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To prove the hypothesis <jats:italic>Tetrahymena pyriformis<\/jats:italic> cultures were (1) starved for 24 h; (2) starved for 24 h and re\u2010fed for 30 min or (3) starved for 30 min. Amount and localization of vertebrate\u2010like hormones, produced by <jats:italic>Tetrahymena<\/jats:italic>, \u03b2\u2010endorphin, adrenocorticotropin (ACTH), serotonin, histamine, insulin and triiodothyronine (T<jats:sub>3<\/jats:sub>) were studied by immunocytochemical methods using flow cytometry and confocal microscopy. Long starvation elevated with 50% the hormone levels, while short starvation moderately elevated only the serotonin level in the cells. After short re\u2010feeding endorphin and histamine returned to the basal level, ACTH and serotonin approached the basal level, however, remained significantly higher, while insulin and T<jats:sub>3<\/jats:sub> stood at the starvation level. The results show that such a stress as long starvation provokes the enhanced production of hormones which likely needed for tolerating the life\u2010threatening effect of stress.<\/jats:p>","DOI":"10.1016\/j.cellbi.2007.02.007","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T18:58:32Z","timestamp":1172516312000},"page":"924-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Increased hormone levels in <i>Tetrahymena<\/i> after long\u2010lasting starvation"],"prefix":"10.1002","volume":"31","author":[{"given":"G.","family":"Csaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"P\u00e1llinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01425-2"},{"key":"e_1_2_1_3_1","first-page":"301","article-title":"Mechanisms controlling death, survival and proliferation in a model unicellular eukaryote Tetrahymena thermophila","volume":"2","author":"Christensen S.T.","year":"1995","journal-title":"Cell Death Differ"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62233-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2000"},{"key":"e_1_2_1_6_1","first-page":"361","article-title":"Effect of hormones on Protozoa. 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