{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:39:05Z","timestamp":1792175945483,"version":"4.4.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002957","name":"Technische Universit\u00e4t Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["324141047"],"award-info":[{"award-number":["324141047"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR205"],"award-info":[{"award-number":["SFB-TRR205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR 127"],"award-info":[{"award-number":["SFB-TRR 127"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cell.2025.12.010","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:12:30Z","timestamp":1767888750000},"page":"3-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["When heme is low, copper kills cancer"],"prefix":"10.1016","volume":"189","author":[{"given":"Andreas","family":"Linkermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2025.12.010_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41589-022-01145-w","article-title":"Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals","volume":"19","author":"Barayeu","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2025.12.010_bib2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/s41586-025-09389-x","article-title":"Multiple oestradiol functions inhibit ferroptosis and acute kidney injury","volume":"645","author":"Tonnus","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.12.010_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.12.010_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbpa.2017.11.003","article-title":"Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease","volume":"42","author":"Rowland","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cell.2025.12.010_bib5","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2025.12.010_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2025.10.028","article-title":"Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia","volume":"189","author":"Lewis","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2025.12.010_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-med-042921-123602","article-title":"Update on the Porphyrias","volume":"75","author":"Dickey","year":"2024","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cell.2025.12.010_bib8","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s00018-016-2201-6","article-title":"The role of glycine in regulated cell death","volume":"73","author":"Weinberg","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2025.12.010_bib9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41586-023-06017-4","article-title":"A druggable copper-signalling pathway that drives inflammation","volume":"617","author":"Solier","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2025.12.010_bib10","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s42255-025-01352-4","article-title":"BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states","volume":"7","author":"Rizzollo","year":"2025","journal-title":"Nat. Metab."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425014230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867425014230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:22:10Z","timestamp":1791375730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425014230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0092867425014230"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2025.12.010","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"When heme is low, copper kills cancer","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2025.10.028","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}