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Total and post\u2010mitochondrial heme content in liver was found to depend on both the level of hemolysis products in blood and agent's capacity to modify heme and hemoproteins. The increase of activity of 5\u2010aminolevulinate synthase (ALAS) and\/or heme accumulation in mitochondria was accompanied by increase of tryptophan\u20102,3\u2010dioxygenase (TDO) heme saturation. Membrane stabilisation by tocopherol or prevention of early ALAS induction by cycloheximide prevented both mitochondrial heme accumulation and increase of TDO heme saturation. Modification of heme fully prevented the alterations of total heme content even under severe hemolysis as well as the increase of TDO heme saturation if no increase of heme synthesis occurred. Thus heme synthesis can greatly contribute to heme intracellular redistribution under oxidative stress.<\/jats:p>","DOI":"10.1016\/j.cellbi.2004.11.004","type":"journal-article","created":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T12:53:44Z","timestamp":1106830424000},"page":"9-14","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intracellular redistribution of heme in rat liver under oxidative stress: the role of heme synthesis*"],"prefix":"10.1002","volume":"29","author":[{"given":"Pavel A.","family":"Kaliman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Barannik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Strel'chenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Inshina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(90)90032-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(94)90171-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1360885"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.6.1700"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj2020211","article-title":"The role of cytosolic proteins in the intracellular transport of haem in rat liver. 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