{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:19:21Z","timestamp":1790111961402,"version":"4.0.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,7,9]],"date-time":"2027-07-09T00:00:00Z","timestamp":1815091200000},"content-version":"am","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["948476"],"award-info":[{"award-number":["948476"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGY0085\/2019"],"award-info":[{"award-number":["RGY0085\/2019"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R35GM138061"],"award-info":[{"award-number":["1R35GM138061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cell.2026.05.008","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:49:49Z","timestamp":1780411789000},"page":"4342-4358.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense"],"prefix":"10.1016","volume":"189","author":[{"given":"Chew","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliya","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souradeep R.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Nanes Sarfati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Gershoni-Yahalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jacobs-Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawa Racine","family":"Thiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyamin","family":"Rosental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-1432","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.05.008_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2005.08.001","article-title":"Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis","volume":"23","author":"Keefe","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.05.008_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cell.2016.01.021","article-title":"Cytotoxic T cells use mechanical force to potentiate target cell killing","volume":"165","author":"Basu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib3","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1016\/j.cell.2024.07.014","article-title":"Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay","volume":"187","author":"Mihlan","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib4","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.micinf.2003.09.008","article-title":"Neutrophil granules and secretory vesicles in inflammation","volume":"5","author":"Faurschou","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cell.2026.05.008_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0160-9327(80)90006-X","article-title":"Phylogeny of cytotoxicity","volume":"4","author":"Cooper","year":"1980","journal-title":"Endeavour"},{"key":"10.1016\/j.cell.2026.05.008_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature12467","article-title":"Evolutionary implications of a third lymphocyte lineage in lampreys","volume":"501","author":"Hirano","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.008_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41586-018-0783-x","article-title":"Complex mammalian-like haematopoietic system found in a colonial chordate","volume":"564","author":"Rosental","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.008_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41577-018-0003-9","article-title":"A cold-blooded view of adaptive immunity","volume":"18","author":"Flajnik","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-042617-053028","article-title":"Evolution of alternative adaptive immune systems in vertebrates","volume":"36","author":"Boehm","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.it.2023.03.007","article-title":"Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance","volume":"44","author":"Milo","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib11","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.immuni.2020.04.022","article-title":"Endocrine autoimmune disease as a fragility of immune surveillance against hypersecreting mutants","volume":"52","author":"Korem Kohanim","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.05.008_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1440045","article-title":"Antigen-specific T cell responses in autoimmune diabetes","volume":"15","author":"Dwyer","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41586-021-04248-x","article-title":"An autoimmune stem-like CD8 T cell population drives type 1 diabetes","volume":"602","author":"Gearty","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.008_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2018.09.021","article-title":"The cellular and molecular basis for planarian regeneration","volume":"175","author":"Reddien","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00427-012-0426-4","article-title":"Stem cell systems and regeneration in planaria","volume":"223","author":"Rink","year":"2013","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.cell.2026.05.008_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrg759","article-title":"Not your father\u2019s planarian: a classic model enters the era of functional genomics","volume":"3","author":"Newmark","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2026.05.008_bib17","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120457119","article-title":"Multicellularity in animals: The potential for within-organism conflict","volume":"119","author":"Howe","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.008_bib18","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107208118","article-title":"Human islet T cells are highly reactive to preproinsulin in type 1 diabetes","volume":"118","author":"Anderson","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.008_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009466","article-title":"Activin-2 is required for regeneration of polarity on the planarian anterior-posterior axis","volume":"17","author":"Cloutier","year":"2021","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cell.2026.05.008_bib20","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1073\/pnas.1214053110","article-title":"Follistatin antagonizes Activin signaling and acts with Notum to direct planarian head regeneration","volume":"110","author":"Roberts-Galbraith","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.008_bib21","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.celrep.2018.11.004","article-title":"Cellular and molecular responses unique to major injury are dispensable for planarian regeneration","volume":"25","author":"Tewari","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.05.008_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1478-7","article-title":"Wnt and TGF\u03b2 coordinate growth and patterning to regulate size-dependent behaviour","volume":"572","author":"Arnold","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.008_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaq1736","article-title":"Cell type transcriptome atlas for the planarian Schmidtea mediterranea","volume":"360","author":"Fincher","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaq1723","article-title":"Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics","volume":"360","author":"Plass","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16793","article-title":"Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1\/MKK\/p38","volume":"5","author":"Arnold","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.008_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.dci.2018.12.005","article-title":"The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections","volume":"93","author":"Maciel","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07405","article-title":"Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ","volume":"4","author":"Thi-Kim Vu","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.008_bib28","series-title":"Planarian Regeneration","author":"Br\u00f8ndsted","year":"1969"},{"key":"10.1016\/j.cell.2026.05.008_bib29","article-title":"Planarian immobilization, partial irradiation, and tissue transplantation","volume":"66","author":"Guedelhoefer","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cell.2026.05.008_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1203983","article-title":"Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration","volume":"332","author":"Wagner","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib31","doi-asserted-by":"crossref","first-page":"e00623-20","DOI":"10.1128\/JVI.00623-20","article-title":"A Novel taxon of monosegmented double-stranded RNA viruses endemic to Triclad flatworms","volume":"94","author":"Burrows","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.cell.2026.05.008_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43267-2","article-title":"Fate specification is spatially intermingled across planarian stem cells","volume":"14","author":"Park","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.008_bib33","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.1909546117","article-title":"NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture","volume":"117","author":"Thiam","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.008_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.008_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00081","article-title":"Neutrophil extracellular traps and its implications in inflammation: an overview","volume":"8","author":"Delgado-Rizo","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: a regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.cell.2026.05.008_bib38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-291X(03)00618-1","article-title":"Mitochondrial permeability transition: a common pathway to necrosis and apoptosis","volume":"304","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2026.05.008_bib39","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102778","article-title":"Calcium as a master regulator of ferroptosis and other types of regulated necrosis","volume":"114","author":"Pedrera","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cell.2026.05.008_bib41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/jpet.106.111344","volume":"321","author":"Wannamaker","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cell.2026.05.008_bib43","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1016\/j.cub.2018.10.030","article-title":"foxF-1 controls specification of non-body wall muscle and phagocytic cells in planarians","volume":"28","author":"Scimone","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib44","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.05.008_bib45","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe7729","article-title":"Neutrophils self-limit swarming to contain bacterial growth in vivo","volume":"372","author":"Kienle","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00247","article-title":"Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling","volume":"2","author":"Gavi\u00f1o","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.008_bib48","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004010","article-title":"IP(3) receptors: toward understanding their activation","volume":"2","author":"Taylor","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib49","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/j.1476-5381.2010.00771.x","article-title":"The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle","volume":"160","author":"MacMillan","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2026.05.008_bib50","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/sj.bjp.0704662","article-title":"Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells","volume":"135","author":"Oka","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2026.05.008_bib51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg2703","article-title":"Origin and evolution of the adaptive immune system: genetic events and selective pressures","volume":"11","author":"Flajnik","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2026.05.008_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27041","article-title":"The Human Cell Atlas","volume":"6","author":"Regev","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.008_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.abk2432","article-title":"Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib54","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1016\/j.cell.2024.09.047","article-title":"A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors","volume":"187","author":"Lange","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib55","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1126\/science.1465619","article-title":"Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate","volume":"258","author":"Allbritton","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.008_bib56","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1006\/bbrc.1996.1735","article-title":"Phospholipase C-\u03b31 binds to actin-cytoskeleton via its C-terminal SH2 domain in vitro","volume":"228","author":"Pei","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2026.05.008_bib57","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263503","article-title":"The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction","volume":"138","author":"Townson","year":"2025","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cell.2026.05.008_bib58","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1016\/j.cell.2023.06.019","article-title":"Ultrafast distant wound response is essential for whole-body regeneration","volume":"186","author":"Fan","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.008_bib59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining \u2018T cell exhaustion\u2019","volume":"19","author":"Blank","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.609196","article-title":"Cyclophilins A, B, and C role in human T lymphocytes upon inflammatory conditions","volume":"12","author":"Gegunde","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2026.05.008_bib61","article-title":"Flexible use of conserved motif vocabularies constrains genome access in cell type evolution","author":"Chai","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2026.05.008_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54041-3","article-title":"Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model","volume":"15","author":"Stockinger","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.008_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-38016-4","article-title":"Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells","volume":"14","author":"Hulett","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.008_bib64","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1038\/s44318-025-00621-y","article-title":"Glycogen phase separation drives macromolecular rearrangement and asymmetric division in E. coli","volume":"44","author":"Thappeta","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2026.05.008_bib65","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.05.008_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib67","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gr.209601.116","article-title":"UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy","volume":"27","author":"Smith","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2026.05.008_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.cell.2026.05.008_bib69","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48994","article-title":"Self-assembling manifolds in single-cell RNA sequencing data","volume":"8","author":"Tarashansky","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cell.2026.05.008_bib70","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaa151","article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","volume":"9","author":"Young","year":"2020","journal-title":"GigaScience"},{"key":"10.1016\/j.cell.2026.05.008_bib71","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.05.008_bib72","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1832-y","article-title":"OrthoFinder: phylogenetic orthology inference for comparative genomics","volume":"20","author":"Emms","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib73","doi-asserted-by":"crossref","first-page":"D309","DOI":"10.1093\/nar\/gky1085","article-title":"eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses","volume":"47","author":"Huerta-Cepas","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.05.008_bib74","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41587-023-01773-0","article-title":"Fast and accurate protein structure search with Foldseek","volume":"42","author":"van Kempen","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.05.008_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114580","article-title":"Adaptive robustness through incoherent signaling mechanisms in a regenerative brain","volume":"43","author":"Bray","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.05.008_bib76","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-1-4939-7802-1_7","article-title":"Small- and large-Scale high molecular weight genomic DNA extraction from planarians","volume":"1774","author":"Grohme","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000509","article-title":"Genome-wide analyses reveal a role for peptide hormones in planarian germline development","volume":"8","author":"Collins","year":"2010","journal-title":"PLOS Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib78","doi-asserted-by":"crossref","DOI":"10.1186\/1471-213X-13-8","article-title":"In situ hybridization protocol for enhanced detection of gene expression in the planarian Schmidtea mediterranea","volume":"13","author":"King","year":"2013","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib79","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/978-1-4939-7802-1_16","article-title":"Detection of apoptotic cells in planarians by whole-mount TUNEL","volume":"1774","author":"Stubenhaus","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cell.2026.05.008_bib80","doi-asserted-by":"crossref","first-page":"D812","DOI":"10.1093\/nar\/gky1070","article-title":"PlanMine 3.0\u2014improvements to a mineable resource of flatworm biology and biodiversity","volume":"47","author":"Rozanski","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426005672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426005672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:46:40Z","timestamp":1785959200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426005672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":80,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0092867426005672"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.008","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}