{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:34:39Z","timestamp":1792758879021,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["1SH9524N"],"award-info":[{"award-number":["1SH9524N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["S001522N"],"award-info":[{"award-number":["S001522N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["765608"],"award-info":[{"award-number":["765608"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Foundation Against Cancer","doi-asserted-by":"publisher","award":["F\/2022\/2067"],"award-info":[{"award-number":["F\/2022\/2067"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01EJ2205A"],"award-info":[{"award-number":["01EJ2205A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["031L0315A"],"award-info":[{"award-number":["031L0315A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006114","name":"S\u00e4chsisches Staatsministerium f\u00fcr Wissenschaft und Kunst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006298","name":"S\u00e4chsische Aufbaubank","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012331","name":"Agentschap Innoveren en Ondernemen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["1R00424F"],"award-info":[{"award-number":["1R00424F"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"University of Antwerp","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FE 1236\/8-1"],"award-info":[{"award-number":["FE 1236\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FE 1236\/5-1"],"award-info":[{"award-number":["FE 1236\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cell.2026.04.024","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:56:00Z","timestamp":1778252160000},"page":"3991-4004.e26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ferroptosis inhibition enhances liver and lung graft function"],"prefix":"10.1016","volume":"189","author":[{"given":"Geraldine","family":"Veeckmans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Devos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Gilbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Van Beersel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Scarpellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Blondeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Walravens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Klejborowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lanthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"W\u00f6lk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Gaillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Colombeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrouz","family":"Hassannia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"L\u00e4ngin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Michael","family":"Abicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reichart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens J.","family":"Ceulemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Jochmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Augustyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethard","family":"Monbaliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Neyrinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-0974","authenticated-orcid":false,"given":"Tom","family":"Vanden Berghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.04.024_bib1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.04.024_bib2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.04.024_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28718-6","article-title":"Targeting ferroptosis protects against experimental (multi)organ dysfunction and death","volume":"13","author":"Van Coillie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.04.024_bib5","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2026.04.024_bib6","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.tips.2023.08.012","article-title":"Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors","volume":"44","author":"Scarpellini","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cell.2026.04.024_bib7","doi-asserted-by":"crossref","first-page":"e539","DOI":"10.1097\/TP.0000000000005405","article-title":"The Efficacy of Ferroptosis Inhibition on Ischemia-Reperfusion Injury of Abdominal Organs: A Systematic Review and Meta-analysis","volume":"109","author":"Devos","year":"2025","journal-title":"Transplantation"},{"key":"10.1016\/j.cell.2026.04.024_bib8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib9","doi-asserted-by":"crossref","first-page":"10126","DOI":"10.1021\/acs.jmedchem.8b01299","article-title":"Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy","volume":"61","author":"Devisscher","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib10","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/ajt.15773","article-title":"Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis","volume":"20","author":"Yamada","year":"2020","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.cell.2026.04.024_bib11","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","article-title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","volume":"608","author":"Mishima","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.04.024_bib12","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"Synchronized renal tubular cell death involves ferroptosis","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.04.024_bib13","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation","volume":"129","author":"Li","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2026.04.024_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8963987","article-title":"Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cell.2026.04.024_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2026.04.024_bib16","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2026.04.024_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-0506-0","article-title":"Ferroptosis-inducing agents compromise in vitro human islet viability and function","volume":"9","author":"Bruni","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2026.04.024_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/STROKEAHA.116.014790","article-title":"12\/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke","volume":"48","author":"Liu","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.cell.2026.04.024_bib19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cell.2026.04.024_bib20","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/mp.2017.171","article-title":"Tau-mediated iron export prevents ferroptotic damage after ischemic stroke","volume":"22","author":"Tuo","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cell.2026.04.024_bib21","article-title":"Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma","volume":"17","author":"Lorente","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2026.04.024_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","article-title":"A randomized trial of normothermic preservation in liver transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.04.024_bib23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tiv.2015.01.014","article-title":"Predicting in vivo phospholipidosis-inducing potential of drugs by a combined high content screening and in silico modelling approach","volume":"29","author":"Bauch","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.cell.2026.04.024_bib24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41570-018-0030-x","article-title":"Visualizing biologically active small molecules in cells using click chemistry","volume":"2","author":"Ca\u00f1eque","year":"2018","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib25","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41556-025-01668-z","article-title":"Endoplasmic reticulum-mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis","volume":"27","author":"Sassano","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib26","article-title":"Complexes of iron with o-phenylenediamine","volume":"75\u201378","author":"Renovitch","year":"1969","journal-title":"J. Chem. Soc. A"},{"key":"10.1016\/j.cell.2026.04.024_bib27","doi-asserted-by":"crossref","first-page":"7343","DOI":"10.1039\/D1CS00265A","article-title":"Autoxidation vs. antioxidants \u2013 the fight for forever","volume":"50","author":"Helberg","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.cell.2026.04.024_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj3620137","article-title":"Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor","volume":"362","author":"Petrat","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2026.04.024_bib29","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1039\/C4OB00935E","article-title":"A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin","volume":"12","author":"Niwa","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/aor.14717","article-title":"The dynamics of cytokine release during 24 hours continuous normothermic machine perfusion liver preservation: An explorative porcine study","volume":"48","author":"Gilbo","year":"2024","journal-title":"Artif. Organs"},{"key":"10.1016\/j.cell.2026.04.024_bib31","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/lt.24728","article-title":"Hepatic ischemia\/reperfusion injury associates with acute kidney injury in liver transplantation: Prospective cohort study","volume":"23","author":"Jochmans","year":"2017","journal-title":"Liver Transpl."},{"key":"10.1016\/j.cell.2026.04.024_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.0819","article-title":"Effect of a Combined Drug Approach on the Severity of Ischemia-Reperfusion Injury During Liver Transplant: A Randomized Clinical Trial","volume":"6","author":"Meurisse","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cell.2026.04.024_bib33","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/lt.22091","article-title":"Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors","volume":"16","author":"Olthoff","year":"2010","journal-title":"Liver Transpl."},{"key":"10.1016\/j.cell.2026.04.024_bib34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-018-0765-z","article-title":"Consistent success in life-supporting porcine cardiac xenotransplantation","volume":"564","author":"L\u00e4ngin","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.04.024_bib35","article-title":"Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation","volume":"28","author":"L\u00e4ngin","year":"2020","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.cell.2026.04.024_bib36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of Mitochondria in Ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2026.04.024_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41589-022-01249-3","article-title":"Identification of essential sites of lipid peroxidation in ferroptosis","volume":"19","author":"von Krusenstiern","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib39","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41586-025-08974-4","article-title":"Activation of lysosomal iron triggers ferroptosis in cancer","volume":"642","author":"Ca\u00f1eque","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.04.024_bib40","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s42255-025-01352-4","article-title":"BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states","volume":"7","author":"Rizzollo","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2026.04.024_bib41","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1517\/14740338.5.4.567","article-title":"Drug-induced phospholipidosis: issues and future directions","volume":"5","author":"Reasor","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.cell.2026.04.024_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s40472-018-0178-9","article-title":"From \"Gut Feeling\" to Objectivity: Machine Preservation of the Liver as a Tool to Assess Organ Viability","volume":"5","author":"Watson","year":"2018","journal-title":"Curr. Transplant. Rep."},{"key":"10.1016\/j.cell.2026.04.024_bib44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.04.024_bib45","article-title":"Ferroptosis in the post-transplantation inflammatory response","volume":"393\u2013394","author":"Bai","year":"2023","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.cell.2026.04.024_bib46","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/TP.0000000000003763","article-title":"Coagulation Factors Accumulate During Normothermic Liver Machine Perfusion Regardless of Donor Type and Severity of Ischemic Injury","volume":"106","author":"Gilbo","year":"2022","journal-title":"Transplantation"},{"key":"10.1016\/j.cell.2026.04.024_bib47","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib49","doi-asserted-by":"crossref","DOI":"10.3791\/65336","article-title":"Porcine Normothermic Isolated Liver Perfusion","author":"Blondeel","year":"2023","journal-title":"J. Vis. Exp"},{"key":"10.1016\/j.cell.2026.04.024_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2019.00505","article-title":"Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR\/PGC1\u03b1\/TFAM Pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.cell.2026.04.024_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-021-01900-y","article-title":"Analysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation","volume":"22","author":"Chacon-Alberty","year":"2021","journal-title":"Respir. Res."},{"key":"10.1016\/j.cell.2026.04.024_bib52","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1021\/ja309153x","article-title":"Besting Vitamin E: Sidechain Substitution is Key to the Reactivity of Naphthyridinol Antioxidants in Lipid Bilayers","volume":"135","author":"Li","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2026.04.024_bib53","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.chembiol.2019.09.007","article-title":"Beyond DPPH: Use of Fluorescence-Enabled Inhibited Autoxidation to Predict Oxidative Cell Death Rescue","volume":"26","author":"Shah","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cell.2026.04.024_bib54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/cr60214a002","article-title":"Inhibition of the Autoxidation of Organic Substances in the Liquid Phase","volume":"61","author":"Ingold","year":"1961","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cell.2026.04.024_bib55","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/tx9701790","article-title":"Reactions of 1-Methyl-2-phenylindole with Malondialdehyde and 4-Hydroxyalkenals. Analytical Applications to a Colorimetric Assay of Lipid Peroxidation","volume":"11","author":"G\u00e9rard-Monnier","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cell.2026.04.024_bib56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15363-z","article-title":"LPPtiger software for lipidome-specific prediction and identification of oxidized phospholipids from LC-MS datasets","volume":"7","author":"Ni","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.04.024_bib58","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/acs.jproteome.9b00640","article-title":"Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics","volume":"19","author":"Adams","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cell.2026.04.024_bib59","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.04.024_bib60","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.04.024_bib61","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1021\/acs.jcim.9b00269","article-title":"PACKMOL-Memgen: A Simple-To-Use, Generalized Workflow for Membrane-Protein\u2013Lipid-Bilayer System Building","volume":"59","author":"Schott-Verdugo","year":"2019","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cell.2026.04.024_bib62","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","article-title":"AmberTools","volume":"63","author":"Case","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cell.2026.04.024_bib63","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.cell.2026.04.024_bib64","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.jctc.1c01217","article-title":"Lipid21: Complex Lipid Membrane Simulations with AMBER","volume":"18","author":"Dickson","year":"2022","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.cell.2026.04.024_bib65","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/acs.jctc.8b01039","article-title":"Assessment of GAFF2 and OPLS-AA General Force Fields in Combination with the Water Models TIP3P, SPCE, and OPC3 for the Solvation Free Energy of Druglike Organic Molecules","volume":"15","author":"Vassetti","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.cell.2026.04.024_bib66","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.cell.2026.04.024_bib67","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1096-987X(20000130)21:2<132::AID-JCC5>3.0.CO;2-P","article-title":"Fast, efficient generation of high-quality atomic charges. AM1-BCC model: I. Method","volume":"21","author":"Jakalian","year":"2000","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib68","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/acs.jcim.6b00022","article-title":"Simulation-Based Approaches for Determining Membrane Permeability of Small Compounds","volume":"56","author":"Lee","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cell.2026.04.024_bib69","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1021\/acs.jpcb.1c05438","article-title":"Predicting the Membrane Permeability of Fentanyl and Its Analogues by Molecular Dynamics Simulations","volume":"125","author":"Faulkner","year":"2021","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.cell.2026.04.024_bib70","unstructured":"Grossfield, A. WHAM: the weighted histogram analysis method. Version WHAM-release-2.1.0. http:\/\/membrane.urmc.rochester.edu\/content\/wham\/."},{"key":"10.1016\/j.cell.2026.04.024_bib71","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/jcc.540161104","article-title":"Multidimensional free-energy calculations using the weighted histogram analysis method","volume":"16","author":"Kumar","year":"1995","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cell.2026.04.024_bib72","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001276","article-title":"Porcine Liver Normothermic Machine Perfusion: Methodological Framework and Potential Pitfalls","volume":"8","author":"Gilbo","year":"2022","journal-title":"Transplant. Direct"},{"key":"10.1016\/j.cell.2026.04.024_bib73","author":"Devos"},{"key":"10.1016\/j.cell.2026.04.024_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197185","article-title":"Autophagy Dynamics and Modulation in a Rat Model of Renal Ischemia-Reperfusion Injury","volume":"21","author":"Decuypere","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426004599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426004599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:07:36Z","timestamp":1783429656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426004599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":74,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0092867426004599"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.04.024","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis inhibition enhances liver and lung graft function","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}