{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:16:22Z","timestamp":1793081782516,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018558","name":"Shanghai Shuguang Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.cell.2026.01.001","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:57:51Z","timestamp":1770307071000},"page":"1039-1055.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment"],"prefix":"10.1016","volume":"189","author":[{"given":"Si-Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-Tian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yuan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfei","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-148X","authenticated-orcid":false,"given":"Zhi-Ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.01.001_bib1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2026.01.001_bib2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJMoa2112651","article-title":"Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer","volume":"386","author":"Schmid","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib3","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJMoa1910549","article-title":"Pembrolizumab for Early Triple-Negative Breast Cancer","volume":"382","author":"Schmid","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2202809","article-title":"Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer","volume":"387","author":"Cortes","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2018.04.006","article-title":"Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection","volume":"173","author":"Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41568-023-00556-8","article-title":"The neural addiction of cancer","volume":"23","author":"Magnon","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib8","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.cmet.2022.10.012","article-title":"Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies","volume":"34","author":"Zhang","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.01.001_bib9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.medj.2024.02.002","article-title":"Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs","volume":"5","author":"Darragh","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.cell.2026.01.001_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5435","article-title":"Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases","volume":"7","author":"Kaduri","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2026.01.001_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41523-022-00485-z","article-title":"Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3","volume":"8","author":"Le","year":"2022","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41586-024-07767-5","article-title":"Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis","volume":"633","author":"Padmanaban","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ccell.2019.02.001","article-title":"Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies","volume":"35","author":"Jiang","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92343-4","article-title":"Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer","volume":"11","author":"Narayan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.01.001_bib16","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s43018-021-00232-6","article-title":"Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression","volume":"2","author":"Vanhersecke","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/sc.2013.51","article-title":"Postpartum hypogalactia in a woman with Brown-S\u00e9quard-plus syndrome: a case report","volume":"51","author":"Liu","year":"2013","journal-title":"Spinal Cord"},{"key":"10.1016\/j.cell.2026.01.001_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s43018-024-00725-0","article-title":"Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities","volume":"5","author":"Jiang","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib19","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.cell.2024.04.027","article-title":"Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity","volume":"187","author":"Wu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib20","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1158\/2159-8290.CD-19-1384","article-title":"Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer","volume":"10","author":"Kieffer","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2026.01.001_bib21","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1158\/0008-5472.CAN-22-1427","article-title":"Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer","volume":"82","author":"Timperi","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.01.001_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-019-1110-6","article-title":"Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology","volume":"38","author":"Nissen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cell.2026.01.001_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006720","article-title":"A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer","volume":"11","author":"Liu","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41586-021-04057-2","article-title":"Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion","volume":"599","author":"Sun","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-05289-6","article-title":"Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis","volume":"610","author":"Filliol","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s40164-025-00691-y","article-title":"Targeting collagen to optimize cancer immunotherapy","volume":"14","author":"Wang","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.cell.2026.01.001_bib27","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.ccell.2022.11.011","article-title":"Tipping the balance: New insights into stromal regulation of cancer","volume":"40","author":"Castro","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015042","article-title":"Resiniferatoxin: Nature's Precision Medicine to Silence TRPV1-Positive Afferents","volume":"24","author":"Szallasi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2026.01.001_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-023-01008-4","article-title":"The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue","volume":"13","author":"Di Donato","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cell.2026.01.001_bib30","article-title":"Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.01.001_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ccell.2018.01.011","article-title":"Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer","volume":"33","author":"Costa","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib32","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1016\/j.cell.2021.07.020","article-title":"Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy","volume":"184","author":"Koikawa","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00048.2019","article-title":"Diversity and Biology of Cancer-Associated Fibroblasts","volume":"101","author":"Biffi","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2026.01.001_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.canlet.2017.10.010","article-title":"Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180","volume":"412","author":"Koikawa","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cell.2026.01.001_bib35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41591-021-01323-8","article-title":"A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer","volume":"27","author":"Bassez","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1403122","article-title":"Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistance","volume":"12","author":"Kazakova","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2026.01.001_bib37","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2026.01.001_bib38","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib39","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41586-020-03057-y","article-title":"Nociceptive nerves regulate haematopoietic stem cell mobilization","volume":"589","author":"Gao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib40","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2026.01.001_bib41","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.cmet.2025.08.009","article-title":"HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer","volume":"37","author":"Xiao","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.01.001_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-023-06568-6","article-title":"The \u03b21-adrenergic receptor links sympathetic nerves to T cell exhaustion","volume":"622","author":"Globig","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","article-title":"Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis","volume":"640","author":"Zhi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40314-w","article-title":"Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment","volume":"14","author":"Xue","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.01.001_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41577-020-0387-1","article-title":"Neuronal regulation of immunity: why, how and where?","volume":"21","author":"Schiller","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.01.001_bib46","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.immuni.2020.10.001","article-title":"Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens","volume":"53","author":"Perner","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.01.001_bib47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2026.01.001_bib49","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and \u03b3\u03b4 T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.01.001_bib50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-021-03563-7","article-title":"Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions","volume":"594","author":"Hoeffel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib51","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies - successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cell.2026.01.001_bib52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/313054a0","article-title":"Calcitonin gene-related peptide is a potent vasodilator","volume":"313","author":"Brain","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.01.001_bib53","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1073\/pnas.83.15.5731","article-title":"Calcitonin gene-related peptide: functional role in cerebrovascular regulation","volume":"83","author":"McCulloch","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.01.001_bib54","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib55","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/amiajnl-2012-001469","article-title":"Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data","volume":"20","author":"Gutman","year":"2013","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"10.1016\/j.cell.2026.01.001_bib56","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1002\/cncr.24396","article-title":"Perineural invasion in cancer: a review of the literature","volume":"115","author":"Liebig","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.cell.2026.01.001_bib57","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.01.001_bib58","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.cmet.2022.08.016","article-title":"Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1","volume":"34","author":"Chen","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.01.001_bib59","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/hep.29652","article-title":"\u03b2-Catenin and interleukin-1\u03b2\u2013dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis","volume":"67","author":"Kaffe","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cell.2026.01.001_bib60","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ccell.2021.02.007","article-title":"Type I collagen deletion in \u03b1SMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer","volume":"39","author":"Chen","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41587-021-00830-w","article-title":"Robust decomposition of cell type mixtures in spatial transcriptomics","volume":"40","author":"Cable","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.01.001_bib62","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1038\/s41467-024-50904-x","article-title":"Inferring histology-associated gene expression gradients in spatial transcriptomic studies","volume":"15","author":"Kueckelhaus","year":"2024","journal-title":"Nature Communications"},{"key":"10.1016\/j.cell.2026.01.001_bib63","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.01.001_bib64","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jneumeth.2007.08.029","article-title":"NeuriteTracer: a novel ImageJ plugin for automated quantification of neurite outgrowth","volume":"168","author":"Pool","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cell.2026.01.001_bib65","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41422-022-00766-z","article-title":"Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria","volume":"33","author":"Xie","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2026.01.001_bib66","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ncb3478","article-title":"A mechanically active heterotypic E-cadherin\/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion","volume":"19","author":"Labernadie","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.01.001_bib67","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41422-023-00909-w","article-title":"ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer","volume":"34","author":"Ge","year":"2024","journal-title":"Cell Res."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426000486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426000486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:09:02Z","timestamp":1783429742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426000486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0092867426000486"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.01.001","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}