{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:36:44Z","timestamp":1792773404469,"version":"4.5.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cell.2026.09.061","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:04:52Z","timestamp":1792767892000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages"],"prefix":"10.1016","author":[{"given":"Chenyang","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungjin","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rae","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hee","family":"Youm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Orliaguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Dlugos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ravussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janset","family":"Onyuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal M.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Siebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"LeBrasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa Deep","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2026.09.061_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological Actions of Taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2026.09.061_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1079\/BJN19860082","article-title":"Taurine concentrations in the diet, plasma, urine and breast milk of vegans compared with omnivores","volume":"56","author":"Rana","year":"1986","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.cell.2026.09.061_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn9257","article-title":"Taurine deficiency as a driver of aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl2116","article-title":"Is taurine an aging biomarker?","volume":"388","author":"Fernandez","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature24022","article-title":"Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing","volume":"550","author":"Camell","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","article-title":"Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging","volume":"18","author":"Youm","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.smim.2018.09.001","article-title":"NLRP3 inflammasome activation in inflammaging","volume":"40","author":"Latz","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib8","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.4049\/jimmunol.1501336","article-title":"Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances","volume":"197","author":"Bauernfeind","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib9","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.1016\/j.cell.2025.06.047","article-title":"Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures","volume":"188","author":"Ding","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41586-026-10542-3","article-title":"Universal transcriptomic hallmarks of mammalian ageing and mortality","volume":"654","author":"Tyshkovskiy","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13050","article-title":"NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice","volume":"19","author":"Mar\u00edn-Aguilar","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc7409","article-title":"Inhibition of the NLRP3 inflammasome prevents ovarian aging","volume":"7","author":"Navarro-Pando","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cell.2026.09.061_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imr.12608","article-title":"Metabolic regulation of NLRP3","volume":"281","author":"Hughes","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cell.2026.09.061_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer's disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41556-022-01053-0","article-title":"Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing","volume":"25","author":"Mitchell","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2026.09.061_bib16","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2026.09.061_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?","volume":"13","author":"Wen","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.09.061_bib19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cmet.2019.10.006","article-title":"Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis","volume":"30","author":"Camell","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.celrep.2011.11.005","article-title":"The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence","volume":"1","author":"Youm","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.09.061_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib25","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","article-title":"Mitochondria in the regulation of innate and adaptive immunity","volume":"42","author":"Weinberg","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.it.2023.01.006","article-title":"Oxidized mitochondrial DNA: a protective signal gone awry","volume":"44","author":"Xian","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib27","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360\u00b0 view of the inflammasome: Mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib28","first-page":"67","article-title":"Physiological adaptation to unstable environments","volume":"65","author":"Mangum","year":"1977","journal-title":"Am. Sci."},{"key":"10.1016\/j.cell.2026.09.061_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.abg7292","article-title":"Caloric restriction in humans reveals immunometabolic regulators of health span","volume":"375","author":"Spadaro","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mam.2011.07.001","article-title":"Caloric restriction","volume":"32","author":"Speakman","year":"2011","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.cell.2026.09.061_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116317","article-title":"Taurine transport is a critical modulator of ionic fluxes during NLRP3 inflammasome activation","volume":"44","author":"Rossi-Smith","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2026.09.061_bib32","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/S0168-8278(97)80470-9","article-title":"Taurine is an osmolyte in rat liver macrophages (Kupffer cells)","volume":"26","author":"Warskulat","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cell.2026.09.061_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1471-4159.1998.71020827.x","article-title":"Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine","volume":"71","author":"Brand","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2026.09.061_bib34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cmet.2019.06.018","article-title":"Identification and Application of Gene Expression Signatures Associated with Lifespan Extension","volume":"30","author":"Tyshkovskiy","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib35","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mad.2006.01.001","article-title":"Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse","volume":"127","author":"Uthus","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cell.2026.09.061_bib36","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.cell.2023.05.002","article-title":"Distinct longevity mechanisms across and within species and their association with aging","volume":"186","author":"Tyshkovskiy","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jn\/120.8.837","article-title":"Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes","volume":"120","author":"Rao","year":"1990","journal-title":"J. Nutr."},{"key":"10.1016\/j.cell.2026.09.061_bib38","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s42255-025-01297-8","article-title":"Cysteine depletion triggers adipose tissue thermogenesis and weight loss","volume":"7","author":"Lee","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib39","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1471-4159.1990.tb02332.x","article-title":"Specific antiserum and monoclonal antibodies against the taurine biosynthesis enzyme cysteine sulfinate decarboxylase: identity of brain and liver enzyme","volume":"54","author":"Remy","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2026.09.061_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(75)90918-X","article-title":"Cysteine oxidase in brain","volume":"97","author":"Misra","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2026.09.061_bib41","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/dmd.119.089995","article-title":"Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine","volume":"48","author":"Veeravalli","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cell.2026.09.061_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cell.2026.09.061_bib43","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nm.3898","article-title":"beta2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis","volume":"21","author":"Smith","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.09.061_bib44","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib46","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1016\/j.cell.2021.07.004","article-title":"Selective activation of PFKL suppresses the phagocytic oxidative burst","volume":"184","author":"Amara","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.765477","article-title":"Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation","volume":"12","author":"Shim","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib48","doi-asserted-by":"crossref","first-page":"10404","DOI":"10.1016\/S0021-9258(18)90979-8","article-title":"Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines","volume":"259","author":"Grisham","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2026.09.061_bib49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2026.09.061_bib50","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.immuni.2009.02.005","article-title":"The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA","volume":"30","author":"Allen","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib51","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20081667","article-title":"Inflammasome recognition of influenza virus is essential for adaptive immune responses","volume":"206","author":"Ichinohe","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2026.09.061_bib53","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib54","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","article-title":"KEfflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria","volume":"45","author":"Gro\u00df","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/B:NERE.0000010433.08577.96","article-title":"Regulation of the cellular content of the organic osmolyte taurine in mammalian cells","volume":"29","author":"Lambert","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cell.2026.09.061_bib56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.immuni.2012.06.013","article-title":"Cell volume regulation modulates NLRP3 inflammasome activation","volume":"37","author":"Compan","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7931","article-title":"Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation","volume":"6","author":"Ip","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.061_bib58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib59","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib60","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2009.05.005","article-title":"Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity","volume":"30","author":"Brydges","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2026.09.061_bib61","first-page":"G609","article-title":"Distinction between Chloride-Dependent Transport Systems for Taurine and Beta-Alanine in Rabbit Ileum","volume":"262","author":"Munck","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2026.09.061_bib62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00232716","article-title":"The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers","volume":"145","author":"Thwaites","year":"1995","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.cell.2026.09.061_bib63","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1042\/bj3000893","article-title":"Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta","volume":"300","author":"Ramamoorthy","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2026.09.061_bib64","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.bbamem.2008.04.012","article-title":"Function of taurine transporter (Slc6a6\/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells","volume":"1778","author":"Tomi","year":"2008","journal-title":"BBA-Biomembranes"},{"key":"10.1016\/j.cell.2026.09.061_bib65","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1113\/jphysiol.2008.164228","article-title":"Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl(-)-dependent TauT (SLC6A6)","volume":"587","author":"Anderson","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.cell.2026.09.061_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","article-title":"2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial","volume":"7","author":"Kraus","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.cell.2026.09.061_bib67","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s43587-026-01107-0","article-title":"Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging","volume":"6","author":"Mishra","year":"2026","journal-title":"Nat Aging"},{"key":"10.1016\/j.cell.2026.09.061_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36181-0","article-title":"FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans","volume":"14","author":"Choi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2026.09.061_bib69","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1126\/science.aac9257","article-title":"Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span","volume":"350","author":"Leiser","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib70","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2020.11.026","article-title":"Methionine transsulfuration pathway is upregulated in long-lived humans","volume":"162","author":"Mota-Martorell","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cell.2026.09.061_bib71","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140327","article-title":"COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status","volume":"5","author":"Thomas","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.cell.2026.09.061_bib72","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-021-05945-8","article-title":"Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak","volume":"21","author":"Sabaka","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cell.2026.09.061_bib73","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.cmet.2025.09.009","article-title":"Aged mice exhibit widespread metabolic changes but preserved major fluxes","volume":"37","author":"Jankowski","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib74","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1126\/science.286.5449.2498","article-title":"Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase","volume":"286","author":"Est\u00e9vez","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003543","article-title":"Two Distinct Modes of Hypoosmotic Medium-Induced Release of Excitatory Amino Acids and Taurine in the Rat Brain In Vivo","volume":"3","author":"Haskew-Layton","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2026.09.061_bib76","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41586-024-07585-9","article-title":"Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair","volume":"631","author":"Mehrotra","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib77","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.cell.2025.01.043","article-title":"Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response","volume":"188","author":"He","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib78","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.clinbiochem.2005.01.018","article-title":"Measurement of intracellular vitamin C levels in human lymphocytes by reverse phase high performance liquid chromatography (HPLC)","volume":"38","author":"Emadi-Konjin","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cell.2026.09.061_bib79","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jlb.48.2.174","article-title":"Taurine and Hypotaurine Content of Human Leukocytes","volume":"48","author":"Learn","year":"1990","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cell.2026.09.061_bib80","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cmet.2020.11.008","article-title":"Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity","volume":"33","author":"Brestoff","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2026.09.061_bib81","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1021\/jacs.5b06181","article-title":"Taurine Boosts Cellular Uptake of Small D-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly","volume":"137","author":"Zhou","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cell.2026.09.061_bib82","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1152\/physrev.1968.48.2.424","article-title":"Biochemistry and physiology of taurine and taurine derivatives","volume":"48","author":"Jacobsen","year":"1968","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2026.09.061_bib83","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nri.2016.151","article-title":"Homeostasis-altering molecular processes as mechanisms of inflammasome activation","volume":"17","author":"Liston","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2026.09.061_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","article-title":"Approaching the asymptote? Evolution and revolution in immunology","volume":"54","author":"Janeway","year":"1989","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.cell.2026.09.061_bib85","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.cell.2026.09.061_bib86","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41586-024-07801-6","article-title":"PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity","volume":"633","author":"Wei","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib87","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13749","article-title":"Platelet response to influenza vaccination reflects effects of aging","volume":"22","author":"Konstorum","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib88","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","article-title":"Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib89","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2026.09.061_bib90","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cell.2026.09.061_bib91","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2026.09.061_bib92","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.cell.2026.09.061_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010538","article-title":"Quantitative metabolomics by H-NMR and LC-MS\/MS confirms altered metabolic pathways in diabetes","volume":"5","author":"Lanza","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2026.09.061_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-02442-4","article-title":"Metabolomics biomarkers to predict acamprosate treatment response in alcohol-dependent subjects","volume":"7","author":"Hinton","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2026.09.061_bib95","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cell.2018.02.055","article-title":"IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation","volume":"173","author":"Karki","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cell.2026.09.061_bib96","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.immuni.2022.04.015","article-title":"Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs","volume":"55","author":"Eisenstein","year":"2022","journal-title":"Immunity"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426012079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867426012079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:05:05Z","timestamp":1792767905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867426012079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":96,"alternative-id":["S0092867426012079"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2026.09.061","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.09.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}