{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:36:45Z","timestamp":1792773405194,"version":"4.5.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002112","name":"A P Giannini Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"Tobacco-Related Disease Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cell.2026.09.045","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:04:50Z","timestamp":1792767890000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer"],"prefix":"10.1016","author":[{"given":"Jun W.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Bebber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Edenhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"R\u00f6sner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Berning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan B.","family":"Leak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Stroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindesh","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali T.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Prymidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando J.","family":"Olivos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuyen","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ting","family":"Shue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nishiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros P.","family":"Drainas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Chaikovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystina","family":"Szylo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun P.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvathy","family":"Manoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro Quintanal","family":"Villalonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Rudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina M.","family":"DeNicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"von Karstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-9968","authenticated-orcid":false,"given":"Julien","family":"Sage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.09.045_bib1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2020.03.007","article-title":"Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance","volume":"37","author":"Marusyk","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s43018-023-00595-y","article-title":"Cancer cell plasticity during tumor progression, metastasis and response to therapy","volume":"4","author":"P\u00e9rez-Gonz\u00e1lez","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature22323","article-title":"Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer","volume":"545","author":"Lim","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s43018-019-0020-z","article-title":"Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer","volume":"1","author":"Stewart","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ccell.2020.12.014","article-title":"Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities","volume":"39","author":"Gay","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13322","article-title":"Vasculogenic mimicry in small cell lung cancer","volume":"7","author":"Williamson","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib7","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ccell.2021.09.008","article-title":"Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer","volume":"39","author":"Chan","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ccell.2016.12.005","article-title":"MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition","volume":"31","author":"Mollaoglu","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29517-9","article-title":"Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models","volume":"13","author":"Lissa","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jtho.2021.08.763","article-title":"Molecular Subtypes of Primary SCLC Tumors and Their Associations With Neuroendocrine and Therapeutic Markers","volume":"17","author":"Qu","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.cell.2026.09.045_bib11","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.jtho.2020.09.009","article-title":"SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization","volume":"15","author":"Baine","year":"2020","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.cell.2026.09.045_bib12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41568-019-0133-9","article-title":"Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data","volume":"19","author":"Rudin","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ccr.2010.12.021","article-title":"A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer","volume":"19","author":"Calbo","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ccell.2020.05.001","article-title":"MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate","volume":"38","author":"Ireland","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30416-2","article-title":"A conserved YAP\/Notch\/REST network controls the neuroendocrine cell fate in the lungs","volume":"13","author":"Shue","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg1850","article-title":"YAP drives fate conversion and chemoresistance of small cell lung cancer","volume":"7","author":"Wu","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2026.09.045_bib17","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jtho.2023.07.012","article-title":"Lineage Plasticity in SCLC Generates Non-Neuroendocrine Cells Primed for Vasculogenic Mimicry","volume":"18","author":"Pearsall","year":"2023","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.cell.2026.09.045_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aau2922","article-title":"Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition","volume":"12","author":"Augert","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cell.2026.09.045_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24164-y","article-title":"Notch signaling and efficacy of PD-1\/PD-L1 blockade in relapsed small cell lung cancer","volume":"12","author":"Roper","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib20","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1101\/gad.314815.118","article-title":"POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer","volume":"32","author":"Huang","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2026.09.045_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22336-4","article-title":"Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes","volume":"12","author":"Bebber","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib22","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1158\/1078-0432.CCR-18-4140","article-title":"MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion","volume":"25","author":"Chalishazar","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib23","article-title":"Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities","volume":"5","author":"Desai","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cell.2026.09.045_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11371-x","article-title":"MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer","volume":"10","author":"Dammert","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib25","article-title":"FDA approves first DLL3 \u00d7 CD3 bispecific T-cell engager for lung cancer","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2026.09.045_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175217","article-title":"Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer","volume":"134","author":"Ku","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2026.09.045_bib27","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41556-023-01210-z","article-title":"KDM6A epigenetically regulates subtype plasticity in small cell lung cancer","volume":"25","author":"Duplaquet","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib28","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1158\/2159-8290.CD-20-0913","article-title":"Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity","volume":"11","author":"Mahadevan","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2026.09.045_bib29","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1158\/2159-8290.CD-20-1863","article-title":"Multiomic analysis of lung tumors defines pathways activated in neuroendocrine transformation","volume":"11","author":"Quintanal-Villalonga","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2026.09.045_bib30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1101\/gad.348295.121","article-title":"ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer","volume":"35","author":"Olsen","year":"2021","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2026.09.045_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.devcel.2020.06.018","article-title":"Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments","volume":"54","author":"Li","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","article-title":"The hallmarks of cancer metabolism: Still emerging","volume":"34","author":"Pavlova","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41573-021-00339-6","article-title":"Targeting cancer metabolism in the era of precision oncology","volume":"21","author":"Stine","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2026.09.045_bib34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Mart\u00ednez-Reyes","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib35","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s41586-023-06130-4","article-title":"Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours","volume":"618","author":"Gavish","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cell.2015.12.034","article-title":"Metabolic Heterogeneity in Human Lung Tumors","volume":"164","author":"Hensley","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-019-1847-2","article-title":"Metabolic heterogeneity confers differences in melanoma metastatic potential","volume":"577","author":"Tasdogan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib38","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.cell.2023.01.038","article-title":"What is cancer metabolism?","volume":"186","author":"Finley","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccell.2023.01.009","article-title":"Metabolic programming and immune suppression in the tumor microenvironment","volume":"41","author":"Arner","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.102362","article-title":"Spatial metabolomics principles and application to cancer research","volume":"76","author":"Planque","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cmet.2018.06.005","article-title":"Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers","volume":"28","author":"Huang","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cell.2026.09.045_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature14664","article-title":"Comprehensive genomic profiles of small cell lung cancer","volume":"524","author":"George","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: the bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cell.2026.09.045_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-cancerbio-030518-055844","article-title":"The hallmarks of ferroptosis","volume":"3","author":"Dixon","year":"2019","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib46","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib47","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib48","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41556-020-0565-1","article-title":"Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture","volume":"22","author":"Riegman","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010164","article-title":"Ferroptosis in Cancer Cell Biology","volume":"12","author":"Bebber","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cell.2026.09.045_bib51","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1158\/0008-5472.CAN-19-1027","article-title":"The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer","volume":"80","author":"Cristea","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1535-6108(03)00220-4","article-title":"Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model","volume":"4","author":"Meuwissen","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.copbio.2021.03.001","article-title":"Glutathione and its precursors in cancer","volume":"68","author":"Asantewaa","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.cell.2026.09.045_bib54","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/cancers3011285","article-title":"Glutathione in cancer cell death","volume":"3","author":"Ortega","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cell.2026.09.045_bib55","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41416-020-01156-1","article-title":"Cysteine metabolic circuitries: druggable targets in cancer","volume":"124","author":"Bonif\u00e1cio","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib56","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1128\/MCB.01408-13","article-title":"Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling","volume":"34","author":"Wakabayashi","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib57","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm9427","article-title":"Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction","volume":"8","author":"Fujihara","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2026.09.045_bib59","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s43018-022-00355-4","article-title":"MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis","volume":"3","author":"Alborzinia","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib61","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.045_bib62","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112899","article-title":"Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy","volume":"42","author":"Kodama","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.09.045_bib64","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nm.4232","article-title":"Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth","volume":"23","author":"Cramer","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.09.045_bib65","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00204-006-0173-2","article-title":"Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria","volume":"81","author":"Santos","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cell.2026.09.045_bib67","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1158\/0008-5472.CAN-22-3000","article-title":"Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors","volume":"83","author":"Yoon","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib68","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cmet.2019.09.009","article-title":"Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation","volume":"30","author":"Zhu","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib66","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2023.12.004","article-title":"Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib69","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/s41586-026-10268-2","article-title":"Catabolism of extracellular glutathione supplies cysteine to support tumours","volume":"653","author":"Hecht","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib70","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.cell.2026.09.045_bib71","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1158\/1541-7786.MCR-22-0594","article-title":"BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation","volume":"21","author":"Chen","year":"2023","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib73","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/s41388-022-02240-x","article-title":"Therapeutic targeting of BAP1\/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer","volume":"41","author":"Tsuboyama","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2026.09.045_bib74","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114841","article-title":"Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells","volume":"14","author":"Costanzo","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cell.2026.09.045_bib75","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.celrep.2016.06.081","article-title":"ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs","volume":"16","author":"Borromeo","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.09.045_bib76","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nn1247","article-title":"Ascl1\/Mash1 is required for the development of central serotonergic neurons","volume":"7","author":"Pattyn","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2026.09.045_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01366-4","article-title":"Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons","volume":"11","author":"Earley","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.09.045_bib78","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0006-291X(68)90309-4","article-title":"The effect of variation of cofactor and substrate structure on the action of phenylalanine hydroxylase","volume":"32","author":"Storm","year":"1968","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib79","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2174\/1570159X18666200729103529","article-title":"Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry","volume":"19","author":"Fanet","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cell.2026.09.045_bib80","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib81","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1158\/0008-5472.CAN-21-2964","article-title":"Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy","volume":"82","author":"Quintanal-Villalonga","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29794-4","article-title":"Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts","volume":"13","author":"Caeser","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib83","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nchembio.1986","article-title":"Correlating chemical sensitivity and basal gene expression reveals mechanism of action","volume":"12","author":"Rees","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib84","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1158\/2159-8290.CD-15-0235","article-title":"Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset","volume":"5","author":"Seashore-Ludlow","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cell.2026.09.045_bib85","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2013.08.003","article-title":"An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules","volume":"154","author":"Basu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib86","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2026.09.045_bib87","doi-asserted-by":"crossref","first-page":"14788","DOI":"10.1073\/pnas.1410419111","article-title":"ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers","volume":"111","author":"Augustyn","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cell.2026.09.045_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11050678","article-title":"The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival","volume":"11","author":"Combs","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cell.2026.09.045_bib89","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/s42255-020-0253-2","article-title":"Polyamine pathway activity promotes cysteine essentiality in cancer cells","volume":"2","author":"Zhang","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib90","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ijc.28420","article-title":"A novel role of the tumor suppressor GNMT in cellular defense against DNA damage","volume":"134","author":"Wang","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib91","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chembiol.2020.03.015","article-title":"Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit","volume":"27","author":"Zou","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib92","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/febs.15842","article-title":"Understanding the role of cysteine in ferroptosis: progress & paradoxes","volume":"289","author":"Poltorack","year":"2022","journal-title":"FEBS Journal"},{"key":"10.1016\/j.cell.2026.09.045_bib93","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib94","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.celrep.2016.07.009","article-title":"Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis","volume":"16","author":"Padanad","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.09.045_bib95","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1016\/j.molcel.2023.08.004","article-title":"Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response","volume":"83","author":"Swanda","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib96","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.stem.2015.12.003","article-title":"Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming","volume":"18","author":"Gasc\u00f3n","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib97","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.stem.2026.04.017","article-title":"Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging","volume":"33","author":"Zhang","year":"2026","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-67142-4","article-title":"Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression","volume":"16","author":"Androulidaki","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib99","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2026.09.045_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2026.1756238","article-title":"A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity","volume":"14","author":"Seidel","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib101","doi-asserted-by":"crossref","DOI":"10.1186\/s40170-021-00270-9","article-title":"Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer","volume":"9","author":"Cargill","year":"2021","journal-title":"Cancer Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib102","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41586-024-08575-7","article-title":"Intrinsic electrical activity drives small-cell lung cancer progression","volume":"639","author":"Peinado","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.045_bib103","doi-asserted-by":"crossref","DOI":"10.1186\/s40170-025-00382-6","article-title":"Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation","volume":"13","author":"Solta","year":"2025","journal-title":"Cancer Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib104","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00280-008-0894-4","article-title":"The xc- cystine\/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine","volume":"64","author":"Guan","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.cell.2026.09.045_bib105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cllc.2020.07.012","article-title":"Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer","volume":"21","author":"Hall","year":"2020","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib106","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/bjc.2011.524","article-title":"Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase","volume":"106","author":"Kelly","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib107","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s43018-023-00649-1","article-title":"Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma","volume":"5","author":"Recouvreux","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib108","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.cmet.2023.10.005","article-title":"Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice","volume":"35","author":"Green","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib109","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s43018-023-00647-3","article-title":"Targeting pancreatic cancer metabolic dependencies through glutamine antagonism","volume":"5","author":"Encarnaci\u00f3n-Rosado","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib110","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"Kremer","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib111","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/s42255-023-00919-3","article-title":"Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells","volume":"5","author":"Linder","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2026.09.045_bib112","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20223-y","article-title":"Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy","volume":"12","author":"Tajan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.045_bib113","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/s41416-022-01965-6","article-title":"Sensitisation of cancer cells to radiotherapy by serine and glycine starvation","volume":"127","author":"Falcone","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2026.09.045_bib114","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41589-026-02145-w","article-title":"Defining and refining the cysteine redoxome through sulfur chemical biology","volume":"22","author":"Carroll","year":"2026","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2026.09.045_bib118","doi-asserted-by":"crossref","DOI":"10.21105\/joss.03167","article-title":"Visualizations with statistical details: The'ggstatsplot'approach","volume":"6","author":"Patil","year":"2021","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.cell.2026.09.045_bib120","doi-asserted-by":"crossref","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.cell.2026.09.045_bib117","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.09.045_bib115","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Ginestet","year":"2011"},{"key":"10.1016\/j.cell.2026.09.045_bib116","article-title":"EnhancedVolcano: Publication-ready volcano plots with 667 enhanced colouring and labeling. R package version 1.6","volume":"0","author":"Blighe","year":"2020","journal-title":"Com"},{"key":"10.1016\/j.cell.2026.09.045_bib119","unstructured":"Kolde R., Kolde M.R. Package \u2018pheatmap\u2019. R. Package 2015;1:790. https:\/\/www.vps.fmvz.usp.br\/CRAN\/web\/packages\/pheatmap\/pheatmap.pdf."},{"key":"10.1016\/j.cell.2026.09.045_bib121","doi-asserted-by":"crossref","first-page":"D129","DOI":"10.1093\/nar\/gkab1030","article-title":"Expression Atlas update: gene and protein expression in multiple species","volume":"50","author":"Moreno","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2026.09.045_bib122","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a Cancer Dependency Map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426011864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426011864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:05:05Z","timestamp":1792767905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426011864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":122,"alternative-id":["S0092867426011864"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.09.045","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.09.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}