{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:42:41Z","timestamp":1792215761447,"version":"4.4.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD04073"],"award-info":[{"award-number":["2023ZD04073"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0630000"],"award-info":[{"award-number":["XDB0630000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1240000"],"award-info":[{"award-number":["XDB1240000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1820000"],"award-info":[{"award-number":["XDB1820000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918200"],"award-info":[{"award-number":["2024YFA0918200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32088102"],"award-info":[{"award-number":["32088102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32425001"],"award-info":[{"award-number":["32425001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070270"],"award-info":[{"award-number":["32070270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cell.2026.07.033","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:40:48Z","timestamp":1792075248000},"page":"6847-6864.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal co-transcriptomics uncovers coordinated rhizobia-legume stress programs supporting nitrogen fixation in Medicago"],"prefix":"10.1016","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8888-3225","authenticated-orcid":false,"given":"Wenwen","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunhuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanmin","family":"Guang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-3530","authenticated-orcid":false,"given":"Ertao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.07.033_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.environ.032108.105046","article-title":"Nitrogen in agriculture: balancing the cost of an essential resource","volume":"34","author":"Robertson","year":"2009","journal-title":"Annu. Rev. Environ. Resour."},{"key":"10.1016\/j.cell.2026.07.033_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.arplant.59.032607.092839","article-title":"Coordinating nodule morphogenesis with rhizobial infection in legumes","volume":"59","author":"Oldroyd","year":"2008","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-genet-110410-132549","article-title":"The rules of engagement in the legume-rhizobial symbiosis","volume":"45","author":"Oldroyd","year":"2011","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cell.2026.07.033_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.genet.42.110807.091427","article-title":"Molecular determinants of a symbiotic chronic infection","volume":"42","author":"Gibson","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cell.2026.07.033_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jipb.13207","article-title":"Mechanisms underlying legume-rhizobium symbioses","volume":"64","author":"Yang","year":"2022","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib6","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.1093038","article-title":"A putative Ca2+ and calmodulin-dependent protein kinase required for bacterial and fungal symbioses","volume":"303","author":"L\u00e9vy","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib7","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature04812","article-title":"Nodulation independent of rhizobia induced by a calcium-activated kinase lacking autoinhibition","volume":"441","author":"Gleason","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.033_bib8","doi-asserted-by":"crossref","first-page":"20540","DOI":"10.1073\/pnas.0806858105","article-title":"CYCLOPS, a mediator of symbiotic intracellular accommodation","volume":"105","author":"Yano","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.07.033_bib9","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1094\/MPMI-20-8-0912","article-title":"A novel nuclear protein interacts with the symbiotic DMI3 calcium- and calmodulin-dependent protein kinase of Medicago truncatula","volume":"20","author":"Messinese","year":"2007","journal-title":"Mol. Plant Microbe Interact."},{"key":"10.1016\/j.cell.2026.07.033_bib10","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1105\/tpc.15.00461","article-title":"The NIN transcription factor coordinates diverse nodulation programs in different tissues of the Medicago truncatula root","volume":"27","author":"Verni\u00e9","year":"2015","journal-title":"Plant Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib11","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41477-018-0261-3","article-title":"NIN interacts with NLPs to mediate nitrate inhibition of nodulation in Medicago truncatula","volume":"4","author":"Lin","year":"2018","journal-title":"Nat. Plants"},{"key":"10.1016\/j.cell.2026.07.033_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-020-3016-z","article-title":"An SHR\u2013SCR module specifies legume cortical cell fate to enable nodulation","volume":"589","author":"Dong","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.033_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1105\/tpc.19.00279","article-title":"Celebrating 20 years of genetic discoveries in legume nodulation and symbiotic nitrogen fixation","volume":"32","author":"Roy","year":"2020","journal-title":"Plant Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro2990","article-title":"Speak, friend, and enter: signalling systems that promote beneficial symbiotic associations in plants","volume":"11","author":"Oldroyd","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cell.2026.07.033_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature22009","article-title":"Plant signalling in symbiosis and immunity","volume":"543","author":"Zipfel","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.033_bib16","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.molp.2022.10.021","article-title":"Cell-specific pathways recruited for symbiotic nodulation in the Medicago truncatula legume","volume":"15","author":"Cervantes-P\u00e9rez","year":"2022","journal-title":"Mol. Plant"},{"key":"10.1016\/j.cell.2026.07.033_bib17","doi-asserted-by":"crossref","first-page":"7171","DOI":"10.1038\/s41467-023-42911-1","article-title":"Single-cell analysis identifies genes facilitating rhizobium infection in Lotus japonicus","volume":"14","author":"Frank","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/pbi.13778","article-title":"Single cell-type transcriptome profiling reveals genes that promote nitrogen fixation in the infected and uninfected cells of legume nodules","volume":"20","author":"Wang","year":"2022","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.cell.2026.07.033_bib19","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.molp.2022.10.019","article-title":"Differentiation trajectories and biofunctions of symbiotic and un-symbiotic fate cells in root nodules of Medicago truncatula","volume":"15","author":"Ye","year":"2022","journal-title":"Mol. Plant"},{"key":"10.1016\/j.cell.2026.07.033_bib20","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41477-023-01524-8","article-title":"Single-nucleus transcriptomes reveal spatiotemporal symbiotic perception and early response in Medicago","volume":"9","author":"Liu","year":"2023","journal-title":"Nat. Plants"},{"key":"10.1016\/j.cell.2026.07.033_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113747","article-title":"The single-cell transcriptome program of nodule development cellular lineages in Medicago truncatula","volume":"43","author":"Pereira","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.07.033_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.xplc.2024.100984","article-title":"Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process","volume":"5","author":"Cervantes-P\u00e9rez","year":"2024","journal-title":"Plant Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41586-019-1049-y","article-title":"Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH","volume":"568","author":"Eng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.033_bib24","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaw1219","article-title":"Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution","volume":"363","author":"Rodriques","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib25","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2020.10.026","article-title":"High-spatial-resolution multi-omics sequencing via deterministic barcoding in tissue","volume":"183","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa6090","article-title":"RNA imaging: spatially resolved, highly multiplexed RNA profiling in single cells","volume":"348","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics","volume":"353","author":"St\u00e5hl","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib28","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.cell.2022.04.003","article-title":"Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays","volume":"185","author":"Chen","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41477-023-01387-z","article-title":"Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule maturation","volume":"9","author":"Liu","year":"2023","journal-title":"Nat. Plants"},{"key":"10.1016\/j.cell.2026.07.033_bib30","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1038\/s41467-024-50737-8","article-title":"Mapping the molecular landscape of Lotus japonicus nodule organogenesis through spatiotemporal transcriptomics","volume":"15","author":"Ye","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib31","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cell.2024.10.050","article-title":"A spatially resolved multi-omic single-cell atlas of soybean development","volume":"188","author":"Zhang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1469-8137.1992.tb04227.x","article-title":"Developmental biology of legume nodulation","volume":"122","author":"Hirsch","year":"1992","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1744-7909.2010.00899.x","article-title":"Molecular analysis of legume nodule development and autoregulation","volume":"52","author":"Ferguson","year":"2010","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib34","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.cub.2019.09.005","article-title":"NODULE INCEPTION recruits the lateral root developmental program for symbiotic nodule organogenesis in Medicago truncatula","volume":"29","author":"Schiessl","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib35","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1038\/s41467-023-43738-6","article-title":"A micro RNA mediates shoot control of root branching","volume":"14","author":"Sexauer","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib36","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.aax2153","article-title":"A shared gene drives lateral root development and root nodule symbiosis pathways in Lotus","volume":"366","author":"Soyano","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11103-019-00936-5","article-title":"A phylogenetically conserved APETALA2\/ETHYLENE RESPONSE FACTOR, ERF12, regulates Arabidopsis floral development","volume":"102","author":"Chandler","year":"2020","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib38","doi-asserted-by":"crossref","first-page":"12433","DOI":"10.1038\/ncomms12433","article-title":"DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways","volume":"7","author":"Jin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib39","doi-asserted-by":"crossref","first-page":"12636","DOI":"10.1038\/ncomms12636","article-title":"DELLA-mediated gibberellin signalling regulates Nod factor signalling and rhizobial infection","volume":"7","author":"Fonouni-Farde","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-313X.2003.01759.x","article-title":"Dominant repression of target genes by chimeric repressors that include the EAR motif, a repression domain, in Arabidopsis","volume":"34","author":"Hiratsu","year":"2003","journal-title":"Plant J."},{"key":"10.1016\/j.cell.2026.07.033_bib41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1365-313X.2008.03644.x","article-title":"Fast, transient and specific intracellular ROS changes in living root hair cells responding to Nod factors (NFs)","volume":"56","author":"C\u00e1rdenas","year":"2008","journal-title":"Plant J."},{"key":"10.1016\/j.cell.2026.07.033_bib42","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/nph.18434","article-title":"Signaling by reactive molecules and antioxidants in legume nodules","volume":"236","author":"Minguill\u00f3n","year":"2022","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib43","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/nph.12881","article-title":"A nonRD receptor-like kinase prevents nodule early senescence and defense-like reactions during symbiosis","volume":"203","author":"Berrabah","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4161\/psb.4.2.7693","article-title":"Positioning the nodule, the hormone dictum","volume":"4","author":"Ding","year":"2009","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.cell.2026.07.033_bib45","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/jipb.12653","article-title":"Hormone modulation of legume-rhizobial symbiosis","volume":"60","author":"Liu","year":"2018","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib46","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1128\/JB.182.9.2551-2558.2000","article-title":"The Sinorhizobium meliloti Lon protease is involved in regulating exopolysaccharide synthesis and is required for nodulation of alfalfa","volume":"182","author":"Summers","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cell.2026.07.033_bib47","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1128\/jb.178.23.6802-6809.1996","article-title":"Cloning and characterization of the katA gene of Rhizobium meliloti encoding a hydrogen peroxide-inducible catalase","volume":"178","author":"H\u00e9rouart","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cell.2026.07.033_bib48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.vetmic.2006.12.013","article-title":"The response of Mannheimia haemolytica to iron limitation: implications for the acquisition of iron in the bovine lung","volume":"121","author":"Roehrig","year":"2007","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.cell.2026.07.033_bib49","doi-asserted-by":"crossref","first-page":"796045","DOI":"10.3389\/fpls.2021.796045","article-title":"The rhizobium-legume symbiosis: co-opting successful stress management","volume":"12","author":"Hawkins","year":"2021","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1105\/tpc.19.00494","article-title":"Gene expression in nitrogen-fixing symbiotic nodule cells in Medicago truncatula and other nodulating plants","volume":"32","author":"Mergaert","year":"2020","journal-title":"Plant Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib51","doi-asserted-by":"crossref","first-page":"881456","DOI":"10.3389\/fpls.2022.881456","article-title":"Transcriptome analysis of leaf senescence regulation under alkaline stress in Medicago truncatula","volume":"13","author":"Dong","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib52","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.plantsci.2011.01.002","article-title":"Overexpression of FTL1\/DDF1, an AP2 transcription factor, enhances tolerance to cold, drought, and heat stresses in Arabidopsis thaliana","volume":"180","author":"Kang","year":"2011","journal-title":"Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016463","article-title":"Transcription reprogramming during root nodule development in Medicago truncatula","volume":"6","author":"Moreau","year":"2011","journal-title":"PLOS One"},{"key":"10.1016\/j.cell.2026.07.033_bib54","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3390\/ijms20051204","article-title":"Transcriptomic changes in Medicago truncatula and Lotus japonicus root nodules during drought stress","volume":"20","author":"Sa\u0144ko-Sawczenko","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12870-020-2301-1","article-title":"Identification of tissue-specific and cold-responsive lncRNAs in Medicago truncatula by high-throughput RNA sequencing","volume":"20","author":"Zhao","year":"2020","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib56","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1093\/jxb\/err210","article-title":"Role of DREBs in regulation of abiotic stress responses in plants","volume":"62","author":"Lata","year":"2011","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.cell.2026.07.033_bib57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbagrm.2011.08.004","article-title":"AP2\/ERF family transcription factors in plant abiotic stress responses","volume":"1819","author":"Mizoi","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2026.07.033_bib58","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/s41598-021-82450-7","article-title":"Involvement of the miR156\/SPL module in flooding response in Medicago sativa","volume":"11","author":"Feyissa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.07.033_bib59","doi-asserted-by":"crossref","first-page":"1044918","DOI":"10.3389\/fpls.2023.1044918","article-title":"DOF transcription factors: specific regulators of plant biological processes","volume":"14","author":"Zou","year":"2023","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib60","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2229-11-109","article-title":"Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses","volume":"11","author":"Li","year":"2011","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib61","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.3390\/ijms22094326","article-title":"Delineating the Tnt1 insertion landscape of the model legume Medicago truncatula cv. R108 at the Hi-C resolution using a chromosome-length genome assembly","volume":"22","author":"Kaur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib62","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-313X.2008.03418.x","article-title":"Large-scale insertional mutagenesis using the Tnt1 retrotransposon in the model legume Medicago truncatula","volume":"54","author":"Tadege","year":"2008","journal-title":"Plant J."},{"key":"10.1016\/j.cell.2026.07.033_bib63","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1094\/MPMI-01-21-0019-R","article-title":"Salt stress enhances early symbiotic gene expression in Medicago truncatula and induces a stress-specific set of rhizobium-responsive genes","volume":"34","author":"Chakraborty","year":"2021","journal-title":"Mol. Plant Microbe Interact."},{"key":"10.1016\/j.cell.2026.07.033_bib64","doi-asserted-by":"crossref","first-page":"ME24023","DOI":"10.1264\/jsme2.ME24023","article-title":"Effects of NaCl treatment on root nodule formation, isoflavone secretion in soybean, and nodulation gene expression in rhizobia","volume":"39","author":"Nitawaki","year":"2024","journal-title":"Microbes Environ."},{"key":"10.1016\/j.cell.2026.07.033_bib65","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1105\/tpc.104.030106","article-title":"The sulfate transporter SST1 is crucial for symbiotic nitrogen fixation in Lotus japonicus root nodules","volume":"17","author":"Krusell","year":"2005","journal-title":"Plant Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cub.2005.01.042","article-title":"Symbiotic leghemoglobins are crucial for nitrogen fixation in legume root nodules but not for general plant growth and development","volume":"15","author":"Ott","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib67","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.1184057","article-title":"Plant peptides govern terminal differentiation of bacteria in symbiosis","volume":"327","author":"Van de Velde","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib68","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/pcp\/pcr167","article-title":"The integral membrane protein SEN1 is required for symbiotic nitrogen fixation in Lotus japonicus nodules","volume":"53","author":"Hakoyama","year":"2012","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.cell.2026.07.033_bib69","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/jxb\/eru545","article-title":"Multiple steps control immunity during the intracellular accommodation of rhizobia","volume":"66","author":"Berrabah","year":"2015","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.cell.2026.07.033_bib70","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.1184096","article-title":"A nodule-specific protein secretory pathway required for nitrogen-fixing symbiosis","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib112","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1105\/tpc.113.114017","article-title":"The C2H2 transcription factor regulator of symbiosome differentiation represses transcription of the secretory pathway gene VAMP721a and promotes symbiosome development in Medicago truncatula","volume":"25","author":"Sinharoy","year":"2013","journal-title":"Plant Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib71","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.07.033_bib72","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-313X.1991.00027.x","article-title":"Leghaemoglobin gene transcription is triggered in a single cell layer in the indeterminate nitrogen-fixing root nodule of alfalfa","volume":"1","author":"De Billy","year":"1991","journal-title":"Plant J."},{"key":"10.1016\/j.cell.2026.07.033_bib73","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/nph.12091","article-title":"Medicago truncatula DNF2 is a PI-PLC-XD-containing protein required for bacteroid persistence and prevention of nodule early senescence and defense-like reactions","volume":"197","author":"Bourcy","year":"2013","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib74","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41477-024-01666-3","article-title":"Spatial co-transcriptomics reveals discrete stages of the arbuscular mycorrhizal symbiosis","volume":"10","author":"Serrano","year":"2024","journal-title":"Nat. Plants"},{"key":"10.1016\/j.cell.2026.07.033_bib75","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41576-021-00413-0","article-title":"Abiotic stress responses in plants","volume":"23","author":"Zhang","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2026.07.033_bib76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/pce.13348","article-title":"Legume nodulation: the host controls the party","volume":"42","author":"Ferguson","year":"2018","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.cell.2026.07.033_bib77","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.molp.2020.12.015","article-title":"GSK3-mediated stress signaling inhibits legume\u2013rhizobium symbiosis by phosphorylating GmNSP1 in soybean","volume":"14","author":"He","year":"2021","journal-title":"Mol. Plant"},{"key":"10.1016\/j.cell.2026.07.033_bib78","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/nph.18627","article-title":"Discovering the genetic modules controlling root nodule symbiosis under abiotic stresses: salinity as a case study","volume":"237","author":"Singh","year":"2022","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1104\/pp.74.1.72","article-title":"Effect of salinity on nodule formation by soybean","volume":"74","author":"Singleton","year":"1984","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cell.2026.07.033_bib80","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2010.10.020","article-title":"Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root","volume":"143","author":"Tsukagoshi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib81","article-title":"Root-specific photoreception directs early root development by HY5-regulated ROS balance","volume":"121","author":"Li","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.07.033_bib82","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1469-8137.2004.01285.x","article-title":"Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process","volume":"165","author":"Puppo","year":"2005","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1104\/pp.121.1.97","article-title":"Stress-induced legume root nodule senescence: physiological, biochemical, and structural alterations","volume":"121","author":"Matamoros","year":"1999","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cell.2026.07.033_bib84","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tplants.2019.01.004","article-title":"Hormesis: a compelling platform for sophisticated plant science","volume":"24","author":"Agathokleous","year":"2019","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib85","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tplants.2016.08.002","article-title":"ROS are good","volume":"22","author":"Mittler","year":"2017","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.cell.2026.07.033_bib86","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/nph.12714","article-title":"RbohB, a Phaseolus vulgaris NADPH oxidase gene, enhances symbiosome number, bacteroid size, and nitrogen fixation in nodules and impairs mycorrhizal colonization","volume":"202","author":"Arthikala","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib87","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1469-8137.2010.03509.x","article-title":"A Medicago truncatula NADPH oxidase is involved in symbiotic nodule functioning","volume":"189","author":"Marino","year":"2011","journal-title":"New Phytol."},{"key":"10.1016\/j.cell.2026.07.033_bib88","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2026.01.001","article-title":"Evolution of root nodule symbiosis via paleopolyploidy and modular pathway rewiring","volume":"34","author":"Liu","year":"2026","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2026.07.033_bib89","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.07.033_bib90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.07.033_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11257","article-title":"Fast and sensitive taxonomic classification for metagenomics with Kaiju","volume":"7","author":"Menzel","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.033_bib92","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.07.033_bib93","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cell.2026.07.033_bib94","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cell.2026.07.033_bib95","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmeth.4285","article-title":"ModelFinder: fast model selection for accurate phylogenetic estimates","volume":"14","author":"Kalyaanamoorthy","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.07.033_bib96","doi-asserted-by":"crossref","first-page":"W78","DOI":"10.1093\/nar\/gkae268","article-title":"Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool","volume":"52","author":"Letunic","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.07.033_bib97","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.07.033_bib98","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2026.07.033_bib99","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-021-02286-2","article-title":"Giotto: a toolbox for integrative analysis and visualization of spatial expression data","volume":"22","author":"Dries","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.07.033_bib100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"Mfuzz: a software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation"},{"key":"10.1016\/j.cell.2026.07.033_bib101","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cell.2026.07.033_bib102","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2026.07.033_bib103","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41477-018-0286-7","article-title":"Whole-genome landscape of Medicago truncatula symbiotic genes","volume":"4","author":"Pecrix","year":"2018","journal-title":"Nat. Plants"},{"key":"10.1016\/j.cell.2026.07.033_bib109","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1060966","article-title":"The composite genome of the legume symbiont Sinorhizobium meliloti","volume":"293","author":"Galibert","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.033_bib104","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.07.033_bib105","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.033_bib106","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.molp.2017.01.003","article-title":"CRISPR-P 2.0: an improved CRISPR-Cas9 tool for genome editing in plants","volume":"10","author":"Liu","year":"2017","journal-title":"Mol. Plant"},{"key":"10.1016\/j.cell.2026.07.033_bib107","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1094\/MPMI.2001.14.6.695","article-title":"Agrobacterium rhizogenes-transformed roots of Medicago truncatula for the study of nitrogen-fixing and endomycorrhizal symbiotic associations","volume":"14","author":"Boisson-Dernier","year":"2001","journal-title":"Mol. Plant Microbe Interact."},{"key":"10.1016\/j.cell.2026.07.033_bib108","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gkw982","article-title":"PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants","volume":"45","author":"Jin","year":"2017","journal-title":"Nucleic Acids Res."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426008652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426008652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:12:53Z","timestamp":1792213973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426008652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":110,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0092867426008652"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.07.033","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal co-transcriptomics uncovers coordinated rhizobia-legume stress programs supporting nitrogen fixation in Medicago","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}