{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:03:07Z","timestamp":1792519387058,"version":"4.5.0"},"reference-count":102,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cell.2025.11.010","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:53:31Z","timestamp":1764863611000},"page":"123-142.e30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease"],"prefix":"10.1016","volume":"189","author":[{"given":"Karen","family":"Lahme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Froembling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Loreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00f6ttcher-Dierks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik-Michael","family":"Hann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Arkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Reichelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Sgries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Surmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gaffling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie R.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo J.","family":"S\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Wedekind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Lampert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tasika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saftig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Conze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Th\u00fcnauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinah","family":"Skuza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Neitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zielinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Michalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"V\u00f6lker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wiech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias N.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Fester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-5188","authenticated-orcid":false,"given":"Catherine","family":"Meyer-Schwesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.11.010_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/d41586-024-00961-5","article-title":"Time to sound the alarm about the hidden epidemic of kidney disease","volume":"628","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.010_bib2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1681\/ASN.2021060794","article-title":"Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology","volume":"33","author":"Watts","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib4","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1409354","article-title":"Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy","volume":"371","author":"Tomas","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib5","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0272-6386(00)70258-7","article-title":"Changing incidence of glomerular diseases in adults","volume":"35","author":"Braden","year":"2000","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cell.2025.11.010_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-33748-1","article-title":"A slit-diaphragm-associated protein network for dynamic control of renal filtration","volume":"13","author":"Kocylowski","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.010_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1009742","article-title":"Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy","volume":"364","author":"Stanescu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMc1511702","article-title":"A Mechanism for Cancer-Associated Membranous Nephropathy","volume":"374","author":"Hoxha","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib9","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/S0140-6736(22)02039-6","article-title":"Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy","volume":"400","author":"Wiech","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.11.010_bib10","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1681\/ASN.2017020178","article-title":"PLA2R and THSD7A: Disparate Paths to the Same Disease?","volume":"28","author":"Beck","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41581-022-00564-1","article-title":"Membranous nephropathy: new pathogenic mechanisms and their clinical implications","volume":"18","author":"Hoxha","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00441-021-03429-4","article-title":"Perspectives in membranous nephropathy","volume":"385","author":"Tomas","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cell.2025.11.010_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.kint.2023.01.003","article-title":"Mapping antigens of membranous nephropathy: almost there","volume":"103","author":"Sethi","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2025.11.010_bib14","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1681\/ASN.2018090941","article-title":"Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes","volume":"30","author":"Herwig","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1681\/ASN.0000000000000068","article-title":"Pathogenicity of Human anti-PLA 2R1 Antibodies in Minipigs: A Pilot Study","volume":"34","author":"Reinhard","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib16","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1172\/JCI85265","article-title":"Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy","volume":"126","author":"Tomas","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.010_bib17","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1084\/jem.188.7.1353","article-title":"Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis","volume":"188","author":"Schiller","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4049\/jimmunol.143.2.546","article-title":"Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy","volume":"143","author":"Kerjaschki","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2025.11.010_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36068-0","article-title":"The classical pathway triggers pathogenic complement activation in membranous nephropathy","volume":"14","author":"Seifert","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.010_bib20","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.ki.5002450","article-title":"A new mouse model of immune-mediated podocyte injury","volume":"72","author":"Meyer","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2025.11.010_bib21","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1053\/j.ajkd.2015.07.006","article-title":"AJKD Atlas of Renal Pathology: Membranous Nephropathy","volume":"66","author":"Fogo","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cell.2025.11.010_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/jmbi.1994.0031","article-title":"Expression and structural analysis of 14\u20133-3 proteins","volume":"245","author":"Jones","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cell.2025.11.010_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049671","article-title":"The peripheral binding of 14\u20133-3gamma to membranes involves isoform-specific histidine residues","volume":"7","author":"Bustad","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.11.010_bib24","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1046\/j.1471-4159.1994.63062259.x","article-title":"Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies","volume":"63","author":"Martin","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2025.11.010_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4161\/pri.28123","article-title":"14-3-3 and aggresome formation: implications in neurodegenerative diseases","volume":"8","author":"Jia","year":"2014","journal-title":"Prion"},{"key":"10.1016\/j.cell.2025.11.010_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39700-1","article-title":"Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers","volume":"14","author":"Arnold","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.010_bib27","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1681\/ASN.2017010030","article-title":"A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy","volume":"28","author":"Tomas","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib28","doi-asserted-by":"crossref","first-page":"12499","DOI":"10.1021\/bi991353h","article-title":"Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display","volume":"38","author":"Wang","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2025.11.010_bib29","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1021\/acs.jproteome.4c01085","article-title":"Comparison of Protein Solubilization and Normalization Methods for Proteomics Analysis of Extracellular Vesicles from Urine","volume":"24","author":"Wang","year":"2025","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cell.2025.11.010_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10040607","article-title":"Advances in Membranous Nephropathy","volume":"10","author":"Ronco","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib31","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMoa012895","article-title":"Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies","volume":"346","author":"Debiec","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.kint.2020.09.016","article-title":"Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis","volume":"100","author":"Caza","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2025.11.010_bib33","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1681\/ASN.2018080852","article-title":"Exostosin 1\/Exostosin 2-Associated Membranous Nephropathy","volume":"30","author":"Sethi","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib34","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1681\/ASN.2020101395","article-title":"Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy","volume":"32","author":"Al-Rabadi","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib35","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.34067\/KID.0001492021","article-title":"Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy","volume":"360","author":"Caza","year":"2021","journal-title":"Kidney"},{"key":"10.1016\/j.cell.2025.11.010_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107480","article-title":"Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17","volume":"300","author":"Dolla","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.010_bib37","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.kint.2025.04.010","article-title":"Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10)","volume":"108","author":"Rosenbaum","year":"2025","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2025.11.010_bib38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJMoa2314471","article-title":"Autoantibodies Targeting Nephrin in Podocytopathies","volume":"391","author":"Hengel","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib39","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186769","article-title":"Passive transfer of patient-derived anti-nephrin autoantibodies causes a podocytopathy with minimal change lesions","volume":"135","author":"Hengel","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.010_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119165","article-title":"Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease","volume":"1869","author":"Meyer-Schwesinger","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cell.2025.11.010_bib41","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1681\/ASN.2020081213","article-title":"ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage","volume":"32","author":"Sachs","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib42","article-title":"Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis","volume":"14","author":"Reichelt","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.010_bib43","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1681\/ASN.2020091346","article-title":"Tripartite Separation of Glomerular Cell Types and Proteomes from Reporter-Free Mice","volume":"32","author":"Hatje","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib44","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1681\/ASN.2013040430","article-title":"Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy","volume":"25","author":"Hoxha","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib45","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1172\/JCI117499","article-title":"Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen","volume":"94","author":"Neale","year":"1994","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.010_bib46","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1096\/fj.201700417R","article-title":"Lipidomic and proteomic analysis of exosomes from mouse cortical collecting duct cells","volume":"31","author":"Dang","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2025.11.010_bib47","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300865R","article-title":"14-3-3 Proteins stabilize actin and vimentin filaments to maintain processes in renal glomerular podocyte","volume":"37","author":"Yasuda","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2025.11.010_bib48","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","article-title":"The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A","volume":"14","author":"Faul","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(01)00421-4","article-title":"Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes","volume":"106","author":"Reddy","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.010_bib50","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1681\/ASN.2013050522","article-title":"Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases","volume":"25","author":"Beeken","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib51","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1002\/pmic.201500127","article-title":"Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy","volume":"15","author":"Rood","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.cell.2025.11.010_bib52","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1681\/ASN.2017020143","article-title":"The Evolving Complexity of the Podocyte Cytoskeleton","volume":"28","author":"Schell","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells13110890","article-title":"Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond","volume":"13","author":"Tolerico","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.cell.2025.11.010_bib54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-020-03375-7","article-title":"Lysosome function in glomerular health and disease","volume":"385","author":"Meyer-Schwesinger","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cell.2025.11.010_bib55","article-title":"Genes and podocytes - new insights into mechanisms of podocytopathy","volume":"5","author":"Bierzynska","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cell.2025.11.010_bib56","doi-asserted-by":"crossref","first-page":"755","DOI":"10.34067\/KID.0006152020","article-title":"Podocyte Lipotoxicity in CKD","volume":"360","author":"Kim","year":"2021","journal-title":"Kidney"},{"key":"10.1016\/j.cell.2025.11.010_bib57","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1681\/ASN.2012070700","article-title":"Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis","volume":"24","author":"Bechtel","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101410118","article-title":"Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS\/MAPK signaling","volume":"118","author":"Cooper","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.010_bib59","doi-asserted-by":"crossref","first-page":"8767","DOI":"10.1523\/JNEUROSCI.0615-12.2012","article-title":"Spreading of neurodegenerative pathology via neuron-to-neuron transmission of beta-amyloid","volume":"32","author":"Nath","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2025.11.010_bib60","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1681\/ASN.2008121259","article-title":"Autoimmunity in membranous nephropathy targets aldose reductase and SOD2","volume":"21","author":"Prunotto","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib61","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1681\/ASN.2014111061","article-title":"Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy","volume":"27","author":"Seitz-Polski","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib62","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature21362","article-title":"C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress","volume":"542","author":"Melentijevic","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.010_bib63","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052071","article-title":"Muscle-derived exophers promote reproductive fitness","volume":"22","author":"Turek","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cell.2025.11.010_bib64","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2020.09.014","article-title":"Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection","volume":"32","author":"Bartelt","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.11.010_bib65","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart","volume":"183","author":"Nicol\u00e1s-\u00c1vila","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.010_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002231","article-title":"Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis","volume":"3","author":"Fornoni","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/1478-811X-11-76","article-title":"The proteases HtrA2\/Omi and UCH-L1 regulate TNF-induced necroptosis","volume":"11","author":"Sosna","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cell.2025.11.010_bib68","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ki.2012.487","article-title":"Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks","volume":"83","author":"Boerries","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2025.11.010_bib69","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.freeradbiomed.2013.08.177","article-title":"PLA2R1 kills cancer cells by inducing mitochondrial stress","volume":"65","author":"Augert","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib70","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41592-022-01507-1","article-title":"TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines","volume":"19","author":"Ershov","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.010_bib71","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: An open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.cell.2025.11.010_bib72","doi-asserted-by":"crossref","unstructured":"van den Brand, T. (2022). ggh4x: Hacks for 'ggplot2'. R package version 0.3.1. https:\/\/CRAN.R-project.org\/package=ggh4x.","DOI":"10.32614\/CRAN.package.ggh4x"},{"key":"10.1016\/j.cell.2025.11.010_bib73","unstructured":"Wilke, C.O. and Wiernik, B.M. (2022). ggtext: Improved Text Rendering Support for 'ggplot2'. R package version 0.1.2. https:\/\/cran.r-project.org\/web\/packages\/ggtext\/readme\/README.html."},{"key":"10.1016\/j.cell.2025.11.010_bib74","unstructured":"Hester, J. and Bryan, J. (2024). glue: Interpreted String Literals. R package version 1.8.0. https:\/\/glue.tidyverse.org\/."},{"key":"10.1016\/j.cell.2025.11.010_bib75","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.24956.2","article-title":"gprofiler2 -- an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler","volume":"9","author":"Kolberg","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.cell.2025.11.010_bib76","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1109\/TMI.2014.2361784","article-title":"A Gauss-Seidel iteration scheme for reference-free 3-D histological image reconstruction","volume":"34","author":"Gaffling","year":"2015","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.cell.2025.11.010_bib77","article-title":"R: A language and environment for statistical computing","year":"2018","journal-title":"R Foundation for Statistical Computing"},{"key":"10.1016\/j.cell.2025.11.010_bib78","series-title":"OpenIntro Statistics","author":"Diez","year":"2012"},{"key":"10.1016\/j.cell.2025.11.010_bib79","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.cell.2025.11.010_bib80","first-page":"1074","article-title":"Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy","volume":"372","author":"Meyer-Schwesinger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib81","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1681\/ASN.2017070805","article-title":"The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy","volume":"29","author":"Seifert","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib82","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2025.11.010_bib83","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-1-4939-7701-7_26","article-title":"Leukocyte Migration and Deformation in Collagen Gels and Microfabricated Constrictions","volume":"1749","author":"S\u00e1ez","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cell.2025.11.010_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-025-06696-9","article-title":"The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies","volume":"23","author":"Siegerist","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.010_bib85","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0002-9440(10)64239-3","article-title":"A new method for large scale isolation of kidney glomeruli from mice","volume":"161","author":"Takemoto","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2025.11.010_bib86","article-title":"Comparative Analysis of Podocyte Foot Process Morphology in Three Species by 3D Super-Resolution Microscopy","volume":"5","author":"Artelt","year":"2018","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.cell.2025.11.010_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11553-x","article-title":"Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement","volume":"7","author":"Siegerist","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.010_bib88","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.453","article-title":"scikit-image: image processing in Python","volume":"2","author":"van der Walt","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.cell.2025.11.010_bib89","first-page":"713","article-title":"A Fast Algorithm for Multilevel Thresholding","volume":"17","author":"Liao","year":"2001","journal-title":"J. Inf. Sci. Eng."},{"key":"10.1016\/j.cell.2025.11.010_bib90","series-title":"2014 22nd International Conference on Pattern Recognition (IEEE)","first-page":"996","article-title":"Compact Watershed and Preemptive SLIC: On Improving Trade-offs of Superpixel Segmentation Algorithms","author":"Neubert","year":"2014"},{"key":"10.1016\/j.cell.2025.11.010_bib91","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/0306-4522(82)90035-5","article-title":"A note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry","volume":"7","author":"Somogyi","year":"1982","journal-title":"Neuroscience"},{"key":"10.1016\/j.cell.2025.11.010_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cell.2025.11.010_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12026","article-title":"The proteomic landscape of small urinary extracellular vesicles during kidney transplantation","volume":"10","author":"Braun","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cell.2025.11.010_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12093","article-title":"Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles","volume":"10","author":"Erdbr\u00fcgger","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cell.2025.11.010_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2020.107474","article-title":"Direct comparison of optical and electron microscopy methods for structural characterization of extracellular vesicles","volume":"210","author":"Noble","year":"2020","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.cell.2025.11.010_bib96","unstructured":"Abr\u00e0moff, M.D., Magalh\u00e3es, P.J., and Ram, S.J.J.B.I. (2004). Image processing with ImageJ 11, 36\u201342. https:\/\/dspace.library.uu.nl\/handle\/1874\/204900."},{"key":"10.1016\/j.cell.2025.11.010_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201900192","article-title":"Improving Proteome Coverage for Small Sample Amounts: An Advanced Method for Proteomics Approaches with Low Bacterial Cell Numbers","volume":"19","author":"Blankenburg","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.cell.2025.11.010_bib98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2025.11.010_bib99","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Aleksander","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2025.11.010_bib100","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2025.11.010_bib101","doi-asserted-by":"crossref","first-page":"W193","DOI":"10.1093\/nar\/gkm226","article-title":"g: Profiler--a web-based toolset for functional profiling of gene lists from large-scale experiments","volume":"35","author":"Reimand","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2025.11.010_bib102","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1713526","article-title":"MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments","volume":"9","author":"Welsh","year":"2020","journal-title":"J. Extracell. Vesicles"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425013066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425013066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:21:17Z","timestamp":1791375677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425013066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0092867425013066"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.11.010","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}