{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:03:25Z","timestamp":1791291805905,"version":"4.1.0"},"reference-count":258,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006083","name":"AGA Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005883","name":"Hertz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016872","name":"Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cell.2025.11.031","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T15:42:57Z","timestamp":1766418177000},"page":"435-460.e28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hepatic adaptation to chronic metabolic stress primes tumorigenesis"],"prefix":"10.1016","volume":"189","author":[{"given":"Constantine N.","family":"Tzouanas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.S.","family":"Shay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler T.","family":"Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Lehrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Patterson-Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Butzlaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyeko D.","family":"Mana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie E.","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Walesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Pepe-Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colton J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Prakadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Ramseier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou Evelyn","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Joung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangtao","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McMahon-Skates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L.","family":"Winston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jeong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Aney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Nissim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan P.","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Lauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Goessling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer H.","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-8778","authenticated-orcid":false,"given":"Alex K.","family":"Shalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.11.031_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev-immunol-061020-053734","article-title":"Tissue Homeostasis and Inflammation","volume":"39","author":"Meizlish","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.11.031_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005975","article-title":"Cell and tissue engineering for liver disease","volume":"6","author":"Bhatia","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib4","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: Liver regeneration and normal liver tissue maintenance","volume":"65","author":"Michalopoulos","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-021-00373-7","article-title":"Liver regeneration and inflammation: from fundamental science to clinical applications","volume":"22","author":"Campana","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib7","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib8","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease","volume":"31","author":"Younossi","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.80","article-title":"Nonalcoholic fatty liver disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cell.2025.11.031_bib10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-pathol-012615-044224","article-title":"Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum","volume":"11","author":"Hardy","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cell.2025.11.031_bib11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib13","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib14","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1172\/JCI77995","article-title":"Hepatocellular carcinoma originates from hepatocytes and not from the progenitor\/biliary compartment","volume":"125","author":"Mu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.031_bib15","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2025.11.031_bib16","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/hep.31845","article-title":"Cancer Risk in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study","volume":"74","author":"Simon","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3350\/cmh.2015.21.3.220","article-title":"The mutational landscape of hepatocellular carcinoma","volume":"21","author":"Lee","year":"2015","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jhep.2020.01.019","article-title":"The landscape of gene mutations in cirrhosis and hepatocellular carcinoma","volume":"72","author":"M\u00fcller","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib19","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.cell.2019.03.026","article-title":"Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease","volume":"177","author":"Zhu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-021-03974-6","article-title":"Convergent somatic mutations in metabolism genes in chronic liver disease","volume":"598","author":"Ng","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj0486","article-title":"Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis","volume":"373","author":"Del Poggetto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.11.031_bib22","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.devcel.2023.11.008","article-title":"An epigenetic memory of inflammation controls context-dependent lineage plasticity in the pancreas","volume":"58","author":"Falvo","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109212","article-title":"High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity","volume":"35","author":"Mana","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-022-04919-3","article-title":"Inflammatory memory and tissue adaptation in sickness and in health","volume":"607","author":"Naik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature24271","article-title":"Inflammatory memory sensitizes skin epithelial stem cells to tissue damage","volume":"550","author":"Naik","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib27","article-title":"AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance","author":"Li","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2025.11.031_bib28","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41586-023-06342-8","article-title":"Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells","volume":"620","author":"Goyal","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib29","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s42255-022-00700-y","article-title":"A researcher\u2019s guide to preclinical mouse NASH models","volume":"4","author":"Gallage","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ccell.2014.09.003","article-title":"Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes","volume":"26","author":"Wolf","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41568-021-00383-9","article-title":"The immunological and metabolic landscape in primary and metastatic liver cancer","volume":"21","author":"Li","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2025.11.031_bib32","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41575-023-00832-w","article-title":"Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis","volume":"20","author":"Sharma","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41575-023-00754-7","article-title":"Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment","volume":"20","author":"Llovet","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/j.gastro.2020.05.046","article-title":"Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?","volume":"165","author":"Ratziu","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2025.11.031_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101412","article-title":"Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPAR\u03b3 expression","volume":"30","author":"Li","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14477","article-title":"Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance","volume":"8","author":"Cho","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib37","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab175","article-title":"Rosiglitazone Requires Hepatocyte PPAR\u03b3 Expression to Promote Steatosis in Male Mice With Diet-Induced Obesity","volume":"162","author":"Lee","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.cell.2025.11.031_bib38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep.22572","article-title":"Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist","volume":"49","author":"Cable","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib39","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/hep.31897","article-title":"A Systematic Review of Animal Models of NAFLD Finds High-Fat, High-Fructose Diets Most Closely Resemble Human NAFLD","volume":"74","author":"Im","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib40","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","article-title":"An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"6","author":"Vacca","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib41","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1101\/gad.1567107","article-title":"Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria","volume":"21","author":"Leu","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.11.031_bib42","doi-asserted-by":"crossref","first-page":"15955","DOI":"10.3748\/wjg.v20.i43.15955","article-title":"Histopathology of hepatocellular carcinoma","volume":"20","author":"Schlageter","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cell.2025.11.031_bib43","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1053\/j.gastro.2013.02.009","article-title":"Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma","volume":"144","author":"Tschaharganeh","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2025.11.031_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154515","article-title":"\u03b2-Catenin signaling in hepatocellular carcinoma","volume":"132","author":"Xu","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.031_bib45","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3390\/jcm8101736","article-title":"Normal Alpha-Fetoprotein Hepatocellular Carcinoma: Are They Really Normal?","volume":"8","author":"Lee","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib46","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/s12876-021-01984-2","article-title":"Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma","volume":"21","author":"Wu","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.cell.2025.11.031_bib47","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.11.031_bib48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41419-019-1407-6","article-title":"BCL-2 family isoforms in apoptosis and cancer","volume":"10","author":"Warren","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2025.11.031_bib49","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/s41418-018-0239-8","article-title":"The transcription factor c-Jun\/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression","volume":"26","author":"Schulien","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2025.11.031_bib50","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/sj.cdd.4402114","article-title":"KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis","volume":"14","author":"Sirach","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2025.11.031_bib51","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jhep.2006.08.011","article-title":"Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4","volume":"46","author":"Qiu","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib52","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/hep.27447","article-title":"Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6\/STAT3","volume":"61","author":"Xu","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib53","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hep.510250311","article-title":"Regulation of cyclin-dependent kinase inhibitor p21(WAF1\/Cip1\/Sdi1) gene expression in hepatic regeneration","volume":"25","author":"Albrecht","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/\u03b2-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology","volume":"13","author":"Russell","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cell.2025.11.031_bib55","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1111\/bph.15622","article-title":"Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma","volume":"178","author":"Wirtz","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2025.11.031_bib56","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1096\/fj.14-256776","article-title":"Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis","volume":"28","author":"Heinrichs","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2025.11.031_bib57","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1073\/pnas.1701428114","article-title":"CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation","volume":"114","author":"Zeissig","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.031_bib58","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.4049\/jimmunol.144.9.3478","article-title":"The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9","volume":"144","author":"Rollins","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2025.11.031_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1160440","article-title":"Mitochondrial CPT1A: Insights into structure, function, and basis for drug development","volume":"14","author":"Liang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cell.2025.11.031_bib60","doi-asserted-by":"crossref","first-page":"E3880","DOI":"10.1073\/pnas.1414748111","article-title":"Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging","volume":"111","author":"Sapir","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.031_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106004","article-title":"Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-\u03b21 pathway: therapeutic role of roflumilast","volume":"175","author":"Tao","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cell.2025.11.031_bib62","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101186R","article-title":"Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice","volume":"35","author":"Montgomery","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2025.11.031_bib63","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jhep.2013.11.031","article-title":"Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends","volume":"60","author":"Matter","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41419-019-2214-9","article-title":"Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2025.11.031_bib65","doi-asserted-by":"crossref","first-page":"E305","DOI":"10.1152\/ajpendo.00034.2014","article-title":"Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor","volume":"307","author":"Zhang","year":"2014","journal-title":"Am. J. Physiol., Endocrinol. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib66","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1101\/gad.14.4.464","article-title":"Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha","volume":"14","author":"Li","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.11.031_bib67","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1016\/S0021-9258(17)36409-8","article-title":"Ketogenesis and Cholesterol Synthesis in Normal and Neoplastic Tissues of the Rat","volume":"244","author":"McGarry","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.031_bib68","doi-asserted-by":"crossref","first-page":"16724","DOI":"10.1074\/jbc.RA118.004049","article-title":"Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways","volume":"293","author":"Young","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.031_bib69","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbamcr.2015.09.035","article-title":"Hepatic dysfunction in peroxisomal disorders","volume":"1863","author":"Baes","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2025.11.031_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011107","article-title":"Pantothenate Kinase 1 Is Required to Support the Metabolic Transition from the Fed to the Fasted State","volume":"5","author":"Leonardi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.11.031_bib71","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00204-014-1400-x","article-title":"Toxicogenomics directory of chemically exposed human hepatocytes","volume":"88","author":"Grinberg","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cell.2025.11.031_bib72","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/toxsci\/kfy106","article-title":"Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis","volume":"164","author":"Li","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cell.2025.11.031_bib73","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40396","article-title":"NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte","volume":"8","author":"Udden","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.11.031_bib74","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4161\/auto.2.2.2459","article-title":"DAPk Protein Family and Cancer","volume":"2","author":"Gozuacik","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.cell.2025.11.031_bib75","doi-asserted-by":"crossref","first-page":"24784","DOI":"10.1074\/jbc.M111.329318","article-title":"Abcb11 Deficiency Induces Cholestasis Coupled to Impaired \u03b2-Fatty Acid Oxidation in Mice","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.031_bib76","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1073\/pnas.1822173116","article-title":"Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury","volume":"116","author":"Park","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.031_bib77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/cmi.2015.97","article-title":"Hepatocytes: a key cell type for innate immunity","volume":"13","author":"Zhou","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cell.2025.11.031_bib78","doi-asserted-by":"crossref","first-page":"25650","DOI":"10.1074\/jbc.M801027200","article-title":"Lipolysis Stimulated Lipoprotein Receptor: A Novel Molecular Link Between Hyperlipidemia, Weight Gain, and Atherosclerosis in Mice","volume":"283","author":"Yen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.031_bib79","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/embor.2011.49","article-title":"Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway","volume":"12","author":"Tong","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib80","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1128\/MCB.01484-13","article-title":"Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6\u03b1 Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance","volume":"34","author":"Higa","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27452-9","article-title":"A targetable LIFR\u2212NF-\u03baB\u2212LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis","volume":"12","author":"Yao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib82","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba4448","article-title":"Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis","volume":"12","author":"Govaere","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103549","article-title":"In vitro models for non-alcoholic fatty liver disease: emerging platforms and their applications","volume":"25","author":"Ramos","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.cell.2025.11.031_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150662","article-title":"Alterations in liver triglyceride profiles in CCl4-induced liver regeneration","volume":"734","author":"Li","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib85","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cmet.2025.01.016","article-title":"Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism","volume":"37","author":"Jiang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib86","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41586-024-07787-1","article-title":"Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer","volume":"633","author":"Soula","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib87","article-title":"Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver","volume":"5","author":"Fletcher","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2025.11.031_bib88","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167442","article-title":"Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver","volume":"133","author":"Fu","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.031_bib89","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/liv.12769","article-title":"Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans","volume":"35","author":"M\u00e4nnist\u00f6","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.cell.2025.11.031_bib90","doi-asserted-by":"crossref","first-page":"E493","DOI":"10.1152\/ajpendo.00336.2023","article-title":"Relationship between serum \u03b2-hydroxybutyrate and hepatic fatty acid oxidation in individuals with obesity and NAFLD","volume":"326","author":"Moore","year":"2024","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib91","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/hep.28601","article-title":"Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant \u03b2-catenin","volume":"64","author":"Tao","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib92","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/hep.31730","article-title":"Nuclear factor erythroid 2\u2013related factor 2 and \u03b2-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications","volume":"74","author":"Tao","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib93","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41575-024-01024-w","article-title":"Precision models in hepatocellular carcinoma","volume":"22","author":"Barcena-Varela","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-025-01127-y","article-title":"WNT\u2013\u03b2-catenin signalling in hepatocellular carcinoma: from bench to clinical trials","author":"Lehrich","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-60457-2","article-title":"Precision targeting of \u03b2-catenin induces tumor reprogramming and immunity in hepatocellular cancers","volume":"16","author":"Lehrich","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib96","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2014.05.004","article-title":"Activation of \u03b2-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice","volume":"147","author":"Tao","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2025.11.031_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo4474","article-title":"Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease","volume":"14","author":"Fujiwara","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib98","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-05289-6","article-title":"Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis","volume":"610","author":"Filliol","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib99","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92264","article-title":"Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPAR\u03b1-regulated dermatopontin","volume":"2","author":"Lefebvre","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2025.11.031_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48746-5","article-title":"Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease","volume":"9","author":"Hoang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96966-5","article-title":"Molecular characterization and cell type composition deconvolution of fibrosis in NAFLD","volume":"11","author":"Pantano","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib102","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202210947","article-title":"Dynamic human liver proteome atlas reveals functional insights into disease pathways","volume":"18","author":"Niu","year":"2022","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib103","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma","volume":"169","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2025.11.031_bib105","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Aleksander","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2025.11.031_bib106","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn5683","article-title":"Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes","volume":"8","author":"Tang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2025.11.031_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110730","article-title":"In vivo partial cellular reprogramming enhances liver plasticity and regeneration","volume":"39","author":"Hishida","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib108","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.29353","article-title":"A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation","volume":"66","author":"Yang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49236-7","article-title":"Cell atlas of the regenerating human liver after portal vein embolization","volume":"15","author":"Brazovskaja","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib110","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.stem.2022.04.017","article-title":"Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues","volume":"29","author":"Ma","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib111","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41556-022-00989-7","article-title":"Single-cell atlas of human liver development reveals pathways directing hepatic cell fates","volume":"24","author":"Wesley","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib112","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1158\/0008-5472.CAN-09-1089","article-title":"Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma","volume":"69","author":"Hoshida","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2025.11.031_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19558-3","article-title":"Functional compensation precedes recovery of tissue mass following acute liver injury","volume":"11","author":"Walesky","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib114","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib115","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41587-019-0071-9","article-title":"A comparison of single-cell trajectory inference methods","volume":"37","author":"Saelens","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2025.11.031_bib116","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41577-019-0263-z","article-title":"Distribution and storage of inflammatory memory in barrier tissues","volume":"20","author":"Ordovas-Montanes","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.11.031_bib117","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ydbio.2015.05.012","article-title":"Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts","volume":"404","author":"Poncy","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib118","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41575-018-0075-9","article-title":"Wnt\u2013\u03b2-catenin signalling in liver development, health and disease","volume":"16","author":"Perugorria","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib119","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg3679","article-title":"Hippo signaling instructs ectopic but not normal organ growth","volume":"378","author":"Kowalczyk","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.11.031_bib120","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100294","article-title":"Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth","volume":"37","author":"Cox","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.11.031_bib121","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41576-018-0089-8","article-title":"Chromatin accessibility and the regulatory epigenome","volume":"20","author":"Klemm","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2025.11.031_bib122","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.molcel.2018.06.044","article-title":"Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data","volume":"71","author":"Pliner","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib123","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1158\/0008-5472.CAN-21-3914","article-title":"GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma","volume":"82","author":"Suzuki","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2025.11.031_bib124","doi-asserted-by":"crossref","first-page":"10859","DOI":"10.1073\/pnas.0800647105","article-title":"Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver","volume":"105","author":"Xie","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.031_bib125","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41586-025-08677-w","article-title":"Hepatic stellate cells control liver zonation, size and functions via R-spondin 3","volume":"640","author":"Sugimoto","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib126","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-025-09183-9","article-title":"Mouse liver assembloids model periportal architecture and biliary fibrosis","volume":"644","author":"Dowbaj","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib127","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27923-z","article-title":"RNF43\/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state","volume":"13","author":"Belenguer","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib128","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002955","article-title":"Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice","volume":"23","author":"Uno","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib129","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s42255-019-0109-9","article-title":"Spatial sorting enables comprehensive characterization of liver zonation","volume":"1","author":"Ben-Moshe","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib130","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.stem.2021.05.013","article-title":"ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation","volume":"28","author":"Sun","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib131","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023113898","article-title":"Single-cell transcriptomics stratifies organoid models of metabolic dysfunction-associated steatotic liver disease","volume":"42","author":"Hess","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.11.031_bib132","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrrheum.2016.192","article-title":"Causes and consequences of endoplasmic reticulum stress in rheumatic disease","volume":"13","author":"Navid","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cell.2025.11.031_bib133","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2036205","article-title":"A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH","volume":"385","author":"Francque","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib134","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2025.11.031_bib135","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.celrep.2013.02.009","article-title":"Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis","volume":"3","author":"Jin","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101119","article-title":"Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease","volume":"50","author":"Xiao","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib137","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib138","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1038\/s41591-024-02958-z","article-title":"Opportunities and challenges following approval of resmetirom for MASH liver disease","volume":"30","author":"Lazarus","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib139","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2022.11.026","article-title":"A transcription factor atlas of directed differentiation","volume":"186","author":"Joung","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib140","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/612089","article-title":"Peroxisome Proliferator-Activated Receptor Alpha Target Genes","volume":"2010","author":"Rakhshandehroo","year":"2010","journal-title":"PPAR Res."},{"key":"10.1016\/j.cell.2025.11.031_bib141","doi-asserted-by":"crossref","DOI":"10.11131\/2015\/101185","article-title":"Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism","volume":"2","author":"Cook","year":"2015","journal-title":"Nucl. Recept. Res."},{"key":"10.1016\/j.cell.2025.11.031_bib142","first-page":"7986","article-title":"A database and functional annotation of NF-\u03baB target genes","volume":"9","author":"Yang","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib143","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/hep.24699","article-title":"The Transcription Factor c-Jun Protects Against Sustained Hepatic Endoplasmic Reticulum Stress Thereby Promoting Hepatocyte Survival","volume":"55","author":"Fuest","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib144","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71591","article-title":"Generation of functional hepatocytes by forward programming with nuclear receptors","volume":"11","author":"Tomaz","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cell.2025.11.031_bib145","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/cac2.12600","article-title":"Galectin 3-binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor-\u03b21 (TGF-\u03b21) availability and inhibits hepatocarcinogenesis","volume":"44","author":"Kim","year":"2024","journal-title":"Cancer Commun. (Lond)"},{"key":"10.1016\/j.cell.2025.11.031_bib146","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/MCB.00886-12","article-title":"Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes","volume":"32","author":"Conforto","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib147","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1136\/gutjnl-2018-317440","article-title":"Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance","volume":"68","author":"Xiang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.cell.2025.11.031_bib148","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/j.1349-7006.2012.02315.x","article-title":"Villin 1 is a predictive factor for the recurrence of high serum alpha-fetoprotein-associated hepatocellular carcinoma after hepatectomy","volume":"103","author":"Xieraili","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cell.2025.11.031_bib149","first-page":"1","article-title":"Anthropometric Reference Data for Children and Adults: United States, 2015-2018","volume":"36","author":"McDowell","year":"2021","journal-title":"Vital Health Stat. 3"},{"key":"10.1016\/j.cell.2025.11.031_bib150","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.chembiol.2021.12.008","article-title":"An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance","volume":"29","author":"Matsushita","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib151","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99958-7","article-title":"Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways","volume":"11","author":"Paquette","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib152","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.885039","article-title":"Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2\/NLRP3 pathway","volume":"13","author":"Yue","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cell.2025.11.031_bib153","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib154","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-021-03362-0","article-title":"NASH limits anti-tumour surveillance in immunotherapy-treated HCC","volume":"592","author":"Pfister","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib155","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-021-03233-8","article-title":"Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH","volume":"592","author":"Dudek","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib156","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-024-07465-2","article-title":"Acquisition of epithelial plasticity in human chronic liver disease","volume":"630","author":"Gribben","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib157","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.29834","article-title":"Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice","volume":"68","author":"Duan","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib158","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1074-7613(02)00423-5","article-title":"The Lymphotoxin-\u03b2 Receptor Induces Different Patterns of Gene Expression via Two NF-\u03baB Pathways","volume":"17","author":"Dejardin","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.11.031_bib159","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe1692","article-title":"Hepatocyte TLR4 triggers inter-hepatocyte Jagged1\/Notch signaling to determine NASH-induced fibrosis","volume":"13","author":"Yu","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib160","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1136\/gutjnl-2019-319226","article-title":"Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker","volume":"69","author":"Baselli","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.cell.2025.11.031_bib161","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41575-023-00775-2","article-title":"Fetal liver development and implications for liver disease pathogenesis","volume":"20","author":"Lotto","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib162","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12834-1","article-title":"The prognostic correlation of AFP level at diagnosis with pathological grade, progression, and survival of patients with hepatocellular carcinoma","volume":"7","author":"Bai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib163","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.3748\/wjg.v17.i41.4563","article-title":"Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma","volume":"17","author":"Li","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cell.2025.11.031_bib164","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1172\/JCI66024","article-title":"Cancer stem cells in the development of liver cancer","volume":"123","author":"Yamashita","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.031_bib165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2025.11.031_bib166","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.11.031_bib167","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13073-022-01071-5","article-title":"Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease","volume":"14","author":"Assante","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.cell.2025.11.031_bib168","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib169","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/s42255-023-00935-3","article-title":"Metabolic Messengers: ketone bodies","volume":"5","author":"Nelson","year":"2023","journal-title":"Nat. Metab."},{"issue":"12","key":"10.1016\/j.cell.2025.11.031_bib256","doi-asserted-by":"crossref","DOI":"10.1172\/JCI191021","article-title":"Ketogenesis mitigates metabolic dysfunction-associated steatotic liver disease through mechanisms that extend beyond fat oxidation","volume":"135","author":"Queathem","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2025.11.031_bib257","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1172\/JCI76388","article-title":"Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia","volume":"124","author":"Cotter","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2025.11.031_bib258","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99762","article-title":"Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome","volume":"3","author":"d\u2019Avignon","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2025.11.031_bib170","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1002\/jcp.26177","article-title":"Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression","volume":"233","author":"Rescigno","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cell.2025.11.031_bib171","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0904187106","article-title":"FGF21 induces PGC-1\u03b1 and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response","volume":"106","author":"Potthoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.031_bib172","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12020-019-02124-3","article-title":"Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis","volume":"67","author":"Watanabe","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.cell.2025.11.031_bib173","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41387-024-00277-3","article-title":"Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis","volume":"14","author":"Guo","year":"2024","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.cell.2025.11.031_bib174","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.stem.2021.07.001","article-title":"Establishment, maintenance, and recall of inflammatory memory","volume":"28","author":"Larsen","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib175","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib176","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrd.2015.3","article-title":"Non-alcoholic steatohepatitis: Emerging molecular targets and therapeutic strategies","volume":"15","author":"Musso","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2025.11.031_bib177","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.cmet.2023.07.010","article-title":"GIPR\/GLP-1R dual agonist therapies for diabetes and weight loss\u2014chemistry, physiology, and clinical applications","volume":"35","author":"Campbell","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib178","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib179","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa2413258","article-title":"Phase 3 Trial of Semaglutide in Metabolic Dysfunction\u2013Associated Steatohepatitis","volume":"392","author":"Sanyal","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib180","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2025.11.031_bib181","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molmed.2016.03.002","article-title":"Noncanonical NF-\u03baB Signaling in Health and Disease","volume":"22","author":"Cildir","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cell.2025.11.031_bib182","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cell.2025.11.031_bib183","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver\u2014linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib184","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ccr.2009.12.048","article-title":"Hepatocyte IKK\u03b2\/NF-\u03baB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation","volume":"17","author":"He","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib185","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.immuni.2023.05.017","article-title":"Sublethal necroptosis signaling promotes inflammation and liver cancer","volume":"56","author":"Vucur","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.11.031_bib186","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3 \u2013 key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2025.11.031_bib187","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ccell.2015.10.001","article-title":"NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis","volume":"28","author":"Kondylis","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib188","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ccr.2009.08.021","article-title":"A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma","volume":"16","author":"Haybaeck","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib189","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","article-title":"IKK\u03b2 Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis","volume":"121","author":"Maeda","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib190","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-45939-z","article-title":"Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity","volume":"15","author":"Katsuda","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib191","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41575-021-00508-3","article-title":"Cancer stem cells in hepatocellular carcinoma \u2014 from origin to clinical implications","volume":"19","author":"Lee","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib192","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12598","article-title":"LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression","volume":"7","author":"Chen","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib193","article-title":"A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib194","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cels.2018.12.008","article-title":"Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type","volume":"8","author":"Adler","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2025.11.031_bib195","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.3254","article-title":"Inferring biological tasks using Pareto analysis of high-dimensional data","volume":"12","author":"Hart","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib196","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s42255-019-0118-8","article-title":"Control strategies in systemic metabolism","volume":"1","author":"Ye","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2025.11.031_bib197","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib198","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.946474","article-title":"Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease","volume":"13","author":"Mooli","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cell.2025.11.031_bib199","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.cell.2023.01.038","article-title":"What is cancer metabolism?","volume":"186","author":"Finley","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib200","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cell.2019.07.048","article-title":"Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet","volume":"178","author":"Cheng","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib201","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41575-024-00980-7","article-title":"Dietary and metabolic effects on intestinal stem cells in health and disease","volume":"22","author":"Shay","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib202","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib203","article-title":"STARsolo: accurate, fast and versatile mapping\/quantification of single-cell and single-nucleus RNA-seq data","author":"Kaminow","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2025.11.031_bib204","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41592-020-0905-x","article-title":"Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2025.11.031_bib206","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib207","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib208","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jhep.2022.01.011","article-title":"Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD","volume":"76","author":"Brunt","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib209","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/path.2888","article-title":"Increased production of sonic hedgehog by ballooned hepatocytes","volume":"224","author":"Rangwala","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.cell.2025.11.031_bib210","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jhep.2008.01.026","article-title":"Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis","volume":"48","author":"Lackner","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib211","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1001\/jama.289.22.3000","article-title":"Nonalcoholic Fatty Liver Disease: An Underrecognized Cause of Cryptogenic Cirrhosis","volume":"289","author":"Clarke","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2025.11.031_bib212","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hep.26072","article-title":"Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?","volume":"57","author":"Van Der Poorten","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib213","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","article-title":"Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic \u03b2 Cell-specific Gene Knock-outs Using Cre Recombinase","volume":"274","author":"Postic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.031_bib214","article-title":"Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes","volume":"133","author":"Dinger","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cell.2025.11.031_bib215","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1369\/0022155417719419","article-title":"Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections","volume":"65","author":"Bolognesi","year":"2017","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.cell.2025.11.031_bib216","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005970","article-title":"CellProfiler 3.0: Next-generation image processing for biology","volume":"16","author":"McQuin","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib217","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100235","article-title":"Profiling of mouse macrophage lipidome using direct infusion shotgun mass spectrometry","volume":"2","author":"Hsieh","year":"2021","journal-title":"Star Protoc."},{"key":"10.1016\/j.cell.2025.11.031_bib218","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/jasms.1c00203","article-title":"A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics","volume":"32","author":"Su","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.cell.2025.11.031_bib219","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.immuni.2020.09.015","article-title":"Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies","volume":"53","author":"Hughes","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2025.11.031_bib220","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jhep.2011.08.022","article-title":"p53, a novel regulator of lipid metabolism pathways","volume":"56","author":"Goldstein","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2025.11.031_bib221","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25390-0","article-title":"O-GlcNAcylated p53 in the liver modulates hepatic glucose production","volume":"12","author":"Gonzalez-Rellan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib222","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/ijms19030921","article-title":"p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine","volume":"19","author":"Krstic","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2025.11.031_bib223","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/hep.31414","article-title":"Telomere Dysfunction Activates p53 and Represses HNF4\u03b1 Expression Leading to Impaired Human Hepatocyte Development and Function","volume":"72","author":"Munroe","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2025.11.031_bib224","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/BJ20060614","article-title":"Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4\u03b1 (HNF4\u03b1)","volume":"400","author":"Maeda","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2025.11.031_bib225","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1158\/0008-5472.CAN-21-4390","article-title":"Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-cell Autonomous Liver Carcinogenesis","volume":"82","author":"Makino","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2025.11.031_bib226","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8466","article-title":"A metabolic stress-inducible miR-34a-HNF4\u03b1 pathway regulates lipid and lipoprotein metabolism","volume":"6","author":"Xu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib227","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2147\/CMAR.S162595","article-title":"Marker of proliferation Ki-67 expression is associated with transforming growth factor beta 1 and can predict the prognosis of patients with hepatic B virus-related hepatocellular carcinoma","volume":"10","author":"Yang","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.cell.2025.11.031_bib228","article-title":"A 3D Cell Culture Model Identifies Wnt\/\u03b2-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration","volume":"7","author":"Oliva-Vilarnau","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cell.2025.11.031_bib229","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1101\/gad.390506","article-title":"c-Jun\/AP-1 controls liver regeneration by repressing p53\/p21 and p38 MAPK activity","volume":"20","author":"Stepniak","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2025.11.031_bib230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nmeth.4612","article-title":"Bias, robustness and scalability in single-cell differential expression analysis","volume":"15","author":"Soneson","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib231","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","article-title":"Single-cell chromatin state analysis with Signac","volume":"18","author":"Stuart","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib232","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cell.2025.11.031_bib233","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.cell.2020.09.056","article-title":"Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin","volume":"183","author":"Ma","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.11.031_bib234","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202210979","article-title":"Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations","volume":"18","author":"Kiani","year":"2022","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib235","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12864-022-08637-y","article-title":"Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs","volume":"23","author":"Merrill","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cell.2025.11.031_bib236","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1011971","article-title":"On the identification of differentially-active transcription factors from ATAC-seq data","volume":"20","author":"Gerbaldo","year":"2024","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib237","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41576-023-00618-5","article-title":"Gene regulatory network inference in the era of single-cell multi-omics","volume":"24","author":"Badia-i-Mompel","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2025.11.031_bib238","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41592-019-0690-6","article-title":"Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data","volume":"17","author":"Pratapa","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib239","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.coisb.2021.04.007","article-title":"Gene regulatory network inference in single-cell biology","volume":"26","author":"Akers","year":"2021","journal-title":"Curr. Opin. Syst. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib240","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12859-015-0728-4","article-title":"NetBenchmark: a bioconductor package for reproducible benchmarks of gene regulatory network inference","volume":"16","author":"Bellot","year":"2015","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cell.2025.11.031_bib241","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03843-3","article-title":"Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm","volume":"9","author":"Ding","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2025.11.031_bib242","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-i-Mompel","year":"2022","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.cell.2025.11.031_bib243","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13059-020-1949-z","article-title":"Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data","volume":"21","author":"Holland","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib244","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1101\/gr.240663.118","article-title":"Benchmark and integration of resources for the estimation of human transcription factor activities","volume":"29","author":"Garcia-Alonso","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2025.11.031_bib245","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41586-022-05279-8","article-title":"Inferring and perturbing cell fate regulomes in human brain organoids","volume":"621","author":"Fleck","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib246","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41586-022-05688-9","article-title":"Dissecting cell identity via network inference and in silico gene perturbation","volume":"614","author":"Kamimoto","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib247","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41592-023-01938-4","article-title":"SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks","volume":"20","author":"Bravo Gonz\u00e1lez-Blas","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2025.11.031_bib248","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cels.2022.08.004","article-title":"Nonparametric single-cell multiomic characterization of trio relationships between transcription factors, target genes, and cis-regulatory regions","volume":"13","author":"Jiang","year":"2022","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2025.11.031_bib249","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature20123","article-title":"Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma","volume":"539","author":"Tirosh","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.11.031_bib250","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3170\/2007-8-18312","article-title":"Spatial ordination of vegetation data using a generalization of Wartenberg\u2019s multivariate spatial correlation","volume":"19","author":"Dray","year":"2008","journal-title":"J. Veg. Sci."},{"key":"10.1016\/j.cell.2025.11.031_bib251","article-title":"Voyager: exploratory single-cell genomics data analysis with geospatial statistics","author":"Moses","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2025.11.031_bib252","unstructured":"Dray, S., Bauman, D., Blanchet, G., Borcard, D., Clappe, S., Gu\u00e9nard, G., Jombart, T., Larocque, G., Legendre, P., Madi, N., et al. adespatial: Multivariate Multiscale Spatial Analysis. Version 0.3-24. https:\/\/cran.r-project.org\/web\/packages\/adespatial\/index.html."},{"key":"10.1016\/j.cell.2025.11.031_bib253","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.11.031_bib254","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209923","article-title":"Integrated intra- and intercellular signaling knowledge for multicellular omics analysis","volume":"17","author":"T\u00fcrei","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cell.2025.11.031_bib255","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1093\/bioinformatics\/btaa1009","article-title":"glmGamPoi: fitting Gamma-Poisson generalized linear models on single cell count data","volume":"36","author":"Ahlmann-Eltze","year":"2021","journal-title":"Bioinformatics"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425013662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425013662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:11:35Z","timestamp":1770239495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425013662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":258,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0092867425013662"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.11.031","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.30.569407","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic adaptation to chronic metabolic stress primes tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}