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Microbiol."},{"key":"10.1016\/j.cell.2025.11.036_bib69","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/emboj\/21.4.602","article-title":"Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast","volume":"21","author":"Gurunathan","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2025.11.036_bib70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.141.1.71","article-title":"Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis","volume":"141","author":"Wendland","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cell.2025.11.036_bib71","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.128.5.779","article-title":"A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast","volume":"128","author":"Vida","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cell.2025.11.036_bib72","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.200305077","article-title":"Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis","volume":"162","author":"Sekiya-Kawasaki","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cell.2025.11.036_bib73","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1091\/mbc.e05-05-0452","article-title":"Defects in Structural Integrity of Ergosterol and the Cdc50p-Drs2p Putative Phospholipid Translocase Cause Accumulation of Endocytic Membranes, onto Which Actin Patches Are Assembled in Yeast","volume":"16","author":"Kishimoto","year":"2005","journal-title":"Mol. Biol. 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Cancer"},{"key":"10.1016\/j.cell.2025.11.036_bib82","doi-asserted-by":"crossref","first-page":"12037","DOI":"10.1073\/pnas.192206699","article-title":"Crystal structure of calcineurin\u2013cyclophilin\u2013cyclosporin shows common but distinct recognition of immunophilin\u2013drug complexes","volume":"99","author":"Huai","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.036_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011056","article-title":"Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond","volume":"19","author":"Rivera","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2025.11.036_bib84","doi-asserted-by":"crossref","first-page":"27531","DOI":"10.1074\/jbc.270.46.27531","article-title":"TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin","volume":"270","author":"Lorenz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2025.11.036_bib85","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.273.5272.239","article-title":"Structure of the FKBP12\u2013rapamycin complex interacting with the binding domain of human FRAP","volume":"273","author":"Choi","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.11.036_bib86","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1534\/genetics.119.302290","article-title":"Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans","volume":"213","author":"Pianalto","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2025.11.036_bib87","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(92)90603-M","article-title":"Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector","volume":"111","author":"MacNeil","year":"1992","journal-title":"Gene"},{"key":"10.1016\/j.cell.2025.11.036_bib88","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1101\/gr.81002","article-title":"Physical Maps for Genome Analysis of Serotype A and D Strains of the Fungal Pathogen Cryptococcus neoformans","volume":"12","author":"Schein","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2025.11.036_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062790","article-title":"Evidence for Mitotic Recombination within the Basidia of a Hybrid Cross of Cryptococcus neoformans","volume":"8","author":"Vogan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2025.11.036_bib90","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/genetics\/163.4.1315","article-title":"Mitochondria are inherited from the MATa parent in crosses of the basidiomycete fungus Cryptococcus neoformans","volume":"163","author":"Yan","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2025.11.036_bib91","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00342-10","article-title":"Genome Variation in Cryptococcus gattii, an Emerging Pathogen of Immunocompetent Hosts","volume":"2","author":"D\u2019Souza","year":"2011","journal-title":"mBio"},{"key":"10.1016\/j.cell.2025.11.036_bib92","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/EC.4.2.298-309.2005","article-title":"Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans","volume":"4","author":"Noble","year":"2005","journal-title":"Eukaryot. 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Fungal disease registry of the Canadian infectious Disease Society","volume":"160","author":"Yamamura","year":"1999","journal-title":"CMAJ"},{"key":"10.1016\/j.cell.2025.11.036_bib96","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1073\/pnas.91.22.10541","article-title":"Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer","volume":"91","author":"Glover","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2025.11.036_bib97","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1021\/ja00011a006","article-title":"High-field FT NMR application of Mosher\u2019s method. The absolute configurations of marine terpenoids","volume":"113","author":"Ohtani","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2025.11.036_bib98","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1038\/nprot.2007.354","article-title":"Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons","volume":"2","author":"Hoye","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2025.11.036_bib99","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/ja00783a034","article-title":"Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and.alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters","volume":"95","author":"Dale","year":"1973","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2025.11.036_bib100","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/jo981810k","article-title":"Stereochemical Determination of Acyclic Structures Based on Carbon\u2212Proton Spin-Coupling Constants. A Method of Configuration Analysis for Natural Products","volume":"64","author":"Matsumori","year":"1999","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.cell.2025.11.036_bib101","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2105-15-182","article-title":"Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads","volume":"15","author":"Jiang","year":"2014","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cell.2025.11.036_bib102","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.11.036_bib103","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.cell.2025.11.036_bib104","doi-asserted-by":"crossref","first-page":"W46","DOI":"10.1093\/nar\/gkad344","article-title":"antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation","volume":"51","author":"Blin","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2025.11.036_bib105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.mie.2019.02.026","article-title":"Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination","volume":"621","author":"Zhang","year":"2019","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cell.2025.11.036_bib106","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00130-18","article-title":"Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity","volume":"62","author":"Widdick","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cell.2025.11.036_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cell.2025.11.036_bib108","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1128\/AAC.44.8.2081-2085.2000","article-title":"Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis","volume":"44","author":"Arthington-Skaggs","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cell.2025.11.036_bib109","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nprot.2017.005","article-title":"Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography-mass spectrometry","volume":"12","author":"M\u00fcller","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2025.11.036_bib110","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-2275(20)31658-8","article-title":"Ergosterol biosynthesis in novel melanized fungi from hypersaline environments","volume":"42","author":"M\u00e9janelle","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cell.2025.11.036_bib111","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1590\/S0074-02762012000500003","article-title":"Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology","volume":"107","author":"Guerra","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.cell.2025.11.036_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000961","article-title":"The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi","volume":"6","author":"Metin","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2025.11.036_bib113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004261","article-title":"Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation","volume":"10","author":"Janbon","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2025.11.036_bib114","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.11.036_bib115","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2025.11.036_bib116","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2025.11.036_bib117","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.cell.2025.11.036_bib118","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1002\/cpmc.75","article-title":"Cryptococcus neoformans Mating and Genetic Crosses","volume":"53","author":"Sun","year":"2019","journal-title":"Curr. 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