{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:50:52Z","timestamp":1792522252977,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008562","name":"University of Texas at Austin","doi-asserted-by":"publisher","award":["U24CA274212"],"award-info":[{"award-number":["U24CA274212"]}],"id":[{"id":"10.13039\/100008562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008562","name":"University of Texas at Austin","doi-asserted-by":"publisher","award":["R03CA270725"],"award-info":[{"award-number":["R03CA270725"]}],"id":[{"id":"10.13039\/100008562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["R01CA255080"],"award-info":[{"award-number":["R01CA255080"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RP230072"],"award-info":[{"award-number":["RP230072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cell.2026.05.036","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:43:15Z","timestamp":1782139395000},"page":"5359-5377.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance"],"prefix":"10.1016","volume":"189","author":[{"given":"Guang","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengze","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengrong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchuang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ting","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"Puebla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hampartsoum","family":"Barsoumian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Kae Jack","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara","family":"Vaporciyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Heymach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjian James","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-6040","authenticated-orcid":false,"given":"Boyi","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.05.036_bib1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cell.2026.05.036_bib2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.05.036_bib3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/procel\/pwae003","article-title":"Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond","volume":"15","author":"Mao","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.trecan.2025.12.002","article-title":"Cuproptosis in cancer: from molecular mechanisms to therapeutic intervention","volume":"12","author":"Jiang","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.cell.2026.05.036_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202370152","article-title":"Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with \u03b1PD-L1 for Enhanced Cancer Immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.cell.2026.05.036_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202403253","article-title":"A Vacancy-Engineering Ferroelectric Nanomedicine for Cuproptosis\/Apoptosis Co-Activated Immunotherapy","volume":"36","author":"Du","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.cell.2026.05.036_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54469-7","article-title":"Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy","volume":"15","author":"Guan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.05.036_bib10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic cell death in cancer and infectious disease","volume":"17","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/imr.13301","article-title":"Decoding immunogenic cell death from a dendritic cell perspective","volume":"321","author":"Janssens","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cell.2026.05.036_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.05.036_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.cell.2026.05.036_bib16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41577-025-01238-2","article-title":"Guidelines for T cell nomenclature","volume":"26","author":"Masopust","year":"2026","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccr.2014.05.016","article-title":"Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy","volume":"25","author":"Ries","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib18","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.apsb.2021.03.027","article-title":"Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment","volume":"11","author":"Xie","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cell.2026.05.036_bib19","doi-asserted-by":"crossref","first-page":"15623","DOI":"10.1073\/pnas.95.26.15623","article-title":"Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays","volume":"95","author":"Der","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.036_bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cell.2022.12.038","article-title":"Human IRF1 governs macrophagic IFN-gamma immunity to mycobacteria","volume":"186","author":"Rosain","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib21","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","article-title":"IRF family of transcription factors as regulators of host defense","volume":"19","author":"Taniguchi","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","article-title":"The IRF family transcription factors in immunity and oncogenesis","volume":"26","author":"Tamura","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","article-title":"Mitochondrial metabolism promotes adaptation to proteotoxic stress","volume":"15","author":"Tsvetkov","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.05.036_bib24","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/bi0525674","article-title":"Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants","volume":"45","author":"Liddle","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2026.05.036_bib25","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1073\/pnas.0609852104","article-title":"Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis","volume":"104","author":"Park","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.036_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2013.02.012","article-title":"Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells","volume":"370","author":"Imamichi","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cell.2026.05.036_bib27","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cell.2023.03.006","article-title":"Immune checkpoint therapy-current perspectives and future directions","volume":"186","author":"Sharma","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib28","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1158\/0008-5472.CAN-20-0471","article-title":"Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion","volume":"80","author":"Voli","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib29","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00277-018-3407-5","article-title":"Copper deficiency anemia: review article","volume":"97","author":"Myint","year":"2018","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.cell.2026.05.036_bib30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrc.2016.2","article-title":"Acquired resistance to immunotherapy and future challenges","volume":"16","author":"Restifo","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.05.036_bib32","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.ccell.2024.09.010","article-title":"The hallmarks of cancer immune evasion","volume":"42","author":"Galassi","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1158\/0008-5472.CAN-15-3142","article-title":"Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy","volume":"77","author":"Wang","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add4817","article-title":"Restoring tumor immunogenicity with dendritic cell reprogramming","volume":"8","author":"Zimmermannova","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1158\/0008-5472.CAN-14-3619","article-title":"Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors","volume":"76","author":"Baird","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib36","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1158\/0008-5472.CAN-13-3723","article-title":"CSF1\/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models","volume":"74","author":"Zhu","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19192-z","article-title":"Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s","volume":"11","author":"Oba","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib38","doi-asserted-by":"crossref","first-page":"11774","DOI":"10.1073\/pnas.1410626111","article-title":"Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.036_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14979","article-title":"Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade","volume":"8","author":"Ouzounova","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100787","article-title":"Hypoxia as a driver of resistance to immunotherapy","volume":"59","author":"Kopecka","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.cell.2026.05.036_bib41","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1alpha drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib42","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s43018-022-00470-2","article-title":"Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer","volume":"3","author":"Cappellesso","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.05.036_bib43","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib44","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib45","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1016\/j.apsb.2024.04.028","article-title":"Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy","volume":"14","author":"Yan","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cell.2026.05.036_bib46","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1021\/jacsau.4c00712","article-title":"Signaling Mechanism of Cuproptosis Activating cGAS-STING Immune Pathway","volume":"4","author":"Zhu","year":"2024","journal-title":"JACS Au"},{"key":"10.1016\/j.cell.2026.05.036_bib47","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/j.cell.2025.11.002","article-title":"Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib48","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1158\/2159-8290.CD-23-1220","article-title":"BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers","volume":"14","author":"Lei","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2026.05.036_bib49","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1096\/fj.201801225R","article-title":"STIM2 interacts with AMPK and regulates calcium-induced AMPK activation","volume":"33","author":"Chauhan","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2026.05.036_bib50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.036_bib51","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1080\/15384101.2016.1249545","article-title":"lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1","volume":"15","author":"Liu","year":"2016","journal-title":"Cell Cycle (Georget. Tex.)"},{"key":"10.1016\/j.cell.2026.05.036_bib52","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.1074\/jbc.M117.798405","article-title":"The glutamate\/cystine antiporter SLC7A11\/xCT enhances cancer cell dependency on glucose by exporting glutamate","volume":"292","author":"Koppula","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2026.05.036_bib53","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/procel\/pwae004","article-title":"Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis","volume":"15","author":"Liu","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29905-1","article-title":"A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers","volume":"13","author":"Koppula","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.05.036_bib56","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/s41592-024-02235-4","article-title":"Assessing GPT-4 for cell type annotation in single-cell RNA-seq analysis","volume":"21","author":"Hou","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.05.036_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114289","article-title":"Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity","volume":"43","author":"Purbey","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.05.036_bib58","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.05.036_bib59","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2026.05.036_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf6724","article-title":"Immune checkpoint B7-H3 is a therapeutic vulnerability in prostate cancer harboring PTEN and TP53 deficiencies","volume":"15","author":"Shi","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2026.05.036_bib61","article-title":"Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib62","doi-asserted-by":"crossref","first-page":"19134","DOI":"10.18632\/oncotarget.8102","article-title":"BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cell.2026.05.036_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102649","article-title":"KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition","volume":"24","author":"Koppula","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.cell.2026.05.036_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121987119","article-title":"A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria","volume":"119","author":"Wu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.05.036_bib65","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ccr.2010.10.019","article-title":"FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis","volume":"18","author":"Gan","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib66","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1158\/0008-5472.CAN-13-1729","article-title":"FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway","volume":"74","author":"Lin","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib67","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1038\/onc.2013.273","article-title":"The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress","volume":"33","author":"Lin","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2026.05.036_bib68","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","article-title":"BAP1 links metabolic regulation of ferroptosis to tumour suppression","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.05.036_bib69","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41565-024-01758-3","article-title":"Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade","volume":"19","author":"Tan","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.cell.2026.05.036_bib70","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ccell.2023.04.011","article-title":"Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer","volume":"41","author":"Li","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib71","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1093\/annonc\/mdx518","article-title":"Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: post-progression outcomes from the phase II IMvigor210 study","volume":"28","author":"Necchi","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cell.2026.05.036_bib72","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1038\/s41591-019-0654-5","article-title":"Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma","volume":"25","author":"Liu","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.036_bib73","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s41591-020-0839-y","article-title":"Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma","volume":"26","author":"Braun","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.05.036_bib74","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2017.09.028","article-title":"Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab","volume":"171","author":"Riaz","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015074","article-title":"Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome","volume":"5","author":"Kim","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2026.05.036_bib76","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/omi.2012.0039","article-title":"A seven-gene signature aggregates a subgroup of stage II colon cancers with stage III","volume":"16","author":"Laibe","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.cell.2026.05.036_bib77","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1158\/1078-0432.CCR-06-2765","article-title":"Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series","volume":"13","author":"Desmedt","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2026.05.036_bib78","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.molcel.2024.04.009","article-title":"Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers","volume":"84","author":"Mao","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2026.05.036_bib79","article-title":"SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.05.036_bib80","doi-asserted-by":"crossref","DOI":"10.1186\/s13000-014-0221-9","article-title":"Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review","volume":"9","author":"Fedchenko","year":"2014","journal-title":"Diagn. Pathol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426006367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426006367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:34:36Z","timestamp":1790829276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426006367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":80,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0092867426006367"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.036","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}