author":"Maeda","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.10.042_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64865-w","article-title":"The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent","volume":"10","author":"Skopelja-Gardner","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.10.042_bib100","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ado1710","article-title":"Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity","volume":"10","author":"Klein","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2025.10.042_bib101","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1074\/jbc.M117.787119","article-title":"\u03b22-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway","volume":"292","author":"Galaz-Montoya","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.10.042_bib102","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.20030966","article-title":"Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model","volume":"198","author":"Turley","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2025.10.042_bib103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2007.06.010","article-title":"Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes","volume":"27","author":"Kim","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.10.042_bib104","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41586-023-06866-z","article-title":"A break in mitochondrial endosymbiosis as a basis for inflammatory diseases","volume":"626","author":"Murphy","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.10.042_bib105","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jid.2019.09.014","article-title":"Migration and Function of Memory CD8+ T Cells in Skin","volume":"140","author":"Hirai","year":"2020","journal-title":"J. Invest. 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Proc."},{"key":"10.1016\/j.cell.2025.10.042_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cell.2025.10.042_bib110","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cell.2025.10.042_bib111","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1346-8138.2011.01437.x","article-title":"Alopecia areata triggered or exacerbated by swine flu virus infection","volume":"39","author":"Ito","year":"2012","journal-title":"J. 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Cell Biol."},{"key":"10.1016\/j.cell.2025.10.042_bib124","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. 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