{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:07:17Z","timestamp":1793941637267,"version":"4.8.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"The Francis Crick Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007038","name":"Lung Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011913","name":"A Breath of Hope Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008700","name":"Centre International de Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","award":["ID16584"],"award-info":[{"award-number":["ID16584"]}],"id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["EP\/Y031091\/1"],"award-info":[{"award-number":["EP\/Y031091\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["202060447"],"award-info":[{"award-number":["202060447"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["835297"],"award-info":[{"award-number":["835297"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","award":["DRG-2560-25"],"award-info":[{"award-number":["DRG-2560-25"]}],"id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP240441"],"award-info":[{"award-number":["RP240441"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["16\/46\/01"],"award-info":[{"award-number":["16\/46\/01"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF-23-157"],"award-info":[{"award-number":["BCRF-23-157"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017027","name":"State of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032590","name":"Stoneygate Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CC2041"],"award-info":[{"award-number":["CC2041"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CC2085"],"award-info":[{"award-number":["CC2085"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00004\/01"],"award-info":[{"award-number":["MC_UU_00004\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N003284\/1"],"award-info":[{"award-number":["MR\/N003284\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y013662\/1"],"award-info":[{"award-number":["MR\/Y013662\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00006\/1"],"award-info":[{"award-number":["MC_UU_00006\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G9901012"],"award-info":[{"award-number":["G9901012"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC-UU_12015\/1"],"award-info":[{"award-number":["MC-UU_12015\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0801228"],"award-info":[{"award-number":["G0801228"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020252","name":"Cancer Research UK Lung Cancer Centre of Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["NU58DP007114"],"award-info":[{"award-number":["NU58DP007114"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA164975"],"award-info":[{"award-number":["U01 CA164975"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","award":["21-029-ASP"],"award-info":[{"award-number":["21-029-ASP"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","award":["23-034-ASP"],"award-info":[{"award-number":["23-034-ASP"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","award":["G-001522"],"award-info":[{"award-number":["G-001522"]}],"id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011319","name":"Skin Treatment and Research Trust","doi-asserted-by":"publisher","award":["EP\/Z534298\/1"],"award-info":[{"award-number":["EP\/Z534298\/1"]}],"id":[{"id":"10.13039\/100011319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["SEBCATP-2024\/100003"],"award-info":[{"award-number":["SEBCATP-2024\/100003"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C11496\/A17786"],"award-info":[{"award-number":["C11496\/A17786"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8221\/A29017"],"award-info":[{"award-number":["C8221\/A29017"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C864\/A14136"],"award-info":[{"award-number":["C864\/A14136"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C416\/A21999"],"award-info":[{"award-number":["C416\/A21999"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["DRCPFA-Nov23\/100003"],"award-info":[{"award-number":["DRCPFA-Nov23\/100003"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["EDDPMA-Nov21\/100034"],"award-info":[{"award-number":["EDDPMA-Nov21\/100034"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C11496\/A30025"],"award-info":[{"award-number":["C11496\/A30025"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5759\/A27412"],"award-info":[{"award-number":["C5759\/A27412"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014534","name":"School of Public Health, Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EDDCPJT\/100022"],"award-info":[{"award-number":["EDDCPJT\/100022"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RF\\u2216ERE\\u2216231118"],"award-info":[{"award-number":["RF\\u2216ERE\\u2216231118"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RP\/EA\/180007"],"award-info":[{"award-number":["RP\/EA\/180007"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["211179\/Z\/18\/Z"],"award-info":[{"award-number":["211179\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016338","name":"Imperial Experimental Cancer Medicine Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013748","name":"Hope Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL134320"],"award-info":[{"award-number":["R01 HL134320"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023796","name":"Human Developmental Biology Resource","doi-asserted-by":"publisher","award":["226202\/Z\/22\/Z"],"award-info":[{"award-number":["226202\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/501100023796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023796","name":"Human Developmental Biology Resource","doi-asserted-by":"publisher","award":["MR\/X008304\/1"],"award-info":[{"award-number":["MR\/X008304\/1"]}],"id":[{"id":"10.13039\/501100023796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00004"],"award-info":[{"award-number":["75N92022D00004"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00001"],"award-info":[{"award-number":["75N92022D00001"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00005"],"award-info":[{"award-number":["75N92022D00005"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00002"],"award-info":[{"award-number":["75N92022D00002"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00003"],"award-info":[{"award-number":["75N92022D00003"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cell.2026.05.005","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:40:44Z","timestamp":1780584044000},"page":"3903-3921.e26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Plasma signals of lung tumor promotion for molecular cancer prevention"],"prefix":"10.1016","volume":"189","author":[{"given":"Tej","family":"Pandya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zagorulya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus","family":"Augustine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino-Maija","family":"Lepp\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulysse","family":"Baruchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Wi","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Klockner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Mugabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Griffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Blyuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysante S.","family":"Iliakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalie","family":"Grenov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Hung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon A.","family":"Burk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Le Marois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Pazukhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Slawinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cian","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Snoeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Suarez-Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon L.","family":"Priestnall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Chardas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpkaan","family":"Celik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Jimenez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Zahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Mont\u00e9gut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton H.","family":"Durney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Karasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel C.H.","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Serrano-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Crnogorac-Jurcevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Apostolidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Zaikin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gunu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.","family":"Whitwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonglun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Dolores","family":"Chirlaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Martijn","family":"Kolijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aghiles","family":"Guenoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeloffer","family":"Mookherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjan","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Hua","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Pe\u2019er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Sahai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Freytag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Chyr","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Platz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"LaFave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Smith-Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Jamal-Hanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Litchfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno R.","family":"Nene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"McGranahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Weeden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Swanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.05.005_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jtho.2023.07.019","article-title":"Current and Future Perspectives on Computed Tomography Screening for Lung Cancer: A Roadmap From 2023 to 2027 From the International Association for the Study of Lung Cancer","volume":"19","author":"Lam","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.cell.2026.05.005_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ijc.33522","article-title":"Low positive predictive value of computed tomography screening for lung cancer irrespective of commonly employed definitions of target population","volume":"149","author":"Krilaviciute","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cell.2026.05.005_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41571-023-00844-0","article-title":"Lung cancer in patients who have never smoked - an emerging disease","volume":"21","author":"LoPiccolo","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cell.2026.05.005_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41586-020-1961-1","article-title":"Tobacco smoking and somatic mutations in human bronchial epithelium","volume":"578","author":"Yoshida","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41568-021-00335-3","article-title":"Clonal expansion in non-cancer tissues","volume":"21","author":"Kakiuchi","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.05.005_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05874-3","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib7","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1\u03b2 inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2026.05.005_bib8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.23.00910","article-title":"Canakinumab as Adjuvant Therapy in Patients With Completely Resected Non\u2013Small-Cell Lung Cancer: Results From the CANOPY-A Double-Blind, Randomized Clinical Trial","volume":"42","author":"Garon","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cell.2026.05.005_bib9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1200\/JCO.23.00980","article-title":"Canakinumab Versus Placebo in Combination With First-Line Pembrolizumab Plus Chemotherapy for Advanced Non\u2013Small-Cell Lung Cancer: Results From the CANOPY-1 Trial","volume":"42","author":"Tan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cell.2026.05.005_bib10","doi-asserted-by":"crossref","unstructured":"Nikoli\u0107, M.Z., and Hogan, B.L.M., eds. (2021). Lung Stem Cells in Development, Health and Disease, First Edition (European Respiratory Society). https:\/\/doi.org\/10.1183\/2312508X.erm9121.","DOI":"10.1183\/2312508X.erm9121"},{"key":"10.1016\/j.cell.2026.05.005_bib11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1101\/gad.338228.120","article-title":"Cells of origin of lung cancers: lessons from mouse studies","volume":"34","author":"Ferone","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2026.05.005_bib12","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1073\/pnas.1112499109","article-title":"Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma","volume":"109","author":"Xu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.005_bib13","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1073\/pnas.1319963111","article-title":"Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma","volume":"111","author":"Sutherland","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.005_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45571","article-title":"Club cells form lung adenocarcinomas and maintain the alveoli of adult mice","volume":"8","author":"Spella","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.005_bib15","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/s41586-023-06324-w","article-title":"KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming","volume":"619","author":"Juul","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ccell.2020.06.012","article-title":"Emergence of a High-Plasticity Cell State during Lung Cancer Evolution","volume":"38","author":"Marjanovic","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41586-024-07113-9","article-title":"An atlas of epithelial cell states and plasticity in lung adenocarcinoma","volume":"627","author":"Han","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41586-025-09985-x","article-title":"Critical role for a high-plasticity cell state in lung cancer","volume":"651","author":"Chan","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ccell.2025.10.004","article-title":"Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions","volume":"44","author":"Peng","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.005_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.stem.2020.06.020","article-title":"Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration","volume":"27","author":"Choi","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib22","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41556-020-0542-8","article-title":"Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis","volume":"22","author":"Kobayashi","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.005_bib23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.stem.2025.01.011","article-title":"Sustained NF-\u03baB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation","volume":"32","author":"England","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41586-024-07926-8","article-title":"An aberrant immune-epithelial progenitor niche drives viral lung sequelae","volume":"634","author":"Narasimhan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adh0908","article-title":"Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis","volume":"15","author":"Lang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2026.05.005_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib31","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.176.4.2069","article-title":"Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods","volume":"176","author":"Pisabarro","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2026.05.005_bib32","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1158\/0008-5472.CAN-20-2978","article-title":"The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention","volume":"81","author":"Khan","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.005_bib108","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.4049\/jimmunol.2001406","article-title":"CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease","volume":"206","author":"Lun","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2026.05.005_bib33","doi-asserted-by":"crossref","first-page":"L510","DOI":"10.1152\/ajplung.00062.2019","article-title":"GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis","volume":"317","author":"Zhang","year":"2019","journal-title":"Am. J. Physiol., Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2026.05.005_bib34","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1164\/rccm.202401-0043LE","article-title":"The IgA-pIgR System Is Dysregulated in Idiopathic Pulmonary Fibrosis","volume":"210","author":"Plant\u00e9-Bordeneuve","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cell.2026.05.005_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01622","article-title":"B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure","volume":"11","author":"Nascimento","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2026.05.005_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2821","article-title":"Regulation of cell signalling by uPAR","volume":"11","author":"Smith","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.005_bib37","doi-asserted-by":"crossref","first-page":"23824","DOI":"10.1016\/S0021-9258(20)80459-1","article-title":"Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages","volume":"268","author":"Shapiro","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2026.05.005_bib38","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-013-9444-6","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis","volume":"32","author":"Beauchemin","year":"2013","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.cell.2026.05.005_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/1465-9921-7-61","article-title":"WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung","volume":"7","author":"Bingle","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.cell.2026.05.005_bib109","doi-asserted-by":"crossref","first-page":"102513","DOI":"10.1016\/j.xcrm.2025.102513","article-title":"Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy","volume":"6","author":"Chen","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2003-0251OC","article-title":"Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney","volume":"30","author":"Verghese","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cell.2026.05.005_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009619","article-title":"LAMP3 deficiency affects surfactant homeostasis in mice","volume":"17","author":"Lunding","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cell.2026.05.005_bib42","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1513\/AnnalsATS.201411-507FR","article-title":"The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections","volume":"12","author":"Han","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.cell.2026.05.005_bib28","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/S0140-6736(21)00731-5","article-title":"Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","volume":"397","author":"Menon","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2026.05.005_bib44","article-title":"The blood proteome of imminent lung cancer diagnosis","volume":"14","author":"Albanes","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.005_bib45","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib46","doi-asserted-by":"crossref","first-page":"e470","DOI":"10.1016\/S2589-7500(24)00087-6","article-title":"Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study","volume":"6","author":"Carrasco-Zanini","year":"2024","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.cell.2026.05.005_bib47","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s44161-024-00545-6","article-title":"Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank","volume":"3","author":"Lind","year":"2024","journal-title":"Nat CardioVasc Res."},{"key":"10.1016\/j.cell.2026.05.005_bib48","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2023.11.021","article-title":"Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis","volume":"83","author":"Shelbaya","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cell.2026.05.005_bib49","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.05.005_bib29","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","article-title":"An integrated cell atlas of the lung in health and disease","volume":"29","author":"Sikkema","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib30","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Aguet","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.005_bib50","doi-asserted-by":"crossref","first-page":"e614","DOI":"10.1016\/S2589-7500(24)00123-7","article-title":"Evaluation of risk prediction models to select lung cancer screening participants in Europe: a prospective cohort consortium analysis","volume":"6","author":"Feng","year":"2024","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.cell.2026.05.005_bib51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thoraxjnl-2020-215158","article-title":"Liverpool Lung Project lung cancer risk stratification model: calibration and prospective validation","volume":"76","author":"Field","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.cell.2026.05.005_bib52","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41591-023-02232-8","article-title":"Body composition and lung cancer-associated cachexia in TRACERx","volume":"29","author":"Al-Sawaf","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-2600(23)00338-7","article-title":"Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study","volume":"12","author":"Chang","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib54","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ccr.2011.04.019","article-title":"Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung","volume":"19","author":"Sutherland","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib55","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ccell.2016.09.001","article-title":"SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin","volume":"30","author":"Ferone","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-47606-9","article-title":"Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling","volume":"15","author":"Hobor","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.005_bib57","first-page":"169","article-title":"Differing histopathology and prognosis in pulmonary adenocarcinoma at central and peripheral locations","volume":"8","author":"Moon","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.cell.2026.05.005_bib58","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ncb3580","article-title":"Local lung hypoxia determines epithelial fate decisions during alveolar regeneration","volume":"19","author":"Xi","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.005_bib59","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.aam6603","article-title":"Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells","volume":"359","author":"Nabhan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.005_bib60","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1101\/gad.1417406","article-title":"Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors","volume":"20","author":"Politi","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2026.05.005_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.112803","article-title":"Defining the effects of traffic-related air pollution on the human plasma proteome using an aptamer proteomic array: A dose-dependent increase in atherosclerosis-related proteins","volume":"209","author":"Mookherjee","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.cell.2026.05.005_bib62","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib63","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.1182\/bloodadvances.2023011578","article-title":"Effects of IL-1\u03b2 inhibition on anemia and clonal hematopoiesis in the randomized CANTOS trial","volume":"7","author":"Woo","year":"2023","journal-title":"Blood Adv."},{"key":"10.1016\/j.cell.2026.05.005_bib64","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1158\/0008-5472.CAN-24-0821","article-title":"Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers","volume":"85","author":"Chen","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.005_bib65","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","article-title":"Extending support for mouse data in the Molecular Signatures Database (MSigDB)","volume":"20","author":"Castanza","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.05.005_bib66","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41571-025-01033-x","article-title":"Promises and pitfalls of multi-cancer early detection using liquid biopsy tests","volume":"22","author":"Wan","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cell.2026.05.005_bib67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2009.12.008","article-title":"Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation","volume":"17","author":"Takahashi","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib68","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ccell.2023.03.019","article-title":"Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer","volume":"41","author":"Weeden","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccr.2011.08.007","article-title":"Lung cancer signatures in plasma based on proteome profiling of mouse tumor models","volume":"20","author":"Taguchi","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay1813","article-title":"Tumor-initiating cells establish an IL-33-TGF-\u03b2 niche signaling loop to promote cancer progression","volume":"369","author":"Taniguchi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.005_bib71","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.devcel.2024.05.020","article-title":"Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche","volume":"59","author":"Rodrigues","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2026.05.005_bib72","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-025-09503-z","article-title":"Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer","volume":"647","author":"Ireland","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib73","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1038\/s41588-025-02418-5","article-title":"Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas","volume":"57","author":"Panja","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.05.005_bib74","doi-asserted-by":"crossref","DOI":"10.1126\/science.ads9145","article-title":"Aberrant basal cell clonal dynamics shape early lung carcinogenesis","volume":"388","author":"G\u00f3mez-L\u00f3pez","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.005_bib76","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/S0140-6736(14)61730-X","article-title":"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials","volume":"385","author":"Mega","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2026.05.005_bib77","first-page":"345","article-title":"Molecular cancer prevention: Current status and future directions","volume":"65","author":"Maresso","year":"2015","journal-title":"CA A Cancer J. Clinicians"},{"key":"10.1016\/j.cell.2026.05.005_bib78","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1164\/rccm.202307-1129OC","article-title":"Proteomic Biomarkers of Quantitative Interstitial Abnormalities in COPDGene and CARDIA Lung Study","volume":"209","author":"Choi","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cell.2026.05.005_bib79","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41591-021-01499-z","article-title":"Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial","volume":"27","author":"Kyriazopoulou","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.005_bib80","doi-asserted-by":"crossref","DOI":"10.1126\/science.adx2678","article-title":"A human pan-disease blood atlas of the circulating proteome","volume":"390","author":"\u00c1lvez","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.005_bib81","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/1055-9965.EPI-14-0745","article-title":"Lung cancer detectability by test, histology, stage and gender: estimates from the NLST and the PLCO trials","volume":"24","author":"ten Haaf","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.cell.2026.05.005_bib83","doi-asserted-by":"crossref","first-page":"D792","DOI":"10.1093\/nar\/gkp1005","article-title":"PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification","volume":"38","author":"Spandidos","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.05.005_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/1756-9966-29-92","article-title":"Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion","volume":"29","author":"Yang","year":"2010","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cell.2026.05.005_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.05.005_bib86","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.nbd.2007.10.004","article-title":"Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology","volume":"29","author":"Wang","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cell.2026.05.005_bib87","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1101\/gad.14.8.994","article-title":"Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum","volume":"14","author":"Marino","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2026.05.005_bib88","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s44318-024-00328-6","article-title":"A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease","volume":"44","author":"Lim","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2026.05.005_bib89","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.005_bib90","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.05.005_bib91","doi-asserted-by":"crossref","DOI":"10.1242\/dev.173476","article-title":"Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development","volume":"146","author":"Li","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.cell.2026.05.005_bib92","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41586-020-03147-x","article-title":"A gene-environment-induced epigenetic program initiates tumorigenesis","volume":"590","author":"Alonso-Curbelo","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib93","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.05.005_bib94","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.05.005_bib95","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-023-05706-4","article-title":"Genomic-transcriptomic evolution in lung cancer and metastasis","volume":"616","author":"Mart\u00ednez-Ruiz","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.005_bib96","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v045.i03","article-title":"mice: Multivariate Imputation by Chained Equations in R","volume":"45","author":"Buuren","year":"2011","journal-title":"J. Stat. Soft."},{"key":"10.1016\/j.cell.2026.05.005_bib97","first-page":"2623","article-title":"Optuna: A Next-generation Hyperparameter Optimization Framework","author":"Akiba","year":"2019","journal-title":"Proc. ACM SIGKDD Int. Conf. Knowl. Discov. Data Mining"},{"key":"10.1016\/j.cell.2026.05.005_bib98","first-page":"785","article-title":"XGBoost: A Scalable Tree Boosting System","author":"Chen","year":"2016","journal-title":"Proc. ACM SIGKDD Int. Conf. on Knowl. Discov. Data Mining"},{"key":"10.1016\/j.cell.2026.05.005_bib99","first-page":"559","article-title":"Imbalanced-Learn: A Python Toolbox to Tackle the Curse of Imbalanced Datasets in Machine Learning","volume":"18","author":"Lemaitre","year":"2017","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.cell.2026.05.005_bib100","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1038\/s41416-021-01278-0","article-title":"Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom","volume":"124","author":"Robbins","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2026.05.005_bib101","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.jacc.2021.04.035","article-title":"The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3\/8","volume":"77","author":"Wright","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cell.2026.05.005_bib102","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1158\/1055-9965.EPI-17-0696","article-title":"Enhancing the Infrastructure of the Atherosclerosis Risk in Communities (ARIC) Study for Cancer Epidemiology Research: ARIC Cancer","volume":"27","author":"Joshu","year":"2018","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.cell.2026.05.005_bib103","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/jnci\/djag004","article-title":"A smoking-related plasma protein score and smoking-related cancer risk and mortality in ARIC","volume":"118","author":"Ru","year":"2026","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.cell.2026.05.005_bib104","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41588-022-01051-w","article-title":"Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies","volume":"54","author":"Zhang","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.05.005_bib105","doi-asserted-by":"crossref","first-page":"15287","DOI":"10.1021\/acs.est.1c05309","article-title":"Monthly Global Estimates of Fine Particulate Matter and Their Uncertainty","volume":"55","author":"van Donkelaar","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cell.2026.05.005_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.rse.2023.113624","article-title":"Assessment of the impact of discontinuity in satellite instruments and retrievals on global PM2.5 estimates","volume":"294","author":"Hammer","year":"2023","journal-title":"Remote Sens. Environ."},{"key":"10.1016\/j.cell.2026.05.005_bib107","first-page":"100975","article-title":"APEX: A Web-Based Tool for Assessing Long-Term Outdoor PM2.5 Exposure\u2013Brief Report.","volume":"7","author":"Durney","year":"2026","journal-title":"JTO Clin. Res. Rep."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426005222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426005222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:54:37Z","timestamp":1785905677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426005222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":106,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0092867426005222"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.005","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma signals of lung tumor promotion for molecular cancer prevention","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}