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Commun."},{"key":"10.1016\/j.cell.2026.07.045_bib39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. 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Neurosci."},{"key":"10.1016\/j.cell.2026.07.045_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111189","article-title":"Disease-associated oligodendrocyte responses across neurodegenerative diseases","volume":"40","author":"Pandey","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.07.045_bib47","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41593-023-01334-3","article-title":"Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease","volume":"26","author":"Sun","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2026.07.045_bib48","doi-asserted-by":"crossref","first-page":"19466","DOI":"10.1074\/jbc.M113.530972","article-title":"Neuroligin 1 induces blood vessel maturation by cooperating with the \u03b16 integrin","volume":"289","author":"Samarelli","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2026.07.045_bib49","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301984","article-title":"Basonuclin-2 regulates extracellular matrix production and degradation","volume":"6","author":"Orang","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.cell.2026.07.045_bib50","article-title":"Multiciliated ependymal cells: an update on biology and pathology in the adult brain","volume":"148","author":"Groh","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.cell.2026.07.045_bib51","article-title":"Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.045_bib52","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2026.07.045_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrm.2015.16","article-title":"Mechanisms of ephrin-Eph signalling in development, physiology and disease","volume":"17","author":"Kania","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2026.07.045_bib54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41583-020-00415-7","article-title":"Neurexins: molecular codes for shaping neuronal synapses","volume":"22","author":"Gomez","year":"2021","journal-title":"Nat. Rev. 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Ther."},{"key":"10.1016\/j.cell.2026.07.045_bib58","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1016\/j.cell.2024.05.058","article-title":"Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain","volume":"187","author":"Scott-Hewitt","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.045_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49596-0","article-title":"Adult microglial TGF\u03b21 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice","volume":"15","author":"Bedolla","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.045_bib60","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.it.2020.07.003","article-title":"The Role of TGFbeta Signaling in Microglia Maturation and Activation","volume":"41","author":"Spittau","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cell.2026.07.045_bib61","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.stem.2022.11.010","article-title":"Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease","volume":"29","author":"Herdy","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2026.07.045_bib62","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.neurobiolaging.2013.04.013","article-title":"Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice","volume":"34","author":"Xie","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cell.2026.07.045_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111773","article-title":"The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model","volume":"11","author":"Bauch","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cell.2026.07.045_bib64","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nn.2220","article-title":"PDGFRA\/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice","volume":"11","author":"Rivers","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2026.07.045_bib65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-019-0204-5","article-title":"The ageing epigenome and its rejuvenation","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2026.07.045_bib66","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41422-022-00719-6","article-title":"Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain","volume":"32","author":"Zhang","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.cell.2026.07.045_bib67","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1016\/j.cell.2023.08.040","article-title":"Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion","volume":"186","author":"Xiong","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.07.045_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf7044","article-title":"A comparative atlas of single-cell chromatin accessibility in the human brain","volume":"382","author":"Li","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.045_bib69","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41586-019-1917-5","article-title":"Decoding the development of the human hippocampus","volume":"577","author":"Zhong","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.045_bib70","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1523\/JNEUROSCI.22-13-05354.2002","article-title":"Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein","volume":"22","author":"Yao","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2026.07.045_bib71","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s43587-022-00214-y","article-title":"Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila","volume":"2","author":"Schmid","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.cell.2026.07.045_bib72","article-title":"CTCF and transcription influence chromatin structure re-configuration after mitosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.045_bib73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.07.045_bib74","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/s41591-024-02960-5","article-title":"Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants","volume":"30","author":"Rahman","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.07.045_bib75","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1474-4422(11)70105-3","article-title":"Vascular aspects of multiple sclerosis","volume":"10","author":"D'haeseleer","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cell.2026.07.045_bib76","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41588-020-00776-w","article-title":"Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes","volume":"53","author":"Schwartzentruber","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.07.045_bib77","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/s43587-024-00734-9","article-title":"Phenome-wide associations of human aging uncover sex-specific dynamics","volume":"4","author":"Reicher","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.cell.2026.07.045_bib78","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41582-025-01071-0","article-title":"Alzheimer disease seen through the lens of sex and gender","volume":"21","author":"Castro-Aldrete","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cell.2026.07.045_bib79","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1093\/nar\/gkq636","article-title":"Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures","volume":"38","author":"Plaisier","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.07.045_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-27903-2","article-title":"Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach","volume":"8","author":"Cahill","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.07.045_bib81","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajp.22375","article-title":"Managing the Cayo Santiago rhesus macaque population: The role of density","volume":"78","author":"Hernandez-Pacheco","year":"2016","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.cell.2026.07.045_bib82","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1098\/rstb.2005.1771","article-title":"Normal brain ageing: models and mechanisms","volume":"360","author":"Toescu","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond., B Biol. Sci."},{"key":"10.1016\/j.cell.2026.07.045_bib83","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrn3200","article-title":"The ageing cortical synapse: hallmarks and implications for cognitive decline","volume":"13","author":"Morrison","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2026.07.045_bib84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuron.2024.10.019","article-title":"White matter aging and its impact on brain function","volume":"113","author":"Groh","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2026.07.045_bib85","article-title":"Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level","author":"Mesecar","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.cell.2026.07.045_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/science.aea9795","article-title":"Lifelong behavioral screen reveals an architecture of vertebrate aging","volume":"391","author":"Bedbrook","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.045_bib87","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf5357","article-title":"Single-cell DNA methylation and 3D genome architecture in the human brain","volume":"382","author":"Tian","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.07.045_bib88","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41586-025-08596-w","article-title":"Integrated analysis of the complete sequence of a macaque genome","volume":"640","author":"Zhang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.045_bib89","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41592-023-01943-7","article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","volume":"20","author":"Fleming","year":"2023","journal-title":"Nat. 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Biotechnol."},{"key":"10.1016\/j.cell.2026.07.045_bib93","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2026.07.045_bib94","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.07.045_bib95","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.07.045_bib96","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1093\/bioinformatics\/btac562","article-title":"The FASTQ+ format and PISA","volume":"38","author":"Shi","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.07.045_bib97","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41588-021-00790-6","article-title":"ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis","volume":"53","author":"Granja","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2026.07.045_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based Analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.07.045_bib99","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.07.045_bib100","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.07.045_bib101","doi-asserted-by":"crossref","first-page":"D1243","DOI":"10.1093\/nar\/gkae974","article-title":"The UCSC Genome Browser database: 2025 update","volume":"53","author":"Perez","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.07.045_bib102","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1038\/s41596-021-00514-4","article-title":"Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications","volume":"16","author":"Maitra","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2026.07.045_bib103","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41586-022-04625-0","article-title":"Rolling back human pluripotent stem cells to an eight-cell embryo-like stage","volume":"605","author":"Mazid","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.07.045_bib104","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-025-03652-0","article-title":"Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis","volume":"26","author":"Deng","year":"2025","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.07.045_bib105","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/s41587-023-01881-x","article-title":"Systematic benchmarking of single-cell ATAC-sequencing protocols","volume":"42","author":"De Rop","year":"2024","journal-title":"Nat. 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