{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:06:51Z","timestamp":1790719611547,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cell.2026.07.028","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:09:20Z","timestamp":1785856160000},"page":"5688-5705.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer"],"prefix":"10.1016","volume":"189","author":[{"given":"YaTing","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LingJie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenWen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingFei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YangYue","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiYang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunZhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XingChao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MengWen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaocai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiGang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongBin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GaoXiang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Arial","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiHui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianJun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-1691","authenticated-orcid":false,"given":"JianFeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.07.028_bib1","article-title":"Depression and anxiety in patients with cancer","volume":"361","author":"Pitman","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.cell.2026.07.028_bib2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0140-6736(09)60660-7","article-title":"Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001\u201305: an epidemiological survey","volume":"373","author":"Phillips","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2026.07.028_bib3","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.3390\/curroncol29110689","article-title":"Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis","volume":"29","author":"Cheng","year":"2022","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.cell.2026.07.028_bib4","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/npp.2017.86","article-title":"Modern Clinical Research on LSD","volume":"42","author":"Liechti","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cell.2026.07.028_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/09540261.2018.1482261","article-title":"Therapeutic use of classic psychedelics to treat cancer-related psychiatric distress","volume":"30","author":"Ross","year":"2018","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.cell.2026.07.028_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0269881114555249","article-title":"LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: a qualitative study of acute and sustained subjective effects","volume":"29","author":"Gasser","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.cell.2026.07.028_bib7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/acs.chemrev.3c00375","article-title":"Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants","volume":"124","author":"Duan","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cell.2026.07.028_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/hbm.20035","article-title":"Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain","volume":"22","author":"Varn\u00e4s","year":"2004","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.cell.2026.07.028_bib9","doi-asserted-by":"crossref","first-page":"G877","DOI":"10.1152\/ajpgi.00435.2001","article-title":"5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice","volume":"282","author":"Fiorica-Howells","year":"2002","journal-title":"Am. J. Physiol., Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cell.2026.07.028_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0165-1781(99)00059-1","article-title":"Serotonin-2A receptor polymorphism (102T\/C) in mood disorders","volume":"87","author":"Tsai","year":"1999","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.cell.2026.07.028_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1139\/jpn.0427","article-title":"The therapeutic role of 5-HT1A and 5-HT2A receptors in depression","volume":"29","author":"Celada","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.cell.2026.07.028_bib12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/s41386-022-01324-2","article-title":"Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice","volume":"47","author":"P\u0119dzich","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cell.2026.07.028_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00068","article-title":"Dual Role of Endogenous Serotonin in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis","volume":"7","author":"Rapalli","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cell.2026.07.028_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1440-1681.1978.tb00657.x","article-title":"The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats","volume":"5","author":"Tutton","year":"1978","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cell.2026.07.028_bib15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1053\/j.gastro.2012.05.007","article-title":"Neuronal serotonin regulates growth of the intestinal mucosa in mice","volume":"143","author":"Gross","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2026.07.028_bib16","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.immuni.2023.09.005","article-title":"CD8+ T cells in the cancer-immunity cycle","volume":"56","author":"Giles","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.07.028_bib17","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ccell.2021.11.010","article-title":"Toward a better understanding of T cells in cancer","volume":"39","author":"Oh","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib18","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.euroneuro.2016.05.001","article-title":"Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens","volume":"26","author":"Rickli","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.cell.2026.07.028_bib19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/01.CIR.0000139856.20505.57","article-title":"Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts","volume":"110","author":"Jaffr\u00e9","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2026.07.028_bib20","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1161\/01.CIR.102.23.2836","article-title":"Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications","volume":"102","author":"Rothman","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2026.07.028_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02424-0","article-title":"Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution","volume":"9","author":"Efremova","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.028_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-023-00605-4","article-title":"Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer","volume":"9","author":"Borr\u00e0s","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.cell.2026.07.028_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168277","article-title":"Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1","volume":"133","author":"Beach","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2026.07.028_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117285","article-title":"5-HT2aR contributes to pulmonary arterial hypertension by modulating the AHR pathway","volume":"242","author":"Lu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cell.2026.07.028_bib25","article-title":"Author Correction: Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons","volume":"32","author":"Zhu","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2026.07.028_bib26","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2014.09.040","article-title":"Enteric glial cells: recent developments and future directions","volume":"147","author":"Neunlist","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2026.07.028_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.595892","article-title":"Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer","volume":"10","author":"Yuan","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cell.2026.07.028_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-50438-2","article-title":"IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer","volume":"15","author":"van Baarle","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.028_bib29","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jcmgh.2021.06.008","article-title":"Enteric Glia Regulate Lymphocyte Activation via Autophagy-Mediated MHC-II Expression","volume":"12","author":"Chow","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2026.07.028_bib30","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2018.08.069","article-title":"Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses","volume":"175","author":"White","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib31","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1073\/pnas.1203543109","article-title":"Regulation of innate CD8+ T-cell activation mediated by cytokines","volume":"109","author":"Freeman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.07.028_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41584-023-01053-w","article-title":"Biological and clinical roles of IL-18 in inflammatory diseases","volume":"20","author":"Landy","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cell.2026.07.028_bib33","doi-asserted-by":"crossref","first-page":"E2357","DOI":"10.1073\/pnas.1701219114","article-title":"Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids","volume":"114","author":"Fumagalli","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.07.028_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41575-021-00423-7","article-title":"Enteric glial biology, intercellular signalling and roles in gastrointestinal disease","volume":"18","author":"Seguella","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cell.2026.07.028_bib35","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nature18644","article-title":"Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence","volume":"535","author":"Ibiza","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.028_bib36","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41385-022-00563-2","article-title":"Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation","volume":"15","author":"Stakenborg","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cell.2026.07.028_bib37","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.cell.2023.05.001","article-title":"The enteric nervous system relays psychological stress to intestinal inflammation","volume":"186","author":"Schneider","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41586-021-04006-z","article-title":"Regulation of intestinal immunity and tissue repair by enteric glia","volume":"599","author":"Progatzky","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.028_bib39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pharmthera.2016.10.008","article-title":"New therapeutic opportunities for 5-HT2 receptor ligands","volume":"170","author":"Maroteaux","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cell.2026.07.028_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1517\/13543776.2016.1113257","article-title":"Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004\u20132014)","volume":"26","author":"Yang","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.cell.2026.07.028_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abh2383","article-title":"Targeting monoamine oxidase A for T cell-based cancer immunotherapy","volume":"6","author":"Wang","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cell.2026.07.028_bib42","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1016\/j.cell.2025.04.032","article-title":"Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis","volume":"188","author":"Li","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib43","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.molmed.2016.02.003","article-title":"Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored","volume":"22","author":"Li","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cell.2026.07.028_bib44","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1158\/1078-0432.CCR-18-3684","article-title":"Loss of SMAD4 Promotes Colorectal Cancer Progression by Recruiting Tumor-Associated Neutrophils via the CXCL1\/8-CXCR2 Axis","volume":"25","author":"Ogawa","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2026.07.028_bib45","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2022.07.016","article-title":"SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20\/CCR6-mediated Inflammation","volume":"163","author":"Hanna","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2026.07.028_bib46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.028_bib47","doi-asserted-by":"crossref","first-page":"44162","DOI":"10.1021\/jacs.5c13607","article-title":"Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5-HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis","volume":"147","author":"Zhou","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2026.07.028_bib48","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature21713","article-title":"A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer","volume":"543","author":"de Sousa e Melo","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.028_bib49","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.cell.2025.02.031","article-title":"Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force","volume":"188","author":"Xie","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib50","article-title":"Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse","volume":"138","author":"Wang","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cell.2026.07.028_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/09636897231215233","article-title":"Isolation, Expansion, and Endoscopic Delivery of Autologous Enteric Neuronal Stem Cells in Swine","volume":"32","author":"Hotta","year":"2023","journal-title":"Cell Transplant."},{"key":"10.1016\/j.cell.2026.07.028_bib52","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/modpathol.2017.156","article-title":"Implications of the tumor immune microenvironment for staging and therapeutics","volume":"31","author":"Taube","year":"2018","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.cell.2026.07.028_bib53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-018-0024-3","article-title":"Intra-tumour diversification in colorectal cancer at the single-cell level","volume":"556","author":"Roerink","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.028_bib54","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2015.03.053","article-title":"Prospective derivation of a living organoid biobank of colorectal cancer patients","volume":"161","author":"van de Wetering","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.028_bib55","article-title":"Cell-based flow cytometry assay to measure cytotoxic activity","volume":"82","author":"Noto","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cell.2026.07.028_bib56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41596-019-0232-9","article-title":"Tumor organoid-T-cell coculture systems","volume":"15","author":"Cattaneo","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2026.07.028_bib57","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00213-013-3006-z","article-title":"Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement","volume":"227","author":"Halberstadt","year":"2013","journal-title":"Psychopharmacol."},{"key":"10.1016\/j.cell.2026.07.028_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49913-4","article-title":"Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo","volume":"9","author":"de la Fuente Revenga","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.07.028_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejps.2004.03.003","article-title":"Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides","volume":"22","author":"De Marco","year":"2004","journal-title":"Eur. J. Pharm. Sci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426008263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426008263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:03:59Z","timestamp":1788447839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426008263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":59,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0092867426008263"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.07.028","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.07.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}